CA2376199A1 - Use of verapamil and verapamil derivatives for producing medicaments with an inhibiting effect on .beta.-glucuronidase in human tissue - Google Patents

Use of verapamil and verapamil derivatives for producing medicaments with an inhibiting effect on .beta.-glucuronidase in human tissue Download PDF

Info

Publication number
CA2376199A1
CA2376199A1 CA002376199A CA2376199A CA2376199A1 CA 2376199 A1 CA2376199 A1 CA 2376199A1 CA 002376199 A CA002376199 A CA 002376199A CA 2376199 A CA2376199 A CA 2376199A CA 2376199 A1 CA2376199 A1 CA 2376199A1
Authority
CA
Canada
Prior art keywords
verapamil
glucuronidase
glucuronide
beta
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002376199A
Other languages
English (en)
French (fr)
Inventor
Gerd Geisslinger
Heyo K. Kroemer
Bernhard Sperker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PAZ ARZNEIMITTEL-ENTWICKLUNGS GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2376199A1 publication Critical patent/CA2376199A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
CA002376199A 1999-06-07 2000-05-27 Use of verapamil and verapamil derivatives for producing medicaments with an inhibiting effect on .beta.-glucuronidase in human tissue Abandoned CA2376199A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19925810.4 1999-06-07
DE19925810A DE19925810A1 (de) 1999-06-07 1999-06-07 Anwendung von Verapamil und Verapamilderivaten zur Herstellung von Arzneimitteln mit Glucuronidase hemmender Wirkung
PCT/EP2000/004848 WO2000074670A1 (de) 1999-06-07 2000-05-27 VERWENDUNG VON VERAPAMIL UND VERAPAMILDERIVATEN ZUR HERSTELLUNG VON ARZNEIMITTELN MIT β-GLUCURONIDASE IM HUMANEN GEWEBE HEMMENDER WIRKUNG

Publications (1)

Publication Number Publication Date
CA2376199A1 true CA2376199A1 (en) 2000-12-14

Family

ID=7910362

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002376199A Abandoned CA2376199A1 (en) 1999-06-07 2000-05-27 Use of verapamil and verapamil derivatives for producing medicaments with an inhibiting effect on .beta.-glucuronidase in human tissue

Country Status (5)

Country Link
EP (1) EP1183023A1 (de)
JP (1) JP2003501384A (de)
CA (1) CA2376199A1 (de)
DE (1) DE19925810A1 (de)
WO (1) WO2000074670A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10106530C2 (de) * 2001-02-13 2002-06-27 Heinz Kiefer Arzneimittel zur Entgiftung des Körpers
EP2192178B1 (de) * 2007-09-20 2015-11-18 Kao Corporation B-glucuronidasehemmer
CA2752849C (en) 2009-07-24 2014-07-08 Bernd G. Seigfried Liquid compositions capable of foaming and including active agents, and methods for making or developing same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0753665B2 (ja) * 1984-04-20 1995-06-07 財団法人癌研究会 抗転移剤
DE3635930A1 (de) * 1986-10-22 1988-04-28 Basf Ag Wirkstoffe zur anwendung bei der behandlung von tumoren
JPH0798752B2 (ja) * 1991-08-09 1995-10-25 株式会社ツムラ β−グルクロニダーゼ阻害剤
DE4236237A1 (de) * 1992-10-27 1994-04-28 Behringwerke Ag Prodrugs, ihre Herstellung und Verwendung als Arzneimittel
EP0647450A1 (de) * 1993-09-09 1995-04-12 BEHRINGWERKE Aktiengesellschaft Verbesserte Prodrogen für Enzym-vermittelten-Aktivierungen
DE19631288A1 (de) * 1996-08-02 1998-02-05 Hoechst Ag Neue Inhibitoren der ß-Glucuronidase

Also Published As

Publication number Publication date
DE19925810A1 (de) 2000-12-14
WO2000074670A1 (de) 2000-12-14
EP1183023A1 (de) 2002-03-06
JP2003501384A (ja) 2003-01-14

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Legal Events

Date Code Title Description
FZDE Dead