CA2379047A1 - Nitroxy derivatives of (r) and (s)-carnitine - Google Patents

Nitroxy derivatives of (r) and (s)-carnitine Download PDF

Info

Publication number
CA2379047A1
CA2379047A1 CA002379047A CA2379047A CA2379047A1 CA 2379047 A1 CA2379047 A1 CA 2379047A1 CA 002379047 A CA002379047 A CA 002379047A CA 2379047 A CA2379047 A CA 2379047A CA 2379047 A1 CA2379047 A1 CA 2379047A1
Authority
CA
Canada
Prior art keywords
formula
compound
carnitine
treatment
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002379047A
Other languages
English (en)
French (fr)
Inventor
Oreste Piccolo
Roberto Castagnani
Paolo De Witt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2379047A1 publication Critical patent/CA2379047A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002379047A 1999-08-05 2000-07-31 Nitroxy derivatives of (r) and (s)-carnitine Abandoned CA2379047A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT1999RM000508A IT1306184B1 (it) 1999-08-05 1999-08-05 Nitrilossi derivati della (r) e (s)-carnitina.
ITRM99A000508 1999-08-05
PCT/IT2000/000325 WO2001010819A1 (en) 1999-08-05 2000-07-31 Nitroxy derivatives of (r) and (s)-carnitine

Publications (1)

Publication Number Publication Date
CA2379047A1 true CA2379047A1 (en) 2001-02-15

Family

ID=11406927

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002379047A Abandoned CA2379047A1 (en) 1999-08-05 2000-07-31 Nitroxy derivatives of (r) and (s)-carnitine

Country Status (16)

Country Link
US (2) US6395923B2 (da)
EP (1) EP1224161B1 (da)
JP (1) JP2003506429A (da)
KR (1) KR100772205B1 (da)
AT (1) ATE276231T1 (da)
AU (1) AU6470400A (da)
CA (1) CA2379047A1 (da)
CZ (1) CZ20025A3 (da)
DE (1) DE60013876T2 (da)
DK (1) DK1224161T3 (da)
ES (1) ES2226896T3 (da)
HU (1) HUP0203034A3 (da)
IT (1) IT1306184B1 (da)
PT (1) PT1224161E (da)
SK (1) SK287134B6 (da)
WO (1) WO2001010819A1 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20010456A1 (it) * 2001-07-26 2003-01-27 Sigma Tau Ind Farmaceuti Procedimento per la preparazione di (r)- o (s)- amminocarnitina sale interno, dei suoi sali e dei suoi derivati.
WO2019193539A1 (en) 2018-04-06 2019-10-10 Optimedica Corporation Methods and systems for changing a refractive property of an implantable intraocular lens
WO2020092243A1 (en) * 2018-10-29 2020-05-07 Lonza Inc. Method and composition for increasing the bioavailability of carnitine
US10703707B2 (en) 2018-11-07 2020-07-07 Industrial Technology Research Institute Method for preparing nitrate ester

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3830931A (en) * 1972-11-06 1974-08-20 Felice S De Carnitine and its use in the treatment of arrhythmia and impaired cardiac function
US5214166A (en) * 1986-11-29 1993-05-25 The United States Of America As Represented By The Secretary Of The Navy Method of synthesizing nitrato alkyl oxetanes
CH679856A5 (da) * 1990-07-04 1992-04-30 Lonza Ag
IT1256705B (it) * 1992-12-21 1995-12-12 Sigma Tau Ind Farmaceuti Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.
IT1261231B (it) * 1993-04-08 1996-05-09 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.
IT1261489B (it) * 1993-07-29 1996-05-23 Sigma Tau Ind Farmaceuti Procedimento per la produzione di r amminocarnitina e s amminocarnitina.
NZ501414A (en) * 1997-06-11 2001-12-21 Isis Pharma Gmbh Pentaerythritol derivatives, the production and uses thereof and intermediate products for the synthesis of active agents for treating heart/circulation and vascular illnesses

Also Published As

Publication number Publication date
US6548693B2 (en) 2003-04-15
JP2003506429A (ja) 2003-02-18
DE60013876D1 (de) 2004-10-21
PL358333A1 (en) 2004-08-09
KR100772205B1 (ko) 2007-11-01
ITRM990508A1 (it) 2001-02-05
IT1306184B1 (it) 2001-05-30
KR20020025213A (ko) 2002-04-03
US20020119965A1 (en) 2002-08-29
US20010011074A1 (en) 2001-08-02
SK1752002A3 (en) 2002-06-04
DE60013876T2 (de) 2005-09-29
US6395923B2 (en) 2002-05-28
ES2226896T3 (es) 2005-04-01
HUP0203034A2 (hu) 2003-02-28
EP1224161B1 (en) 2004-09-15
DK1224161T3 (da) 2005-01-24
CZ20025A3 (cs) 2002-07-17
AU6470400A (en) 2001-03-05
EP1224161A1 (en) 2002-07-24
ATE276231T1 (de) 2004-10-15
WO2001010819A1 (en) 2001-02-15
HUP0203034A3 (en) 2003-11-28
ITRM990508A0 (it) 1999-08-05
SK287134B6 (sk) 2010-01-07
PT1224161E (pt) 2005-01-31

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued