CA2348688A1 - Recepteurs non-endogenes de la proteine g humaine ayant une activite constitutive - Google Patents

Recepteurs non-endogenes de la proteine g humaine ayant une activite constitutive Download PDF

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Publication number
CA2348688A1
CA2348688A1 CA002348688A CA2348688A CA2348688A1 CA 2348688 A1 CA2348688 A1 CA 2348688A1 CA 002348688 A CA002348688 A CA 002348688A CA 2348688 A CA2348688 A CA 2348688A CA 2348688 A1 CA2348688 A1 CA 2348688A1
Authority
CA
Canada
Prior art keywords
leu
ala
val
ser
ile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002348688A
Other languages
English (en)
Inventor
Dominic P. Behan
Derek T. Chalmers
Ruoping Chen
Chen W. Liaw
Kevin Lowitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arena Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/170,496 external-priority patent/US6555339B1/en
Application filed by Individual filed Critical Individual
Publication of CA2348688A1 publication Critical patent/CA2348688A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention se rapporte à des récepteurs transmembranaires, notamment au récepteur de la protéine G humaine pour lequel le ligand endogène est connu ("récepteurs GPCR orphelins") et, plus particulièrement, à des versions mutées (non endogènes) des GPCR humains pouvant révéler une activité constitutive.
CA002348688A 1998-10-13 1999-10-13 Recepteurs non-endogenes de la proteine g humaine ayant une activite constitutive Abandoned CA2348688A1 (fr)

Applications Claiming Priority (65)

Application Number Priority Date Filing Date Title
US09/170,496 1998-10-13
US09/170,496 US6555339B1 (en) 1997-04-14 1998-10-13 Non-endogenous, constitutively activated human protein-coupled receptors
US10802998P 1998-11-12 1998-11-12
US60/108,029 1998-11-12
US10921398P 1998-11-20 1998-11-20
US60/109,213 1998-11-20
US11006098P 1998-11-27 1998-11-27
US60/110,060 1998-11-27
US12041699P 1999-02-16 1999-02-16
US60/120,416 1999-02-16
US12185299P 1999-02-26 1999-02-26
US60/121,852 1999-02-26
US12394499P 1999-03-12 1999-03-12
US12394999P 1999-03-12 1999-03-12
US12395199P 1999-03-12 1999-03-12
US12394899P 1999-03-12 1999-03-12
US12394599P 1999-03-12 1999-03-12
US12394699P 1999-03-12 1999-03-12
US60/123,951 1999-03-12
US60/123,948 1999-03-12
US60/123,944 1999-03-12
US60/123,945 1999-03-12
US60/123,946 1999-03-12
US60/123,949 1999-03-12
US13713199P 1999-05-28 1999-05-28
US13712799P 1999-05-28 1999-05-28
US13643999P 1999-05-28 1999-05-28
US13656799P 1999-05-28 1999-05-28
US13643699P 1999-05-28 1999-05-28
US13643799P 1999-05-28 1999-05-28
US60/136,437 1999-05-28
US60/136,567 1999-05-28
US60/136,439 1999-05-28
US60/137,131 1999-05-28
US60/137,127 1999-05-28
US60/136,436 1999-05-28
US14144899P 1999-06-29 1999-06-29
US60/141,448 1999-06-29
US15111499P 1999-08-27 1999-08-27
US60/151,114 1999-08-27
US15252499P 1999-09-03 1999-09-03
US60/152,524 1999-09-03
US15665399P 1999-09-29 1999-09-29
US15655599P 1999-09-29 1999-09-29
US15663499P 1999-09-29 1999-09-29
US15663399P 1999-09-29 1999-09-29
US60/156,653 1999-09-29
US60/156,634 1999-09-29
US60/156,555 1999-09-29
US60/156,633 1999-09-29
US15729399P 1999-10-01 1999-10-01
US15728199P 1999-10-01 1999-10-01
US15729499P 1999-10-01 1999-10-01
US15728099P 1999-10-01 1999-10-01
US15728299P 1999-10-01 1999-10-01
US60/157,293 1999-10-01
US60/157,282 1999-10-01
US60/157,294 1999-10-01
US60/157,280 1999-10-01
US60/157,281 1999-10-01
US41704499A 1999-10-12 1999-10-12
US41676099A 1999-10-12 1999-10-12
US09/417,044 1999-10-12
US09/416,760 1999-10-12
PCT/US1999/024065 WO2000022131A2 (fr) 1998-10-13 1999-10-13 Recepteurs non-endogenes de la proteine g humaine ayant une activite constitutive

Publications (1)

Publication Number Publication Date
CA2348688A1 true CA2348688A1 (fr) 2000-04-20

Family

ID=27586908

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002348688A Abandoned CA2348688A1 (fr) 1998-10-13 1999-10-13 Recepteurs non-endogenes de la proteine g humaine ayant une activite constitutive

Country Status (5)

Country Link
KR (1) KR20010080882A (fr)
CA (1) CA2348688A1 (fr)
IL (1) IL142153A0 (fr)
NZ (1) NZ510712A (fr)
WO (1) WO2000022131A2 (fr)

Families Citing this family (71)

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US6555339B1 (en) 1997-04-14 2003-04-29 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human protein-coupled receptors
EP1029916B1 (fr) * 1997-11-11 2007-05-23 Ono Pharmaceutical Co., Ltd. Recepteur d'acide lysophosphatidique humain et utilisation dudit recepteur
ES2264267T3 (es) * 1998-03-12 2006-12-16 Astellas Pharma Inc. Nuevas proteinas de receptores copulados a proteina g.
US7094593B1 (en) 1998-09-01 2006-08-22 Basf Aktiengesellschaft Method for improving the function of heterologous G protein-coupled receptors
WO2000026339A2 (fr) * 1998-11-03 2000-05-11 Smithkline Beecham Corporation Recepteur couple aux proteines g, dit axor-14
US7816492B2 (en) 1998-11-20 2010-10-19 Arena Pharmaceuticals, Inc. Human G protein-coupled receptors
US20030017528A1 (en) 1998-11-20 2003-01-23 Ruoping Chen Human orphan G protein-coupled receptors
USRE42190E1 (en) 1998-11-20 2011-03-01 Arena Pharmaceuticals, Inc. Method of identifying a compound for inhibiting or stimulating human G protein-coupled receptors
KR100963367B1 (ko) * 1998-11-20 2010-06-14 아레나 파마슈티칼스, 인크. 사람의 오르판 ｇ 단백질 커플링 수용체
US6221660B1 (en) 1999-02-22 2001-04-24 Synaptic Pharmaceutical Corporation DNA encoding SNORF25 receptor
WO2000078809A1 (fr) * 1999-06-21 2000-12-28 Smithkline Beecham Corporation Axor16, récepteur couplé à une protéine g
CA2381437A1 (fr) * 1999-07-30 2001-02-08 Merck Patent Gesellschaft Mit Beschraenkter Haftung Recepteur couple g-proteine et sequences adn de celui-ci
EP1207201A4 (fr) * 1999-08-27 2003-03-12 Takeda Chemical Industries Ltd Proteine recepteur couplee a une proteine g et adn correspondant
EP1207169A4 (fr) * 1999-08-27 2003-03-19 Takeda Chemical Industries Ltd Nouvelle proteine receptrice couplee a une proteine g, et son adn
JP2003225088A (ja) * 1999-09-10 2003-08-12 Meiji Seika Kaisha Ltd ヒト・ロイコトリエンｂ４第二受容体及びそれをコードするｄｎａ
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Also Published As

Publication number Publication date
NZ510712A (en) 2004-11-26
WO2000022131A2 (fr) 2000-04-20
WO2000022131A3 (fr) 2001-02-22
IL142153A0 (en) 2002-03-10
KR20010080882A (ko) 2001-08-25

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued