CA2365900A1 - Pegylated interferon alfa-ccr5 antagonist combination hiv therapy - Google Patents

Pegylated interferon alfa-ccr5 antagonist combination hiv therapy Download PDF

Info

Publication number
CA2365900A1
CA2365900A1 CA002365900A CA2365900A CA2365900A1 CA 2365900 A1 CA2365900 A1 CA 2365900A1 CA 002365900 A CA002365900 A CA 002365900A CA 2365900 A CA2365900 A CA 2365900A CA 2365900 A1 CA2365900 A1 CA 2365900A1
Authority
CA
Canada
Prior art keywords
alkyl
phenyl
hydrogen
group
independently selected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002365900A
Other languages
English (en)
French (fr)
Inventor
Mark A. Laughlin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2365900A1 publication Critical patent/CA2365900A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA002365900A 1999-05-04 2000-05-01 Pegylated interferon alfa-ccr5 antagonist combination hiv therapy Abandoned CA2365900A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30489799A 1999-05-04 1999-05-04
US09/304,897 1999-05-04
PCT/US2000/011634 WO2000066141A2 (en) 1999-05-04 2000-05-01 Pegylated interferon alfa-ccr5 antagonist combination hiv therapy

Publications (1)

Publication Number Publication Date
CA2365900A1 true CA2365900A1 (en) 2000-11-09

Family

ID=23178462

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002365900A Abandoned CA2365900A1 (en) 1999-05-04 2000-05-01 Pegylated interferon alfa-ccr5 antagonist combination hiv therapy

Country Status (21)

Country Link
EP (1) EP1175224B1 (enExample)
JP (1) JP2002543144A (enExample)
CN (1) CN1349408A (enExample)
AR (1) AR023824A1 (enExample)
AT (1) ATE289516T1 (enExample)
AU (1) AU776541B2 (enExample)
BR (1) BR0010593A (enExample)
CA (1) CA2365900A1 (enExample)
DE (1) DE60018273T2 (enExample)
ES (1) ES2238277T3 (enExample)
HK (1) HK1039278B (enExample)
HU (1) HUP0202734A3 (enExample)
MX (1) MXPA01011116A (enExample)
MY (1) MY127670A (enExample)
NO (1) NO328679B1 (enExample)
NZ (1) NZ514519A (enExample)
PE (1) PE20010283A1 (enExample)
PT (1) PT1175224E (enExample)
TW (1) TWI289454B (enExample)
WO (1) WO2000066141A2 (enExample)
ZA (1) ZA200108870B (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050065319A1 (en) * 2000-12-19 2005-03-24 Baroudy Bahige M. Combination method for treating viral infections
CA2517888C (en) 2003-03-14 2012-05-01 Ono Pharmaceutical Co., Ltd. Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient
EP2364982A1 (en) 2003-04-18 2011-09-14 ONO Pharmaceutical Co., Ltd. Spiro-piperidine compounds as chemokine receptor antagonists and medicinal use thereof
EP1616862A4 (en) * 2003-04-18 2008-07-16 Ono Pharmaceutical Co HETEROCYCLIC NITROGEN COMPOUND AND USE THEREOF
ES2294589T3 (es) 2004-04-29 2008-04-01 F. Hoffmann-La Roche Ag Variacion de la secuencia nucleosida de ns5a como marcador.
PE20060598A1 (es) 2004-09-13 2006-08-21 Ono Pharmaceutical Co Derivado heterociclo conteniendo nitrogeno como antagonista de quimiocina ccr5
AU2006216731A1 (en) * 2005-02-23 2006-08-31 Schering Corporation Piperidinyl piperazine derivatives useful as inhibitors of chemokine receptors
US20110052612A1 (en) 2005-05-31 2011-03-03 Ono Pharmaceutical Co., Ltd. Spiropiperidine compound and medicinal use thereof
EP2657235A1 (en) 2005-10-28 2013-10-30 Ono Pharmaceutical Co., Ltd. Compound containing basic group and use thereof
US8168783B2 (en) 2005-11-18 2012-05-01 Ono Pharmaceutical Co., Ltd. Chemokine receptor antagonists and use thereof
KR20090008217A (ko) 2006-03-10 2009-01-21 오노 야꾸힝 고교 가부시키가이샤 질소 함유 복소환 유도체 및 이들을 유효 성분으로 하는 약제
WO2007132846A1 (ja) 2006-05-16 2007-11-22 Ono Pharmaceutical Co., Ltd. 保護されていてもよい酸性基を含有する化合物およびその用途
US20090325992A1 (en) 2006-07-31 2009-12-31 Ono Pharmaceutical Co., Ltd. Compound having cyclic group bound thereto through spiro binding and use thereof
WO2010129351A1 (en) 2009-04-28 2010-11-11 Schepens Eye Research Institute Method to identify and treat age-related macular degeneration
WO2013024022A1 (en) 2011-08-12 2013-02-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for treatment of pulmonary hypertension
AU2012338581B2 (en) 2011-11-18 2016-12-08 Nxera Pharma Uk Limited Muscarinic M1 receptor agonists
SG11201605440TA (en) 2014-01-08 2016-08-30 Immunovative Therapies Ltd Treatment of human immunodeficiency virus/acquired immunodeficiency syndrome
GB201404922D0 (en) 2014-03-19 2014-04-30 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201513743D0 (en) 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonists
GB201519352D0 (en) 2015-11-02 2015-12-16 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds
US11629196B2 (en) 2020-04-27 2023-04-18 Incelldx, Inc. Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5889006A (en) * 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
US5908621A (en) * 1995-11-02 1999-06-01 Schering Corporation Polyethylene glycol modified interferon therapy
ES2214551T3 (es) * 1995-11-02 2004-09-16 Schering Corporation Terapia de infusion continua de citocinas a baja dosis.
GB9609932D0 (en) * 1996-05-13 1996-07-17 Hoffmann La Roche Use of IL-12 and IFN alpha for the treatment of infectious diseases
WO1998025617A1 (en) * 1996-12-13 1998-06-18 Merck & Co., Inc. Substituted aryl piperazines as modulators of chemokine receptor activity
AR013669A1 (es) * 1997-10-07 2001-01-10 Smithkline Beecham Corp Compuestos y metodos

Also Published As

Publication number Publication date
EP1175224B1 (en) 2005-02-23
JP2002543144A (ja) 2002-12-17
BR0010593A (pt) 2002-02-13
PT1175224E (pt) 2005-07-29
ES2238277T3 (es) 2005-09-01
AU776541B2 (en) 2004-09-16
HUP0202734A2 (hu) 2002-12-28
AR023824A1 (es) 2002-09-04
WO2000066141A3 (en) 2001-02-08
TWI289454B (en) 2007-11-11
DE60018273D1 (de) 2005-03-31
DE60018273T2 (de) 2005-08-18
NO20015367L (no) 2002-01-03
ZA200108870B (en) 2003-03-26
NO328679B1 (no) 2010-04-26
NZ514519A (en) 2003-07-25
MXPA01011116A (es) 2002-06-04
HK1039278B (en) 2005-06-30
CN1349408A (zh) 2002-05-15
WO2000066141A2 (en) 2000-11-09
HK1039278A1 (en) 2002-04-19
MY127670A (en) 2006-12-29
PE20010283A1 (es) 2001-03-16
AU4681500A (en) 2000-11-17
HUP0202734A3 (en) 2003-11-28
EP1175224A2 (en) 2002-01-30
ATE289516T1 (de) 2005-03-15
NO20015367D0 (no) 2001-11-02

Similar Documents

Publication Publication Date Title
EP1175224B1 (en) Pegylated interferon alfa-ccr5 antagonist combination hiv therapy
TWI473810B (zh) 治療用組成物
RU2411042C2 (ru) Композиции и способы для лечения острого респираторного синдрома (sars)
JP2004511513A (ja) リバビリン−ＰＥＧ化インターフェロンαＨＣＶ併用治療
US6635646B1 (en) Pegylated interferon alfa-CCR5 antagonist combination HIV therapy
EP1536839B1 (en) Combination therapy comprising omega-interferon for treating infection with hepatitis c virus or yellow fever virus
AU2010236606A1 (en) Interferon-alfa sensitivity biomarkers
US20020004584A1 (en) HIV immune adjuvant therapy
US20050065319A1 (en) Combination method for treating viral infections
CA2299893A1 (en) Hiv therapy
US20020182179A1 (en) HIV Therapy
HK1027286A (en) Hiv therapy
AU2002245148A1 (en) CCR5 antagonist and DP-178 polypeptide for treating viral infections
JPWO2006093211A1 (ja) 抗ウイルス剤
Pockros Current status of immunomodulatory therapies in HCV infection

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued