AU3659200A - Prodrugs of thrombin inhibitors - Google Patents

Prodrugs of thrombin inhibitors Download PDF

Info

Publication number
AU3659200A
AU3659200A AU36592/00A AU3659200A AU3659200A AU 3659200 A AU3659200 A AU 3659200A AU 36592/00 A AU36592/00 A AU 36592/00A AU 3659200 A AU3659200 A AU 3659200A AU 3659200 A AU3659200 A AU 3659200A
Authority
AU
Australia
Prior art keywords
alkyl
pico
pyr
cycloalkyl
cha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU36592/00A
Other languages
English (en)
Inventor
Gisela Backfisch
Dorit Baucke
Jurgen Delzer
Wilfried Hornberger
Helmut Mack
Werner Seitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26004346&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU3659200(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by BASF SE filed Critical BASF SE
Publication of AU3659200A publication Critical patent/AU3659200A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
AU36592/00A 1999-04-09 2000-04-05 Prodrugs of thrombin inhibitors Abandoned AU3659200A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19915930 1999-04-09
DE19915930 1999-04-09
DE10006799 2000-02-15
DE10006799 2000-02-15
PCT/EP2000/003008 WO2000061577A1 (de) 1999-04-09 2000-04-05 Prodrugs von thrombininhibitoren

Publications (1)

Publication Number Publication Date
AU3659200A true AU3659200A (en) 2000-11-14

Family

ID=26004346

Family Applications (1)

Application Number Title Priority Date Filing Date
AU36592/00A Abandoned AU3659200A (en) 1999-04-09 2000-04-05 Prodrugs of thrombin inhibitors

Country Status (16)

Country Link
EP (1) EP1169318A1 (pt)
JP (1) JP2002541254A (pt)
KR (1) KR20020004995A (pt)
CN (1) CN1349526A (pt)
AU (1) AU3659200A (pt)
BG (1) BG105985A (pt)
BR (1) BR0009653A (pt)
CA (1) CA2368830A1 (pt)
HK (1) HK1045516A1 (pt)
HU (1) HUP0202431A3 (pt)
IL (1) IL145670A0 (pt)
NO (1) NO20014807L (pt)
PL (1) PL352834A1 (pt)
SK (1) SK14092001A3 (pt)
TR (1) TR200102914T2 (pt)
WO (1) WO2000061577A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10064797A1 (de) * 2000-12-22 2002-06-27 Knoll Ag Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon
CA2489470A1 (en) * 2002-06-14 2003-12-24 Takeda Pharmaceutical Company Limited Prodrug and process for producing the same
TWI387053B (zh) 2004-08-23 2013-02-21 Rokko Systems Pte Ltd 用於積體電路切割裝置之夾盤的供給機構

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4421052A1 (de) * 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
CN1198839C (zh) * 1995-02-17 2005-04-27 艾伯特有限及两合公司 作为凝血酶抑制剂的新的二肽脒类
DE19631084A1 (de) * 1996-08-01 1998-02-05 Basf Ag Verwendung von (Meth)acrylsäure-Copolymeren zur Erhöhung der Permeabilität der Schleimhaut
DE19635674A1 (de) * 1996-09-03 1998-03-05 Basf Ag Verfahren zur Herstellung von Amidinen

Also Published As

Publication number Publication date
SK14092001A3 (sk) 2002-05-09
KR20020004995A (ko) 2002-01-16
PL352834A1 (en) 2003-09-08
BG105985A (en) 2002-06-28
TR200102914T2 (tr) 2002-01-21
WO2000061577A1 (de) 2000-10-19
NO20014807D0 (no) 2001-10-03
CN1349526A (zh) 2002-05-15
NO20014807L (no) 2001-12-04
HUP0202431A3 (en) 2003-03-28
CA2368830A1 (en) 2000-10-19
IL145670A0 (en) 2002-06-30
BR0009653A (pt) 2002-01-08
EP1169318A1 (de) 2002-01-09
HK1045516A1 (zh) 2002-11-29
HUP0202431A2 (hu) 2002-11-28
JP2002541254A (ja) 2002-12-03

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Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted