KR910000169A - 포유류에서 이식 거부를 억제시키는 라파마이신의 용도 - Google Patents

포유류에서 이식 거부를 억제시키는 라파마이신의 용도 Download PDF

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KR910000169A
KR910000169A KR1019900008274A KR900008274A KR910000169A KR 910000169 A KR910000169 A KR 910000169A KR 1019900008274 A KR1019900008274 A KR 1019900008274A KR 900008274 A KR900008274 A KR 900008274A KR 910000169 A KR910000169 A KR 910000169A
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rapamycin
administered
amount
day
transplant rejection
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KR1019900008274A
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KR0160957B1 (ko
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로이 캘튼 서
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로이 캘튼 서
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

내용 없음

Description

포유류에서 이식 거부를 억제시키는 라파마이신의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (25)

  1. 필요성 있는 포유류에서 기관 또는 조직 이식 거부를 억제시키기 위한 라파마이신의 용도.
  2. 제1항에 있어서, 상기 라파마이신을 상기 포유류에 약 0.5-약50㎎/㎏/일의 양으로 투여하는 것을 특징으로 하는 라파마이신의 용도.
  3. 제2항에 있어서, 상기의 양이 약 1-약5㎎/㎏/일로 구성된 것을 특징으로 하는 라파마이신의 용도.
  4. 제1항에 있어서, 상기 라파마이신을 약 0.01-약10㎎/㎏/일의 양으로 투여하는 것을 특징으로 하는 라파마이신의 용도.
  5. 제4항에 있어서, 상기의 양이 약 0.025-약5㎎/㎏/일로 구성된 것을 특징으로 하는 라파마이신의 용도.
  6. 제1항에 있어서, 상기 라파마이신을 상기 포유류에 약1-약180일로 이루어진 기간동안 투여하는 것을 특징으로 하는 라파마이신의 용도.
  7. 제1항에 있어서, 상기 라파마이신을 경구투여형태로 투여하는 것을 특징으로 하는 라파마이신의 용도.
  8. 제1항에 있어서, 상기 라파마이신을 비경구 투여형태로 투여하는 것을 특징으로 하는 라파마이신의 용도.
  9. 기관 또는 조직 이식 거부를 억제시키고 그 기관 또는 조직 이식 거부의 억제를 유지시키기 위한 라파마이신의 용도.
  10. 제9항에 있어서, 상기 라파마이신을 약 0.5-약50㎎/㎏/일의 양으로 투여하는 것을 특징으로 하는 라파마이신의 용도.
  11. 제10항에 있어서, 상기의 양이 약1-약5㎎/㎏/일로 구성된 것을 특징으로 하는 라파마이신의 용도.
  12. 제9항에 있어서, 상기 라파마이신을 약 0.01-약10㎎/㎏/일의 양으로 투여하는 것을 특징으로 하는 라파마이신의 용도.
  13. 제12항에 있어서, 상기 양이 약 0.025-약5㎎/㎏/일로 구성된 것을 특징으로 하는 라파마이신의 용도.
  14. 제9항에 있어서, 상기 라파마이신을 약1-약180일로 이루어진 기간동안 투여하는 것을 특징으로 하는 라파마이신의 용도.
  15. 제9항에 있어서, 상기 라파마이신을 경구투여형태로 투여하는 것을 특징으로 하는 라파마이신의 용도.
  16. 제9항에 있어서, 상기 라파마이신을 비경구 투여형태로 투여하는 것을 특징으로 하는 라파마이신의 용도.
  17. 한가지 또는 그 이상의 화학요법제와 조합하여 필요성이 있는 포유류에서 기관 또는 조직 이식 거부를 억제시키기 위한 라파마이신의 용도.
  18. 제17항에 있어서, 상기 화학요법제가 아자티오프린, 코르티코스테로이드, 시클로스포린, FK505, OKT3 및 이들의 조합물중에서 선택되는 것을 특징으로 하는 라파마이신의 용도.
  19. 제17항에 있어서, 상기의 라파마이신을 약 0.5-약50㎎/㎏/일의 양으로 투여하는 것을 특징으로 하는 라파마이신의 용도.
  20. 제19항에 있어서, 상기의 양이 약1-약5㎎/㎏/일로 구성된 것을 특징으로 하는 라파마이신의 용도.
  21. 제17항에 있어서, 상기의 라파마이신을 약 0.01-약10㎎/㎏/일의 양으로 투여하는 것을 특징으로 하는 라파마이신의 용도.
  22. 제21항에 있어서, 상기의 양이 약 0.025-약5㎎/㎏/일로 구성된 것을 특징으로 하는 라파마이신의 용도.
  23. 제17항에 있어서, 상기의 라파마이신과 화학요법제를 상기 포유류에 약1-약180이로 이루어진 기간동안 투여하는 것을 특징으로 하는 라파마이신의 용도.
  24. 제17항에 있어서, 상기 라파마이신을 경구투여형태로 투여하는 것을 특징으로 하는 라파마이신의 용도.
  25. 제17항에 있어서, 상기 라파마이신을 비경구 투여형태로 투여하는 것을 특징으로 하는 라파마이신의 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900008274A 1989-06-06 1990-06-05 포유류에서 이식 거부를 억제시키는 라파마이신조성물 KR0160957B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US362,354 1989-06-06
GB362354 1989-06-06
US07/362,354 US5100899A (en) 1989-06-06 1989-06-06 Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof

Publications (2)

Publication Number Publication Date
KR910000169A true KR910000169A (ko) 1991-01-29
KR0160957B1 KR0160957B1 (ko) 1998-12-01

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US (5) US5100899A (ko)
EP (1) EP0401747B1 (ko)
JP (1) JP2969150B2 (ko)
KR (1) KR0160957B1 (ko)
AT (1) ATE135215T1 (ko)
AU (1) AU638253B2 (ko)
CA (1) CA2018287C (ko)
DE (2) DE10199045I2 (ko)
DK (1) DK0401747T3 (ko)
ES (1) ES2085299T3 (ko)
GR (1) GR3019792T3 (ko)
HK (1) HK1005704A1 (ko)
HU (1) HU206974B (ko)
IL (1) IL94634A (ko)
LU (1) LU90831I2 (ko)
MX (1) MX173183B (ko)
NL (1) NL300056I2 (ko)
SG (1) SG44632A1 (ko)

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JPH0373158A (ja) 1991-03-28
GR3019792T3 (en) 1996-07-31
LU90831I2 (fr) 2001-11-12
US5461058A (en) 1995-10-24
HK1005704A1 (en) 1999-01-22
DE10199045I1 (de) 2003-06-05
DE69025803T2 (de) 1996-07-25
EP0401747A2 (en) 1990-12-12
ES2085299T3 (es) 1996-06-01
EP0401747B1 (en) 1996-03-13
DE10199045I2 (de) 2006-07-13
DK0401747T3 (da) 2004-03-08
DE69025803D1 (de) 1996-04-18
CA2018287C (en) 2001-11-20
US5212155A (en) 1993-05-18
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JP2969150B2 (ja) 1999-11-02
SG44632A1 (en) 1997-12-19
US5308847A (en) 1994-05-03
US5100899A (en) 1992-03-31
NL300056I1 (nl) 2001-12-01
HU206974B (en) 1993-03-01
US5403833A (en) 1995-04-04
CA2018287A1 (en) 1990-12-06
MX173183B (es) 1994-02-07
IL94634A0 (en) 1991-04-15
KR0160957B1 (ko) 1998-12-01
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