CA2450167A1 - Macrocycles useful in the treatment of alzheimer's disease - Google Patents

Info

Publication number

CA2450167A1

CA2450167A1 CA002450167A CA2450167A CA2450167A1 CA 2450167 A1 CA2450167 A1 CA 2450167A1 CA 002450167 A CA002450167 A CA 002450167A CA 2450167 A CA2450167 A CA 2450167A CA 2450167 A1 CA2450167 A1 CA 2450167A1

Authority

CA

Canada

Prior art keywords

ethyl

alkyl

oxa

fluoro

hydroxy

Prior art date

2001-06-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

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• 238000011282 treatment Methods 0.000 title claims abstract description 33
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• 238000000034 method Methods 0.000 claims abstract description 100
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 58
• 201000010099 disease Diseases 0.000 claims abstract description 53
• -1 5-Ethyl-pyridin-3-ylmethyl Chemical group 0.000 claims description 173
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 143
• 229910052736 halogen Inorganic materials 0.000 claims description 121
• 150000002367 halogens Chemical class 0.000 claims description 118
• 125000000217 alkyl group Chemical group 0.000 claims description 95
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 76
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 71
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 69
• 125000003118 aryl group Chemical group 0.000 claims description 67
• 125000004663 dialkyl amino group Chemical group 0.000 claims description 66
• 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 49
• 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims description 49
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 47
• 125000001072 heteroaryl group Chemical group 0.000 claims description 45
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 42
• 125000000623 heterocyclic group Chemical group 0.000 claims description 39
• 229910052739 hydrogen Inorganic materials 0.000 claims description 37
• 150000003839 salts Chemical class 0.000 claims description 37
• OSVMTWJCGUFAOD-KZQROQTASA-N formestane Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1O OSVMTWJCGUFAOD-KZQROQTASA-N 0.000 claims description 35
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