PT1429845E - Tratamento ou profilaxia da rejeição de enxertos de células produtoras de insulina - Google Patents
Tratamento ou profilaxia da rejeição de enxertos de células produtoras de insulina Download PDFInfo
- Publication number
- PT1429845E PT1429845E PT02754637T PT02754637T PT1429845E PT 1429845 E PT1429845 E PT 1429845E PT 02754637 T PT02754637 T PT 02754637T PT 02754637 T PT02754637 T PT 02754637T PT 1429845 E PT1429845 E PT 1429845E
- Authority
- PT
- Portugal
- Prior art keywords
- graft rejection
- producing cell
- insulin
- cell graft
- prophylaxis
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
- 102000004877 Insulin Human genes 0.000 title abstract 2
- 108090001061 Insulin Proteins 0.000 title abstract 2
- 206010052779 Transplant rejections Diseases 0.000 title abstract 2
- 229940125396 insulin Drugs 0.000 title abstract 2
- 238000011321 prophylaxis Methods 0.000 title 1
- 238000011282 treatment Methods 0.000 title 1
- 229940124073 Complement inhibitor Drugs 0.000 abstract 1
- 102000010789 Interleukin-2 Receptors Human genes 0.000 abstract 1
- 108010038453 Interleukin-2 Receptors Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000004074 complement inhibitor Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 150000002596 lactones Chemical class 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29706901P | 2001-06-08 | 2001-06-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1429845E true PT1429845E (pt) | 2009-06-15 |
Family
ID=23144725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT02754637T PT1429845E (pt) | 2001-06-08 | 2002-06-07 | Tratamento ou profilaxia da rejeição de enxertos de células produtoras de insulina |
Country Status (18)
| Country | Link |
|---|---|
| US (5) | US20030003099A1 (pt) |
| EP (1) | EP1429845B1 (pt) |
| JP (1) | JP4476623B2 (pt) |
| CN (1) | CN1524002A (pt) |
| AT (1) | ATE424893T1 (pt) |
| AU (1) | AU2002320828B2 (pt) |
| BR (1) | BR0209319A (pt) |
| CA (1) | CA2445605A1 (pt) |
| DE (1) | DE60231522D1 (pt) |
| ES (1) | ES2322442T3 (pt) |
| IL (1) | IL158384A0 (pt) |
| NO (1) | NO20035434D0 (pt) |
| NZ (1) | NZ529044A (pt) |
| PL (1) | PL364359A1 (pt) |
| PT (1) | PT1429845E (pt) |
| RU (1) | RU2003136730A (pt) |
| WO (1) | WO2002100148A2 (pt) |
| ZA (1) | ZA200307893B (pt) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1368015E (pt) * | 2001-02-22 | 2006-12-29 | Novartis Ag | Utilização de agentes de alojamento linfocitário acelerado no fabrico de um medicamento para o tratamento da função de enxerto retardada |
| DK1755674T3 (en) * | 2004-05-14 | 2015-02-09 | Alexion Pharma Inc | PROLONGED SURVIVAL OF A allograft by inhibiting complement activity |
| PL1772145T3 (pl) * | 2004-07-16 | 2011-08-31 | Kyorin Seiyaku Kk | Sposób skutecznego stosowania leku i sposób dotyczący zapobiegania efektom ubocznym |
| JP2008521827A (ja) * | 2004-11-29 | 2008-06-26 | ノバルティス アクチエンゲゼルシャフト | Ｓ１ｐ受容体アゴニストの投与レジメン |
| BRPI0607740A2 (pt) * | 2005-02-08 | 2009-09-29 | Novartis Ag | indução de anticorpos antilinfócitos |
| US20090191218A1 (en) | 2005-05-11 | 2009-07-30 | Fengchun Li | DNA Vaccines And Methods For The Prevention Of Transplantation Rejection |
| EP2058393B1 (en) * | 2005-05-11 | 2010-07-07 | Loma Linda University | Compositions and methods for preventing and treating immune-mediated inflammatory disorders |
| PL1961734T3 (pl) | 2005-12-15 | 2012-02-29 | Mitsubishi Tanabe Pharma Corp | Związek aminowy i jego zastosowanie do celów medycznych |
| PL1988882T3 (pl) * | 2006-03-02 | 2015-04-30 | Alexion Pharma Inc | Wydłużanie przeżycia alloprzeszczepu poprzez inhibowanie aktywności dopełniacza |
| EP2069375B1 (en) * | 2006-09-28 | 2012-03-28 | Loma Linda University | Apoptotic cell-mediated transfection of mammalian cells with interfering RNA |
| TW200946105A (en) | 2008-02-07 | 2009-11-16 | Kyorin Seiyaku Kk | Therapeutic agent or preventive agent for inflammatory bowel disease containing amino alcohol derivative as active ingredient |
| AU2009223148B2 (en) * | 2008-03-12 | 2013-03-14 | Loma Linda University | DNA vaccines and methods for the prevention of transplantation rejection |
| WO2009115954A1 (en) | 2008-03-17 | 2009-09-24 | Actelion Pharmaceuticals Ltd | Dosing regimen for a selective s1p1 receptor agonist |
| BRPI0921533A2 (pt) * | 2008-11-11 | 2016-01-12 | Novartis Ag | composto orgânicos |
| JP2012508216A (ja) * | 2008-11-11 | 2012-04-05 | ノバルティス アーゲー | 有機化合物 |
| JP5871797B2 (ja) * | 2009-06-30 | 2016-03-01 | ライフスキャン・スコットランド・リミテッド | 糖尿病管理システム及び方法 |
| CA2766944C (en) * | 2009-06-30 | 2019-10-29 | Lifescan, Inc. | Analyte testing methods and device for calculating basal insulin therapy |
| CA2957595C (en) * | 2009-09-29 | 2020-06-02 | Lifescan Scotland Limited | Analyte testing method and device for diabetes management |
| US9563743B2 (en) * | 2010-02-25 | 2017-02-07 | Lifescan Scotland Limited | Analyte testing method and system with high and low blood glucose trends notification |
| EP3760226A1 (en) | 2011-09-23 | 2021-01-06 | Loma Linda University | Bacterial strains expressing methylase genes and uses thereof |
| US11680273B2 (en) | 2011-09-23 | 2023-06-20 | Loma Linda University | Treatment of autoimmune diseases |
| CN114306643A (zh) * | 2021-11-30 | 2022-04-12 | 中国科学院昆明动物研究所 | 一种恒河猴免疫抑制模型的构建方法及在car-t细胞植活上的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0155015B1 (ko) * | 1992-10-21 | 1998-12-01 | 고우야 마사시 | 2-아미노-1,3-프로판디올 화합물 및 면역 억제제 |
| US5679546A (en) * | 1993-09-24 | 1997-10-21 | Cytomed, Inc. | Chimeric proteins which block complement activation |
| ES2204944T3 (es) * | 1994-03-03 | 2004-05-01 | Alexion Pharmaceuticals, Inc. | Genes y proteinas de fusion inhibidores del complemento terminal. |
| GB9624038D0 (en) * | 1996-11-19 | 1997-01-08 | Sandoz Ltd | Organic compounds |
| JPH1180026A (ja) * | 1997-09-02 | 1999-03-23 | Yoshitomi Pharmaceut Ind Ltd | 新規免疫抑制剤、その使用方法およびその同定方法 |
| PT1368015E (pt) * | 2001-02-22 | 2006-12-29 | Novartis Ag | Utilização de agentes de alojamento linfocitário acelerado no fabrico de um medicamento para o tratamento da função de enxerto retardada |
-
2002
- 2002-06-07 CN CNA028098498A patent/CN1524002A/zh active Pending
- 2002-06-07 ES ES02754637T patent/ES2322442T3/es not_active Expired - Lifetime
- 2002-06-07 WO PCT/EP2002/006278 patent/WO2002100148A2/en active IP Right Grant
- 2002-06-07 US US10/164,755 patent/US20030003099A1/en not_active Abandoned
- 2002-06-07 IL IL15838402A patent/IL158384A0/xx unknown
- 2002-06-07 CA CA002445605A patent/CA2445605A1/en not_active Abandoned
- 2002-06-07 AU AU2002320828A patent/AU2002320828B2/en not_active Ceased
- 2002-06-07 PL PL02364359A patent/PL364359A1/xx not_active Application Discontinuation
- 2002-06-07 PT PT02754637T patent/PT1429845E/pt unknown
- 2002-06-07 AT AT02754637T patent/ATE424893T1/de active
- 2002-06-07 RU RU2003136730/15A patent/RU2003136730A/ru not_active Application Discontinuation
- 2002-06-07 JP JP2003502981A patent/JP4476623B2/ja not_active Expired - Fee Related
- 2002-06-07 BR BR0209319-7A patent/BR0209319A/pt not_active IP Right Cessation
- 2002-06-07 NZ NZ529044A patent/NZ529044A/en unknown
- 2002-06-07 EP EP02754637A patent/EP1429845B1/en not_active Expired - Lifetime
- 2002-06-07 DE DE60231522T patent/DE60231522D1/de not_active Expired - Lifetime
-
2003
- 2003-10-09 ZA ZA200307893A patent/ZA200307893B/en unknown
- 2003-12-05 NO NO20035434A patent/NO20035434D0/no not_active Application Discontinuation
-
2006
- 2006-03-09 US US11/372,383 patent/US20060153842A1/en not_active Abandoned
-
2008
- 2008-04-22 US US12/107,726 patent/US20080199465A1/en not_active Abandoned
-
2011
- 2011-06-06 US US13/154,106 patent/US20110236382A1/en not_active Abandoned
-
2013
- 2013-12-05 US US14/098,179 patent/US20140093502A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20030003099A1 (en) | 2003-01-02 |
| BR0209319A (pt) | 2004-07-20 |
| RU2003136730A (ru) | 2005-05-20 |
| PL364359A1 (en) | 2004-12-13 |
| EP1429845A2 (en) | 2004-06-23 |
| CA2445605A1 (en) | 2002-12-19 |
| JP4476623B2 (ja) | 2010-06-09 |
| WO2002100148A2 (en) | 2002-12-19 |
| DE60231522D1 (de) | 2009-04-23 |
| NO20035434D0 (no) | 2003-12-05 |
| NZ529044A (en) | 2008-03-28 |
| IL158384A0 (en) | 2004-05-12 |
| EP1429845B1 (en) | 2009-03-11 |
| JP2004534788A (ja) | 2004-11-18 |
| AU2002320828B2 (en) | 2006-02-02 |
| ATE424893T1 (de) | 2009-03-15 |
| US20060153842A1 (en) | 2006-07-13 |
| ZA200307893B (en) | 2004-09-06 |
| ES2322442T3 (es) | 2009-06-22 |
| US20110236382A1 (en) | 2011-09-29 |
| CN1524002A (zh) | 2004-08-25 |
| US20080199465A1 (en) | 2008-08-21 |
| WO2002100148A3 (en) | 2004-04-22 |
| US20140093502A1 (en) | 2014-04-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT1429845E (pt) | Tratamento ou profilaxia da rejeição de enxertos de células produtoras de insulina | |
| TNSN00010A1 (fr) | DIPHENYLUREE A SUBSTITUTION ω CARBOXYARYLE SERVANT D'INHIBUTEURS DE RAF KINASE. | |
| ATE218581T1 (de) | Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung | |
| HK1053783A1 (en) | Use of ritonavir (ABT-538) for improving the pharmacokinetics of drugs metabolized by cytochrome p450 in a method of treating aids | |
| KR910000169A (ko) | 포유류에서 이식 거부를 억제시키는 라파마이신의 용도 | |
| IL101145A0 (en) | Pharmaceutical compositions containing synergistic combinations of nucleoside derivatives | |
| YU46200A (sh) | N-(supstituisani peto-članog di-ili triaza dinezasićenog prstena)karbonil/guanidin derivati za tretiranje ishemije | |
| EP0828481A4 (en) | ORAL DELIVERY COMPOSITION FOR INTESTINAL RELEASE AND METHOD OF USE | |
| NO954996D0 (no) | Anvendelse av nona- og dekapeptider for fremstilling av et legemiddel for behandling av AIDS | |
| MY109834A (en) | Benzoxazinones as inhibitors of hiv reverse transcriptase | |
| PL323490A1 (en) | Tetralinic compounds exibiting acitity against multgiple-drug refractoriness | |
| AU2855399A (en) | Vascularization inhibitors | |
| ZA967880B (en) | Compositions and methods for inhibition of the patho-physiologic actions in mammals in tumor necrosis facto-alpha | |
| IL127542A0 (en) | Administration regimen of H+ K+ -ATPase inhibitors | |
| WO2001078653A3 (en) | Graft rejection inhibition with ccr2 inhibitors | |
| NZ330944A (en) | Peptide derivatives | |
| IT1294931B1 (it) | Derivati della 2-amminotetralina procedimento per la loro preparazione e composizioni farmaceutiche che li contengono, attive nella | |
| HK1045456A1 (en) | Novel therapeutic use of viral inflammation modulatory protein in blocking xenograft rejection | |
| UA66932C2 (en) | Complex of eletriptan and sulphobutylether-beta-cyclodextrin, pharmaceutical composition, method for their manufacture and method for treating migraine | |
| AU4565000A (en) | Organic compounds | |
| WO2001056551A3 (en) | Method and formulation for treatment of vasoconstriction | |
| AP9801307A0 (en) | Use of 3-amino-4-hydroxbenzoic acid for treatment of retroviral infections. | |
| HRP20040165B1 (en) | Citalopram for the treatment of elevated blood pressure | |
| HK1064610A1 (en) | Composition and method for treating chronic allograft rejection | |
| AU5625194A (en) | Rectal flunisolide compositions for treating inflammatory intestinal disorders |