CA2352249C - Process for the synthesis of 5-(.alpha.-hydroxyalkyl) benzo[1,3]dioxols - Google Patents

Process for the synthesis of 5-(.alpha.-hydroxyalkyl) benzo[1,3]dioxols Download PDF

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Publication number
CA2352249C
CA2352249C CA002352249A CA2352249A CA2352249C CA 2352249 C CA2352249 C CA 2352249C CA 002352249 A CA002352249 A CA 002352249A CA 2352249 A CA2352249 A CA 2352249A CA 2352249 C CA2352249 C CA 2352249C
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CA
Canada
Prior art keywords
benzo
dioxol
formula
reaction
process according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002352249A
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English (en)
French (fr)
Other versions
CA2352249A1 (en
Inventor
Valerio Borzatta
Dario Brancaleoni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Endura SpA
Original Assignee
Endura SpA
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Filing date
Publication date
Application filed by Endura SpA filed Critical Endura SpA
Publication of CA2352249A1 publication Critical patent/CA2352249A1/en
Application granted granted Critical
Publication of CA2352249C publication Critical patent/CA2352249C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/54Radicals substituted by oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Fats And Perfumes (AREA)
CA002352249A 1998-12-30 1999-10-14 Process for the synthesis of 5-(.alpha.-hydroxyalkyl) benzo[1,3]dioxols Expired - Lifetime CA2352249C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI98A002857 1998-12-30
IT1998MI002857A IT1304513B1 (it) 1998-12-30 1998-12-30 Processo per la sintesi di 5-(alfa-idrossialchil)benzo(1,3)diossoli.
PCT/EP1999/007743 WO2000040575A1 (en) 1998-12-30 1999-10-14 PROCESS FOR THE SYNTHESIS OF 5-(α -HYDROXYALKYL) BENZO[1, 3]DIOXOLS

Publications (2)

Publication Number Publication Date
CA2352249A1 CA2352249A1 (en) 2000-07-13
CA2352249C true CA2352249C (en) 2007-09-11

Family

ID=11381378

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002352249A Expired - Lifetime CA2352249C (en) 1998-12-30 1999-10-14 Process for the synthesis of 5-(.alpha.-hydroxyalkyl) benzo[1,3]dioxols

Country Status (13)

Country Link
US (1) US6342613B1 (enExample)
EP (1) EP1140894B1 (enExample)
JP (1) JP4845266B2 (enExample)
KR (1) KR100682160B1 (enExample)
CN (1) CN1138769C (enExample)
AT (1) ATE256676T1 (enExample)
AU (1) AU756172B2 (enExample)
BR (1) BR9916471B1 (enExample)
CA (1) CA2352249C (enExample)
DE (1) DE69913735T2 (enExample)
IT (1) IT1304513B1 (enExample)
RU (1) RU2243224C2 (enExample)
WO (1) WO2000040575A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005023124D1 (de) * 2004-01-28 2010-10-07 Hoffmann La Roche Spirobenzodioxole und deren verwendung als cb1-antagonisten
WO2010079423A1 (en) * 2009-01-12 2010-07-15 Council Of Scientific & Industrial Research Inhibitors of phosphatidylinositol-3-kinase (pi3) and inducers of nitric oxide (no)
EP2289889A1 (en) 2009-08-18 2011-03-02 Endura S.p.a. Substituted alkynyl phenoxy compounds and their uses
CN102070596B (zh) * 2011-01-22 2013-02-27 浙江大学 二氢黄樟素的制备方法
GB201104156D0 (en) 2011-03-11 2011-04-27 Rothamstead Res Ltd Compositions and methods for controlling pesticide resistant pests
EP3141115A1 (en) 2015-09-09 2017-03-15 Endura S.p.a. Substituted methylenedioxybenzyl compounds and their uses as synergists
EP3141116B1 (en) 2015-09-09 2018-06-13 Endura S.p.a. 5,7-disubstituted 2,3-dihydrobenzofurans and their use as synergists
CN106632228B (zh) * 2016-08-05 2019-07-02 成都建中香料香精有限公司 一种二氢黄樟素的制备方法
WO2018150230A1 (en) 2017-02-14 2018-08-23 Anthea Aromatics Private Limited A process for preparation of alkenyl and alkyl derivatives of alkylenedioxybenzene
WO2022161628A1 (en) 2021-01-29 2022-08-04 Endura S.P.A. Process for the preparation of 3,4-methylenedioxypropiophenone

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1097270A (en) * 1965-10-13 1968-01-03 Shell Int Research Process for the preparation of methylene dioxybenzene, 1,3-benzoxathiole and derivatives thereof
US3908000A (en) * 1971-03-19 1975-09-23 Hoffmann La Roche Propynyl benzyl ethers as insecticidal agents
US3946040A (en) * 1971-03-19 1976-03-23 Hoffmann-La Roche Inc. Propynyl benzyl ethers
CH583677A5 (enExample) * 1972-02-03 1977-01-14 Basf Ag
JPS56164178A (en) * 1980-05-23 1981-12-17 Mitsubishi Chem Ind Ltd Preparation of 4-hydroxy-1,3-benzodioxole
EP0095454A3 (de) * 1982-05-13 1985-04-03 Gerot-Pharmazeutika Gesellschaft m.b.H. Neue kernsubstituierte Pyrogallol-Derivate
JP2521739B2 (ja) * 1987-01-27 1996-08-07 新日本薬品株式会社 肝臓疾患治療剤
ATE61588T1 (de) * 1987-08-03 1991-03-15 Delagrange Lab 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
US5420301A (en) * 1988-03-18 1995-05-30 Ciba-Geigy Corporation Process for the preparation of substituted difluorobenzo-1,3-dioxoles
JP2760998B2 (ja) * 1988-08-16 1998-06-04 新日本薬品株式会社 肝臓疾患治療剤
SU1703648A1 (ru) * 1989-12-26 1992-01-07 Туркменский Государственный Университет Им.А.М.Горького 2-/2-Цианоэтил/-4,5-бензо-1,3-диоксолан, обладающий акарицидной активностью против иксодовых клещей рода Шаломма
DE4133155A1 (de) * 1991-10-07 1993-04-08 Bayer Ag Verfahren zur herstellung von 2,2-difluorbenzo (1,3)-dioxol-carbaldehyden und neuen zwischenprodukten
US5696301A (en) * 1996-01-23 1997-12-09 Ube Industries, Ltd. Process for preparing protocatechualdehyde

Also Published As

Publication number Publication date
AU756172B2 (en) 2003-01-09
ITMI982857A0 (it) 1998-12-30
IT1304513B1 (it) 2001-03-19
JP2002534423A (ja) 2002-10-15
JP4845266B2 (ja) 2011-12-28
CN1332736A (zh) 2002-01-23
EP1140894B1 (en) 2003-12-17
BR9916471B1 (pt) 2010-12-14
WO2000040575A1 (en) 2000-07-13
DE69913735T2 (de) 2004-07-29
CN1138769C (zh) 2004-02-18
ATE256676T1 (de) 2004-01-15
EP1140894A1 (en) 2001-10-10
CA2352249A1 (en) 2000-07-13
BR9916471A (pt) 2001-09-18
KR20010083955A (ko) 2001-09-03
DE69913735D1 (de) 2004-01-29
KR100682160B1 (ko) 2007-02-12
AU1037700A (en) 2000-07-24
US6342613B1 (en) 2002-01-29
ITMI982857A1 (it) 2000-06-30
RU2243224C2 (ru) 2004-12-27

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