DE60018273T2 - Pegyliertes interferon alpha in kombination mit einem ccr5 antagonisten für eine hiv-therapie - Google Patents

Pegyliertes interferon alpha in kombination mit einem ccr5 antagonisten für eine hiv-therapie Download PDF

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Publication number
DE60018273T2
DE60018273T2 DE60018273T DE60018273T DE60018273T2 DE 60018273 T2 DE60018273 T2 DE 60018273T2 DE 60018273 T DE60018273 T DE 60018273T DE 60018273 T DE60018273 T DE 60018273T DE 60018273 T2 DE60018273 T2 DE 60018273T2
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DE
Germany
Prior art keywords
alkyl
phenyl
hydrogen
group
independently selected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60018273T
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German (de)
English (en)
Other versions
DE60018273D1 (de
Inventor
A. Mark LAUGHLIN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of DE60018273D1 publication Critical patent/DE60018273D1/de
Application granted granted Critical
Publication of DE60018273T2 publication Critical patent/DE60018273T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE60018273T 1999-05-04 2000-05-01 Pegyliertes interferon alpha in kombination mit einem ccr5 antagonisten für eine hiv-therapie Expired - Lifetime DE60018273T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30489799A 1999-05-04 1999-05-04
US304897 1999-05-04
PCT/US2000/011634 WO2000066141A2 (en) 1999-05-04 2000-05-01 Pegylated interferon alfa-ccr5 antagonist combination hiv therapy

Publications (2)

Publication Number Publication Date
DE60018273D1 DE60018273D1 (de) 2005-03-31
DE60018273T2 true DE60018273T2 (de) 2005-08-18

Family

ID=23178462

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60018273T Expired - Lifetime DE60018273T2 (de) 1999-05-04 2000-05-01 Pegyliertes interferon alpha in kombination mit einem ccr5 antagonisten für eine hiv-therapie

Country Status (21)

Country Link
EP (1) EP1175224B1 (enExample)
JP (1) JP2002543144A (enExample)
CN (1) CN1349408A (enExample)
AR (1) AR023824A1 (enExample)
AT (1) ATE289516T1 (enExample)
AU (1) AU776541B2 (enExample)
BR (1) BR0010593A (enExample)
CA (1) CA2365900A1 (enExample)
DE (1) DE60018273T2 (enExample)
ES (1) ES2238277T3 (enExample)
HK (1) HK1039278B (enExample)
HU (1) HUP0202734A3 (enExample)
MX (1) MXPA01011116A (enExample)
MY (1) MY127670A (enExample)
NO (1) NO328679B1 (enExample)
NZ (1) NZ514519A (enExample)
PE (1) PE20010283A1 (enExample)
PT (1) PT1175224E (enExample)
TW (1) TWI289454B (enExample)
WO (1) WO2000066141A2 (enExample)
ZA (1) ZA200108870B (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050065319A1 (en) * 2000-12-19 2005-03-24 Baroudy Bahige M. Combination method for treating viral infections
NZ542304A (en) 2003-03-14 2009-07-31 Ono Pharmaceutical Co Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient
EP1619193A4 (en) 2003-04-18 2010-08-11 Ono Pharmaceutical Co SPIROPIPERIDINE COMPOUND AND MEDICINAL USE THEREOF
JPWO2004092136A1 (ja) * 2003-04-18 2006-07-06 小野薬品工業株式会社 含窒素複素環化合物およびその用途
ES2294589T3 (es) 2004-04-29 2008-04-01 F. Hoffmann-La Roche Ag Variacion de la secuencia nucleosida de ns5a como marcador.
BRPI0515164A (pt) 2004-09-13 2008-07-08 Ono Pharmaceutical Co derivado heterocìclico nitrogenado e medicamento contendo o mesmo como um ingrediente ativo
CA2598651A1 (en) * 2005-02-23 2006-08-31 Schering Corporation Piperidinyl piperazine derivatives useful as inhibitors of chemokine receptors
WO2006129679A1 (ja) 2005-05-31 2006-12-07 Ono Pharmaceutical Co., Ltd. スピロピペリジン化合物およびその医薬用途
EP1942108B1 (en) 2005-10-28 2013-09-04 Ono Pharmaceutical Co., Ltd. Compound containing basic group and use thereof
DK1961744T3 (da) 2005-11-18 2013-07-15 Ono Pharmaceutical Co Forbindelse indeholdende basiske grupper samt anvendelse deraf
KR20090008217A (ko) 2006-03-10 2009-01-21 오노 야꾸힝 고교 가부시키가이샤 질소 함유 복소환 유도체 및 이들을 유효 성분으로 하는 약제
JP5257068B2 (ja) 2006-05-16 2013-08-07 小野薬品工業株式会社 保護されていてもよい酸性基を含有する化合物およびその用途
JP5245827B2 (ja) 2006-07-31 2013-07-24 小野薬品工業株式会社 スピロ結合した環状基を含有する化合物およびその用途
WO2010129351A1 (en) 2009-04-28 2010-11-11 Schepens Eye Research Institute Method to identify and treat age-related macular degeneration
US20140271680A1 (en) 2011-08-12 2014-09-18 Universite Paris-Est Creteil Val De Marne Methods and pharmaceutical compositions for treatment of pulmonary hypertension
PT2780015T (pt) 2011-11-18 2017-03-23 Heptares Therapeutics Ltd Agonistas de recetor muscarínico m1
CN105899219B (zh) 2014-01-08 2021-08-13 免疫创新治疗有限公司 人类免疫缺陷病毒/获得性免疫缺陷综合症的治疗
GB201404922D0 (en) 2014-03-19 2014-04-30 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201513743D0 (en) 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonists
GB201519352D0 (en) 2015-11-02 2015-12-16 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds
US11629196B2 (en) 2020-04-27 2023-04-18 Incelldx, Inc. Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5889006A (en) * 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
ATE262920T1 (de) * 1995-11-02 2004-04-15 Schering Corp Kontinuierliche, niedrigdosierte zytokine- infusionstherapie
US5908621A (en) * 1995-11-02 1999-06-01 Schering Corporation Polyethylene glycol modified interferon therapy
GB9609932D0 (en) * 1996-05-13 1996-07-17 Hoffmann La Roche Use of IL-12 and IFN alpha for the treatment of infectious diseases
WO1998025617A1 (en) * 1996-12-13 1998-06-18 Merck & Co., Inc. Substituted aryl piperazines as modulators of chemokine receptor activity
AR013669A1 (es) * 1997-10-07 2001-01-10 Smithkline Beecham Corp Compuestos y metodos

Also Published As

Publication number Publication date
JP2002543144A (ja) 2002-12-17
ATE289516T1 (de) 2005-03-15
MXPA01011116A (es) 2002-06-04
AU776541B2 (en) 2004-09-16
ES2238277T3 (es) 2005-09-01
PT1175224E (pt) 2005-07-29
HK1039278A1 (en) 2002-04-19
WO2000066141A3 (en) 2001-02-08
DE60018273D1 (de) 2005-03-31
NZ514519A (en) 2003-07-25
CN1349408A (zh) 2002-05-15
TWI289454B (en) 2007-11-11
ZA200108870B (en) 2003-03-26
AR023824A1 (es) 2002-09-04
MY127670A (en) 2006-12-29
BR0010593A (pt) 2002-02-13
HK1039278B (en) 2005-06-30
HUP0202734A2 (hu) 2002-12-28
WO2000066141A2 (en) 2000-11-09
PE20010283A1 (es) 2001-03-16
HUP0202734A3 (en) 2003-11-28
NO20015367L (no) 2002-01-03
AU4681500A (en) 2000-11-17
CA2365900A1 (en) 2000-11-09
NO20015367D0 (no) 2001-11-02
NO328679B1 (no) 2010-04-26
EP1175224A2 (en) 2002-01-30
EP1175224B1 (en) 2005-02-23

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