HUP0202734A2 - Pegilezett alfa-interferon és egy CCR5 antagonista kombinációjának alkalmazása HIV-terápiára - Google Patents
Pegilezett alfa-interferon és egy CCR5 antagonista kombinációjának alkalmazása HIV-terápiáraInfo
- Publication number
- HUP0202734A2 HUP0202734A2 HU0202734A HUP0202734A HUP0202734A2 HU P0202734 A2 HUP0202734 A2 HU P0202734A2 HU 0202734 A HU0202734 A HU 0202734A HU P0202734 A HUP0202734 A HU P0202734A HU P0202734 A2 HUP0202734 A2 HU P0202734A2
- Authority
- HU
- Hungary
- Prior art keywords
- hiv
- pegylated
- ccr5 antagonist
- interfron
- alfa
- Prior art date
Links
- 239000003067 chemokine receptor CCR5 antagonist Substances 0.000 title abstract 3
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 241000713772 Human immunodeficiency virus 1 Species 0.000 abstract 2
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 abstract 2
- 229960000329 ribavirin Drugs 0.000 abstract 2
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
A találmány tárgya pegilezett alfa-interferon és egy CCR5 antagonistaalkalmazása HIV-1-fertőzött, illetve pegilezett alfa-interferon, egyCCRS antagonista, ribavirin és a HAART hatóanyagai alkalmazása a HIV-1és HCV által együttesen fertőzött páciensek kezelésére szolgálógyógyszerkészítmény előállítására. A kezelés pegilezett alfa-interferon terápiásan hatásos mennyiségének, egy CCR5 antagonistaterápiásan hatásos mennyiségének, valamint adott esetben ribavirin ésmás anti-HIV-1 hatóanyagok terápiásan hatásos, a HIV-1-RNS, illetve aHCV-RNS csökkentéséhez elegendő mennyiségének egymással összefüggőbeadásából áll. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30489799A | 1999-05-04 | 1999-05-04 | |
PCT/US2000/011634 WO2000066141A2 (en) | 1999-05-04 | 2000-05-01 | Pegylated interferon alfa-ccr5 antagonist combination hiv therapy |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0202734A2 true HUP0202734A2 (hu) | 2002-12-28 |
HUP0202734A3 HUP0202734A3 (en) | 2003-11-28 |
Family
ID=23178462
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0202734A HUP0202734A3 (en) | 1999-05-04 | 2000-05-01 | Use of pegylated interfron alfa-ccr5 antagonist combination for hiv therapy |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP1175224B1 (hu) |
JP (1) | JP2002543144A (hu) |
CN (1) | CN1349408A (hu) |
AR (1) | AR023824A1 (hu) |
AT (1) | ATE289516T1 (hu) |
AU (1) | AU776541B2 (hu) |
BR (1) | BR0010593A (hu) |
CA (1) | CA2365900A1 (hu) |
DE (1) | DE60018273T2 (hu) |
ES (1) | ES2238277T3 (hu) |
HK (1) | HK1039278B (hu) |
HU (1) | HUP0202734A3 (hu) |
MX (1) | MXPA01011116A (hu) |
MY (1) | MY127670A (hu) |
NO (1) | NO328679B1 (hu) |
NZ (1) | NZ514519A (hu) |
PE (1) | PE20010283A1 (hu) |
PT (1) | PT1175224E (hu) |
TW (1) | TWI289454B (hu) |
WO (1) | WO2000066141A2 (hu) |
ZA (1) | ZA200108870B (hu) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050065319A1 (en) * | 2000-12-19 | 2005-03-24 | Baroudy Bahige M. | Combination method for treating viral infections |
TW201018661A (en) | 2003-03-14 | 2010-05-16 | Ono Pharmaceutical Co | Heterocyclic rinf having nitrogen atom derivatives and medicament containing the derivatives as active ingredient |
JPWO2004092136A1 (ja) * | 2003-04-18 | 2006-07-06 | 小野薬品工業株式会社 | 含窒素複素環化合物およびその用途 |
WO2004092169A1 (ja) | 2003-04-18 | 2004-10-28 | Ono Pharmaceutical Co., Ltd. | スピロピペリジン化合物およびその医薬用途 |
DE602005002673T2 (de) | 2004-04-29 | 2008-07-24 | F. Hoffmann-La Roche Ag | Nukleotidsequenzvariation im Gen NS5A als Marker |
MX2007002886A (es) | 2004-09-13 | 2007-05-16 | Ono Pharmaceutical Co | Derivado heterociclico que contiene nitrogeno y un farmaco que contiene el mismo como el ingrediente activo. |
KR20070107085A (ko) * | 2005-02-23 | 2007-11-06 | 쉐링 코포레이션 | 케모카인 수용체의 억제제로서 유용한 피페리디닐 피페라진유도체 |
EP1889622A4 (en) | 2005-05-31 | 2009-12-23 | Ono Pharmaceutical Co | SPIROPIPERIDINE COMPOUND AND MEDICINAL USE THEREOF |
PL1942108T3 (pl) | 2005-10-28 | 2014-03-31 | Ono Pharmaceutical Co | Związek zawierający grupę zasadową i jego zastosowanie |
PT1961744E (pt) | 2005-11-18 | 2013-05-15 | Ono Pharmaceutical Co | Composto que contém um grupo básico e sua utilização |
CN101443322A (zh) | 2006-03-10 | 2009-05-27 | 小野药品工业株式会社 | 含氮杂环衍生物及含有该衍生物作为活性成分的药物 |
WO2007132846A1 (ja) | 2006-05-16 | 2007-11-22 | Ono Pharmaceutical Co., Ltd. | 保護されていてもよい酸性基を含有する化合物およびその用途 |
US20090325992A1 (en) | 2006-07-31 | 2009-12-31 | Ono Pharmaceutical Co., Ltd. | Compound having cyclic group bound thereto through spiro binding and use thereof |
WO2010129351A1 (en) | 2009-04-28 | 2010-11-11 | Schepens Eye Research Institute | Method to identify and treat age-related macular degeneration |
US20140271680A1 (en) | 2011-08-12 | 2014-09-18 | Universite Paris-Est Creteil Val De Marne | Methods and pharmaceutical compositions for treatment of pulmonary hypertension |
EP2780015B1 (en) | 2011-11-18 | 2017-01-04 | Heptares Therapeutics Limited | Muscarinic m1 receptor agonists |
US10272143B2 (en) * | 2014-01-08 | 2019-04-30 | Immunovative Therapies Ltd. | Treatment of human immunodeficiency virus/acquired immunodeficiency syndrome |
GB201519352D0 (en) | 2015-11-02 | 2015-12-16 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
GB201617454D0 (en) | 2016-10-14 | 2016-11-30 | Heptares Therapeutics Limited | Pharmaceutical compounds |
GB201810239D0 (en) | 2018-06-22 | 2018-08-08 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
GB201819960D0 (en) | 2018-12-07 | 2019-01-23 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
US11629196B2 (en) | 2020-04-27 | 2023-04-18 | Incelldx, Inc. | Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5889006A (en) * | 1995-02-23 | 1999-03-30 | Schering Corporation | Muscarinic antagonists |
US5908621A (en) * | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
WO1997016204A1 (en) * | 1995-11-02 | 1997-05-09 | Schering Corporation | Continuous low-dose cytokine infusion therapy |
GB9609932D0 (en) * | 1996-05-13 | 1996-07-17 | Hoffmann La Roche | Use of IL-12 and IFN alpha for the treatment of infectious diseases |
WO1998025617A1 (en) * | 1996-12-13 | 1998-06-18 | Merck & Co., Inc. | Substituted aryl piperazines as modulators of chemokine receptor activity |
AR013669A1 (es) * | 1997-10-07 | 2001-01-10 | Smithkline Beecham Corp | Compuestos y metodos |
-
2000
- 2000-05-01 HU HU0202734A patent/HUP0202734A3/hu unknown
- 2000-05-01 ES ES00928604T patent/ES2238277T3/es not_active Expired - Lifetime
- 2000-05-01 CA CA002365900A patent/CA2365900A1/en not_active Abandoned
- 2000-05-01 EP EP00928604A patent/EP1175224B1/en not_active Expired - Lifetime
- 2000-05-01 AU AU46815/00A patent/AU776541B2/en not_active Ceased
- 2000-05-01 JP JP2000615025A patent/JP2002543144A/ja not_active Ceased
- 2000-05-01 NZ NZ514519A patent/NZ514519A/en not_active IP Right Cessation
- 2000-05-01 DE DE60018273T patent/DE60018273T2/de not_active Expired - Lifetime
- 2000-05-01 BR BR0010593-7A patent/BR0010593A/pt not_active Application Discontinuation
- 2000-05-01 MX MXPA01011116A patent/MXPA01011116A/es active IP Right Grant
- 2000-05-01 CN CN00807116A patent/CN1349408A/zh active Pending
- 2000-05-01 WO PCT/US2000/011634 patent/WO2000066141A2/en active IP Right Grant
- 2000-05-01 PT PT00928604T patent/PT1175224E/pt unknown
- 2000-05-01 AT AT00928604T patent/ATE289516T1/de not_active IP Right Cessation
- 2000-05-02 PE PE2000000408A patent/PE20010283A1/es not_active Application Discontinuation
- 2000-05-02 AR ARP000102097A patent/AR023824A1/es unknown
- 2000-05-02 TW TW089108323A patent/TWI289454B/zh not_active IP Right Cessation
- 2000-05-02 MY MYPI20001893A patent/MY127670A/en unknown
-
2001
- 2001-10-26 ZA ZA200108870A patent/ZA200108870B/xx unknown
- 2001-11-02 NO NO20015367A patent/NO328679B1/no not_active IP Right Cessation
-
2002
- 2002-02-02 HK HK02100826.8A patent/HK1039278B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2365900A1 (en) | 2000-11-09 |
AU4681500A (en) | 2000-11-17 |
WO2000066141A3 (en) | 2001-02-08 |
PT1175224E (pt) | 2005-07-29 |
ZA200108870B (en) | 2003-03-26 |
AR023824A1 (es) | 2002-09-04 |
EP1175224A2 (en) | 2002-01-30 |
TWI289454B (en) | 2007-11-11 |
DE60018273D1 (de) | 2005-03-31 |
ATE289516T1 (de) | 2005-03-15 |
WO2000066141A2 (en) | 2000-11-09 |
BR0010593A (pt) | 2002-02-13 |
HK1039278B (zh) | 2005-06-30 |
CN1349408A (zh) | 2002-05-15 |
NO20015367D0 (no) | 2001-11-02 |
JP2002543144A (ja) | 2002-12-17 |
PE20010283A1 (es) | 2001-03-16 |
EP1175224B1 (en) | 2005-02-23 |
MXPA01011116A (es) | 2002-06-04 |
NO328679B1 (no) | 2010-04-26 |
DE60018273T2 (de) | 2005-08-18 |
ES2238277T3 (es) | 2005-09-01 |
HK1039278A1 (en) | 2002-04-19 |
NZ514519A (en) | 2003-07-25 |
MY127670A (en) | 2006-12-29 |
NO20015367L (no) | 2002-01-03 |
AU776541B2 (en) | 2004-09-16 |
HUP0202734A3 (en) | 2003-11-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD9A | Lapse of provisional protection due to non-payment of fees |