CA2445605A1 - Treatment or prophylaxis of insulin-producing cell graft rejection - Google Patents
Treatment or prophylaxis of insulin-producing cell graft rejection Download PDFInfo
- Publication number
- CA2445605A1 CA2445605A1 CA002445605A CA2445605A CA2445605A1 CA 2445605 A1 CA2445605 A1 CA 2445605A1 CA 002445605 A CA002445605 A CA 002445605A CA 2445605 A CA2445605 A CA 2445605A CA 2445605 A1 CA2445605 A1 CA 2445605A1
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- CA
- Canada
- Prior art keywords
- insulin
- antibody
- combination according
- receptor
- producing cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Cell Biology (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29706901P | 2001-06-08 | 2001-06-08 | |
| US60/297,069 | 2001-06-08 | ||
| PCT/EP2002/006278 WO2002100148A2 (en) | 2001-06-08 | 2002-06-07 | Treatment or prophylaxis of insulin-producing cell graft rejection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2445605A1 true CA2445605A1 (en) | 2002-12-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002445605A Abandoned CA2445605A1 (en) | 2001-06-08 | 2002-06-07 | Treatment or prophylaxis of insulin-producing cell graft rejection |
Country Status (18)
| Country | Link |
|---|---|
| US (5) | US20030003099A1 (https=) |
| EP (1) | EP1429845B1 (https=) |
| JP (1) | JP4476623B2 (https=) |
| CN (1) | CN1524002A (https=) |
| AT (1) | ATE424893T1 (https=) |
| AU (1) | AU2002320828B2 (https=) |
| BR (1) | BR0209319A (https=) |
| CA (1) | CA2445605A1 (https=) |
| DE (1) | DE60231522D1 (https=) |
| ES (1) | ES2322442T3 (https=) |
| IL (1) | IL158384A0 (https=) |
| NO (1) | NO20035434D0 (https=) |
| NZ (1) | NZ529044A (https=) |
| PL (1) | PL364359A1 (https=) |
| PT (1) | PT1429845E (https=) |
| RU (1) | RU2003136730A (https=) |
| WO (1) | WO2002100148A2 (https=) |
| ZA (1) | ZA200307893B (https=) |
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| JP4318921B2 (ja) * | 2001-02-22 | 2009-08-26 | ノバルティス アクチエンゲゼルシャフト | 移植片の機能発現遅延の処置のための医薬の製造のためのリンパ球ホーミング促進剤の使用 |
| EP2338511A3 (en) * | 2004-05-14 | 2012-07-25 | Alexion Pharmaceuticals, Inc. | Prolongation of survival of an allograft by inhibiting complement activity |
| US7781617B2 (en) * | 2004-07-16 | 2010-08-24 | Kyorin Pharmaceutical Co., Ltd | Effective use method of medicaments and method of preventing expression of side effect |
| KR20070085465A (ko) * | 2004-11-29 | 2007-08-27 | 노파르티스 아게 | Ｓ１ｐ 수용체 효능제의 투여 용법 |
| CA2595960A1 (en) * | 2005-02-08 | 2006-08-17 | Novartis Ag | Antilymphocyte antibody induction by combination of an s1p receptor agonist/modulator and of immunosuppressive drugs |
| US8778327B2 (en) * | 2005-05-11 | 2014-07-15 | Loma Linda University | Substances, compositions and methods for preventing and treating immune-mediated inflammatory disorders |
| US20090191218A1 (en) | 2005-05-11 | 2009-07-30 | Fengchun Li | DNA Vaccines And Methods For The Prevention Of Transplantation Rejection |
| WO2009114735A1 (en) * | 2008-03-12 | 2009-09-17 | Loma Linda University | Dna vaccines and methods for the prevention of transplantation rejection |
| BRPI0619894B8 (pt) * | 2005-12-15 | 2021-05-25 | Mitsubishi Tanabe Pharma Corp | composto de amina e composição farmacêutica |
| JP5722524B2 (ja) * | 2006-03-02 | 2015-05-20 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 補体活性を抑制することによる同種移植片の生存の延長 |
| EP2489729B1 (en) * | 2006-09-28 | 2015-02-25 | Loma Linda University | Apoptotic cell-mediated transfection of mammalian cells with interfering RNA |
| TW200946105A (en) | 2008-02-07 | 2009-11-16 | Kyorin Seiyaku Kk | Therapeutic agent or preventive agent for inflammatory bowel disease containing amino alcohol derivative as active ingredient |
| PL2278960T5 (pl) | 2008-03-17 | 2020-06-29 | Actelion Pharmaceuticals Ltd. | Schemat dawkowania dla selektywnego agonisty receptora sip1 |
| JP2012508215A (ja) * | 2008-11-11 | 2012-04-05 | ノバルティス アーゲー | 有機化合物 |
| PT2356090T (pt) * | 2008-11-11 | 2017-10-16 | Novartis Ag | Formas cristalinas de fingolimod, hcl |
| JP5654587B2 (ja) * | 2009-06-30 | 2015-01-14 | ライフスキャン・インコーポレイテッドＬｉｆｅｓｃａｎ，Ｉｎｃ． | 基礎インスリン療法を算出する分析物試験方法及び装置 |
| BRPI1015133A2 (pt) * | 2009-06-30 | 2016-04-19 | Lifescan Scotland Ltd | sistemas para o gerenciamento de diabetes e métodos |
| BR112012007134A2 (pt) * | 2009-09-29 | 2016-08-23 | Lifescan Scotland Ltd | dispositivo e método de teste de analito para controle de diabetes |
| US9563743B2 (en) * | 2010-02-25 | 2017-02-07 | Lifescan Scotland Limited | Analyte testing method and system with high and low blood glucose trends notification |
| DK2758074T3 (da) | 2011-09-23 | 2020-07-27 | Univ Loma Linda | Bakteriestammer der udtrykker methylasegener og anvendelser deraf |
| US11680273B2 (en) | 2011-09-23 | 2023-06-20 | Loma Linda University | Treatment of autoimmune diseases |
| CN114306643A (zh) * | 2021-11-30 | 2022-04-12 | 中国科学院昆明动物研究所 | 一种恒河猴免疫抑制模型的构建方法及在car-t细胞植活上的应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69321823T2 (de) * | 1992-10-21 | 1999-06-02 | Taito Co., Ltd., Tokio/Tokyo | 2-amino-1, 3- propandiolverbindung und immunosuppressium |
| US5679546A (en) * | 1993-09-24 | 1997-10-21 | Cytomed, Inc. | Chimeric proteins which block complement activation |
| CA2184356A1 (en) * | 1994-03-03 | 1995-09-08 | Russell P. Rother | Terminal complement inhibitor fusion genes and proteins |
| GB9624038D0 (en) * | 1996-11-19 | 1997-01-08 | Sandoz Ltd | Organic compounds |
| JPH1180026A (ja) * | 1997-09-02 | 1999-03-23 | Yoshitomi Pharmaceut Ind Ltd | 新規免疫抑制剤、その使用方法およびその同定方法 |
| JP4318921B2 (ja) * | 2001-02-22 | 2009-08-26 | ノバルティス アクチエンゲゼルシャフト | 移植片の機能発現遅延の処置のための医薬の製造のためのリンパ球ホーミング促進剤の使用 |
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2002
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- 2002-06-07 EP EP02754637A patent/EP1429845B1/en not_active Expired - Lifetime
- 2002-06-07 JP JP2003502981A patent/JP4476623B2/ja not_active Expired - Fee Related
- 2002-06-07 CA CA002445605A patent/CA2445605A1/en not_active Abandoned
- 2002-06-07 CN CNA028098498A patent/CN1524002A/zh active Pending
- 2002-06-07 PL PL02364359A patent/PL364359A1/xx not_active Application Discontinuation
- 2002-06-07 AU AU2002320828A patent/AU2002320828B2/en not_active Ceased
- 2002-06-07 WO PCT/EP2002/006278 patent/WO2002100148A2/en not_active Ceased
- 2002-06-07 AT AT02754637T patent/ATE424893T1/de active
- 2002-06-07 NZ NZ529044A patent/NZ529044A/en unknown
- 2002-06-07 IL IL15838402A patent/IL158384A0/xx unknown
- 2002-06-07 RU RU2003136730/15A patent/RU2003136730A/ru not_active Application Discontinuation
- 2002-06-07 US US10/164,755 patent/US20030003099A1/en not_active Abandoned
- 2002-06-07 DE DE60231522T patent/DE60231522D1/de not_active Expired - Lifetime
- 2002-06-07 ES ES02754637T patent/ES2322442T3/es not_active Expired - Lifetime
- 2002-06-07 PT PT02754637T patent/PT1429845E/pt unknown
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2003
- 2003-10-09 ZA ZA200307893A patent/ZA200307893B/en unknown
- 2003-12-05 NO NO20035434A patent/NO20035434D0/no not_active Application Discontinuation
-
2006
- 2006-03-09 US US11/372,383 patent/US20060153842A1/en not_active Abandoned
-
2008
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2011
- 2011-06-06 US US13/154,106 patent/US20110236382A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| PL364359A1 (en) | 2004-12-13 |
| EP1429845A2 (en) | 2004-06-23 |
| WO2002100148A3 (en) | 2004-04-22 |
| DE60231522D1 (de) | 2009-04-23 |
| WO2002100148A2 (en) | 2002-12-19 |
| US20030003099A1 (en) | 2003-01-02 |
| PT1429845E (pt) | 2009-06-15 |
| US20080199465A1 (en) | 2008-08-21 |
| ES2322442T3 (es) | 2009-06-22 |
| NZ529044A (en) | 2008-03-28 |
| US20060153842A1 (en) | 2006-07-13 |
| EP1429845B1 (en) | 2009-03-11 |
| IL158384A0 (en) | 2004-05-12 |
| RU2003136730A (ru) | 2005-05-20 |
| JP4476623B2 (ja) | 2010-06-09 |
| NO20035434D0 (no) | 2003-12-05 |
| US20110236382A1 (en) | 2011-09-29 |
| ATE424893T1 (de) | 2009-03-15 |
| JP2004534788A (ja) | 2004-11-18 |
| AU2002320828B2 (en) | 2006-02-02 |
| ZA200307893B (en) | 2004-09-06 |
| BR0209319A (pt) | 2004-07-20 |
| US20140093502A1 (en) | 2014-04-03 |
| CN1524002A (zh) | 2004-08-25 |
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