CA2463101A1 - Azole derivatives and pharmaceutical compositions containing them - Google Patents

Azole derivatives and pharmaceutical compositions containing them Download PDF

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Publication number
CA2463101A1
CA2463101A1 CA002463101A CA2463101A CA2463101A1 CA 2463101 A1 CA2463101 A1 CA 2463101A1 CA 002463101 A CA002463101 A CA 002463101A CA 2463101 A CA2463101 A CA 2463101A CA 2463101 A1 CA2463101 A1 CA 2463101A1
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CA
Canada
Prior art keywords
optionally substituted
alkyl
imidazol
iodo
phenoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002463101A
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English (en)
French (fr)
Inventor
Stephen J. Arkinstall
Antonio Arulanandam
Xuliang Jiang
Sharad Magar
Roustem Nabioullin
John Yingsheng Zhang
Peter Blume-Jensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Serono SA
Original Assignee
Individual
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Filing date
Publication date
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Publication of CA2463101A1 publication Critical patent/CA2463101A1/en
Abandoned legal-status Critical Current

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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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CA002463101A 2001-10-23 2002-10-23 Azole derivatives and pharmaceutical compositions containing them Abandoned CA2463101A1 (en)

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WO2011106298A1 (en) 2010-02-25 2011-09-01 Dana-Farber Cancer Institute, Inc. Braf mutations conferring resistance to braf inhibitors
WO2013169858A1 (en) 2012-05-08 2013-11-14 The Broad Institute, Inc. Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy
US11078540B2 (en) 2010-03-09 2021-08-03 Dana-Farber Cancer Institute, Inc. Methods of diagnosing and treating cancer in patients having or developing resistance to a first cancer therapy

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US8546404B2 (en) 2005-12-13 2013-10-01 Merck Sharp & Dohme Compounds that are ERK inhibitors
MX2008010635A (es) 2006-02-16 2008-10-28 Schering Corp Derivados de pirrolidina como inhibidores de cinasa regulada por señales extracelulares.
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US20120263714A1 (en) 2009-10-21 2012-10-18 Bayer Intellectual Property Gmbh Substituted halophenoxybenzamide derivatives
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CN103282351A (zh) 2010-10-29 2013-09-04 拜耳知识产权有限责任公司 取代的苯氧基吡啶
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CN112646123A (zh) * 2020-12-18 2021-04-13 江西瀚泰新材料科技有限公司 一种低粘度水性环氧树脂及其制备方法
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WO2010068738A1 (en) 2008-12-10 2010-06-17 Dana-Farber Cancer Institute, Inc. Mek mutations conferring resistance to mek inhibitors
US9084781B2 (en) 2008-12-10 2015-07-21 Novartis Ag MEK mutations conferring resistance to MEK inhibitors
WO2011106298A1 (en) 2010-02-25 2011-09-01 Dana-Farber Cancer Institute, Inc. Braf mutations conferring resistance to braf inhibitors
US8637246B2 (en) 2010-02-25 2014-01-28 Dana-Farber Cancer Institute, Inc. BRAF mutations conferring resistance to BRAF inhibitors
US9279144B2 (en) 2010-02-25 2016-03-08 Dana-Farber Cancer Institute, Inc. Screening method for BRAF inhibitors
EP3028699A1 (en) 2010-02-25 2016-06-08 Dana-Farber Cancer Institute, Inc. Braf mutations conferring resistance to braf inhibitors
US11078540B2 (en) 2010-03-09 2021-08-03 Dana-Farber Cancer Institute, Inc. Methods of diagnosing and treating cancer in patients having or developing resistance to a first cancer therapy
US12522872B2 (en) 2010-03-09 2026-01-13 Dana-Farber Cancer Institute, Inc. Methods of diagnosing and treating cancer in patients having or developing resistance to a first cancer therapy
WO2013169858A1 (en) 2012-05-08 2013-11-14 The Broad Institute, Inc. Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy

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AU2002359291C1 (en) 2008-11-20
US20070293555A1 (en) 2007-12-20
IL161580A0 (en) 2004-09-27
JP4602667B2 (ja) 2010-12-22
AU2002359291B2 (en) 2008-04-03
WO2003035626A3 (en) 2003-11-06
US20050054706A1 (en) 2005-03-10
EP1438295B1 (en) 2012-08-15
ES2393186T3 (es) 2012-12-19
EP2332922A1 (en) 2011-06-15
WO2003035626A2 (en) 2003-05-01
JP2005508972A (ja) 2005-04-07
US7541375B2 (en) 2009-06-02
AU2008202731A1 (en) 2008-07-17
AU2002359291B8 (en) 2008-04-17
EP1438295A2 (en) 2004-07-21
US7253199B2 (en) 2007-08-07

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