CA2368830A1 - Prodrugs of thrombin inhibitors - Google Patents

Prodrugs of thrombin inhibitors Download PDF

Info

Publication number
CA2368830A1
CA2368830A1 CA002368830A CA2368830A CA2368830A1 CA 2368830 A1 CA2368830 A1 CA 2368830A1 CA 002368830 A CA002368830 A CA 002368830A CA 2368830 A CA2368830 A CA 2368830A CA 2368830 A1 CA2368830 A1 CA 2368830A1
Authority
CA
Canada
Prior art keywords
alkyl
pico
pyr
cycloalkyl
cha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002368830A
Other languages
English (en)
French (fr)
Inventor
Dorit Baucke
Helmut Mack
Werner Seitz
Wilfried Hornberger
Gisela Backfisch
Jurgen Delzer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26004346&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2368830(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2368830A1 publication Critical patent/CA2368830A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
CA002368830A 1999-04-09 2000-04-05 Prodrugs of thrombin inhibitors Abandoned CA2368830A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19915930.0 1999-04-09
DE19915930 1999-04-09
DE10006799 2000-02-15
DE10006799.9 2000-02-15
PCT/EP2000/003008 WO2000061577A1 (de) 1999-04-09 2000-04-05 Prodrugs von thrombininhibitoren

Publications (1)

Publication Number Publication Date
CA2368830A1 true CA2368830A1 (en) 2000-10-19

Family

ID=26004346

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002368830A Abandoned CA2368830A1 (en) 1999-04-09 2000-04-05 Prodrugs of thrombin inhibitors

Country Status (16)

Country Link
EP (1) EP1169318A1 (pt)
JP (1) JP2002541254A (pt)
KR (1) KR20020004995A (pt)
CN (1) CN1349526A (pt)
AU (1) AU3659200A (pt)
BG (1) BG105985A (pt)
BR (1) BR0009653A (pt)
CA (1) CA2368830A1 (pt)
HK (1) HK1045516A1 (pt)
HU (1) HUP0202431A3 (pt)
IL (1) IL145670A0 (pt)
NO (1) NO20014807L (pt)
PL (1) PL352834A1 (pt)
SK (1) SK14092001A3 (pt)
TR (1) TR200102914T2 (pt)
WO (1) WO2000061577A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10064797A1 (de) * 2000-12-22 2002-06-27 Knoll Ag Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon
ATE437642T1 (de) * 2002-06-14 2009-08-15 Takeda Pharmaceutical Prodrugs von imidazol-derivaten, zur verwendung als protonenpumpen-hemmer zur behandlung von z.b. peptischen magengeschwüren
CN101969038B (zh) 2004-08-23 2012-02-15 洛克系统有限公司 支承一组集成电路单元的支承装置

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4421052A1 (de) * 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
KR100388185B1 (ko) * 1995-02-17 2003-11-28 애보트 게엠베하 운트 콤파니 카게 트롬빈 억제제로서의 신규 디펩티드 아미딘
DE19631084A1 (de) * 1996-08-01 1998-02-05 Basf Ag Verwendung von (Meth)acrylsäure-Copolymeren zur Erhöhung der Permeabilität der Schleimhaut
DE19635674A1 (de) * 1996-09-03 1998-03-05 Basf Ag Verfahren zur Herstellung von Amidinen

Also Published As

Publication number Publication date
BG105985A (en) 2002-06-28
CN1349526A (zh) 2002-05-15
NO20014807D0 (no) 2001-10-03
IL145670A0 (en) 2002-06-30
EP1169318A1 (de) 2002-01-09
SK14092001A3 (sk) 2002-05-09
HUP0202431A3 (en) 2003-03-28
KR20020004995A (ko) 2002-01-16
BR0009653A (pt) 2002-01-08
AU3659200A (en) 2000-11-14
HK1045516A1 (zh) 2002-11-29
TR200102914T2 (tr) 2002-01-21
WO2000061577A1 (de) 2000-10-19
HUP0202431A2 (hu) 2002-11-28
NO20014807L (no) 2001-12-04
JP2002541254A (ja) 2002-12-03
PL352834A1 (en) 2003-09-08

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued