CA2463771A1 - Oligoamine compounds and derivatives thereof for cancer therapy - Google Patents

Oligoamine compounds and derivatives thereof for cancer therapy Download PDF

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Publication number
CA2463771A1
CA2463771A1 CA002463771A CA2463771A CA2463771A1 CA 2463771 A1 CA2463771 A1 CA 2463771A1 CA 002463771 A CA002463771 A CA 002463771A CA 2463771 A CA2463771 A CA 2463771A CA 2463771 A1 CA2463771 A1 CA 2463771A1
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CA
Canada
Prior art keywords
group
compound according
compound
another embodiment
butyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002463771A
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English (en)
French (fr)
Inventor
Benjamin Frydman
Aldonia L. Valasinas
Andrei V. Blokhin
Hirak S. Basu
Laurence J. Marton
Venodhar K. Reddy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PROGEN PHARMACEUTICALS Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2463771A1 publication Critical patent/CA2463771A1/en
Abandoned legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/18Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with hydroxy groups and at least two amino groups bound to the carbon skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/14Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
CA002463771A 2001-10-16 2002-10-16 Oligoamine compounds and derivatives thereof for cancer therapy Abandoned CA2463771A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32998201P 2001-10-16 2001-10-16
US60/329,982 2001-10-16
PCT/US2002/032932 WO2003033455A1 (en) 2001-10-16 2002-10-16 Oligoamine compounds and derivatives thereof for cancer therapy

Publications (1)

Publication Number Publication Date
CA2463771A1 true CA2463771A1 (en) 2003-04-24

Family

ID=23287844

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002463771A Abandoned CA2463771A1 (en) 2001-10-16 2002-10-16 Oligoamine compounds and derivatives thereof for cancer therapy

Country Status (7)

Country Link
US (3) US20030130356A1 (enExample)
EP (1) EP1436246A1 (enExample)
JP (1) JP2005506354A (enExample)
AU (2) AU2002340224B2 (enExample)
CA (1) CA2463771A1 (enExample)
IL (1) IL161428A0 (enExample)
WO (1) WO2003033455A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7312244B2 (en) 1999-04-30 2007-12-25 Cellgate, Inc. Polyamine analog-amino acid conjugates useful as anticancer agents
NZ515140A (en) * 1999-04-30 2003-07-25 Slil Biomedical Corp Conformationally restricted polyamine analogs as disease therapies for cancer, epilepsy, alzheimers, infections, grafts and others
MXPA01011008A (es) * 1999-04-30 2003-06-30 Slil Biomedical Corp Conjugados analogos de poliamina y conjugados de quinona novedosos como terapia para canceres y enfermedades de la prostata.
AU2002340224B2 (en) * 2001-10-16 2008-11-27 Progen Pharmaceuticals, Inc Oligoamine compounds and derivatives thereof for cancer therapy
WO2003050072A1 (en) * 2001-12-07 2003-06-19 Slil Biomedical Corporation Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor
MXPA04012841A (es) * 2002-06-26 2005-09-20 Cellgate Inc Conjugados de porfirina-poliamina para terapia de cancer.
US7095075B2 (en) * 2003-07-01 2006-08-22 Micron Technology, Inc. Apparatus and method for split transistor memory having improved endurance
US7241654B2 (en) * 2003-12-17 2007-07-10 Micron Technology, Inc. Vertical NROM NAND flash memory array
US7075146B2 (en) * 2004-02-24 2006-07-11 Micron Technology, Inc. 4F2 EEPROM NROM memory arrays with vertical devices
EP1799200A1 (en) * 2004-10-04 2007-06-27 Cellgate, Inc. Polyamine analogs as therapeutic agents for ocular diseases
WO2006086773A2 (en) * 2005-02-11 2006-08-17 Cellgate, Inc. Polyamine analogs as modulators of cell migration and cell motility
WO2007106554A2 (en) * 2006-03-14 2007-09-20 Progen Pharmaceuticals, Inc. Treatment and prevention of vascular hyperplasia using polyamine and polyamine analog compounds
IL187247A0 (en) * 2007-11-08 2008-12-29 Hadasit Med Res Service Novel synthetic analogs of sphingolipids
FR2932088B1 (fr) * 2008-06-06 2013-04-05 Lvmh Rech Utilisation d'un extrait de lepechinia caulescens comme agent cosmetique, et composition cosmetique le contenant
PL3149025T3 (pl) 2014-05-21 2019-11-29 Entrada Therapeutics Inc Peptydy penetrujące komórkę i sposoby ich wytwarzania i stosowania
US10815276B2 (en) 2014-05-21 2020-10-27 Entrada Therapeutics, Inc. Cell penetrating peptides and methods of making and using thereof
US10456443B2 (en) 2014-08-27 2019-10-29 Ohio State Innovation Foundation Peptidyl calcineurin inhibitors
WO2019070962A1 (en) 2017-10-04 2019-04-11 Ohio State Innovation Foundation BICYCLIC PEPTIDE INHIBITORS
EP3749365A4 (en) 2018-01-29 2022-01-12 Ohio State Innovation Foundation PEPTIDY INHIBITORS OF THE CALCINEURIN-NFAT INTERACTION
WO2019148195A2 (en) 2018-01-29 2019-08-01 Ohio State Innovation Foundation Cyclic peptidyl inhibitors of cal-pdz binding domain
WO2019165183A1 (en) 2018-02-22 2019-08-29 Entrada Therapeutics, Inc. Compositions and methods for treating mitochondrial neurogastrointestinal encephalopathy

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2440724A (en) 1944-10-27 1948-05-04 Commercial Solvents Corp Nu-substituted, 2-butene-1, 4-diamines, and process for preparing
US4013507A (en) 1973-09-18 1977-03-22 California Institute Of Technology Ionene polymers for selectively inhibiting the vitro growth of malignant cells
US3956502A (en) 1974-09-04 1976-05-11 Nalco Chemical Company Polyamine alcohols as microbiocides
PL109855B1 (en) 1977-12-12 1980-06-30 Bath for electro-galvanizing and polishing
US4661509A (en) 1982-09-28 1987-04-28 Gordon Arnold Z Methods for treating leukopenia
US4551550A (en) 1983-12-06 1985-11-05 Merrell Dow Pharmaceuticals Inc. N-2,3-Butadienyl-1,4-butanediamine derivatives
CA1247598A (en) * 1984-12-27 1988-12-28 Harry J. Andress, Jr. Compounds containing amide linkages from mono-and polycarboxylic acids in the same molecule and lubricants and fuels containing same
CS252771B1 (cs) * 1986-01-20 1987-10-15 Josef Urbanek Reakční produkty vyšších nasycených a/nebo nenasycených karboxylových kyselin s polytopickými aminy
US4889851A (en) 1986-11-21 1989-12-26 Fujisawa Pharmaceutical Co, Ltd. Benzothiadiazine compounds, and pharmaceutical composition comprising the same
US5393757A (en) 1986-12-02 1995-02-28 University Of Florida Polyamines and anti-diarrheal and gastrointestinal anti-spasmodic pharmaceutical compositions and methods of treatment
US5342945A (en) 1986-12-02 1994-08-30 University Of Florida Research Foundation, Inc. Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
US6184232B1 (en) 1986-12-02 2001-02-06 University Of Florida Analogs of biologically active, naturally occurring polyamines, pharmaceutical compositions and methods of treatment
US5677351A (en) 1986-12-02 1997-10-14 University Of Florida Research Foundation, Inc. Sterically hindered tetraamines and method for their production
US5091576A (en) 1986-12-02 1992-02-25 University Of Florida Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
USRE38417E1 (en) 1986-12-02 2004-02-03 University Of Florida Research Foundation, Inc. Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
US5654484A (en) 1987-10-08 1997-08-05 Merrell Pharmaceuticals Inc. Polyamine derivatives as antineoplastic agents
US4868219A (en) 1988-04-07 1989-09-19 Thornfeldt Carl R Treatment of skin diseases with aliphatic amines
CA2011367C (en) 1988-08-30 1997-07-08 Henry Ashjian Reaction products of alkenyl succinimides with ethylenediamine carboxy acids as fuel detergents
US5719193A (en) 1989-05-23 1998-02-17 Merrell Pharmaceuticals, Inc. Method of potentiating cell-mediated immunity utilizing polyamine derivatives
US5283367A (en) 1989-08-30 1994-02-01 Ciba-Geigy Corporation Substituted 1,4-diamino-2-butene stabilizers
JP3007391B2 (ja) 1990-08-13 2000-02-07 花王株式会社 新規第4級アンモニウム化合物
GB9111794D0 (en) 1991-05-31 1991-07-24 Robins David J Antifungal compounds
JPH06505996A (ja) 1991-08-23 1994-07-07 フアイザー・インコーポレイテツド 興奮性アミノ酸系神経伝達物質アンタゴニストとしての合成アリールポリアミン
US5185369A (en) 1991-08-23 1993-02-09 Pfizer Inc. Synthetic heteroaryl polyamines as excitatory amino acid neurotransmitter antagonists
US5242684A (en) 1991-10-25 1993-09-07 Isp Investments Inc. Antimicrobial, low toxicity, non-irritating composition comprising a blend of bis-quaternary ammonium compounds coprecipitated with a copolymer of vinylpyrrolidone and an acrylamido or vinyl quaternary ammonium monomer
US6051611A (en) 1991-11-08 2000-04-18 Alcon Laboratories, Inc. Polymeric quaternary ammonium compounds and their use as ophthalmic antimicrobias
US5512597A (en) 1991-11-08 1996-04-30 Alcon Laboratories, Inc. Polymeric quaternary ammonium compounds and their use as ophthalmic antimicrobials
US5530092A (en) 1992-01-13 1996-06-25 Dsm N.V. Dendritic macromolecule and the preparation thereof
GB9220921D0 (en) 1992-10-05 1992-11-18 Merrell Dow Pharma Polyamine derivatives as anticytomegaloviral agents
DE4306152A1 (de) 1993-02-27 1994-09-01 Hoechst Ag Positiv arbeitendes strahlungsempfindliches Gemisch und damit hergestelltes Aufzeichnungsmaterial
US5451347A (en) 1993-06-24 1995-09-19 Lumigen, Inc. Methods and compositions providing enhanced chemiluminescence from chemiluminescent compounds using dicationic surfactants
US5541230A (en) 1993-11-05 1996-07-30 Us Health Therapeutic polyamines
AU690618B2 (en) 1993-12-27 1998-04-30 Novartis Ag Unsaturate amino compounds for use as anticancer and antiprotozoic agent
WO1995020619A1 (en) 1994-01-28 1995-08-03 Dsm N.V. Dendritic macromolecule and a process for the preparation thereof
DE4403039A1 (de) 1994-01-28 1995-08-03 Schering Ag Oktaazamakrocyclen, deren Metallkomplexe, Verfahren zu deren Herstellung, diese Komplexe enthaltende Mittel sowie deren Verwendung in Diagnostik und Therapie
JPH07228589A (ja) 1994-02-16 1995-08-29 Fuji Photo Film Co Ltd リン酸エステル誘導体およびそれを含有するハロゲン化銀写真感光材料
JPH07277964A (ja) 1994-04-08 1995-10-24 Nippon Kayaku Co Ltd 抗腫瘍剤
US5750788A (en) 1994-11-12 1998-05-12 Basf Aktiengesellschaft Preparation of amines from compounds having at least 3 cyano groups
FR2729852A1 (fr) 1995-01-30 1996-08-02 Oreal Composition reductrice comprenant un acide amine basique et un polymere cationique
US6060604A (en) 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
EP0752465A1 (en) 1995-06-01 1997-01-08 The Procter & Gamble Company Betaine esters for delivery of alcohols
US6114108A (en) 1995-08-29 2000-09-05 V.I. Technologies, Inc. Methods and compositions for the selective modification of viral nucleic acids
US6136586A (en) 1995-08-29 2000-10-24 Vi Technologies, Inc. Methods for the selective modification of viral nucleic acids
EP0761680A3 (en) 1995-09-12 1999-05-06 Ono Pharmaceutical Co., Ltd. Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity
US5869715A (en) 1995-09-27 1999-02-09 The Reagents Of The University Of California Polyfunctional cationic cytofectins
US5886051A (en) 1995-11-08 1999-03-23 University Of Florida Research Foundation, Inc. Methods and compositions for the treatment of neurodegeneration
US6126964A (en) 1996-01-04 2000-10-03 Mirus Corporation Process of making a compound by forming a polymer from a template drug
US5962533A (en) * 1996-02-06 1999-10-05 University Of Florida Research Foundation, Inc. Hydroxy polyamines
EP0884944B1 (en) 1996-02-07 2001-11-28 Buckman Laboratories International, Inc. Synergistic antimicrobial compositions containing an ionene polymer and a salt of dodecylamine and methods of using the same
DE19621510A1 (de) 1996-05-29 1997-12-04 Basf Ag Dendritische stickstoffhaltige organische Verbindungen mit planar-chiralen oder axial-chiralen Endgruppen, ihre Herstellung und Verwendung
US6034129A (en) 1996-06-24 2000-03-07 Geltex Pharmaceuticals, Inc. Ionic polymers as anti-infective agents
DE19625982A1 (de) 1996-06-28 1998-01-02 Wella Ag Kosmetisches Mittel zur Haarbehandlung mit Dendrimeren
US5866016A (en) 1997-07-01 1999-02-02 Buckman Laboratories International, Inc. Methods and compositions for controlling biofouling using combinations of an ionene polymer and a salt of dodecylamine
US5958397A (en) 1996-07-22 1999-09-28 Schering-Plough Healthcare Products, Inc. Method and composition for protecting against jellyfish stings
US5906996A (en) 1996-08-21 1999-05-25 Murphy; Michael A. Tetramine treatment of neurological disorders
US6274630B1 (en) 1996-09-13 2001-08-14 University Of Florida Research Foundation, Inc. Method of inhibiting biosynthesis of EIf5A
AU4900797A (en) 1996-10-18 1998-05-15 Wisconsin Alumni Research Foundation Conformationally restricted polyamines and their use as antineoplastic agents
WO1998017747A1 (en) 1996-10-22 1998-04-30 Tonen Corporation Lubricating oil composition for automatic transmissions
US6235794B1 (en) 1997-04-03 2001-05-22 University Of Florida Biologically active spermidine analogues, pharmaceutical compositions and methods of treatment
US6093564A (en) 1997-10-03 2000-07-25 V.I. Technologies, Inc. Methods and compositions for the selective modification of nucleic acids
US6307102B1 (en) 1997-10-15 2001-10-23 Tosoh Corporation Amine catalyst for producing polyurethane and polyisocyanurate
US6046282A (en) 1998-01-06 2000-04-04 Air Products And Chemicals, Inc. Reactive diluents for polyamidoamine epoxy curatives
CA2321200A1 (en) 1998-02-27 1999-09-02 Dnavec Research Inc. Composition for transporting negatively charged substances
AU7131698A (en) 1998-04-21 1999-11-08 Ilex Oncology, Inc. Polyamine transport inhibitors
JP3996274B2 (ja) 1998-07-07 2007-10-24 電気化学工業株式会社 モノビニルアセチレンの製造方法
US6531512B1 (en) 1998-07-31 2003-03-11 Health Research Inc. Method of treating cancer in patients having a deficiency in p53 tumor suppressor gene
GB9817383D0 (en) 1998-08-10 1998-10-07 Ass Octel Diesel fuel compositions
JP2002525131A (ja) 1998-09-25 2002-08-13 ブイ.アイ. テクノロジーズ インク. 生物学的組成物においてウイルスを選択的に不活化する方法
WO2000028998A1 (en) 1998-11-16 2000-05-25 Rohto Pharmaceutical Co., Ltd. Liquid ophthalmic preparations
JP3747355B2 (ja) 1998-12-21 2006-02-22 独立行政法人理化学研究所 鎖状ポリアミン系化合物及びポリアミン系抗ガン剤
US7312244B2 (en) 1999-04-30 2007-12-25 Cellgate, Inc. Polyamine analog-amino acid conjugates useful as anticancer agents
US6649587B1 (en) 1999-04-30 2003-11-18 Slil Biomedical Corporation Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
MXPA01011008A (es) * 1999-04-30 2003-06-30 Slil Biomedical Corp Conjugados analogos de poliamina y conjugados de quinona novedosos como terapia para canceres y enfermedades de la prostata.
US6673890B1 (en) 1999-07-16 2004-01-06 Basf Aktiengesellschaft Zwitterionic polyamines and process for their production
GB9920107D0 (en) 1999-08-26 1999-10-27 Avecia Ltd Fluidising agents
JP2001131449A (ja) 1999-11-01 2001-05-15 Matsushita Electric Ind Co Ltd インクジェット記録用インク
FR2802817B1 (fr) 1999-12-23 2002-10-11 Centre Nat Rech Scient Nouveaux inhibiteurs de glycosidases et leurs applications pharmacologiques, notamment pour traiter le diabete
EP1408941B1 (en) 2000-01-10 2007-05-09 Zetetic Research, Inc. Use of a pharmaceutical composition comprising two quaternary ammonium compounds and an organometallic one in the treatment of viral and fungal infections and diseases
US6494944B1 (en) 2000-03-02 2002-12-17 Akzo Nobel N.V. Amine oxides as asphalt emulsifiers
FI112796B (fi) 2000-04-14 2004-01-15 Valtion Teknillinen Menetelmä oligo-/polymeripihkahappoaimididendrimeerien valmistamiseksi ja niiden käyttö
US6444707B1 (en) 2000-08-22 2002-09-03 West Agro Topically applied hoof treatment composition and concentrate
WO2002022584A1 (en) 2000-09-11 2002-03-21 Merck & Co., Inc. Thrombin inhibitors
AU2001293559A1 (en) 2000-09-19 2002-04-02 Dermal Therapy (Barbados) Inc. Topical analgesic compositions containing aliphatic polyamines and methods of using same
US6545181B1 (en) 2000-10-24 2003-04-08 Pilot Chemical Holdings, Inc. Demulsifying compound and a method of breaking or inhibiting emulsions
WO2002043722A2 (en) 2000-12-01 2002-06-06 The University Of British Columbia Copper chelators for treating ocular inflammation
US7754765B2 (en) 2000-12-01 2010-07-13 Radical Vision Therapeutics Inc Copper chelators for treating ocular inflammation
US6399662B1 (en) 2000-12-13 2002-06-04 University Of Florida Method and composition for the treatment of diarrhea and gastrointestinal spasms
WO2002062341A1 (en) 2001-02-07 2002-08-15 University Of Florida Method and composition for the control of hair growth
US6635679B2 (en) 2001-05-14 2003-10-21 Akzo Nobel N.V. Methods and compositions for inactivating viruses
US6713653B2 (en) 2001-08-24 2004-03-30 E. I. Du Pont De Nemours And Company Polyamines and polymers made therewith
AU2002340224B2 (en) 2001-10-16 2008-11-27 Progen Pharmaceuticals, Inc Oligoamine compounds and derivatives thereof for cancer therapy
US6458795B1 (en) 2001-11-15 2002-10-01 University Of Florida Method and composition for treatment of irritable bowel disease
US7273888B2 (en) 2001-11-16 2007-09-25 Als Therapy Development Foundation, Inc. Use of difluoromethylornithine (DFMO) for the treatment of amyotrophic lateral sclerosis
MXPA04007584A (es) 2002-02-07 2004-12-06 Wisconsin Alumni Res Found Compuestos de poliamina y composiciones para su uso en conjunto con una terapia contra el cancer.
US6881732B2 (en) 2002-06-13 2005-04-19 Chelator Llc Neuroprotection and cardioprotection afforded by chelators with high affinity and specificity for cations of first transition series elements
US7189865B2 (en) 2002-07-23 2007-03-13 Attenuon, Llc Thiomolybdate analogues and uses thereof
US20040019043A1 (en) 2002-07-23 2004-01-29 Dimitri Coucouvanis Thiomolybdate analogues and uses thereof

Also Published As

Publication number Publication date
US7491849B2 (en) 2009-02-17
AU2009200639A1 (en) 2009-03-12
US20090124832A1 (en) 2009-05-14
IL161428A0 (en) 2004-09-27
JP2005506354A (ja) 2005-03-03
EP1436246A1 (en) 2004-07-14
AU2002340224B2 (en) 2008-11-27
US20050080144A1 (en) 2005-04-14
US20030130356A1 (en) 2003-07-10
WO2003033455A1 (en) 2003-04-24

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued