HUP0301205A3 - Use of pamoic acid, its derivatives and its analogues, for the preparation of a medicament for the treatment of diseases characterised by deposits of amyloid aggregates and process for preparation of the compounds - Google Patents

Use of pamoic acid, its derivatives and its analogues, for the preparation of a medicament for the treatment of diseases characterised by deposits of amyloid aggregates and process for preparation of the compounds

Info

Publication number
HUP0301205A3
HUP0301205A3 HU0301205A HUP0301205A HUP0301205A3 HU P0301205 A3 HUP0301205 A3 HU P0301205A3 HU 0301205 A HU0301205 A HU 0301205A HU P0301205 A HUP0301205 A HU P0301205A HU P0301205 A3 HUP0301205 A3 HU P0301205A3
Authority
HU
Hungary
Prior art keywords
preparation
analogues
deposits
medicament
derivatives
Prior art date
Application number
HU0301205A
Other languages
English (en)
Hungarian (hu)
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Priority claimed from PCT/IT2001/000313 external-priority patent/WO2002000603A1/en
Publication of HUP0301205A2 publication Critical patent/HUP0301205A2/hu
Publication of HUP0301205A3 publication Critical patent/HUP0301205A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HU0301205A 2000-06-23 2001-06-15 Use of pamoic acid, its derivatives and its analogues, for the preparation of a medicament for the treatment of diseases characterised by deposits of amyloid aggregates and process for preparation of the compounds HUP0301205A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000RM000341A IT1317049B1 (it) 2000-06-23 2000-06-23 Composti utili per la preparazione di medicamenti ad attivita'inibitrice della fosfodiesterasi iv.
PCT/IT2001/000313 WO2002000603A1 (en) 2000-06-23 2001-06-15 Use of pamoic acid or one of its derivatives, or one of its analogues, for the preparation of a medicament for the treatment of diseases characterised by deposits of amyloid aggregates

Publications (2)

Publication Number Publication Date
HUP0301205A2 HUP0301205A2 (hu) 2003-11-28
HUP0301205A3 true HUP0301205A3 (en) 2004-03-01

Family

ID=11454800

Family Applications (2)

Application Number Title Priority Date Filing Date
HU0301205A HUP0301205A3 (en) 2000-06-23 2001-06-15 Use of pamoic acid, its derivatives and its analogues, for the preparation of a medicament for the treatment of diseases characterised by deposits of amyloid aggregates and process for preparation of the compounds
HU0303399A HUP0303399A3 (en) 2000-06-23 2001-06-15 Compounds useful for the preparation of pharmaceutical compositions with phosphodiesterase iv inhibitory activity

Family Applications After (1)

Application Number Title Priority Date Filing Date
HU0303399A HUP0303399A3 (en) 2000-06-23 2001-06-15 Compounds useful for the preparation of pharmaceutical compositions with phosphodiesterase iv inhibitory activity

Country Status (13)

Country Link
US (1) US7169808B2 (enExample)
EP (1) EP1292563A2 (enExample)
JP (1) JP2004501888A (enExample)
KR (1) KR100764885B1 (enExample)
AU (1) AU2001269420A1 (enExample)
CA (1) CA2411162A1 (enExample)
CZ (1) CZ20023948A3 (enExample)
HU (2) HUP0301205A3 (enExample)
IT (1) IT1317049B1 (enExample)
MX (1) MXPA02012589A (enExample)
PL (1) PL359409A1 (enExample)
SK (1) SK17302002A3 (enExample)
WO (1) WO2002000593A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7842727B2 (en) 2001-03-27 2010-11-30 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7312247B2 (en) 2001-03-27 2007-12-25 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US8026280B2 (en) * 2001-03-27 2011-09-27 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
EP1511477A4 (en) 2002-05-22 2008-04-09 Errant Gene Therapeutics Llc HISTONE DEACETYLASE INHIBITORS BASED ON ALPHA-KETO-EPOXYDE COMPOUNDS
JP2006508986A (ja) * 2002-11-20 2006-03-16 エルラント ゲネ セラペウチクス エルエルシー ヒストンデアセチラーゼ阻害剤による肺細胞の治療方法
WO2005073180A1 (ja) * 2003-12-25 2005-08-11 Kureha Corporation ヒドロキサム酸誘導体、及び該誘導体を含むａｇｅ生成阻害剤
GB0818907D0 (en) * 2008-10-15 2008-11-19 Isis Innovation Histone lysine demethylase inhibitors
EP3691634A4 (en) 2017-10-05 2021-03-31 Biogen Inc. PROCESS FOR THE PREPARATION OF PYRROLIDINE ALPHA-CARBOXAMIDE DERIVATIVES
MX2021012421A (es) * 2019-04-10 2022-02-10 Biogen Inc Procesos para preparar derivados de pirrolidina alfa-carboxamida.

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3714356A (en) * 1971-01-18 1973-01-30 Morton Norwich Products Inc Antibacterial composition and method
GB1419968A (en) 1972-12-21 1975-12-31 Wyeth John & Brother Ltd Aziridine derivatives
AU6889274A (en) * 1973-05-17 1975-11-20 Astra Laekemedel Ab Treatment of neurological disorders
DE3160641D1 (en) * 1980-05-13 1983-08-25 Ciba Geigy Ag Process for the preparation of benzene or naphthalene alkenyl carboxylic acid derivatives
US4820828A (en) * 1987-03-04 1989-04-11 Ortho Pharmaceutical Corporation Cinnamohydroxamic acids
US4971959A (en) * 1987-04-14 1990-11-20 Warner-Lambert Company Trisubstituted phenyl analogs having activity for congestive heart failure
US5232735A (en) * 1990-06-01 1993-08-03 Bioresearch, Inc. Ingestibles containing substantially tasteless sweetness inhibitors as bitter taste reducers or substantially tasteless bitter inhibitors as sweet taste reducers
WO1992000968A1 (en) * 1990-07-10 1992-01-23 Smithkline Beecham Corporation Oxamides
US5191084A (en) * 1991-05-01 1993-03-02 American Home Products Corporation Phenyl pyrazolidinones as bronchodilators and anti-inflammatory agents
PT100441A (pt) * 1991-05-02 1993-09-30 Smithkline Beecham Corp Pirrolidinonas, seu processo de preparacao, composicoes farmaceuticas que as contem e uso
US5665754A (en) 1993-09-20 1997-09-09 Glaxo Wellcome Inc. Substituted pyrrolidines
EP0850215B1 (en) * 1995-07-26 2000-10-18 Pfizer Inc. N-(aroyl)glycine hydroxamic acid derivatives and related compounds
CN1191528A (zh) * 1995-07-26 1998-08-26 武田药品工业株式会社 具有褪黑激素受体结合亲合力的苯并环烯化合物,其生产方法和用途
JP4017214B2 (ja) * 1996-06-11 2007-12-05 興和創薬株式会社 ５−フェニル−３−ピリダジノン誘導体
FI990180A7 (fi) * 1996-08-12 1999-03-08 Celgene Corp Uusia immunoterapeuttisia aineita ja niiden käyttö sytokiini-tasojen pienentämiseksi
GB9618349D0 (en) * 1996-09-03 1996-10-16 Pharmacia Spa N-substituted 2-amino-4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibitory activity
AR017014A1 (es) 1997-07-22 2001-08-22 Astrazeneca Ab Compuestos de triazolo [4,5-d]pirimidina, composiciones farmaceuticas, uso de los mismos para preparar medicamentos y procesos para la preparacionde dichos compuestos
IT1294931B1 (it) * 1997-09-22 1999-04-23 Sigma Tau Ind Farmaceuti Derivati della 2-amminotetralina procedimento per la loro preparazione e composizioni farmaceutiche che li contengono, attive nella
EP1047425A4 (en) 1997-12-17 2009-04-22 Merck & Co Inc INTEGRIN RECEPTOR ANTAGONISTS
US6028116A (en) * 1998-04-03 2000-02-22 Cell Pathways, Inc. Substituted condensation products of 1H-indenyl-hydroxyalkanes with aldehydes for neoplasia
TR200101649T2 (tr) * 1998-12-14 2001-10-22 Fujisawa Pharmaceutical Co., Ltd. Piperazin türevleri.
DE19952146A1 (de) * 1999-10-29 2001-06-07 Boehringer Ingelheim Pharma Arylalkane, Arylalkene und Aryl-azaalkane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
ITRM20000341A1 (it) 2001-12-23
MXPA02012589A (es) 2003-05-14
HUP0303399A3 (en) 2004-10-28
KR20030012870A (ko) 2003-02-12
WO2002000593A3 (en) 2002-05-16
PL359409A1 (en) 2004-08-23
WO2002000593A2 (en) 2002-01-03
US20030195257A1 (en) 2003-10-16
HUP0303399A2 (hu) 2004-01-28
JP2004501888A (ja) 2004-01-22
CZ20023948A3 (cs) 2003-04-16
KR100764885B1 (ko) 2007-10-09
US7169808B2 (en) 2007-01-30
ITRM20000341A0 (it) 2000-06-23
SK17302002A3 (sk) 2003-05-02
CA2411162A1 (en) 2002-01-03
HUP0301205A2 (hu) 2003-11-28
EP1292563A2 (en) 2003-03-19
AU2001269420A1 (en) 2002-01-08
IT1317049B1 (it) 2003-05-26

Similar Documents

Publication Publication Date Title
ZA200306234B (en) Phenethanolamine derivatives for treatment of respiratory diseases.
IL160595A0 (en) Phenethanolamine derivatives for treatment of respiratory diseases
IL196301A0 (en) Medicament for the treatment of hapatitis c
IL213809A0 (en) Use of derivatives of n-phenylpiperazin-1-yl-acetamide for the preparation of a pharmaceutical compositions for treatment of diabetes related conditions
IL154953A0 (en) Substituted cinnamic acid guanidides, process for their preparation, their use as a medicament, and medicament comprising them
PL362711A1 (en) Morpholin-acetamide derivatives for the treatment of inflammatory diseases
AU2000265525A1 (en) Medicament for treating intestinal diseases
IL150817A0 (en) Pyrrole-type compounds, compositions, and methods for treating cancer or viral diseases
MXPA02012730A (es) Uso de acido pamoico o uno de sus derivados o uno de sus analogos para la preparacion de un medicamento para el tratamiento de enfermedades caracterizadas por depositos de agregados de amiloide.
PL366212A1 (en) Formulations containing a glucocorticoid drug for the treatment of bronchopulmonary diseases
AU2002338303A1 (en) Therapeutic compositions for the treatment of a respiratory tract disease
HRP20030677A2 (en) Methods of administering epothilone analogs for the treatment of cancer
AU2562501A (en) Use of melagatran for manufacture of a medicament for the treatment of ischemic disorders
HUP0400495A3 (en) Oral mucosal dosage forms of apomorphine, suitable for the administration via oral mucosal tissue
PL378537A1 (pl) Zastosowanie propionylo L-karnityny do otrzymywania leku do leczenia glaukomii
HUP9801925A3 (en) Use of sodium-hydrogen-exchange-inhibitors for producing pharmaceutical compositions treating diseases caused by protozoons
SI0778025T1 (en) Use of 8,9-dehydroestrone for the manufacture of a medicament for the treatment of diseases caused by free radicals
IL146962A0 (en) Aminotetralin derivatives for the therapy of cardiovascular diseases
WO2007047893A3 (en) Use of dasatinib for the treatment of bone metastasis
NO20021710L (no) Anvendelse av 2-amino-3,4-dihydro-kinazoliner for fremstilling av et medikament for behandling eller profylakse avsykdommer bevirket av iskemiske tilstander
TW200505427A (en) A solid oral dosage form of metformin and glyburide and the method of preparation thereof
HUP0202098A3 (en) Use of 2-aminotetralin derivatives for production of pharmaceutical composition for the therapy of glaucoma
HUP0300032A3 (en) Use of compounds useful for the treatment or prevention of a disease mediated by the alpha-2b-adrenoreceptor for preparation of pharmaceutical composition
HUP0301971A3 (en) Uses of thaliporphine or its derivatives for producing pharmaceutical compositions suitable for treating cardiac diseases and the compounds
HU9800835D0 (en) Pharmaceutical composition for treatment diseases causing by ascophaera apis

Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees