IT1317049B1 - Composti utili per la preparazione di medicamenti ad attivita'inibitrice della fosfodiesterasi iv. - Google Patents
Composti utili per la preparazione di medicamenti ad attivita'inibitrice della fosfodiesterasi iv.Info
- Publication number
- IT1317049B1 IT1317049B1 IT2000RM000341A ITRM20000341A IT1317049B1 IT 1317049 B1 IT1317049 B1 IT 1317049B1 IT 2000RM000341 A IT2000RM000341 A IT 2000RM000341A IT RM20000341 A ITRM20000341 A IT RM20000341A IT 1317049 B1 IT1317049 B1 IT 1317049B1
- Authority
- IT
- Italy
- Prior art keywords
- preparation
- medications
- useful compounds
- inhibiting activities
- phosphodiesterase inhibiting
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 title 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 abstract 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/09—Geometrical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2000RM000341A IT1317049B1 (it) | 2000-06-23 | 2000-06-23 | Composti utili per la preparazione di medicamenti ad attivita'inibitrice della fosfodiesterasi iv. |
| HU0303399A HUP0303399A3 (en) | 2000-06-23 | 2001-06-15 | Compounds useful for the preparation of pharmaceutical compositions with phosphodiesterase iv inhibitory activity |
| MXPA02012589A MXPA02012589A (es) | 2000-06-23 | 2001-06-15 | Compuestos utiles para la preparacion de medicamentos con actividad inhibitoria de la fosfodiesterasa iv. |
| US10/311,756 US7169808B2 (en) | 2000-06-23 | 2001-06-15 | Compounds useful for the preparation of medicaments with phosphodiesterase IV inhibitory activity |
| SK1730-2002A SK17302002A3 (sk) | 2000-06-23 | 2001-06-15 | Zlúčeniny vhodné na prípravu liekov s inhibičnou aktivitou proti fosfodiesteráze IV |
| PCT/IT2001/000312 WO2002000593A2 (en) | 2000-06-23 | 2001-06-15 | Compounds useful for the preparation of medicaments with phosphodiesterase iv inhibitory activity |
| CZ20023948A CZ20023948A3 (cs) | 2000-06-23 | 2001-06-15 | Sloučeniny vhodné k přípravě léčiv s inhibičními účinky na fosfodiesterázu IV |
| KR1020027016531A KR100764885B1 (ko) | 2000-06-23 | 2001-06-15 | 포스포디에스테라제 ｉｖ 억제 활성을 갖는 약제의 제조에유용한 화합물 |
| JP2002505343A JP2004501888A (ja) | 2000-06-23 | 2001-06-15 | ホスホジエステラーゼｉｖ阻害活性を有する薬剤の調製に有用な化合物 |
| HU0301205A HUP0301205A3 (en) | 2000-06-23 | 2001-06-15 | Use of pamoic acid, its derivatives and its analogues, for the preparation of a medicament for the treatment of diseases characterised by deposits of amyloid aggregates and process for preparation of the compounds |
| EP01947782A EP1292563A2 (en) | 2000-06-23 | 2001-06-15 | Compounds useful for the preparation of medicaments with phosphodiesterase iv inhibitory activity |
| CA002411162A CA2411162A1 (en) | 2000-06-23 | 2001-06-15 | Compounds useful for the preparation of medicaments with phosphodiesterase iv inhibitory activity |
| PL01359409A PL359409A1 (en) | 2000-06-23 | 2001-06-15 | Compounds useful for the preparation of medicaments with phosphodiesterase iv inhibitory activity |
| AU2001269420A AU2001269420A1 (en) | 2000-06-23 | 2001-06-15 | Compounds useful for the preparation of medicaments with phosphodiesterase iv inhibitory activity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2000RM000341A IT1317049B1 (it) | 2000-06-23 | 2000-06-23 | Composti utili per la preparazione di medicamenti ad attivita'inibitrice della fosfodiesterasi iv. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITRM20000341A0 ITRM20000341A0 (it) | 2000-06-23 |
| ITRM20000341A1 ITRM20000341A1 (it) | 2001-12-23 |
| IT1317049B1 true IT1317049B1 (it) | 2003-05-26 |
Family
ID=11454800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT2000RM000341A IT1317049B1 (it) | 2000-06-23 | 2000-06-23 | Composti utili per la preparazione di medicamenti ad attivita'inibitrice della fosfodiesterasi iv. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7169808B2 (enExample) |
| EP (1) | EP1292563A2 (enExample) |
| JP (1) | JP2004501888A (enExample) |
| KR (1) | KR100764885B1 (enExample) |
| AU (1) | AU2001269420A1 (enExample) |
| CA (1) | CA2411162A1 (enExample) |
| CZ (1) | CZ20023948A3 (enExample) |
| HU (2) | HUP0301205A3 (enExample) |
| IT (1) | IT1317049B1 (enExample) |
| MX (1) | MXPA02012589A (enExample) |
| PL (1) | PL359409A1 (enExample) |
| SK (1) | SK17302002A3 (enExample) |
| WO (1) | WO2002000593A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7842727B2 (en) | 2001-03-27 | 2010-11-30 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
| US7312247B2 (en) | 2001-03-27 | 2007-12-25 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
| US8026280B2 (en) * | 2001-03-27 | 2011-09-27 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
| EP1511477A4 (en) | 2002-05-22 | 2008-04-09 | Errant Gene Therapeutics Llc | HISTONE DEACETYLASE INHIBITORS BASED ON ALPHA-KETO-EPOXYDE COMPOUNDS |
| JP2006508986A (ja) * | 2002-11-20 | 2006-03-16 | エルラント ゲネ セラペウチクス エルエルシー | ヒストンデアセチラーゼ阻害剤による肺細胞の治療方法 |
| WO2005073180A1 (ja) * | 2003-12-25 | 2005-08-11 | Kureha Corporation | ヒドロキサム酸誘導体、及び該誘導体を含むａｇｅ生成阻害剤 |
| GB0818907D0 (en) * | 2008-10-15 | 2008-11-19 | Isis Innovation | Histone lysine demethylase inhibitors |
| EP3691634A4 (en) | 2017-10-05 | 2021-03-31 | Biogen Inc. | PROCESS FOR THE PREPARATION OF PYRROLIDINE ALPHA-CARBOXAMIDE DERIVATIVES |
| MX2021012421A (es) * | 2019-04-10 | 2022-02-10 | Biogen Inc | Procesos para preparar derivados de pirrolidina alfa-carboxamida. |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3714356A (en) * | 1971-01-18 | 1973-01-30 | Morton Norwich Products Inc | Antibacterial composition and method |
| GB1419968A (en) | 1972-12-21 | 1975-12-31 | Wyeth John & Brother Ltd | Aziridine derivatives |
| AU6889274A (en) * | 1973-05-17 | 1975-11-20 | Astra Laekemedel Ab | Treatment of neurological disorders |
| DE3160641D1 (en) * | 1980-05-13 | 1983-08-25 | Ciba Geigy Ag | Process for the preparation of benzene or naphthalene alkenyl carboxylic acid derivatives |
| US4820828A (en) * | 1987-03-04 | 1989-04-11 | Ortho Pharmaceutical Corporation | Cinnamohydroxamic acids |
| US4971959A (en) * | 1987-04-14 | 1990-11-20 | Warner-Lambert Company | Trisubstituted phenyl analogs having activity for congestive heart failure |
| US5232735A (en) * | 1990-06-01 | 1993-08-03 | Bioresearch, Inc. | Ingestibles containing substantially tasteless sweetness inhibitors as bitter taste reducers or substantially tasteless bitter inhibitors as sweet taste reducers |
| WO1992000968A1 (en) * | 1990-07-10 | 1992-01-23 | Smithkline Beecham Corporation | Oxamides |
| US5191084A (en) * | 1991-05-01 | 1993-03-02 | American Home Products Corporation | Phenyl pyrazolidinones as bronchodilators and anti-inflammatory agents |
| PT100441A (pt) * | 1991-05-02 | 1993-09-30 | Smithkline Beecham Corp | Pirrolidinonas, seu processo de preparacao, composicoes farmaceuticas que as contem e uso |
| US5665754A (en) | 1993-09-20 | 1997-09-09 | Glaxo Wellcome Inc. | Substituted pyrrolidines |
| EP0850215B1 (en) * | 1995-07-26 | 2000-10-18 | Pfizer Inc. | N-(aroyl)glycine hydroxamic acid derivatives and related compounds |
| CN1191528A (zh) * | 1995-07-26 | 1998-08-26 | 武田药品工业株式会社 | 具有褪黑激素受体结合亲合力的苯并环烯化合物,其生产方法和用途 |
| JP4017214B2 (ja) * | 1996-06-11 | 2007-12-05 | 興和創薬株式会社 | ５−フェニル−３−ピリダジノン誘導体 |
| FI990180A7 (fi) * | 1996-08-12 | 1999-03-08 | Celgene Corp | Uusia immunoterapeuttisia aineita ja niiden käyttö sytokiini-tasojen pienentämiseksi |
| GB9618349D0 (en) * | 1996-09-03 | 1996-10-16 | Pharmacia Spa | N-substituted 2-amino-4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibitory activity |
| AR017014A1 (es) | 1997-07-22 | 2001-08-22 | Astrazeneca Ab | Compuestos de triazolo [4,5-d]pirimidina, composiciones farmaceuticas, uso de los mismos para preparar medicamentos y procesos para la preparacionde dichos compuestos |
| IT1294931B1 (it) * | 1997-09-22 | 1999-04-23 | Sigma Tau Ind Farmaceuti | Derivati della 2-amminotetralina procedimento per la loro preparazione e composizioni farmaceutiche che li contengono, attive nella |
| EP1047425A4 (en) | 1997-12-17 | 2009-04-22 | Merck & Co Inc | INTEGRIN RECEPTOR ANTAGONISTS |
| US6028116A (en) * | 1998-04-03 | 2000-02-22 | Cell Pathways, Inc. | Substituted condensation products of 1H-indenyl-hydroxyalkanes with aldehydes for neoplasia |
| TR200101649T2 (tr) * | 1998-12-14 | 2001-10-22 | Fujisawa Pharmaceutical Co., Ltd. | Piperazin türevleri. |
| DE19952146A1 (de) * | 1999-10-29 | 2001-06-07 | Boehringer Ingelheim Pharma | Arylalkane, Arylalkene und Aryl-azaalkane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
-
2000
- 2000-06-23 IT IT2000RM000341A patent/IT1317049B1/it active
-
2001
- 2001-06-15 SK SK1730-2002A patent/SK17302002A3/sk unknown
- 2001-06-15 CZ CZ20023948A patent/CZ20023948A3/cs unknown
- 2001-06-15 AU AU2001269420A patent/AU2001269420A1/en not_active Abandoned
- 2001-06-15 MX MXPA02012589A patent/MXPA02012589A/es active IP Right Grant
- 2001-06-15 KR KR1020027016531A patent/KR100764885B1/ko not_active Expired - Fee Related
- 2001-06-15 HU HU0301205A patent/HUP0301205A3/hu unknown
- 2001-06-15 JP JP2002505343A patent/JP2004501888A/ja active Pending
- 2001-06-15 PL PL01359409A patent/PL359409A1/xx not_active Application Discontinuation
- 2001-06-15 HU HU0303399A patent/HUP0303399A3/hu unknown
- 2001-06-15 WO PCT/IT2001/000312 patent/WO2002000593A2/en not_active Ceased
- 2001-06-15 CA CA002411162A patent/CA2411162A1/en not_active Abandoned
- 2001-06-15 EP EP01947782A patent/EP1292563A2/en not_active Withdrawn
- 2001-06-15 US US10/311,756 patent/US7169808B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ITRM20000341A1 (it) | 2001-12-23 |
| MXPA02012589A (es) | 2003-05-14 |
| HUP0303399A3 (en) | 2004-10-28 |
| KR20030012870A (ko) | 2003-02-12 |
| WO2002000593A3 (en) | 2002-05-16 |
| HUP0301205A3 (en) | 2004-03-01 |
| PL359409A1 (en) | 2004-08-23 |
| WO2002000593A2 (en) | 2002-01-03 |
| US20030195257A1 (en) | 2003-10-16 |
| HUP0303399A2 (hu) | 2004-01-28 |
| JP2004501888A (ja) | 2004-01-22 |
| CZ20023948A3 (cs) | 2003-04-16 |
| KR100764885B1 (ko) | 2007-10-09 |
| US7169808B2 (en) | 2007-01-30 |
| ITRM20000341A0 (it) | 2000-06-23 |
| SK17302002A3 (sk) | 2003-05-02 |
| CA2411162A1 (en) | 2002-01-03 |
| HUP0301205A2 (hu) | 2003-11-28 |
| EP1292563A2 (en) | 2003-03-19 |
| AU2001269420A1 (en) | 2002-01-08 |
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