CA2442428A1 - Nouveaux inhibiteurs de la tyrosine kinase - Google Patents

Nouveaux inhibiteurs de la tyrosine kinase Download PDF

Info

Publication number
CA2442428A1
CA2442428A1 CA002442428A CA2442428A CA2442428A1 CA 2442428 A1 CA2442428 A1 CA 2442428A1 CA 002442428 A CA002442428 A CA 002442428A CA 2442428 A CA2442428 A CA 2442428A CA 2442428 A1 CA2442428 A1 CA 2442428A1
Authority
CA
Canada
Prior art keywords
methyl
pyridin
hydroxy
ethylamino
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002442428A
Other languages
English (en)
Inventor
Mark D. Wittman
Neelakantan Balasubramanian
Upender Velaparthi
Kurt Zimmermann
Mark G. Saulnier
Peiying Liu
Xiaopeng Sang
David B. Frennesson
Karen M. Stoffan
James G. Tarrant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2442428A1 publication Critical patent/CA2442428A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des composés correspondant à la formule (I) et des sels pharmaceutiquement acceptables de ces composés. Lesdits composés inhibent les enzymes du type tyrosine kinase et peuvent donc être utilisés comme agent anticancéreux. Ces composés sont également utiles pour le traitement d'autres maladies qui peuvent être traitées par inhibition des enzymes du type tyrosine kinase.
CA002442428A 2001-03-28 2002-03-26 Nouveaux inhibiteurs de la tyrosine kinase Abandoned CA2442428A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27932701P 2001-03-28 2001-03-28
US60/279,327 2001-03-28
PCT/US2002/009402 WO2002079192A1 (fr) 2001-03-28 2002-03-26 Nouveaux inhibiteurs de la tyrosine kinase

Publications (1)

Publication Number Publication Date
CA2442428A1 true CA2442428A1 (fr) 2002-10-10

Family

ID=23068491

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002442428A Abandoned CA2442428A1 (fr) 2001-03-28 2002-03-26 Nouveaux inhibiteurs de la tyrosine kinase

Country Status (25)

Country Link
EP (1) EP1381598A4 (fr)
JP (1) JP2004534010A (fr)
KR (1) KR20030083016A (fr)
CN (1) CN1514833A (fr)
AR (1) AR035804A1 (fr)
BG (1) BG108206A (fr)
BR (1) BR0208373A (fr)
CA (1) CA2442428A1 (fr)
CZ (1) CZ20032615A3 (fr)
EE (1) EE200300475A (fr)
GE (1) GEP20053660B (fr)
HR (1) HRP20030844A2 (fr)
HU (1) HUP0400323A2 (fr)
IL (1) IL158041A0 (fr)
IS (1) IS6968A (fr)
MX (1) MXPA03008690A (fr)
NO (1) NO20034308L (fr)
PE (1) PE20021015A1 (fr)
PL (1) PL373300A1 (fr)
RU (1) RU2003131693A (fr)
SK (1) SK12002003A3 (fr)
UY (1) UY27234A1 (fr)
WO (1) WO2002079192A1 (fr)
YU (1) YU84603A (fr)
ZA (1) ZA200307466B (fr)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7081454B2 (en) * 2001-03-28 2006-07-25 Bristol-Myers Squibb Co. Tyrosine kinase inhibitors
MXPA04008408A (es) 2002-03-01 2004-11-29 Squibb Bristol Myers Co Mamiferos no humanos, transgenicos, que expresan receptores de la tirosina cinasa activados constitutivamente.
MXPA04012440A (es) * 2002-06-12 2005-04-28 Abbott Lab Antagonistas de receptor de hormona concentradora de melanina.
AU2003293333A1 (en) * 2002-12-02 2004-06-23 Arqule, Inc. Method of treating cancers
US7189716B2 (en) 2003-01-03 2007-03-13 Bristol-Myers Squibb Company Tyrosine kinase inhibitors
JP2006516626A (ja) * 2003-01-28 2006-07-06 スミスクライン ビーチャム コーポレーション 化学的化合物
US7312215B2 (en) 2003-07-29 2007-12-25 Bristol-Myers Squibb Company Benzimidazole C-2 heterocycles as kinase inhibitors
EP1663204B1 (fr) 2003-08-29 2014-05-07 Exelixis, Inc. Modulateurs c-kit et leurs procedes d'utilisation
US20050075358A1 (en) * 2003-10-06 2005-04-07 Carboni Joan M. Methods for treating IGF1R-inhibitor induced hyperglycemia
DE102004010207A1 (de) * 2004-03-02 2005-09-15 Aventis Pharma S.A. Neue 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate
TW201134828A (en) 2004-04-02 2011-10-16 Osi Pharm Inc 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors
CA2591413A1 (fr) * 2004-12-16 2006-06-22 Vertex Pharmaceuticals Incorporated Pyrid-2-ones utiles comme inhibiteurs de proteine kinases de la famille tec pour le traitement de maladies inflammatoires, proliferatives et a mediation immunologique
WO2006130657A2 (fr) 2005-05-31 2006-12-07 Bristol-Myers Squibb Company Procede de reduction stereoselective pour la preparation de composes de pyrrolotriazine
CA2618360C (fr) 2005-08-04 2015-06-09 Sirtris Pharmaceuticals, Inc. Benzothiazols et thiazolopyridines en tant que modulateurs de sirtuine
US8093401B2 (en) 2005-08-04 2012-01-10 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US8088928B2 (en) 2005-08-04 2012-01-03 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US7855289B2 (en) 2005-08-04 2010-12-21 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
EP1919905B1 (fr) 2005-08-29 2011-02-23 Vertex Pharmaceuticals Incorporated Pyrid-2-ones disubstituées en 3, 5, inhibitrices de la famille tec des tyrosine kinases non liées aux recepteurs
ATE548363T1 (de) 2005-08-29 2012-03-15 Vertex Pharma 3,5-disubstituierte pyrid-2-one, die sich als inhibitoren der tec-familie von nicht-rezeptor- tyrosinkinasen eignen
EP1919906B1 (fr) 2005-08-29 2011-10-12 Vertex Pharmaceuticals Incorporated Pyrid-2-ones disubstituees en 3, 5 inhibitrices de la famille tec des tyrosine kinases non receptrices
WO2007026720A1 (fr) * 2005-08-31 2007-03-08 Taisho Pharmaceutical Co., Ltd. Derive de pyrazole a noyau condense
US8575164B2 (en) 2005-12-19 2013-11-05 OSI Pharmaceuticals, LLC Combination cancer therapy
WO2007145203A1 (fr) * 2006-06-13 2007-12-21 Daiichi Fine Chemical Co., Ltd. 2-amino-1-(4-fluorophenyl) éthanol optiquement actif
US8063225B2 (en) 2006-08-14 2011-11-22 Chembridge Corporation Tricyclic compound derivatives useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders
WO2008022747A1 (fr) * 2006-08-21 2008-02-28 F. Hoffmann-La Roche Ag Dérivés tricycliques de lactame, leur fabrication et leur emploi en tant qu'agents pharmaceutiques
WO2008025526A1 (fr) * 2006-08-31 2008-03-06 F. Hoffmann-La Roche Ag Dérivés d'indole, fabrication de ceux-ci et utilisation comme agents pharmaceutiques
EP2145021A2 (fr) 2007-05-17 2010-01-20 Bristol-Myers Squibb Company Biomarqueurs et procédés pour déterminer la sensibilité de modulateurs de récepteur de facteur de croissance de type 1 semblable à l'insuline
TW200916472A (en) 2007-06-20 2009-04-16 Sirtris Pharmaceuticals Inc Sirtuin modulating compounds
CA2690064A1 (fr) * 2007-06-25 2008-12-31 Guy Georges Derives amido du benzimidazole en tant qu'inhibiteurs de kinase
EP2065380A1 (fr) * 2007-08-22 2009-06-03 F.Hoffmann-La Roche Ag Dérivés de pyridoneamide comme inhibiteurs de focal adhesion kinase (FAK) et leur utilisation pour le traitement du cancer
US7816540B2 (en) * 2007-12-21 2010-10-19 Hoffmann-La Roche Inc. Carboxyl- or hydroxyl-substituted benzimidazole derivatives
MX2010007525A (es) 2008-01-22 2010-08-18 Vernalis R&D Ltd Derivados de indolil-piridona que tienen actividad inhibitoria de la cinasa 1 de punto de control.
JP2011520970A (ja) 2008-05-19 2011-07-21 オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド 置換されたイミダゾピラジン類およびイミダゾトリアジン類
MY160006A (en) 2008-12-19 2017-02-15 Sirtris Pharmaceuticals Inc Thiazolopyridine sirtuin modulating compounds
DE102010001064A1 (de) * 2009-03-18 2010-09-23 Bayer Schering Pharma Aktiengesellschaft Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung
JP2012524119A (ja) 2009-04-20 2012-10-11 オーエスアイ・ファーマシューティカルズ，エルエルシー Ｃ−ピラジン−メチルアミンの調製
US8536180B2 (en) * 2009-05-27 2013-09-17 Abbvie Inc. Pyrimidine inhibitors of kinase activity
EP2494070A2 (fr) 2009-10-30 2012-09-05 Bristol-Myers Squibb Company Méthodes pour traiter un cancer chez des patients présentant une résistance à l'inhibiteur d'igf-1r
EA022623B1 (ru) * 2010-10-06 2016-02-29 ГЛАКСОСМИТКЛАЙН ЭлЭлСи Производные бензимидазола в качестве ингибиторов pi3-киназ
WO2012061169A1 (fr) * 2010-11-01 2012-05-10 Boehringer Ingelheim International Gmbh Inhibiteurs benzimidazole de production de leucotriènes
EP2766497A1 (fr) 2011-10-13 2014-08-20 Bristol-Myers Squibb Company Procédés de sélection et de traitement du cancer chez des patients au moyen d'inhibiteurs de l'igf-1r/ir
EP3010918B1 (fr) 2013-06-21 2018-08-15 Zenith Epigenetics Ltd. Nouveaux composés bicycliques substitués utilisés comme inhibiteurs de bromodomaines
PL3010503T3 (pl) 2013-06-21 2020-08-24 Zenith Epigenetics Ltd. Nowe bicykliczne inhibitory bromodomen
EP3027604B1 (fr) 2013-07-31 2019-02-20 Zenith Epigenetics Ltd. Nouvelles quinazolones en tant qu'inhibiteurs de bromodomaine
CN103936719A (zh) * 2014-05-14 2014-07-23 中国药科大学 苯并咪唑类衍生物制备方法及用途
JP2017525351A (ja) 2014-07-30 2017-09-07 イェダ リサーチ アンド ディベロップメント カンパニー リミテッドＹｅｄａ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏ．Ｌｔｄ． 多能性幹細胞の培養用培地
EP3227281A4 (fr) 2014-12-01 2018-05-30 Zenith Epigenetics Ltd. Pyridinones substituées utilisées comme inhibiteurs de bromodomaines
WO2016092375A1 (fr) 2014-12-11 2016-06-16 Zenith Epigenetics Corp. Hétérocycles substitués à titre d'inhibiteurs de bromodomaines
CA2966450A1 (fr) 2014-12-17 2016-06-23 Olesya KHARENKO Inhibiteurs de bromodomaines
CA2982664A1 (fr) * 2015-04-16 2016-10-20 Merck Patent Gmbh Derives de 3-(1h-benzimidazol-2-yl)-1h-pyridin-2-one
EP3914698A1 (fr) 2019-01-23 2021-12-01 Yeda Research and Development Co. Ltd Milieux de culture pour cellules souches pluripotentes
CN117069696B (zh) * 2023-08-17 2024-04-26 中国药科大学 一种双靶点小分子抑制剂及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6162804A (en) * 1997-09-26 2000-12-19 Merck & Co., Inc. Tyrosine kinase inhibitors
PL206826B1 (pl) * 1999-06-23 2010-09-30 Sanofi Aventis Deutschland Podstawione benzimidazole
US7081454B2 (en) * 2001-03-28 2006-07-25 Bristol-Myers Squibb Co. Tyrosine kinase inhibitors

Also Published As

Publication number Publication date
AR035804A1 (es) 2004-07-14
PE20021015A1 (es) 2002-11-10
EP1381598A1 (fr) 2004-01-21
SK12002003A3 (en) 2004-10-05
IS6968A (is) 2003-09-26
EE200300475A (et) 2004-02-16
KR20030083016A (ko) 2003-10-23
HRP20030844A2 (en) 2005-08-31
NO20034308D0 (no) 2003-09-26
EP1381598A4 (fr) 2008-03-19
GEP20053660B (en) 2005-11-10
NO20034308L (no) 2003-11-26
JP2004534010A (ja) 2004-11-11
HUP0400323A2 (hu) 2005-11-28
BG108206A (bg) 2004-11-30
IL158041A0 (en) 2004-03-28
RU2003131693A (ru) 2005-05-10
WO2002079192A1 (fr) 2002-10-10
MXPA03008690A (es) 2003-12-12
CN1514833A (zh) 2004-07-21
CZ20032615A3 (en) 2004-03-17
ZA200307466B (en) 2005-01-13
YU84603A (sh) 2006-03-03
UY27234A1 (es) 2002-10-31
PL373300A1 (en) 2005-08-22
BR0208373A (pt) 2005-02-22

Similar Documents

Publication Publication Date Title
CA2442428A1 (fr) Nouveaux inhibiteurs de la tyrosine kinase
US7081454B2 (en) Tyrosine kinase inhibitors
CA2534921C (fr) Composes d'aminotriazole utiles en tant qu'inhibiteurs des proteines kinases
US7232826B2 (en) Tyrosine kinase inhibitors
US7470696B2 (en) Tyrosine kinase inhibitors
US8129403B2 (en) Chemical compounds
US6515004B1 (en) N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases
JP5261575B2 (ja) 化学化合物
KR20130028732A (ko) 4―아미노피리미딘 유도체 및 아데노신 ａ2ａ 수용체 안타고니스트로서의 이들의 용도
US20080113967A1 (en) Enzyme modulators and treatments
US9346795B2 (en) Substituted sulfonamides useful as antiapoptotic Bcl inhibitors
AU2004212421A1 (en) Heteroaryl substituted pyrolls useful as inhibitors of protein kinases
EA007968B1 (ru) N-замещённые производные пирролидина в качестве ингибиторов дипептидилпептидазы
MXPA04008807A (es) Derivados de 4-(imidazol-5-il)-2-(4-sulfonilanilino)pirimidina con actividad inhibidora de cdk.
US20100029643A1 (en) Heterocyclyc sulfonamides having edg-1 antagonistic activity
CA2547080A1 (fr) Inhibiteurs heterocycliques de proteine kinase et leurs utilisations
CA3079081A1 (fr) Derives de benzimidazole et leurs utilisations
CA2389280C (fr) Triazoles utilises comme inhibiteurs de farnesyl transferase
TW202220980A (zh) 新穎二唑系選擇性hdac6抑制劑
JP2003522174A (ja) サイクリン依存性キナーゼの３−アミノピラゾール阻害剤
AU2003251721A1 (en) Azole methylidene cyanide derivatives and their use as protein kinase modulators
AU2002254399A1 (en) Novel tyrosine kinase inhibitors

Legal Events

Date Code Title Description
FZDE Discontinued