DE69315578T2 - Verfahren zur herstellung von arzneiformulierungen - Google Patents

Verfahren zur herstellung von arzneiformulierungen

Info

Publication number
DE69315578T2
DE69315578T2 DE69315578T DE69315578T DE69315578T2 DE 69315578 T2 DE69315578 T2 DE 69315578T2 DE 69315578 T DE69315578 T DE 69315578T DE 69315578 T DE69315578 T DE 69315578T DE 69315578 T2 DE69315578 T2 DE 69315578T2
Authority
DE
Germany
Prior art keywords
mold
producing medical
medical formulations
disclosed
longitudinal axis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69315578T
Other languages
English (en)
Other versions
DE69315578D1 (de
Inventor
David John Livesley
Ian Michael Daines Gaylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fisons Ltd
Original Assignee
Fisons Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisons Ltd filed Critical Fisons Ltd
Application granted granted Critical
Publication of DE69315578D1 publication Critical patent/DE69315578D1/de
Publication of DE69315578T2 publication Critical patent/DE69315578T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
    • B30B15/02—Dies; Inserts therefor; Mounting thereof; Moulds
    • B30B15/022—Moulds for compacting material in powder, granular of pasta form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/007—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a plurality of pressing members working in different directions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A61M2202/066—Powder made from a compacted product by abrading
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S425/00—Plastic article or earthenware shaping or treating: apparatus
    • Y10S425/014—Expansible and collapsible
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S425/00—Plastic article or earthenware shaping or treating: apparatus
    • Y10S425/044—Rubber mold

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Saccharide Compounds (AREA)
DE69315578T 1992-06-30 1993-06-30 Verfahren zur herstellung von arzneiformulierungen Expired - Lifetime DE69315578T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929213874A GB9213874D0 (en) 1992-06-30 1992-06-30 Process to novel medicament form
PCT/GB1993/001375 WO1994000291A1 (en) 1992-06-30 1993-06-30 Process for production of medicament formulations

Publications (2)

Publication Number Publication Date
DE69315578D1 DE69315578D1 (de) 1998-01-15
DE69315578T2 true DE69315578T2 (de) 1998-04-02

Family

ID=10717946

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69315578T Expired - Lifetime DE69315578T2 (de) 1992-06-30 1993-06-30 Verfahren zur herstellung von arzneiformulierungen

Country Status (11)

Country Link
US (1) US5976436A (de)
EP (1) EP0650410B1 (de)
JP (1) JP3477201B2 (de)
AT (1) ATE160725T1 (de)
CA (1) CA2137826C (de)
DE (1) DE69315578T2 (de)
DK (1) DK0650410T3 (de)
ES (1) ES2110098T3 (de)
GB (1) GB9213874D0 (de)
GR (1) GR3026059T3 (de)
WO (1) WO1994000291A1 (de)

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IL111194A (en) * 1993-10-08 1998-02-08 Fisons Plc Process for the production of drug patramulations
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
DE4436854A1 (de) * 1994-10-15 1996-04-18 Ggu Gesundheits Umweltforsch Arzneistoff-Vorrat zur mechanischen Freisetzung von lungengängigen Wirkstoff-Aerosolen für die inhalative Applikation von Arzneistoffen
US5676967A (en) * 1995-04-18 1997-10-14 Brennen Medical, Inc. Mesh matrix wound dressing
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
DK1280520T4 (en) 2000-05-10 2018-06-25 Novartis Ag Phospholipid based powders for drug delivery
US7134623B2 (en) * 2001-05-17 2006-11-14 Rader Companies Hammermill
JP2004522578A (ja) * 2001-05-17 2004-07-29 レイダー カンパニーズ ハンマーミル
EP1458360B1 (de) 2001-12-19 2011-05-11 Novartis AG Pulmonale verabreichung von aminoglykosiden
SI1494732T1 (sl) 2002-03-20 2008-08-31 Mannking Corp Inhalacijski aparat
DK1572217T3 (da) 2002-12-12 2008-12-15 Nycomed Gmbh Kombinationsmedikament af R,R-formoterol og ciclesonid
MY143936A (en) 2003-03-27 2011-07-29 Nycomed Gmbh Process for preparing crystalline ciclesonide with defined particle size
US8371292B2 (en) 2003-09-16 2013-02-12 Nycomed Gmbh Use of ciclesonide for the treatment of respiratory diseases
US20080090753A1 (en) 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
DE102004026969A1 (de) * 2004-06-02 2005-12-29 Sms Meer Gmbh Vorrichtung zum Herstellen eines Formteils aus Pulver
JP5078014B2 (ja) 2004-08-20 2012-11-21 マンカインド コーポレイション ジケトピペラジン合成の触媒反応
HUE025151T2 (en) 2004-08-23 2016-01-28 Mannkind Corp Diceto-piperazine salts for drug delivery
EP1928423B1 (de) 2005-09-14 2015-12-09 Mannkind Corporation Verfahren zur arzneimittelformulierung basierend auf der affinitätssteigerung von aktiven wirkstoffen für kristalline mikropartikel-flächen
US20070185066A1 (en) * 2005-12-20 2007-08-09 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids
US20070178049A1 (en) * 2005-12-20 2007-08-02 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids having an enhanced pharmacokinetic profile
US20070249572A1 (en) * 2005-12-20 2007-10-25 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids
US20070197486A1 (en) * 2005-12-20 2007-08-23 Verus Pharmaceuticals, Inc. Methods and systems for the delivery of corticosteroids
US20070160542A1 (en) * 2005-12-20 2007-07-12 Verus Pharmaceuticals, Inc. Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile
EP1988880A2 (de) * 2006-02-15 2008-11-12 Tika Läkemedel AB Stabile mischung aus kortikosteroiden
EP1986679B1 (de) 2006-02-22 2017-10-25 MannKind Corporation Verfahren zur verbesserung der pharmazeutischen eigenschaften von mikropartikeln mit diketopiperazin und einem wirkstoff
KR101558026B1 (ko) 2008-06-13 2015-10-06 맨카인드 코포레이션 건조 분말 흡입기 및 약물 투여 시스템
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
CA2728523C (en) 2008-06-20 2020-03-10 Mannkind Corporation An interactive apparatus and method for real-time profiling of inhalation efforts
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
CN102186458A (zh) * 2008-10-14 2011-09-14 艾克蒂维罗有限责任公司 治疗慢性阻塞性肺病及其它肺疾病的方法
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
US8538707B2 (en) 2009-03-11 2013-09-17 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
EP2440184B1 (de) 2009-06-12 2023-04-05 MannKind Corporation Diketopiperazin-mikropartikel mit definierten spefiischen oberflächenbereichen
CA2778698A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
AR079451A1 (es) 2009-12-18 2012-01-25 Nycomed Gmbh Compuestos 3,4,4a,10b-tetrahidro-1h-tiopirano[4,3-c]isoquinolina
CA2801936C (en) 2010-06-21 2021-06-01 Mannkind Corporation Dry powder drug delivery system and methods
KR101940832B1 (ko) 2011-04-01 2019-01-21 맨카인드 코포레이션 의약 카트리지용 블리스터 패키지
EP2721036B1 (de) 2011-06-15 2015-07-22 Takeda GmbH Neuartige 3,4,4a,10b-tetrahydro-1h-thiopyrano[4,3-c]isochinolin-verbindungen
MX2013014888A (es) 2011-06-17 2014-02-27 Takeda Gmbh Novedosos derivados de ftalazinona-pirrolopirimidinacarboxamida.
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
EP2776053A1 (de) 2011-10-24 2014-09-17 MannKind Corporation Verfahren und zusammensetzungen zur schmerzbehandlung
CA2878457C (en) 2012-07-12 2021-01-19 Mannkind Corporation Dry powder drug delivery systems and methods
EP2911690A1 (de) 2012-10-26 2015-09-02 MannKind Corporation Inhalierbare influenza-impfstoffzusammensetzungen und verfahren
WO2014144895A1 (en) 2013-03-15 2014-09-18 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
BR122019026637B1 (pt) 2013-07-18 2023-09-26 Mannkind Corporation Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco
WO2015021064A1 (en) 2013-08-05 2015-02-12 Mannkind Corporation Insufflation apparatus and methods
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
WO2018069210A1 (en) 2016-10-10 2018-04-19 Takeda Gmbh Tetrahydrofuro[3,4-c]isoquinolines as inhibitors of pde4

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
US950567A (en) * 1908-11-30 1910-03-01 Granville Kesling Pipe and tile mold.
US2312381A (en) * 1940-10-24 1943-03-02 Frank J Bickenheuser Medicinal tablet
US2587215A (en) * 1949-04-27 1952-02-26 Frank P Priestly Inhalator
GB881701A (en) * 1959-09-11 1961-11-08 Ici Ltd Production of hollow articles from polytetrafluoroethylene
FR1346567A (fr) * 1962-12-26 1963-12-20 Asea Ab Appareil à haute pression, notamment pour la transformation du graphite en diamant
US3561079A (en) * 1968-03-11 1971-02-09 Robinson Clay Product Co The Apparatus for pressing of clay pipe using an elastomeric mandrel
US3583200A (en) * 1969-05-19 1971-06-08 Grotnes Machine Works Inc Expanding head and improved seal therefor
CA1058814A (en) * 1973-11-13 1979-07-24 Sumitomo Electric Industries, Ltd. Method for producing a tubular multi-layered porous barrier
US5288497A (en) * 1985-05-01 1994-02-22 The University Of Utah Compositions of oral dissolvable medicaments
CA2007683A1 (en) * 1989-02-03 1990-08-03 James C. Danly, Sr. Composite and self-lubricating bushing and method for making same
US5176132A (en) * 1989-05-31 1993-01-05 Fisons Plc Medicament inhalation device and formulation
DE69012458T3 (de) * 1989-05-31 2000-01-20 Fisons Plc Medikament und Inhalationsvorrichtung dafür.

Also Published As

Publication number Publication date
JPH07508194A (ja) 1995-09-14
ES2110098T3 (es) 1998-02-01
US5976436A (en) 1999-11-02
WO1994000291A1 (en) 1994-01-06
JP3477201B2 (ja) 2003-12-10
DE69315578D1 (de) 1998-01-15
GR3026059T3 (en) 1998-05-29
EP0650410B1 (de) 1997-12-03
DK0650410T3 (da) 1998-05-25
GB9213874D0 (en) 1992-08-12
EP0650410A1 (de) 1995-05-03
CA2137826C (en) 2005-01-25
ATE160725T1 (de) 1997-12-15
CA2137826A1 (en) 1994-01-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition