CA2395406C - Method for treating inflammation - Google Patents
Method for treating inflammation Download PDFInfo
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- CA2395406C CA2395406C CA2395406A CA2395406A CA2395406C CA 2395406 C CA2395406 C CA 2395406C CA 2395406 A CA2395406 A CA 2395406A CA 2395406 A CA2395406 A CA 2395406A CA 2395406 C CA2395406 C CA 2395406C
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Liquid Crystal Substances (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47089899A | 1999-12-23 | 1999-12-23 | |
| US09/470,898 | 1999-12-23 | ||
| US21334100P | 2000-06-22 | 2000-06-22 | |
| US60/213,341 | 2000-06-22 | ||
| PCT/US2000/035305 WO2001046261A1 (en) | 1999-12-23 | 2000-12-22 | Method for treating inflammation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2395406A1 CA2395406A1 (en) | 2001-06-28 |
| CA2395406C true CA2395406C (en) | 2013-07-16 |
Family
ID=26907985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2395406A Expired - Fee Related CA2395406C (en) | 1999-12-23 | 2000-12-22 | Method for treating inflammation |
Country Status (10)
| Country | Link |
|---|---|
| EP (6) | EP2295078A3 (OSRAM) |
| JP (3) | JP2003535037A (OSRAM) |
| AT (2) | ATE459369T1 (OSRAM) |
| AU (1) | AU2458001A (OSRAM) |
| CA (1) | CA2395406C (OSRAM) |
| DE (2) | DE60030769T2 (OSRAM) |
| DK (1) | DK1616575T3 (OSRAM) |
| ES (1) | ES2387394T3 (OSRAM) |
| PT (1) | PT1616575E (OSRAM) |
| WO (1) | WO2001046261A1 (OSRAM) |
Families Citing this family (111)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ504751A (en) * | 1997-11-26 | 2001-10-26 | Zymogenetics Inc | Polynucleotide encoding the mouse Zcyto10 polypeptide and related antibodies and anti-idiotypic antibodies |
| US7198789B2 (en) | 1998-03-17 | 2007-04-03 | Genetics Institute, Llc | Methods and compositions for modulating interleukin-21 receptor activity |
| US6057128A (en) | 1998-03-17 | 2000-05-02 | Genetics Institute, Inc. | MU-1, member of the cytokine receptor family |
| US7189400B2 (en) | 1998-03-17 | 2007-03-13 | Genetics Institute, Llc | Methods of treatment with antagonists of MU-1 |
| DE60045139D1 (de) | 1999-12-23 | 2010-12-02 | Zymogenetics Inc | Löslicher Interleukin-20-Rezeptor |
| WO2001046261A1 (en) * | 1999-12-23 | 2001-06-28 | Zymogenetics, Inc. | Method for treating inflammation |
| US7122632B2 (en) | 1999-12-23 | 2006-10-17 | Zymogenetics, Inc. | Soluble Interleukin-20 receptor |
| US6610286B2 (en) | 1999-12-23 | 2003-08-26 | Zymogenetics, Inc. | Method for treating inflammation using soluble receptors to interleukin-20 |
| US20030023033A1 (en) * | 2001-07-26 | 2003-01-30 | Laure Dumoutier | Novel class II cytokine receptors and uses thereof |
| ATE342980T1 (de) | 2000-08-08 | 2006-11-15 | Zymogenetics Inc | Lösliche zcyctor 11 cytokinrezeptoren |
| WO2002022153A2 (en) | 2000-09-15 | 2002-03-21 | Zymogenetics, Inc. | Use of a polypeptide comprising the extracellular domains of il-20rb for the treatment of inflammation |
| EP2000148A1 (en) | 2001-06-20 | 2008-12-10 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of prostate cancer |
| US20050272120A1 (en) | 2001-06-20 | 2005-12-08 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| EP1432431B1 (en) * | 2001-10-04 | 2017-05-10 | Genetics Institute LLC | Methods and compositions for modulating interleukin-21 activity |
| ES2371006T3 (es) | 2001-12-17 | 2011-12-26 | Zymogenetics, Inc. | Procedimiento para el tratamiento del cáncer de cuello de útero. |
| WO2003090779A1 (fr) * | 2002-04-25 | 2003-11-06 | Chugai Seiyaku Kabushiki Kaisha | Remede contre le cancer du poumon |
| US20050276812A1 (en) | 2004-06-01 | 2005-12-15 | Genentech, Inc. | Antibody-drug conjugates and methods |
| US20060134756A1 (en) | 2003-03-24 | 2006-06-22 | Wenfeng Xu | Anti-IL-20 antibodies and binding partners and methods of using in inflammation |
| EP2087905A2 (en) | 2003-08-08 | 2009-08-12 | Novo Nordisk A/S | Interleukin-20 for treating and diagnosing conditions associated with neovascularisation |
| SG149815A1 (en) | 2003-11-06 | 2009-02-27 | Seattle Genetics Inc | Monomethylvaline compounds capable of conjugation to ligands |
| EP2143733A1 (en) | 2003-11-21 | 2010-01-13 | ZymoGenetics, Inc. | ANTI-IL-20 antibodies and binding partners and methods of using in inflammation |
| TR201808537T4 (tr) | 2004-09-23 | 2018-07-23 | Genentech Inc | Sistein değiştirilmiş antikorlar ve konjugatlar. |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
| CA2584157C (en) | 2004-10-22 | 2014-10-14 | Zymogenetics, Inc. | Anti-il-22ra antibodies and binding partners and methods of using in inflammation |
| TW201022288A (en) * | 2008-06-30 | 2010-06-16 | Novo Nordisk As | Anti-human interleukin-20 antibodies |
| JP5860699B2 (ja) * | 2008-10-07 | 2016-02-16 | ナショナル チェン クン ユニバーシティ | 骨粗鬆症の治療のためのｉｌ−２０アンタゴニストの使用 |
| US8454956B2 (en) | 2009-08-31 | 2013-06-04 | National Cheng Kung University | Methods for treating rheumatoid arthritis and osteoporosis with anti-IL-20 antibodies |
| EP2475391B1 (en) | 2009-09-09 | 2018-09-12 | Centrose, LLC | Extracellular targeted drug conjugates |
| CN102939303A (zh) | 2009-12-22 | 2013-02-20 | 诺瓦提斯公司 | 四价cd47-抗体恒定区融合蛋白用于治疗 |
| TWI540136B (zh) | 2010-04-15 | 2016-07-01 | 梅迪繆思有限公司 | 吡咯并苯并二氮呯及其共軛物 |
| AU2011265054B2 (en) | 2010-06-08 | 2016-09-15 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| CA2816426A1 (en) | 2010-11-17 | 2012-06-07 | Genentech, Inc. | Alaninyl maytansinol antibody conjugates |
| EP2707723B1 (en) | 2011-05-12 | 2016-02-10 | Genentech, Inc. | Multiple reaction monitoring lc-ms/ms method to detect therapeutic antibodies in animal samples using framework signature pepides |
| US20140193408A1 (en) | 2011-06-16 | 2014-07-10 | Novartis Ag | Soluble proteins for use as therapeutics |
| UY34347A (es) | 2011-09-26 | 2013-04-30 | Novartis Ag | Proteínas de función dual para tratar trastornos metabólicos |
| US9006400B2 (en) | 2011-09-26 | 2015-04-14 | Novartis Ag | Fibroblast growth factor-21-Fc fusion proteins |
| SG11201401406YA (en) | 2011-10-14 | 2014-05-29 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| EP2812445A2 (en) | 2012-02-10 | 2014-12-17 | Novo Nordisk A/S | Methods related to treatment of inflammatory diseases and disorders |
| WO2013130093A1 (en) | 2012-03-02 | 2013-09-06 | Genentech, Inc. | Biomarkers for treatment with anti-tubulin chemotherapeutic compounds |
| WO2013164440A1 (en) | 2012-05-03 | 2013-11-07 | Novo Nordisk A/S | Methods related to treatment of inflammatory diseases and disorders |
| WO2014015133A1 (en) * | 2012-07-19 | 2014-01-23 | National Cheng Kung University | Treatment of osteoarthritis using il-20 antagonists |
| US8852588B2 (en) | 2012-08-07 | 2014-10-07 | National Cheng Kung University | Treating allergic airway disorders using anti-IL-20 receptor antibodies |
| US8603470B1 (en) | 2012-08-07 | 2013-12-10 | National Cheng Kung University | Use of IL-20 antagonists for treating liver diseases |
| WO2014057120A1 (en) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
| JP6392765B2 (ja) | 2012-10-12 | 2018-09-19 | エイディーシー・セラピューティクス・エス・アーＡｄｃ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｓａ | ピロロベンゾジアゼピン−抗体結合体 |
| WO2014057114A1 (en) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Pyrrolobenzodiazepine-anti-psma antibody conjugates |
| NZ707534A (en) | 2012-10-12 | 2018-08-31 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| RS57104B1 (sr) | 2012-10-12 | 2018-06-29 | Adc Therapeutics Sa | Konjugati pirolobenzodiazepin-antitela |
| EP2906253B9 (en) | 2012-10-12 | 2019-02-27 | ADC Therapeutics SA | Pyrrolobenzodiazepine - anti-psma antibody conjugates |
| AU2013328580B2 (en) | 2012-10-12 | 2016-01-21 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| CA2894961C (en) | 2012-12-21 | 2020-09-15 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| EA032986B1 (ru) | 2012-12-21 | 2019-08-30 | Медимьюн Лимитед | Пирролобензодиазепины |
| MX362970B (es) | 2013-03-13 | 2019-02-28 | Medimmune Ltd | Pirrolobenzodiazepinas y conjugados de las mismas. |
| TWI680766B (zh) | 2013-03-13 | 2020-01-01 | 英商梅迪繆思有限公司 | 吡咯并苯并二氮呯及其共軛物 |
| US9649390B2 (en) | 2013-03-13 | 2017-05-16 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| EP3033111B1 (en) | 2013-08-12 | 2019-03-13 | Genentech, Inc. | 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment |
| EP3054986B1 (en) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| US10010624B2 (en) | 2013-10-11 | 2018-07-03 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| EP3054985B1 (en) | 2013-10-11 | 2018-12-26 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| GB201317982D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| WO2015095227A2 (en) | 2013-12-16 | 2015-06-25 | Genentech, Inc. | Peptidomimetic compounds and antibody-drug conjugates thereof |
| CN105873614B (zh) | 2013-12-16 | 2020-10-30 | 基因泰克公司 | 肽模拟化合物及其抗体-药物缀合物 |
| BR112016013258A2 (pt) | 2013-12-16 | 2018-01-16 | Genentech Inc | composto conjugado anticorpo-droga, composição farmacêutica, método para tratar câncer e kit |
| PL3151921T3 (pl) | 2014-06-06 | 2020-02-28 | Bristol-Myers Squibb Company | Przeciwciała przeciwko receptorowi indukowanego glukokortykoidami czynnika martwicy nowotworu (gitr) i ich zastosowania |
| CN106687141A (zh) | 2014-09-10 | 2017-05-17 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂卓及其缀合物 |
| US10149913B2 (en) | 2014-09-12 | 2018-12-11 | Genentech, Inc. | Anthracycline disulfide intermediates, antibody-drug conjugates and methods |
| BR112017003236A2 (pt) | 2014-09-12 | 2017-11-28 | Genentech Inc | anticorpos elaborados com cisteína, conjugados de droga e anticorpos, método de preparação de conjugado de droga e anticorpo e composição farmacêutica |
| GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| CN107073136A (zh) | 2014-09-17 | 2017-08-18 | 健泰科生物技术公司 | 吡咯并苯并二氮杂卓及其抗体二硫化物偶联物 |
| EP3789399A1 (en) | 2014-11-21 | 2021-03-10 | Bristol-Myers Squibb Company | Antibodies comprising modified heavy constant regions |
| LT3221363T (lt) | 2014-11-21 | 2020-08-10 | Bristol-Myers Squibb Company | Antikūnai prieš cd73 ir jų panaudojimas |
| BR112017011111A2 (pt) | 2014-11-25 | 2017-12-26 | Adc Therapeutics Sa | conjugados de pirrolobenzodiazepina-anticorpo |
| WO2016090050A1 (en) | 2014-12-03 | 2016-06-09 | Genentech, Inc. | Quaternary amine compounds and antibody-drug conjugates thereof |
| GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| MX2017015260A (es) | 2015-06-03 | 2018-02-19 | Squibb Bristol Myers Co | Anticuerpos anti receptor de factor de necrosis tumoral inducible por glucocorticoide (gitr) para diagnostico del cancer. |
| MA43345A (fr) | 2015-10-02 | 2018-08-08 | Hoffmann La Roche | Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation |
| MA43354A (fr) | 2015-10-16 | 2018-08-22 | Genentech Inc | Conjugués médicamenteux à pont disulfure encombré |
| MA45326A (fr) | 2015-10-20 | 2018-08-29 | Genentech Inc | Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation |
| ES2926969T3 (es) | 2015-11-19 | 2022-10-31 | Bristol Myers Squibb Co | Anticuerpos contra el receptor de factor de necrosis de tumor inducido por glucocorticoides (gitr) y usos de los mismos |
| GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
| GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| US20170315132A1 (en) | 2016-03-25 | 2017-11-02 | Genentech, Inc. | Multiplexed total antibody and antibody-conjugated drug quantification assay |
| GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| CN118436801A (zh) | 2016-05-20 | 2024-08-06 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| EP3465221B1 (en) | 2016-05-27 | 2020-07-22 | H. Hoffnabb-La Roche Ag | Bioanalytical method for the characterization of site-specific antibody-drug conjugates |
| US10639378B2 (en) | 2016-06-06 | 2020-05-05 | Genentech, Inc. | Silvestrol antibody-drug conjugates and methods of use |
| CN109689111B (zh) | 2016-08-11 | 2024-04-05 | 基因泰克公司 | 吡咯并苯并二氮杂䓬前药及其抗体缀合物 |
| JP7050770B2 (ja) | 2016-10-05 | 2022-04-08 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 抗体薬物コンジュゲートの調製方法 |
| GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
| GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
| BR112019016373B1 (pt) | 2017-02-08 | 2022-01-25 | Medimmune Limited | Conjugado anticorpo-fármaco que se liga ao axl, composição e composição farmacêutica que compreende o mesmo e uso terapêutico do dito conjugado |
| US11370801B2 (en) | 2017-04-18 | 2022-06-28 | Medimmune Limited | Pyrrolobenzodiazepine conjugates |
| EP3612234B1 (en) | 2017-04-20 | 2024-03-13 | ADC Therapeutics SA | Combination therapy with an anti-axl antibody-drug conjugate |
| US11685787B2 (en) | 2017-05-16 | 2023-06-27 | Bristol-Myers Squibb Company | Treatment of cancer with anti-GITR agonist antibodies |
| JP7145891B2 (ja) | 2017-06-14 | 2022-10-03 | アーデーセー セラピューティクス ソシエテ アノニム | 抗ｃｄ１９ ａｄｃを投与するための投与レジメ |
| PT3668874T (pt) | 2017-08-18 | 2022-02-24 | Medimmune Ltd | Conjugados de pirrolobenzodiazepina |
| EP3684773A1 (en) | 2017-09-20 | 2020-07-29 | pH Pharma Co., Ltd. | Thailanstatin analogs |
| GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
| GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| GB201814281D0 (en) | 2018-09-03 | 2018-10-17 | Femtogenix Ltd | Cytotoxic agents |
| WO2020086858A1 (en) | 2018-10-24 | 2020-04-30 | Genentech, Inc. | Conjugated chemical inducers of degradation and methods of use |
| CN113227119A (zh) | 2018-12-10 | 2021-08-06 | 基因泰克公司 | 用于与含Fc的蛋白质进行位点特异性缀合的光交联肽 |
| GB201901197D0 (en) | 2019-01-29 | 2019-03-20 | Femtogenix Ltd | G-A Crosslinking cytotoxic agents |
| MX2021010477A (es) | 2019-03-15 | 2021-10-01 | Medimmune Ltd | Dimeros de azetidobenzodiazepina y conjugados que los comprenden para uso en el tratamiento de cancer. |
| RU2753282C2 (ru) * | 2019-09-19 | 2021-08-12 | Закрытое Акционерное Общество "Биокад" | ИММУНОЦИТОКИН, ВКЛЮЧАЮЩИЙ ГЕТЕРОДИМЕРНЫЙ БЕЛКОВЫЙ КОМПЛЕКС НА ОСНОВЕ IL-15/IL-15Rα, И ЕГО ПРИМЕНЕНИЕ |
| TW202130364A (zh) | 2019-10-28 | 2021-08-16 | 永福生物科技股份有限公司 | 以介白素２４或介白素２０拮抗劑治療組織纖維化和／或損傷和／或器官衰竭 |
| EP4426727A2 (en) | 2021-11-03 | 2024-09-11 | Hangzhou Dac Biotech Co., Ltd. | Specific conjugation of an antibody |
| CN120417934A (zh) | 2022-12-23 | 2025-08-01 | 基因泰克公司 | Cereblon降解剂缀合物及其用途 |
| AU2024257248A1 (en) | 2023-04-17 | 2025-11-06 | Peak Bio, Inc. | Antibodies and antibody-drug conjugates and methods of use and synthetic processes and intermediates |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5567584A (en) | 1988-01-22 | 1996-10-22 | Zymogenetics, Inc. | Methods of using biologically active dimerized polypeptide fusions to detect PDGF |
| KR19990077015A (ko) | 1996-01-11 | 1999-10-25 | 크리스토퍼 엘. 와이트, 스코트 지. 홀퀴스트, 스티븐 엘. 말라스카 | 진핵 세포 발현 시스템을 위한 발현 증강 서열 요소 (ease) |
| US5945511A (en) | 1997-02-20 | 1999-08-31 | Zymogenetics, Inc. | Class II cytokine receptor |
| US6486301B1 (en) * | 1997-07-16 | 2002-11-26 | Human Genome Sciences, Inc. | Interleukin-20 |
| EP1012260A4 (en) * | 1997-07-16 | 2001-05-09 | Human Genome Sciences Inc | INTERLEUKINE-20 |
| NZ504751A (en) * | 1997-11-26 | 2001-10-26 | Zymogenetics Inc | Polynucleotide encoding the mouse Zcyto10 polypeptide and related antibodies and anti-idiotypic antibodies |
| WO1999046379A2 (en) | 1998-03-09 | 1999-09-16 | Schering Corporation | Human receptor proteins; related reagents and methods |
| AU4411699A (en) * | 1998-06-05 | 1999-12-20 | Human Genome Sciences, Inc. | Interferon receptor hkaef92 |
| EP1141008A1 (en) * | 1998-12-31 | 2001-10-10 | Millennium Pharmaceuticals, Inc. | Class ii cytokine receptor-like proteins and nucleic acids encoding them |
| WO2001046261A1 (en) * | 1999-12-23 | 2001-06-28 | Zymogenetics, Inc. | Method for treating inflammation |
| DE60045139D1 (de) * | 1999-12-23 | 2010-12-02 | Zymogenetics Inc | Löslicher Interleukin-20-Rezeptor |
-
2000
- 2000-12-22 WO PCT/US2000/035305 patent/WO2001046261A1/en not_active Ceased
- 2000-12-22 EP EP10180117A patent/EP2295078A3/en not_active Withdrawn
- 2000-12-22 EP EP10166530A patent/EP2248828A1/en not_active Withdrawn
- 2000-12-22 AT AT06006242T patent/ATE459369T1/de not_active IP Right Cessation
- 2000-12-22 JP JP2001547170A patent/JP2003535037A/ja not_active Withdrawn
- 2000-12-22 EP EP05020542A patent/EP1616575B1/en not_active Expired - Lifetime
- 2000-12-22 CA CA2395406A patent/CA2395406C/en not_active Expired - Fee Related
- 2000-12-22 EP EP00988365A patent/EP1244708B8/en not_active Expired - Lifetime
- 2000-12-22 DE DE60030769T patent/DE60030769T2/de not_active Expired - Lifetime
- 2000-12-22 DK DK05020542.6T patent/DK1616575T3/da active
- 2000-12-22 AT AT00988365T patent/ATE339450T1/de active
- 2000-12-22 ES ES05020542T patent/ES2387394T3/es not_active Expired - Lifetime
- 2000-12-22 EP EP10180136A patent/EP2295079A3/en not_active Withdrawn
- 2000-12-22 DE DE60043957T patent/DE60043957D1/de not_active Expired - Lifetime
- 2000-12-22 PT PT05020542T patent/PT1616575E/pt unknown
- 2000-12-22 EP EP06006242A patent/EP1743648B1/en not_active Expired - Lifetime
- 2000-12-22 AU AU24580/01A patent/AU2458001A/en not_active Abandoned
-
2011
- 2011-06-16 JP JP2011133929A patent/JP2012025737A/ja active Pending
- 2011-09-27 JP JP2011210306A patent/JP2012025766A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2295079A2 (en) | 2011-03-16 |
| ATE459369T1 (de) | 2010-03-15 |
| DE60030769D1 (de) | 2006-10-26 |
| JP2003535037A (ja) | 2003-11-25 |
| EP1616575A1 (en) | 2006-01-18 |
| PT1616575E (pt) | 2012-08-07 |
| EP1616575B1 (en) | 2012-06-06 |
| ES2387394T3 (es) | 2012-09-21 |
| AU2458001A (en) | 2001-07-03 |
| EP2295078A2 (en) | 2011-03-16 |
| WO2001046261A1 (en) | 2001-06-28 |
| EP2295078A3 (en) | 2011-03-23 |
| CA2395406A1 (en) | 2001-06-28 |
| DE60043957D1 (de) | 2010-04-15 |
| EP1244708A1 (en) | 2002-10-02 |
| EP1244708B1 (en) | 2006-09-13 |
| DE60030769T2 (de) | 2007-10-25 |
| EP1743648B1 (en) | 2010-03-03 |
| EP2248828A1 (en) | 2010-11-10 |
| JP2012025766A (ja) | 2012-02-09 |
| DK1616575T3 (da) | 2012-09-10 |
| EP1244708B8 (en) | 2007-03-07 |
| JP2012025737A (ja) | 2012-02-09 |
| ATE339450T1 (de) | 2006-10-15 |
| EP1743648A1 (en) | 2007-01-17 |
| EP2295079A3 (en) | 2011-03-23 |
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| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20171222 |
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| MKLA | Lapsed |
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