CA2371782A1 - Imaging of tissue using polarized light - Google Patents

Imaging of tissue using polarized light Download PDF

Info

Publication number
CA2371782A1
CA2371782A1 CA002371782A CA2371782A CA2371782A1 CA 2371782 A1 CA2371782 A1 CA 2371782A1 CA 002371782 A CA002371782 A CA 002371782A CA 2371782 A CA2371782 A CA 2371782A CA 2371782 A1 CA2371782 A1 CA 2371782A1
Authority
CA
Canada
Prior art keywords
light
tissue
backscattered
fiber
illumination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002371782A
Other languages
English (en)
French (fr)
Inventor
Stephen F. Fulghum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Newton Laboratories Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2371782A1 publication Critical patent/CA2371782A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407—Optical details
    • G02B23/2461—Illumination
    • G02B23/2469—Illumination using optical fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064—Constructional details of the endoscope body
    • A61B1/00071—Insertion part of the endoscope body
    • A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
    • A61B1/00096—Optical elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064—Constructional details of the endoscope body
    • A61B1/00071—Insertion part of the endoscope body
    • A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
    • A61B1/00097—Sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00172—Optical arrangements with means for scanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00186—Optical arrangements with imaging filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407—Optical details
    • G02B23/2423—Optical details of the distal end
    • G02B23/243—Objectives for endoscopes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4704—Angular selective
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4792—Polarisation of scatter light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Astronomy & Astrophysics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Instruments For Viewing The Inside Of Hollow Bodies (AREA)
  • Endoscopes (AREA)
  • Eye Examination Apparatus (AREA)
CA002371782A 1999-01-25 2000-01-25 Imaging of tissue using polarized light Abandoned CA2371782A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11722199P 1999-01-25 1999-01-25
US60/117,221 1999-01-25
PCT/US2000/001764 WO2000043750A2 (en) 1999-01-25 2000-01-25 Imaging of tissue using polarized light

Publications (1)

Publication Number Publication Date
CA2371782A1 true CA2371782A1 (en) 2000-07-27

Family

ID=22371613

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002371782A Abandoned CA2371782A1 (en) 1999-01-25 2000-01-25 Imaging of tissue using polarized light

Country Status (9)

Country Link
EP (1) EP1153280A2 (enExample)
JP (1) JP2002535645A (enExample)
KR (1) KR20010110346A (enExample)
CN (1) CN1341209A (enExample)
AU (1) AU2628200A (enExample)
CA (1) CA2371782A1 (enExample)
HK (1) HK1041727A1 (enExample)
NZ (1) NZ513118A (enExample)
WO (1) WO2000043750A2 (enExample)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002071026A2 (en) * 2001-03-02 2002-09-12 Spectrx, Inc. System and method for determining tissue characteristics
AU2001294997A1 (en) * 2000-08-14 2002-03-13 Oralscan Laboratories, Inc. Detection of epithelial dysplasia
JP2005515473A (ja) * 2002-01-18 2005-05-26 ニユートン・ラボラトリーズ・インコーポレーテツド 分光診断方法とシステム
US7333189B2 (en) 2002-01-18 2008-02-19 Pentax Corporation Spectroscopic diagnostic methods and system
WO2003104775A1 (en) * 2002-06-08 2003-12-18 Korea Basic Science Institute Method for protein chip analysis by using surface plasmon resonance spectroscopic imaging technology
EP1639331B1 (en) * 2003-06-04 2016-08-24 Samsung Electronics Co., Ltd. Measurements of optical inhomogeneity and other properties in substances using propagation modes of light
JP4535697B2 (ja) * 2003-07-23 2010-09-01 オリンパス株式会社 生体組織の光散乱観測内視鏡装置
JP4700001B2 (ja) * 2003-09-19 2011-06-15 ザ ジェネラル ホスピタル コーポレイション 蛍光偏極撮像方法
CN100443041C (zh) * 2004-05-26 2008-12-17 吴冈 具有测量功能的内窥镜系统及其测量方法
US20070167835A1 (en) * 2005-07-25 2007-07-19 Massachusetts Institute Of Technology Tri modal spectroscopic imaging
US7595889B2 (en) * 2005-10-11 2009-09-29 Duke University Systems and methods for endoscopic angle-resolved low coherence interferometry
US8175690B2 (en) * 2007-02-20 2012-05-08 Koninklijke Philips Electronics N.V. Optical device for assessing optical depth in a sample
WO2008110968A1 (en) * 2007-03-12 2008-09-18 Koninklijke Philips Electronics N.V. A system, computer-readable medium, method, and use for combined epithelial early cancer diagnosis and staging
CN100506150C (zh) * 2007-04-28 2009-07-01 马剑文 活体组织光学检测装置及其工作方法
DE202008009859U1 (de) * 2007-12-21 2009-03-05 Berthold Technologies Gmbh & Co. Kg Vorrichtung zur wahlweisen Messung von insbesondere Lumineszenz- und/oder Fluoreszenzstrahlung
JP4575474B2 (ja) * 2008-06-11 2010-11-04 国立大学法人東京工業大学 生体組織識別装置および方法
KR101109968B1 (ko) 2008-07-23 2012-02-17 올림푸스 메디칼 시스템즈 가부시키가이샤 피검체 관측 장치 및 피검체 관측 방법
JP5191831B2 (ja) * 2008-07-23 2013-05-08 オリンパスメディカルシステムズ株式会社 被検体観測装置及び被検体観測装置の作動方法
JP2010025867A (ja) * 2008-07-23 2010-02-04 Olympus Medical Systems Corp 被検体観測装置及び被検体観測方法
CN102227625A (zh) * 2008-12-02 2011-10-26 皇家飞利浦电子股份有限公司 用于通过受抑全内反射来探测目标颗粒的传感器装置
JP5532479B2 (ja) * 2010-03-31 2014-06-25 住友化学株式会社 金型検査方法、防眩製品ヘイズ予測方法および防眩製品反射像鮮明度予測方法
JPWO2012057150A1 (ja) * 2010-10-29 2014-05-12 オリンパス株式会社 光学測定装置およびプローブ
CN103596487B (zh) * 2011-07-15 2015-11-25 奥林巴斯株式会社 探头
WO2013133339A1 (ja) * 2012-03-07 2013-09-12 オリンパス株式会社 測定プローブ
WO2013132400A1 (en) * 2012-03-08 2013-09-12 Koninklijke Philips N.V. Apparatus for determining a property of a tissue
EP2836128B1 (en) 2012-04-13 2023-03-15 Baker Heart and Diabetes Institute Atherosclerotic plaque detection
WO2013175879A1 (ja) * 2012-05-25 2013-11-28 オリンパスメディカルシステムズ株式会社 測定プローブ
JP6173325B2 (ja) * 2012-09-13 2017-08-02 オリンパス株式会社 測定プローブおよび生体光学測定システム
DE102012221527A1 (de) * 2012-11-26 2014-06-12 Heine Optotechnik Gmbh & Co Kg Optisches Diagnoseinstrument
CN105814434A (zh) 2013-04-21 2016-07-27 莫拜尔欧西特有限公司 用于将来自样本表面的光和来自其更深漫射层的光分离的偏振光成像装置及其方法
CN104280350B (zh) * 2013-07-03 2018-06-01 庞小峰 一种特殊锐化的癌症早期诊断和治疗效果检查的装置
KR101503272B1 (ko) 2013-07-26 2015-03-18 연세대학교 원주산학협력단 관절염 진단을 위한 다중 모드 광 영상장치
CN106725250A (zh) * 2017-01-09 2017-05-31 清华大学深圳研究生院 一种头端调制的内窥偏振成像系统及测量方法
JP7461294B2 (ja) * 2017-08-31 2024-04-03 メタレンズ,インコーポレイテッド 透過型メタサーフェスレンズ統合
US12140778B2 (en) 2018-07-02 2024-11-12 Metalenz, Inc. Metasurfaces for laser speckle reduction
US11978752B2 (en) 2019-07-26 2024-05-07 Metalenz, Inc. Aperture-metasurface and hybrid refractive-metasurface imaging systems
AU2021321456B2 (en) 2020-08-04 2022-06-30 Baker Heart and Diabetes Institute Guidewire sensing apparatus
EP4275080A4 (en) 2021-01-06 2024-11-13 Metalenz, Inc. SELF-ALIGNED NANOPILLAR COATINGS AND METHODS OF PREPARATION
CN113075097A (zh) * 2021-03-22 2021-07-06 厦门理工学院 一种基于散射光偏振检测的粒径测量方法、装置及设备
CN118591827A (zh) 2021-12-17 2024-09-03 梅特兰兹股份有限公司 通过照明和成像的抗欺骗面部识别
EP4500265A2 (en) 2022-03-31 2025-02-05 Metalenz, Inc. Polarization sorting metasurface microlens array device
US12699207B2 (en) 2022-10-05 2026-08-04 Metalenz, Inc. Shared-aperture camera system and calibration method

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61129554A (ja) * 1984-11-28 1986-06-17 Nippon Paint Co Ltd 散乱光測定装置
GB8701521D0 (en) * 1987-01-23 1993-12-01 British Aerospace Multi-parameter imaging polarimeter
US4953978A (en) * 1989-03-03 1990-09-04 Coulter Electronics Of New England, Inc. Particle size analysis utilizing polarization intensity differential scattering
ATE160170T1 (de) * 1991-02-22 1997-11-15 Coulter Corp Verfahren und vorrichtung zum reihensichten mikroskopischer zellen unter verwendung von techniken zur streuung polarisierten lichts
JPH0611439A (ja) * 1992-06-29 1994-01-21 Olympus Optical Co Ltd 生体組織の酸素代謝測定装置
US5672875A (en) * 1992-07-15 1997-09-30 Optix Lp Methods of minimizing scattering and improving tissue sampling in non-invasive testing and imaging
US5421339A (en) * 1993-05-12 1995-06-06 Board Of Regents, The University Of Texas System Diagnosis of dysplasia using laser induced fluoroescence
JP3451515B2 (ja) * 1995-04-06 2003-09-29 オムロン株式会社 光学式センサ装置
US5788639A (en) * 1995-07-13 1998-08-04 Lucid Technologies, Inc. Confocal imaging through thick dermal tissue
US5719399A (en) * 1995-12-18 1998-02-17 The Research Foundation Of City College Of New York Imaging and characterization of tissue based upon the preservation of polarized light transmitted therethrough
JPH09297099A (ja) * 1996-05-07 1997-11-18 Hitachi Ltd カラー近接場光学顕微鏡
JPH10246697A (ja) * 1997-03-03 1998-09-14 Nikon Corp 光学的検査方法及び光学的検査装置

Also Published As

Publication number Publication date
WO2000043750A9 (en) 2001-08-30
JP2002535645A (ja) 2002-10-22
HK1041727A1 (zh) 2002-07-19
CN1341209A (zh) 2002-03-20
WO2000043750A2 (en) 2000-07-27
WO2000043750A3 (en) 2000-11-23
EP1153280A2 (en) 2001-11-14
KR20010110346A (ko) 2001-12-13
AU2628200A (en) 2000-08-07
NZ513118A (en) 2004-02-27

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued