PT2356090T - Formas cristalinas de fingolimod, hcl - Google Patents

Formas cristalinas de fingolimod, hcl

Info

Publication number
PT2356090T
PT2356090T PT97483507T PT09748350T PT2356090T PT 2356090 T PT2356090 T PT 2356090T PT 97483507 T PT97483507 T PT 97483507T PT 09748350 T PT09748350 T PT 09748350T PT 2356090 T PT2356090 T PT 2356090T
Authority
PT
Portugal
Prior art keywords
crystalline forms
fingolimod hcl
fingolimod
hcl
crystalline
Prior art date
Application number
PT97483507T
Other languages
English (en)
Inventor
Mutz Michael
Jordine Guido
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PT2356090T publication Critical patent/PT2356090T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
PT97483507T 2008-11-11 2009-11-10 Formas cristalinas de fingolimod, hcl PT2356090T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08168865 2008-11-11

Publications (1)

Publication Number Publication Date
PT2356090T true PT2356090T (pt) 2017-10-16

Family

ID=40521487

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97483507T PT2356090T (pt) 2008-11-11 2009-11-10 Formas cristalinas de fingolimod, hcl

Country Status (14)

Country Link
US (2) US8530522B2 (pt)
EP (1) EP2356090B1 (pt)
JP (4) JP2012508216A (pt)
KR (2) KR101393994B1 (pt)
CN (3) CN107233336A (pt)
AU (1) AU2009315736B2 (pt)
BR (1) BRPI0921826A2 (pt)
CA (1) CA2743232C (pt)
ES (1) ES2643161T3 (pt)
MX (1) MX2011004962A (pt)
PL (1) PL2356090T3 (pt)
PT (1) PT2356090T (pt)
RU (2) RU2549899C2 (pt)
WO (1) WO2010055028A2 (pt)

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CN103228617A (zh) * 2010-10-01 2013-07-31 斯索恩有限公司 制备盐酸芬戈莫德晶体的方法
MX2013004649A (es) 2010-10-28 2013-06-05 Mapi Pharma Ltd Compuestos intermedios y proceso para la preparacion de fingolimod.
WO2012071524A1 (en) 2010-11-24 2012-05-31 Ratiopharm Gmbh Arylsulfonate salts of fingolimod and processes for preparation thereof
WO2012070059A1 (en) 2010-11-25 2012-05-31 Shilpa Medicare Limited Fingolimod polymorphs and their processes
ES2746016T3 (es) 2010-12-28 2020-03-04 Synthon Bv Procedimiento para la preparación de cristales de clorhidrato de fingolimod
WO2012097330A2 (en) * 2011-01-14 2012-07-19 University Of Washington Compositions and methods for treating degenerative muscle conditions
WO2012146980A2 (en) 2011-04-29 2012-11-01 Dr. Reddy's Laboratories Ltd. Preparation of fingolimod and its salts
US9751834B2 (en) 2011-05-26 2017-09-05 Gri Bio, Inc. Oxygenated amino- or ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives and their medical use
US9850265B2 (en) 2011-05-26 2017-12-26 Gri Bio, Inc. Amino- or ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives and their medical use
WO2012160188A1 (en) 2011-05-26 2012-11-29 Jado Technologies Gmbh Hydroxy-substituted amino and ammonium derivatives and their medical use
WO2013019872A1 (en) 2011-08-01 2013-02-07 Teva Pharmaceutical Industries Ltd. Process for preparing pharmaceutical compositions comprising fingolimod
WO2013091704A1 (en) * 2011-12-22 2013-06-27 Synthon Bv Pharmaceutical composition comprising fingolimod
CN102887829B (zh) * 2012-09-05 2014-07-02 中国科学院上海药物研究所 芬戈莫德粘酸盐及其晶体的制备方法和用途
AU2014206588A1 (en) * 2013-01-17 2015-07-23 Shilpa Medicare Limited Process for preparation of Fingolimod and its salts
ES2964891T3 (es) * 2013-03-05 2024-04-10 Biocon Ltd Un proceso para la preparación de compuestos de 2-amino-1,3-propanodiol y sales de los mismos
US20160128951A1 (en) 2013-07-29 2016-05-12 Aizant Drug Research Solutions Pvt Ltd Pharmaceutical compositions of fingolimod
WO2016042493A1 (en) 2014-09-19 2016-03-24 Aizant Drug Research Pvt. Ltd Pharmaceutical compositions of fingolimod
US9925138B2 (en) 2015-01-20 2018-03-27 Handa Pharmaceuticals, Llc Stable solid fingolimod dosage forms
RU2627691C1 (ru) * 2016-07-06 2017-08-10 Олег Ростиславович Михайлов Кристаллическая η-модификация 2-амино-2-(2-(4-октилфенил)этил)пропан-1,3-диол гидрохлорида, способ её получения и фармацевтическая композиция на её основе
CN106860440A (zh) * 2017-01-16 2017-06-20 南京医科大学第二附属医院 盐酸芬戈莫德在制备治疗系统性红斑狼疮脑病药物中的应用
CN106667981B (zh) * 2017-01-16 2019-05-14 南京医科大学第二附属医院 盐酸芬戈莫德在制备治疗药物性肝损伤药物中的应用
GR1009654B (el) 2018-08-31 2019-11-18 Φαρματεν Α.Β.Ε.Ε. Φαρμακευτικο σκευασμα που περιλαμβανει εναν ανοσοτροποποιητικο παραγοντα και μεθοδος για την παρασκευη αυτου
WO2020245775A1 (en) * 2019-06-05 2020-12-10 Biocon Limited Crystalline forms of 2-amino-2-(2-(4-octylphenyl) ethyl) propane-1,3-diol
CA3156298A1 (en) 2019-10-31 2021-05-06 Laetitia POUZOL Combination of a cxcr7 antagonist with an s1p1 receptor modulator
EP4353709A1 (en) 2021-05-31 2024-04-17 Shanghai Yonsun Biotechnology Co., Ltd. Pharmaceutical salt of fingolimod, preparation method therefor, pharmaceutical composition containing same and use thereof
EP4212156A1 (en) 2022-01-13 2023-07-19 Abivax Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator

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EP0627406B1 (en) * 1992-10-21 1998-10-28 Yoshitomi Pharmaceutical Industries, Ltd. 2-amino-1,3-propanediol compound and immunosuppressant
US6476004B1 (en) * 1996-07-18 2002-11-05 Mitsubishi Pharma Corporation Pharmaceutical composition
JP4079505B2 (ja) * 1998-04-28 2008-04-23 田辺三菱製薬株式会社 ２−アミノ−２−［２−（４−オクチルフェニル）エチル］プロパン−１，３−ジオールの新規な製造法
EP1457478B1 (en) * 1998-11-11 2017-07-19 Novartis AG Production of 2-amino-2-[2-(4-alkyl-phenyl)ethyl]propane-1,3-diols
DK1031347T3 (da) * 1999-01-27 2002-07-08 Idea Ag Transnasal transport/immunisering med meget tilpasselige bærere
WO2000047558A1 (fr) * 1999-02-10 2000-08-17 Welfide Corporation Composes amide et leur utilisation medicinale
CN1144779C (zh) * 1999-03-11 2004-04-07 杭州中美华东制药有限公司 制备2-[2-(4-烷基苯基)-乙基]-2-氨基-丙二醇的方法以及其中制得的中间产物
JP4476623B2 (ja) * 2001-06-08 2010-06-09 ノバルティス アーゲー インスリン産生細胞移植片拒絶の処置または予防
US20030144712A1 (en) * 2001-12-20 2003-07-31 Jackson Streeter, M.D. Methods for overcoming organ transplant rejection
EP1944026B1 (en) * 2002-05-16 2013-06-26 Novartis AG Use of EDG receptor binding agents in cancer
GB0217152D0 (en) * 2002-07-24 2002-09-04 Novartis Ag Organic compounds
KR20050121712A (ko) 2003-04-08 2005-12-27 노파르티스 아게 유기 화합물
CN1212308C (zh) * 2003-07-24 2005-07-27 漆又毛 2－氨基－2－（2－（4－辛基苯基）乙基）－1，3－丙二醇盐酸盐的制备方法
CN1241903C (zh) * 2003-10-14 2006-02-15 马启明 制备2－对辛基苯乙基－2－氨基丙二醇的方法
TWI418350B (zh) * 2005-06-24 2013-12-11 Sankyo Co 含有ｐｐａｒ調節劑之醫藥組成物的用途
US20080221200A1 (en) * 2005-09-30 2008-09-11 Malcolm Allison Combination of Organic Compounds
EA013907B1 (ru) * 2005-10-26 2010-08-30 Мерк Сероно С.А. Сульфонамидные производные и их применение для модулирования металлопротеаз
CN1310869C (zh) * 2005-11-22 2007-04-18 江苏吴中苏药医药开发有限责任公司 2－氨基－2－[2－(4－烷基苯基)乙基]－1,3－丙二醇的制备方法
CN100548968C (zh) * 2006-03-01 2009-10-14 徐州师范大学 一种制备2-对辛基苯乙基-2-氨基丙二醇盐酸盐的方法
US8318812B2 (en) * 2006-06-02 2012-11-27 The Ohio State University Research Foundation Therapeutic agents for the treatment of lymphoid malignancies
MX2020001259A (es) * 2006-09-26 2020-03-20 Novartis Ag Composiciones farmaceuticas que comprenden un modulador de s1p.
EP3011958A1 (en) * 2008-06-20 2016-04-27 Novartis AG Paediatric compositions for treating multiple sclerosis
CN103228617A (zh) 2010-10-01 2013-07-31 斯索恩有限公司 制备盐酸芬戈莫德晶体的方法

Also Published As

Publication number Publication date
CN102209705A (zh) 2011-10-05
ES2643161T3 (es) 2017-11-21
RU2549899C2 (ru) 2015-05-10
CA2743232C (en) 2015-12-29
EP2356090A2 (en) 2011-08-17
EP2356090B1 (en) 2017-07-05
WO2010055028A3 (en) 2010-07-08
JP2016028056A (ja) 2016-02-25
US8530522B2 (en) 2013-09-10
US20110229501A1 (en) 2011-09-22
AU2009315736B2 (en) 2013-08-29
US20140051766A1 (en) 2014-02-20
RU2015111229A3 (pt) 2018-11-08
RU2011123371A (ru) 2012-12-20
JP2014139179A (ja) 2014-07-31
WO2010055028A2 (en) 2010-05-20
KR20110069156A (ko) 2011-06-22
RU2015111229A (ru) 2015-11-20
CN107233336A (zh) 2017-10-10
CN104788325A (zh) 2015-07-22
BRPI0921826A2 (pt) 2016-01-12
KR20130109254A (ko) 2013-10-07
CA2743232A1 (en) 2010-05-20
PL2356090T3 (pl) 2017-12-29
JP2012508216A (ja) 2012-04-05
AU2009315736A1 (en) 2010-05-20
MX2011004962A (es) 2011-05-30
JP2018035160A (ja) 2018-03-08
KR101393994B1 (ko) 2014-05-14

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