JP2003206273A - 分枝アミノ酸依存性アミノトランスフェラーゼ阻害剤及び神経変性疾病におけるそれらの使用 - Google Patents
分枝アミノ酸依存性アミノトランスフェラーゼ阻害剤及び神経変性疾病におけるそれらの使用Info
- Publication number
- JP2003206273A JP2003206273A JP2002344313A JP2002344313A JP2003206273A JP 2003206273 A JP2003206273 A JP 2003206273A JP 2002344313 A JP2002344313 A JP 2002344313A JP 2002344313 A JP2002344313 A JP 2002344313A JP 2003206273 A JP2003206273 A JP 2003206273A
- Authority
- JP
- Japan
- Prior art keywords
- group
- hydrazide
- phenylsulfonyl
- benzoic acid
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
- C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014506566A (ja) * | 2011-01-28 | 2014-03-17 | ドイッチェス・クレープスフォルシュングスツェントルム | 脳腫瘍を治療するための分枝鎖アミノトランスフェラーゼ１（ｂｃａｔ１）の阻害剤 |
| JP2014510037A (ja) * | 2011-01-21 | 2014-04-24 | スン プハルマ アドバンセド リサーチ カンパニー リミテド | ジアリールアセチレンヒドラジドを含有するチロシンキナーゼ阻害剤 |
| JP2018524294A (ja) * | 2015-06-09 | 2018-08-30 | モナッシュ ユニバーシティ | アリールスルホノヒドラジド |
| JP2023523200A (ja) * | 2020-04-27 | 2023-06-02 | オートタック インコーポレーテッド | Ｕｂｒボックスドメインリガンドとしての化合物 |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI252847B (en) * | 2001-07-10 | 2006-04-11 | Synta Pharmaceuticals Corp | Synthesis of taxol enhancers |
| MXPA02010231A (es) * | 2001-11-27 | 2004-12-13 | Warner Lambert Co | Inhibidores aminotransferasa dependientes de aminoacidos de cadena ramificada y su uso en el tratamiento de las enfermedades neurodegenerativas. |
| WO2006113695A1 (en) * | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Combination cancer therapy with bis(thiohydrazide) amide compounds |
| WO2008024303A2 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| EP2076254A2 (en) * | 2006-08-31 | 2009-07-08 | Synta Pharmaceuticals Corporation | Combination with bis(thiohydrazide amides) for treating cancer |
| WO2008136976A2 (en) | 2007-04-30 | 2008-11-13 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| TWI490214B (zh) | 2008-05-30 | 2015-07-01 | 艾德克 上野股份有限公司 | 苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途 |
| WO2012033720A1 (en) | 2010-09-08 | 2012-03-15 | Wellstat Therapeutics Corporation | Benzoic acid compounds for reducing uric acid |
| WO2014049471A1 (en) * | 2012-09-29 | 2014-04-03 | Mahesh Kandula | Compositions and methods for the treatment of ventricular arrhythmias and cardiovascular diseases |
| CN104610105B (zh) * | 2015-02-13 | 2016-04-06 | 佛山市赛维斯医药科技有限公司 | 烷基取代的苯磺酰肼类gpr119激动剂、制备方法及其用途 |
| CN104592066B (zh) * | 2015-02-13 | 2016-04-06 | 佛山市赛维斯医药科技有限公司 | 一类苯磺酰肼化合物、制备方法及其用途 |
| CN104649937B (zh) * | 2015-02-13 | 2016-04-13 | 佛山市赛维斯医药科技有限公司 | 苯磺酰肼类gpr119激动剂、制备方法及其用途 |
| CN104592065B (zh) * | 2015-02-13 | 2016-04-06 | 佛山市赛维斯医药科技有限公司 | 卤代苯磺酰肼类gpr119激动剂、制备方法及其用途 |
| CN104649944B (zh) * | 2015-02-13 | 2016-08-31 | 佛山市赛维斯医药科技有限公司 | 一类甲氧苯磺酰肼类gpr119激动剂、制备方法及其用途 |
| CN104649938B (zh) * | 2015-02-13 | 2016-06-01 | 佛山市赛维斯医药科技有限公司 | 硝基苯磺酰肼类gpr119激动剂、制备方法及其用途 |
| CN104610104B (zh) * | 2015-02-13 | 2016-06-01 | 佛山市赛维斯医药科技有限公司 | 一种含苯磺酰肼和硝基苯结构gpr119激动剂及其用途 |
| CN104610103B (zh) * | 2015-02-13 | 2016-04-06 | 佛山市赛维斯医药科技有限公司 | 含苯磺酰肼和卤代苯结构gpr119激动剂、制备方法及其用途 |
| CN104628612B (zh) * | 2015-02-13 | 2016-06-01 | 佛山市赛维斯医药科技有限公司 | 一类腈基苯磺酰肼类gpr119激动剂、制备方法及其用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2212829A1 (en) * | 1995-02-21 | 1996-08-29 | Jiro Takeo | Glutamic acid receptor agonist |
| FR2792314B1 (fr) * | 1999-04-15 | 2001-06-01 | Adir | Nouveaux composes aminotriazoles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EE200100416A (et) * | 1999-12-08 | 2002-12-16 | Warner-Lambert Company | Hargneva ahelaga aminohappe-sõltuvad aminotransferaasinhibiitorid ja nende kasutamine diabeetilise retinopaatia ravis |
| JP2004509880A (ja) * | 2000-09-19 | 2004-04-02 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 分枝鎖アミノ酸依存性アミノトランスフェラーゼ阻害剤及び神経退行性疾患の治療におけるそれらの使用 |
| WO2002044126A2 (en) * | 2000-11-28 | 2002-06-06 | Guilford Pharmaceuticals Inc. | Bisubstituted carbocyclic cyclophilin binding compounds and theirus |
| MXPA02010231A (es) * | 2001-11-27 | 2004-12-13 | Warner Lambert Co | Inhibidores aminotransferasa dependientes de aminoacidos de cadena ramificada y su uso en el tratamiento de las enfermedades neurodegenerativas. |
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2002
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- 2002-10-22 AU AU2002365311A patent/AU2002365311A1/en not_active Abandoned
- 2002-11-21 EP EP02258017A patent/EP1314723A1/en not_active Withdrawn
- 2002-11-25 CA CA002412466A patent/CA2412466A1/en not_active Abandoned
- 2002-11-26 BR BR0204863-9A patent/BR0204863A/pt not_active IP Right Cessation
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- 2002-11-27 JP JP2002344313A patent/JP2003206273A/ja active Pending
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2004
- 2004-05-17 US US10/847,108 patent/US20050014841A1/en not_active Abandoned
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014510037A (ja) * | 2011-01-21 | 2014-04-24 | スン プハルマ アドバンセド リサーチ カンパニー リミテド | ジアリールアセチレンヒドラジドを含有するチロシンキナーゼ阻害剤 |
| JP2014506566A (ja) * | 2011-01-28 | 2014-03-17 | ドイッチェス・クレープスフォルシュングスツェントルム | 脳腫瘍を治療するための分枝鎖アミノトランスフェラーゼ１（ｂｃａｔ１）の阻害剤 |
| JP2018524294A (ja) * | 2015-06-09 | 2018-08-30 | モナッシュ ユニバーシティ | アリールスルホノヒドラジド |
| JP2023523200A (ja) * | 2020-04-27 | 2023-06-02 | オートタック インコーポレーテッド | Ｕｂｒボックスドメインリガンドとしての化合物 |
| JP7677584B2 (ja) | 2020-04-27 | 2025-05-15 | オートタック インコーポレーテッド | Ｕｂｒボックスドメインリガンドとしての化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20050014841A1 (en) | 2005-01-20 |
| AU2002365311A1 (en) | 2003-06-10 |
| US20030149110A1 (en) | 2003-08-07 |
| MXPA02010231A (es) | 2004-12-13 |
| CA2412466A1 (en) | 2003-05-27 |
| EP1314723A1 (en) | 2003-05-28 |
| BR0204863A (pt) | 2004-06-15 |
| WO2003045902A1 (en) | 2003-06-05 |
| US6809119B2 (en) | 2004-10-26 |
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