BG105985A - Prodrugs of thrombin inhibitors - Google Patents

Prodrugs of thrombin inhibitors

Info

Publication number
BG105985A
BG105985A BG105985A BG10598501A BG105985A BG 105985 A BG105985 A BG 105985A BG 105985 A BG105985 A BG 105985A BG 10598501 A BG10598501 A BG 10598501A BG 105985 A BG105985 A BG 105985A
Authority
BG
Bulgaria
Prior art keywords
prodrugs
thrombin inhibitors
relates
amidines
trypsin
Prior art date
Application number
BG105985A
Other languages
Bulgarian (bg)
English (en)
Inventor
Dorit Baucke
Helmut Mack
Werner Seitz
Wilfried Hornberger
Gisela Backfisch
Juergen DELZER
Original Assignee
Abbott Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26004346&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG105985(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Gmbh & Co. Kg filed Critical Abbott Gmbh & Co. Kg
Publication of BG105985A publication Critical patent/BG105985A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
BG105985A 1999-04-09 2001-10-05 Prodrugs of thrombin inhibitors BG105985A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19915930 1999-04-09
DE10006799 2000-02-15
PCT/EP2000/003008 WO2000061577A1 (de) 1999-04-09 2000-04-05 Prodrugs von thrombininhibitoren

Publications (1)

Publication Number Publication Date
BG105985A true BG105985A (en) 2002-06-28

Family

ID=26004346

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105985A BG105985A (en) 1999-04-09 2001-10-05 Prodrugs of thrombin inhibitors

Country Status (16)

Country Link
EP (1) EP1169318A1 (pt)
JP (1) JP2002541254A (pt)
KR (1) KR20020004995A (pt)
CN (1) CN1349526A (pt)
AU (1) AU3659200A (pt)
BG (1) BG105985A (pt)
BR (1) BR0009653A (pt)
CA (1) CA2368830A1 (pt)
HK (1) HK1045516A1 (pt)
HU (1) HUP0202431A3 (pt)
IL (1) IL145670A0 (pt)
NO (1) NO20014807L (pt)
PL (1) PL352834A1 (pt)
SK (1) SK14092001A3 (pt)
TR (1) TR200102914T2 (pt)
WO (1) WO2000061577A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10064797A1 (de) * 2000-12-22 2002-06-27 Knoll Ag Orale und parenterale pharmazeutische Formulierung, umfassend eine niedermolekulare Thrombininhibitor-Pro-Pharmakon
CA2489470A1 (en) * 2002-06-14 2003-12-24 Takeda Pharmaceutical Company Limited Prodrug and process for producing the same
TWI387053B (zh) 2004-08-23 2013-02-21 Rokko Systems Pte Ltd 用於積體電路切割裝置之夾盤的供給機構

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4421052A1 (de) * 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
CN1198839C (zh) * 1995-02-17 2005-04-27 艾伯特有限及两合公司 作为凝血酶抑制剂的新的二肽脒类
DE19631084A1 (de) * 1996-08-01 1998-02-05 Basf Ag Verwendung von (Meth)acrylsäure-Copolymeren zur Erhöhung der Permeabilität der Schleimhaut
DE19635674A1 (de) * 1996-09-03 1998-03-05 Basf Ag Verfahren zur Herstellung von Amidinen

Also Published As

Publication number Publication date
SK14092001A3 (sk) 2002-05-09
KR20020004995A (ko) 2002-01-16
PL352834A1 (en) 2003-09-08
TR200102914T2 (tr) 2002-01-21
WO2000061577A1 (de) 2000-10-19
NO20014807D0 (no) 2001-10-03
CN1349526A (zh) 2002-05-15
NO20014807L (no) 2001-12-04
AU3659200A (en) 2000-11-14
HUP0202431A3 (en) 2003-03-28
CA2368830A1 (en) 2000-10-19
IL145670A0 (en) 2002-06-30
BR0009653A (pt) 2002-01-08
EP1169318A1 (de) 2002-01-09
HK1045516A1 (zh) 2002-11-29
HUP0202431A2 (hu) 2002-11-28
JP2002541254A (ja) 2002-12-03

Similar Documents

Publication Publication Date Title
GEP20074098B (en) Lactam-containing compounds and derivatives thereof as factor xa inhibitors
UA74372C2 (uk) Інгібітори серинових протеаз, фармацевтична композиція на їх основі
BG106013A (en) New compounds and compositions as protease inhibitors
IL147317A0 (en) NITROGEN CONTAINING HETEROBICYCLES AS FACTOR Xa INHIBITORS
BG106585A (en) Kinase inhibitors as therapeutic agents
DK1196414T3 (da) Prolægemiddel af carbamathæmmer for IMPDH
WO2002000651A3 (en) Factor xa inhibitors
WO2000055124A3 (en) Novel compounds and compositions as protease inhibitors
HUP0203130A2 (hu) Hexahidrofuro[2,3-b]furán-3-il-N-{3-(1,3-benzodioxol-5-il-szulfonil)-(izobutil)-amino-1-benzil-2-(hidroxi-propil)}-karbamát mint retrovírus-proteáz-gátló
WO2002020475A3 (en) Inhibitors of serine protease activity of matriptase or mtsp1
GB0030303D0 (en) Compounds
GB0030306D0 (en) Compounds
WO2000061609A3 (de) Prodrugs von thrombininhibitoren
WO2002080853A3 (en) Fused heterocyclic inhibitors of factor xa
BG105866A (en) Heteroaryl amidines, methylamidines and guanidines as protease inhibitors
MXPA03000223A (es) Derivados de pirrolidina como inhibidores de la enzima conversor de endotelina.
HK1053121A1 (en) New amidino derivatives and their use as thrombin inhibitors
MXPA03000368A (es) Derivados de pirrolidina como inhibidores de metalproteasa.
BG105985A (en) Prodrugs of thrombin inhibitors
MY132033A (en) New mandelic acid derivatives and their use as thrombin inhibitors
ATE268322T1 (de) Inhibitoren der tryptase
WO2002094197A3 (en) Bicyclic inhibitors of factor xa
SE9902596D0 (sv) Pharmaceutically active compounds
AU758194C (en) Novel benzimidazoles and benzoxazoles
EP1452522A3 (en) Novel compounds and compositions as protease inhibitors