CA2412466A1 - Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of neurodegenerative diseases - Google Patents
Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of neurodegenerative diseases Download PDFInfo
- Publication number
- CA2412466A1 CA2412466A1 CA002412466A CA2412466A CA2412466A1 CA 2412466 A1 CA2412466 A1 CA 2412466A1 CA 002412466 A CA002412466 A CA 002412466A CA 2412466 A CA2412466 A CA 2412466A CA 2412466 A1 CA2412466 A1 CA 2412466A1
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- CA
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- Prior art keywords
- alkyl
- aryl
- substituted
- pharmaceutically acceptable
- hydrazide
- Prior art date
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- Abandoned
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Obesity (AREA)
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- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33363601P | 2001-11-27 | 2001-11-27 | |
| US60/333,636 | 2001-11-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2412466A1 true CA2412466A1 (en) | 2003-05-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002412466A Abandoned CA2412466A1 (en) | 2001-11-27 | 2002-11-25 | Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of neurodegenerative diseases |
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| Country | Link |
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| US (2) | US6809119B2 (enExample) |
| EP (1) | EP1314723A1 (enExample) |
| JP (1) | JP2003206273A (enExample) |
| AU (1) | AU2002365311A1 (enExample) |
| BR (1) | BR0204863A (enExample) |
| CA (1) | CA2412466A1 (enExample) |
| MX (1) | MXPA02010231A (enExample) |
| WO (1) | WO2003045902A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI252847B (en) * | 2001-07-10 | 2006-04-11 | Synta Pharmaceuticals Corp | Synthesis of taxol enhancers |
| MXPA02010231A (es) * | 2001-11-27 | 2004-12-13 | Warner Lambert Co | Inhibidores aminotransferasa dependientes de aminoacidos de cadena ramificada y su uso en el tratamiento de las enfermedades neurodegenerativas. |
| WO2006113695A1 (en) * | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Combination cancer therapy with bis(thiohydrazide) amide compounds |
| WO2008024303A2 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| EP2076254A2 (en) * | 2006-08-31 | 2009-07-08 | Synta Pharmaceuticals Corporation | Combination with bis(thiohydrazide amides) for treating cancer |
| WO2008136976A2 (en) | 2007-04-30 | 2008-11-13 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| TWI490214B (zh) | 2008-05-30 | 2015-07-01 | 艾德克 上野股份有限公司 | 苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途 |
| WO2012033720A1 (en) | 2010-09-08 | 2012-03-15 | Wellstat Therapeutics Corporation | Benzoic acid compounds for reducing uric acid |
| EA024194B8 (ru) * | 2011-01-21 | 2016-11-30 | Сан Фарма Адвансед Ресьорч Компани Лтд | Содержащие диарилацетиленгидразид ингибиторы тирозинкиназы |
| EP2481801A1 (en) | 2011-01-28 | 2012-08-01 | Deutsches Krebsforschungszentrum | Inhibitors of branched-chain-aminotransferase-1 (BCAT1) for the treatment of neoplasia |
| WO2014049471A1 (en) * | 2012-09-29 | 2014-04-03 | Mahesh Kandula | Compositions and methods for the treatment of ventricular arrhythmias and cardiovascular diseases |
| CN104610105B (zh) * | 2015-02-13 | 2016-04-06 | 佛山市赛维斯医药科技有限公司 | 烷基取代的苯磺酰肼类gpr119激动剂、制备方法及其用途 |
| CN104592066B (zh) * | 2015-02-13 | 2016-04-06 | 佛山市赛维斯医药科技有限公司 | 一类苯磺酰肼化合物、制备方法及其用途 |
| CN104649937B (zh) * | 2015-02-13 | 2016-04-13 | 佛山市赛维斯医药科技有限公司 | 苯磺酰肼类gpr119激动剂、制备方法及其用途 |
| CN104592065B (zh) * | 2015-02-13 | 2016-04-06 | 佛山市赛维斯医药科技有限公司 | 卤代苯磺酰肼类gpr119激动剂、制备方法及其用途 |
| CN104649944B (zh) * | 2015-02-13 | 2016-08-31 | 佛山市赛维斯医药科技有限公司 | 一类甲氧苯磺酰肼类gpr119激动剂、制备方法及其用途 |
| CN104649938B (zh) * | 2015-02-13 | 2016-06-01 | 佛山市赛维斯医药科技有限公司 | 硝基苯磺酰肼类gpr119激动剂、制备方法及其用途 |
| CN104610104B (zh) * | 2015-02-13 | 2016-06-01 | 佛山市赛维斯医药科技有限公司 | 一种含苯磺酰肼和硝基苯结构gpr119激动剂及其用途 |
| CN104610103B (zh) * | 2015-02-13 | 2016-04-06 | 佛山市赛维斯医药科技有限公司 | 含苯磺酰肼和卤代苯结构gpr119激动剂、制备方法及其用途 |
| CN104628612B (zh) * | 2015-02-13 | 2016-06-01 | 佛山市赛维斯医药科技有限公司 | 一类腈基苯磺酰肼类gpr119激动剂、制备方法及其用途 |
| GB201510019D0 (en) * | 2015-06-09 | 2015-07-22 | Cancer Therapeutics Crc Pty Ltd | Compounds |
| TWI879949B (zh) * | 2020-04-27 | 2025-04-11 | 南韓商奧土擇破利悟股份有限公司 | 用於ｕｂｒ盒結構域配體之化合物、組成物以及醫藥組成物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2212829A1 (en) * | 1995-02-21 | 1996-08-29 | Jiro Takeo | Glutamic acid receptor agonist |
| FR2792314B1 (fr) * | 1999-04-15 | 2001-06-01 | Adir | Nouveaux composes aminotriazoles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EE200100416A (et) * | 1999-12-08 | 2002-12-16 | Warner-Lambert Company | Hargneva ahelaga aminohappe-sõltuvad aminotransferaasinhibiitorid ja nende kasutamine diabeetilise retinopaatia ravis |
| JP2004509880A (ja) * | 2000-09-19 | 2004-04-02 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 分枝鎖アミノ酸依存性アミノトランスフェラーゼ阻害剤及び神経退行性疾患の治療におけるそれらの使用 |
| WO2002044126A2 (en) * | 2000-11-28 | 2002-06-06 | Guilford Pharmaceuticals Inc. | Bisubstituted carbocyclic cyclophilin binding compounds and theirus |
| MXPA02010231A (es) * | 2001-11-27 | 2004-12-13 | Warner Lambert Co | Inhibidores aminotransferasa dependientes de aminoacidos de cadena ramificada y su uso en el tratamiento de las enfermedades neurodegenerativas. |
-
2002
- 2002-10-16 MX MXPA02010231A patent/MXPA02010231A/es unknown
- 2002-10-22 WO PCT/IB2002/004386 patent/WO2003045902A1/en not_active Ceased
- 2002-10-22 AU AU2002365311A patent/AU2002365311A1/en not_active Abandoned
- 2002-11-21 EP EP02258017A patent/EP1314723A1/en not_active Withdrawn
- 2002-11-25 CA CA002412466A patent/CA2412466A1/en not_active Abandoned
- 2002-11-26 BR BR0204863-9A patent/BR0204863A/pt not_active IP Right Cessation
- 2002-11-26 US US10/304,803 patent/US6809119B2/en not_active Expired - Fee Related
- 2002-11-27 JP JP2002344313A patent/JP2003206273A/ja active Pending
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2004
- 2004-05-17 US US10/847,108 patent/US20050014841A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20050014841A1 (en) | 2005-01-20 |
| AU2002365311A1 (en) | 2003-06-10 |
| US20030149110A1 (en) | 2003-08-07 |
| MXPA02010231A (es) | 2004-12-13 |
| JP2003206273A (ja) | 2003-07-22 |
| EP1314723A1 (en) | 2003-05-28 |
| BR0204863A (pt) | 2004-06-15 |
| WO2003045902A1 (en) | 2003-06-05 |
| US6809119B2 (en) | 2004-10-26 |
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| FZDE | Discontinued |