CN104610103B - 含苯磺酰肼和卤代苯结构gpr119激动剂、制备方法及其用途 - Google Patents
含苯磺酰肼和卤代苯结构gpr119激动剂、制备方法及其用途 Download PDFInfo
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- CN104610103B CN104610103B CN201510080240.1A CN201510080240A CN104610103B CN 104610103 B CN104610103 B CN 104610103B CN 201510080240 A CN201510080240 A CN 201510080240A CN 104610103 B CN104610103 B CN 104610103B
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- 0 *c(c1c2CCCC1)ccc2N Chemical compound *c(c1c2CCCC1)ccc2N 0.000 description 2
- CNURKVRCIGRWLL-SOKJVCRVSA-N C/C=C(\C=C/C#C)/S(NC)(O)=C Chemical compound C/C=C(\C=C/C#C)/S(NC)(O)=C CNURKVRCIGRWLL-SOKJVCRVSA-N 0.000 description 1
- GLCYSRJUOQVORG-SDPNRITHSA-N C=C/C=C(/N)\Nc(cc1)ccc1NC(Nc(c1c2CCCC1)ccc2Br)=O Chemical compound C=C/C=C(/N)\Nc(cc1)ccc1NC(Nc(c1c2CCCC1)ccc2Br)=O GLCYSRJUOQVORG-SDPNRITHSA-N 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
化合物 | EC50(nM) |
参比化合物D-1 | 20.9 |
化合物I-1 | 6.1 |
化合物I-2 | 8.5 |
化合物I-3 | 7.4 |
化合物I-4 | 9.8 |
Claims (3)
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CN201510080240.1A CN104610103B (zh) | 2015-02-13 | 2015-02-13 | 含苯磺酰肼和卤代苯结构gpr119激动剂、制备方法及其用途 |
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CN201510080240.1A CN104610103B (zh) | 2015-02-13 | 2015-02-13 | 含苯磺酰肼和卤代苯结构gpr119激动剂、制备方法及其用途 |
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CN104610103A CN104610103A (zh) | 2015-05-13 |
CN104610103B true CN104610103B (zh) | 2016-04-06 |
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1314723A1 (en) * | 2001-11-27 | 2003-05-28 | Warner-Lambert Company | Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of neurodegenerative diseases |
WO2009086303A2 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
CN102397257A (zh) * | 2010-09-17 | 2012-04-04 | 北京化工大学 | 一种超细格列本脲颗粒的制备方法 |
Family Cites Families (1)
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JP2976836B2 (ja) * | 1995-03-06 | 1999-11-10 | 日本製紙株式会社 | 感熱記録シート |
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2015
- 2015-02-13 CN CN201510080240.1A patent/CN104610103B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1314723A1 (en) * | 2001-11-27 | 2003-05-28 | Warner-Lambert Company | Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of neurodegenerative diseases |
WO2009086303A2 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
CN102397257A (zh) * | 2010-09-17 | 2012-04-04 | 北京化工大学 | 一种超细格列本脲颗粒的制备方法 |
Non-Patent Citations (2)
Title |
---|
4-(取代嘧啶-2-基)-1-芳磺酰基氨基脲化合物的合成与表征;李鹏飞等;《有机化学》;20051231;第25卷(第9期);第1057-1061页 * |
李占梅等.果糖-1,6-二磷酸酶AMP变构抑制剂的研究进展.《药学学报》.2011,第46卷(第11期),第1291-1300页. * |
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Denomination of invention: GPR119 agonist containing benzenesulfonyl hydrazine and halogenated benzene structures as well as preparation method and application thereof Effective date of registration: 20170816 Granted publication date: 20160406 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
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Date of cancellation: 20190604 Granted publication date: 20160406 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
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Effective date of registration: 20191028 Address after: 221300 north side of Qingnian East Road, Yunhe Town, Pizhou City, Xuzhou City, Jiangsu Province Patentee after: Pizhou Runhong Industry Co., Ltd. Address before: Chancheng district has 528000 Taiwan public in Guangdong province Foshan City No. 32 first floor 1636, shop No. 1637 Patentee before: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. |
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