CA2391978A1 - Procede de preparation de sulfamides - Google Patents

Procede de preparation de sulfamides Download PDF

Info

Publication number
CA2391978A1
CA2391978A1 CA002391978A CA2391978A CA2391978A1 CA 2391978 A1 CA2391978 A1 CA 2391978A1 CA 002391978 A CA002391978 A CA 002391978A CA 2391978 A CA2391978 A CA 2391978A CA 2391978 A1 CA2391978 A1 CA 2391978A1
Authority
CA
Canada
Prior art keywords
optionally substituted
alkyl
formula
phenyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002391978A
Other languages
English (en)
Inventor
Alfio Borghese
Luc Jean Jules Antoine
Jean-Pierre Joseph Sylvain Van Hoeck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2391978A1 publication Critical patent/CA2391978A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/34—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfuric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36—One oxygen atom
    • C07D263/38—One oxygen atom attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

L'invention concerne un procédé de production de sulfamide d'aryle représenté par la formule générale (I) dans laquelle R?1¿, R?2¿ et R?3¿ représentent chacun un hydrogène, un alkyle, un cycloalkyle ou un aryle, à condition qu'au moins un des R?1¿, R?2¿ et R¿3? représente un aryle, consistant à faire réagir un composé de la formule générale (II) dans laquelle R?4¿, R?5¿, R?6¿, R?7¿, R?8¿ et R?9¿ représentent chacun un hydrogène, un alkyle ou un aryle et n est égal à 0 ou 1, avec une amine de la formule R?2¿R?3¿NH (III), en présence d'une base forte.
CA002391978A 1999-11-18 2000-11-03 Procede de preparation de sulfamides Abandoned CA2391978A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9927302A GB2356398A (en) 1999-11-18 1999-11-18 Preparation of arylsulfamides
GB9927302.1 1999-11-18
PCT/US2000/028877 WO2001036383A1 (fr) 1999-11-18 2000-11-03 Procede de preparation de sulfamides

Publications (1)

Publication Number Publication Date
CA2391978A1 true CA2391978A1 (fr) 2001-05-25

Family

ID=10864756

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002391978A Abandoned CA2391978A1 (fr) 1999-11-18 2000-11-03 Procede de preparation de sulfamides

Country Status (6)

Country Link
EP (1) EP1235795A1 (fr)
JP (1) JP2003514797A (fr)
AU (1) AU1434301A (fr)
CA (1) CA2391978A1 (fr)
GB (1) GB2356398A (fr)
WO (1) WO2001036383A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002070467A1 (fr) 2001-02-26 2002-09-12 4Sc Ag Derives de diphenyluree, de diamide d'acide diphenyloxalique et de diamide d'acide diphenylsulfurique et leur utilisation comme medicaments
WO2003006424A1 (fr) 2001-07-10 2003-01-23 4Sc Ag Nouveaux composes utilises comme agents anti-inflammatoires, immunomodulateurs et anti-proliferatoires
GB0423554D0 (en) 2004-10-22 2004-11-24 Cancer Rec Tech Ltd Therapeutic compounds
US7951819B2 (en) 2006-04-26 2011-05-31 Cancer Research Technology Limited Imidazo[4, 5-B]pyridin-2-one and oxazolo[4, 5-B] pyridin-2-one compounds and analogs thereof as cancer therapeutic compounds
BRPI0821227A2 (pt) 2007-12-19 2015-06-16 Cancer Rec Tech Ltd Composto, composição farmacêutica, método para preparar a mesma, uso de um composto, método para tratar uma doença ou distúrbio, para inibir função de raf e para inibir proliferação celular, inibir progressão do ciclo celular, promover apoptose, ou uma combinação de um ou mais dos mesmos
GB0807609D0 (en) 2008-04-25 2008-06-04 Cancer Rec Tech Ltd Therapeutic compounds and their use
CN101569864B (zh) * 2008-04-29 2011-08-03 中山大学 手性磺胺类有机小分子催化剂及其应用
DK2531502T3 (da) 2010-02-01 2014-05-19 Cancer Rec Tech Ltd 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea og associerede forbindelser og ders anvendelse i terapi
GB201320729D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Therapeutic compounds and their use
GB201320732D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Methods of chemical synthesis
CN108250121A (zh) * 2016-12-28 2018-07-06 上海长森药业有限公司 磺酰胺-芳基酰胺类化合物及其治疗乙型肝炎的药物用途

Also Published As

Publication number Publication date
EP1235795A1 (fr) 2002-09-04
GB2356398A (en) 2001-05-23
AU1434301A (en) 2001-05-30
JP2003514797A (ja) 2003-04-22
GB9927302D0 (en) 2000-01-12
WO2001036383A1 (fr) 2001-05-25

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Legal Events

Date Code Title Description
FZDE Discontinued