PT1224161E - Derivados nitroxilo de (r)-carnitina e de (s)-carnitina - Google Patents

Derivados nitroxilo de (r)-carnitina e de (s)-carnitina

Info

Publication number
PT1224161E
PT1224161E PT00951861T PT00951861T PT1224161E PT 1224161 E PT1224161 E PT 1224161E PT 00951861 T PT00951861 T PT 00951861T PT 00951861 T PT00951861 T PT 00951861T PT 1224161 E PT1224161 E PT 1224161E
Authority
PT
Portugal
Prior art keywords
carnitine
derivatives
formula
nitroxyl derivatives
nitroxyl
Prior art date
Application number
PT00951861T
Other languages
English (en)
Inventor
Roberto Castagnani
Paolo De Witt
Oreste Piccolo
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of PT1224161E publication Critical patent/PT1224161E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
PT00951861T 1999-08-05 2000-07-31 Derivados nitroxilo de (r)-carnitina e de (s)-carnitina PT1224161E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999RM000508A IT1306184B1 (it) 1999-08-05 1999-08-05 Nitrilossi derivati della (r) e (s)-carnitina.

Publications (1)

Publication Number Publication Date
PT1224161E true PT1224161E (pt) 2005-01-31

Family

ID=11406927

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00951861T PT1224161E (pt) 1999-08-05 2000-07-31 Derivados nitroxilo de (r)-carnitina e de (s)-carnitina

Country Status (16)

Country Link
US (2) US6395923B2 (pt)
EP (1) EP1224161B1 (pt)
JP (1) JP2003506429A (pt)
KR (1) KR100772205B1 (pt)
AT (1) ATE276231T1 (pt)
AU (1) AU6470400A (pt)
CA (1) CA2379047A1 (pt)
CZ (1) CZ20025A3 (pt)
DE (1) DE60013876T2 (pt)
DK (1) DK1224161T3 (pt)
ES (1) ES2226896T3 (pt)
HU (1) HUP0203034A3 (pt)
IT (1) IT1306184B1 (pt)
PT (1) PT1224161E (pt)
SK (1) SK287134B6 (pt)
WO (1) WO2001010819A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20010456A1 (it) * 2001-07-26 2003-01-27 Sigma Tau Ind Farmaceuti Procedimento per la preparazione di (r)- o (s)- amminocarnitina sale interno, dei suoi sali e dei suoi derivati.
AU2019247903A1 (en) 2018-04-06 2020-10-22 Amo Development, Llc Methods and systems for changing a refractive property of an implantable intraocular lens
EP3855944A4 (en) * 2018-10-29 2022-06-29 Lonza Consumer Health Inc. Method and composition for increasing the bioavailability of carnitine
US10703707B2 (en) 2018-11-07 2020-07-07 Industrial Technology Research Institute Method for preparing nitrate ester

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3830931A (en) * 1972-11-06 1974-08-20 Felice S De Carnitine and its use in the treatment of arrhythmia and impaired cardiac function
US5214166A (en) * 1986-11-29 1993-05-25 The United States Of America As Represented By The Secretary Of The Navy Method of synthesizing nitrato alkyl oxetanes
CH679856A5 (pt) * 1990-07-04 1992-04-30 Lonza Ag
IT1256705B (it) * 1992-12-21 1995-12-12 Sigma Tau Ind Farmaceuti Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.
IT1261231B (it) * 1993-04-08 1996-05-09 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.
IT1261489B (it) * 1993-07-29 1996-05-23 Sigma Tau Ind Farmaceuti Procedimento per la produzione di r amminocarnitina e s amminocarnitina.
TR199903054T2 (xx) * 1997-06-11 2000-07-21 Isis Pharma Gmbh Yeni pentaerythrit t�revleri, bunlar�n imalat� ve kullan�mlar� ile bunlar�n sentezi i�in ara maddeler.

Also Published As

Publication number Publication date
DE60013876T2 (de) 2005-09-29
HUP0203034A3 (en) 2003-11-28
PL358333A1 (en) 2004-08-09
US6548693B2 (en) 2003-04-15
ITRM990508A1 (it) 2001-02-05
AU6470400A (en) 2001-03-05
US20020119965A1 (en) 2002-08-29
ITRM990508A0 (it) 1999-08-05
KR20020025213A (ko) 2002-04-03
EP1224161B1 (en) 2004-09-15
EP1224161A1 (en) 2002-07-24
SK1752002A3 (en) 2002-06-04
SK287134B6 (sk) 2010-01-07
ES2226896T3 (es) 2005-04-01
DE60013876D1 (de) 2004-10-21
CA2379047A1 (en) 2001-02-15
DK1224161T3 (da) 2005-01-24
US20010011074A1 (en) 2001-08-02
JP2003506429A (ja) 2003-02-18
ATE276231T1 (de) 2004-10-15
CZ20025A3 (cs) 2002-07-17
US6395923B2 (en) 2002-05-28
WO2001010819A1 (en) 2001-02-15
HUP0203034A2 (hu) 2003-02-28
IT1306184B1 (it) 2001-05-30
KR100772205B1 (ko) 2007-11-01

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