CA2411162A1 - Compounds useful for the preparation of medicaments with phosphodiesterase iv inhibitory activity - Google Patents

Compounds useful for the preparation of medicaments with phosphodiesterase iv inhibitory activity Download PDF

Info

Publication number
CA2411162A1
CA2411162A1 CA002411162A CA2411162A CA2411162A1 CA 2411162 A1 CA2411162 A1 CA 2411162A1 CA 002411162 A CA002411162 A CA 002411162A CA 2411162 A CA2411162 A CA 2411162A CA 2411162 A1 CA2411162 A1 CA 2411162A1
Authority
CA
Canada
Prior art keywords
methoxyphenyl
compounds according
preparation
compounds
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002411162A
Other languages
English (en)
French (fr)
Inventor
Nicola Fanto'
Maria Ornella Tinti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2411162A1 publication Critical patent/CA2411162A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002411162A 2000-06-23 2001-06-15 Compounds useful for the preparation of medicaments with phosphodiesterase iv inhibitory activity Abandoned CA2411162A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITRM2000A000341 2000-06-23
IT2000RM000341A IT1317049B1 (it) 2000-06-23 2000-06-23 Composti utili per la preparazione di medicamenti ad attivita'inibitrice della fosfodiesterasi iv.
PCT/IT2001/000312 WO2002000593A2 (en) 2000-06-23 2001-06-15 Compounds useful for the preparation of medicaments with phosphodiesterase iv inhibitory activity

Publications (1)

Publication Number Publication Date
CA2411162A1 true CA2411162A1 (en) 2002-01-03

Family

ID=11454800

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002411162A Abandoned CA2411162A1 (en) 2000-06-23 2001-06-15 Compounds useful for the preparation of medicaments with phosphodiesterase iv inhibitory activity

Country Status (13)

Country Link
US (1) US7169808B2 (enExample)
EP (1) EP1292563A2 (enExample)
JP (1) JP2004501888A (enExample)
KR (1) KR100764885B1 (enExample)
AU (1) AU2001269420A1 (enExample)
CA (1) CA2411162A1 (enExample)
CZ (1) CZ20023948A3 (enExample)
HU (2) HUP0301205A3 (enExample)
IT (1) IT1317049B1 (enExample)
MX (1) MXPA02012589A (enExample)
PL (1) PL359409A1 (enExample)
SK (1) SK17302002A3 (enExample)
WO (1) WO2002000593A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7842727B2 (en) 2001-03-27 2010-11-30 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7312247B2 (en) 2001-03-27 2007-12-25 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US8026280B2 (en) * 2001-03-27 2011-09-27 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
EP1511477A4 (en) 2002-05-22 2008-04-09 Errant Gene Therapeutics Llc HISTONE DEACETYLASE INHIBITORS BASED ON ALPHA-KETO-EPOXYDE COMPOUNDS
JP2006508986A (ja) * 2002-11-20 2006-03-16 エルラント ゲネ セラペウチクス エルエルシー ヒストンデアセチラーゼ阻害剤による肺細胞の治療方法
WO2005073180A1 (ja) * 2003-12-25 2005-08-11 Kureha Corporation ヒドロキサム酸誘導体、及び該誘導体を含むａｇｅ生成阻害剤
GB0818907D0 (en) * 2008-10-15 2008-11-19 Isis Innovation Histone lysine demethylase inhibitors
EP3691634A4 (en) 2017-10-05 2021-03-31 Biogen Inc. PROCESS FOR THE PREPARATION OF PYRROLIDINE ALPHA-CARBOXAMIDE DERIVATIVES
MX2021012421A (es) * 2019-04-10 2022-02-10 Biogen Inc Procesos para preparar derivados de pirrolidina alfa-carboxamida.

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3714356A (en) * 1971-01-18 1973-01-30 Morton Norwich Products Inc Antibacterial composition and method
GB1419968A (en) 1972-12-21 1975-12-31 Wyeth John & Brother Ltd Aziridine derivatives
AU6889274A (en) * 1973-05-17 1975-11-20 Astra Laekemedel Ab Treatment of neurological disorders
DE3160641D1 (en) * 1980-05-13 1983-08-25 Ciba Geigy Ag Process for the preparation of benzene or naphthalene alkenyl carboxylic acid derivatives
US4820828A (en) * 1987-03-04 1989-04-11 Ortho Pharmaceutical Corporation Cinnamohydroxamic acids
US4971959A (en) * 1987-04-14 1990-11-20 Warner-Lambert Company Trisubstituted phenyl analogs having activity for congestive heart failure
US5232735A (en) * 1990-06-01 1993-08-03 Bioresearch, Inc. Ingestibles containing substantially tasteless sweetness inhibitors as bitter taste reducers or substantially tasteless bitter inhibitors as sweet taste reducers
WO1992000968A1 (en) * 1990-07-10 1992-01-23 Smithkline Beecham Corporation Oxamides
US5191084A (en) * 1991-05-01 1993-03-02 American Home Products Corporation Phenyl pyrazolidinones as bronchodilators and anti-inflammatory agents
PT100441A (pt) * 1991-05-02 1993-09-30 Smithkline Beecham Corp Pirrolidinonas, seu processo de preparacao, composicoes farmaceuticas que as contem e uso
US5665754A (en) 1993-09-20 1997-09-09 Glaxo Wellcome Inc. Substituted pyrrolidines
EP0850215B1 (en) * 1995-07-26 2000-10-18 Pfizer Inc. N-(aroyl)glycine hydroxamic acid derivatives and related compounds
CN1191528A (zh) * 1995-07-26 1998-08-26 武田药品工业株式会社 具有褪黑激素受体结合亲合力的苯并环烯化合物,其生产方法和用途
JP4017214B2 (ja) * 1996-06-11 2007-12-05 興和創薬株式会社 ５−フェニル−３−ピリダジノン誘導体
FI990180A7 (fi) * 1996-08-12 1999-03-08 Celgene Corp Uusia immunoterapeuttisia aineita ja niiden käyttö sytokiini-tasojen pienentämiseksi
GB9618349D0 (en) * 1996-09-03 1996-10-16 Pharmacia Spa N-substituted 2-amino-4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibitory activity
AR017014A1 (es) 1997-07-22 2001-08-22 Astrazeneca Ab Compuestos de triazolo [4,5-d]pirimidina, composiciones farmaceuticas, uso de los mismos para preparar medicamentos y procesos para la preparacionde dichos compuestos
IT1294931B1 (it) * 1997-09-22 1999-04-23 Sigma Tau Ind Farmaceuti Derivati della 2-amminotetralina procedimento per la loro preparazione e composizioni farmaceutiche che li contengono, attive nella
EP1047425A4 (en) 1997-12-17 2009-04-22 Merck & Co Inc INTEGRIN RECEPTOR ANTAGONISTS
US6028116A (en) * 1998-04-03 2000-02-22 Cell Pathways, Inc. Substituted condensation products of 1H-indenyl-hydroxyalkanes with aldehydes for neoplasia
TR200101649T2 (tr) * 1998-12-14 2001-10-22 Fujisawa Pharmaceutical Co., Ltd. Piperazin türevleri.
DE19952146A1 (de) * 1999-10-29 2001-06-07 Boehringer Ingelheim Pharma Arylalkane, Arylalkene und Aryl-azaalkane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
ITRM20000341A1 (it) 2001-12-23
MXPA02012589A (es) 2003-05-14
HUP0303399A3 (en) 2004-10-28
KR20030012870A (ko) 2003-02-12
WO2002000593A3 (en) 2002-05-16
HUP0301205A3 (en) 2004-03-01
PL359409A1 (en) 2004-08-23
WO2002000593A2 (en) 2002-01-03
US20030195257A1 (en) 2003-10-16
HUP0303399A2 (hu) 2004-01-28
JP2004501888A (ja) 2004-01-22
CZ20023948A3 (cs) 2003-04-16
KR100764885B1 (ko) 2007-10-09
US7169808B2 (en) 2007-01-30
ITRM20000341A0 (it) 2000-06-23
SK17302002A3 (sk) 2003-05-02
HUP0301205A2 (hu) 2003-11-28
EP1292563A2 (en) 2003-03-19
AU2001269420A1 (en) 2002-01-08
IT1317049B1 (it) 2003-05-26

Similar Documents

Publication Publication Date Title
CA3045955A1 (en) Water-soluble allopregnenolone derivative and use thereof
US20030195257A1 (en) Compounds useful for the preparation of medicaments with phosphodiesterase IV inhibitory activity
FR2527204A1 (fr) Nouveaux composes utiles comme medicaments anti-allergiques et procede et intermediaires pour leur separation
JP2887419B2 (ja) バルプロ酸に類似の抗癲癇薬
JP2021535122A (ja) ２−［（３ｒ）−３−メチルモルホリン−４−イル］−４−（１−メチル−１ｈ−ピラゾール−５−イル）−８−（１ｈ−ピラゾール−５−イル）−１，７−ナフチリジンを調製する方法
CN111902139A (zh) 氘代的D-β-羟基丁酸的类似物及其用途
EP3730509A1 (en) Compound for treating metabolic diseases and preparation method and use thereof
JP2000506137A (ja) アミノテトラリン誘導体及び組成物並びにその使用方法
PL186411B1 (pl) Pochodne 3,4-dipodstawionego fenyloetanoloaminotetralinokarboksyamidu, kompozycja farmaceutyczna zawierająca te pochodne, zastosowanie tych pochodnych do wytwarzania kompozycji farmaceutycznej oraz zastosowanie tych pochodnych jako środka leczniczego
JPH0925235A (ja) １−ｏ−アシルグリセロール−２，３−ホスフェート誘導体を有効成分とするがん転移抑制剤
EP1072583A1 (en) 2-methylpropionic acid derivatives and medicinal compositions containing the same
EP0009306B1 (en) Anti-arthritic hydroxyacetic acid derivatives, pharmaceutical compositions thereof, and processes for their manufacture
EP0208621A1 (fr) Amides substitués, leur préparation et compositions qui les contiennent
EP0012072B1 (fr) Bêta-lactones dérivées de l'acide 2-hydroxy cyclopentane carboxylique, procédé pour leur préparation et compositions pharmaceutiques les renfermant
WO2002000609A2 (en) 2,6,7-substituted tetralines useful for the preparation of medicaments with phosphodiesterase iv inhibitory activity
EP0314624A1 (de) Substituierte Azacyclohexyl-Derivate
CN101862317A (zh) 用于治疗纤维肌痛和其它疾病的普加巴林衍生物
CA1037964A (en) 2-((3,5-di-tert-buryl-4-hydroxyphenyl)thio)alkanoic acids and derivatives and esters
JPH0592939A (ja) ６α−ヒドロキシメビン酸誘導体
MC2105A1 (fr) Derives de tetrahydronaphtalene
EP0005422B1 (fr) Dérivés d'acides oméga-dialkylalkanoiques, leurs procédés de préparation ainsi que leur utilisation en thérapeutique
CN115583890B (zh) 一种治疗血脂异常的药物及其用途
GB2357082A (en) Pharmaceutically active indanylidene-acetamide derivatives
BE621255A (enExample)
JPH03106845A (ja) 光学活性２―アリールプロピオン酸類の製造法

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued