CA2347294A1 - Novel g protein coupled receptor protein, dna and its ligand - Google Patents
Novel g protein coupled receptor protein, dna and its ligand Download PDFInfo
- Publication number
- CA2347294A1 CA2347294A1 CA002347294A CA2347294A CA2347294A1 CA 2347294 A1 CA2347294 A1 CA 2347294A1 CA 002347294 A CA002347294 A CA 002347294A CA 2347294 A CA2347294 A CA 2347294A CA 2347294 A1 CA2347294 A1 CA 2347294A1
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- Prior art keywords
- protein
- present
- receptor protein
- salts
- ligand
- Prior art date
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
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- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10/305949 | 1998-10-27 | ||
| JP30594998 | 1998-10-27 | ||
| JP11/27710 | 1999-02-04 | ||
| JP2771099 | 1999-02-04 | ||
| JP11/57207 | 1999-03-04 | ||
| JP5720799 | 1999-03-04 | ||
| JP11/276225 | 1999-09-29 | ||
| JP27622599A JP4486187B2 (ja) | 1998-10-27 | 1999-09-29 | 新規ｇ蛋白質共役型レセプター蛋白質、そのｄｎａおよびそのリガンド |
| PCT/JP1999/005905 WO2000024890A1 (en) | 1998-10-27 | 1999-10-26 | Novel g protein-coupled receptor proteins, dnas thereof and ligands to the same |
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| CA2347294A1 true CA2347294A1 (en) | 2000-05-04 |
Family
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| CA002347294A Abandoned CA2347294A1 (en) | 1998-10-27 | 1999-10-26 | Novel g protein coupled receptor protein, dna and its ligand |
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Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000050563A2 (en) * | 1999-02-24 | 2000-08-31 | Merck & Co., Inc. | G protein-coupled receptor resembling galanin receptors |
| WO2001075104A1 (fr) * | 2000-03-30 | 2001-10-11 | Takeda Chemical Industries, Ltd. | Nouvelle proteine, adn codant pour celle-ci, et son procede de production |
| EP1168259A3 (en) | 2000-06-28 | 2003-12-17 | Hitachi, Ltd. | Data management method and system for IC card |
| EP1314781A4 (en) * | 2000-08-30 | 2004-11-03 | Endo Yaeta Dr | DESIGN AND CONSTRUCTION OF A TRANSCRIPTION MODEL OF ACELLULAR PROTEIN SYNTHESIS, AND DISCONTINUOUS DILUTION METHOD FOR USE IN SYNTHESIS OF ACELLULAR WHEAT GERM PROTEIN |
| JP2002109169A (ja) | 2000-09-29 | 2002-04-12 | Hitachi Ltd | 作業支援方法並びにシステム及び作業支援方法を記録した記録媒体 |
| CA2430934C (en) | 2000-12-01 | 2011-06-21 | Takeda Chemical Industries, Ltd. | A method of producing sustained-release preparations of a bioactive substance using high-pressure gas |
| US20050075494A1 (en) * | 2000-12-18 | 2005-04-07 | Liu Qingyun | Isolated nucleic acid molecules encoding a human and mouse g protein-coupled receptor-gpr54: encoded proteins, cells transformed therewith and uses thereof |
| WO2002057309A1 (fr) * | 2001-01-18 | 2002-07-25 | Takeda Chemical Industries, Ltd. | Nouvelle proteine receptrice couplee a la proteine g et adn de cette proteine |
| WO2002072816A1 (fr) * | 2001-02-26 | 2002-09-19 | Takeda Chemical Industries, Ltd. | Proteine de recepteur murin de type kiss-1 et adn correspondant |
| WO2002083735A1 (fr) * | 2001-04-06 | 2002-10-24 | Takeda Chemical Industries, Ltd. | Nouvelle proteine receptrice et son adn |
| AU2008201996B2 (en) * | 2001-09-18 | 2011-02-10 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| JP2005536439A (ja) | 2001-09-18 | 2005-12-02 | ジェネンテック・インコーポレーテッド | 腫瘍の診断及び治療のための組成物と方法 |
| EP1428835B1 (en) * | 2001-09-19 | 2007-04-18 | Takeda Pharmaceutical Company Limited | Antibody against metastin and use of the same in the diagnosis of pregnancy |
| CA2472423A1 (en) * | 2002-01-11 | 2003-07-24 | Takeda Chemical Industries, Ltd. | Process for producing kiss-1 peptide |
| WO2004024072A2 (en) * | 2002-09-11 | 2004-03-25 | Genentech, Inc. | Novel compositions and methods for the treatment of immune related diseases |
| AU2003292696A1 (en) | 2002-12-26 | 2004-08-10 | Takeda Pharmaceutical Company Limited | Metastin derivative and use thereof |
| US6800611B2 (en) | 2003-01-06 | 2004-10-05 | Takeda Chemical Industries, Ltd. | Metastin derivatives and their use |
| CA2518541C (en) * | 2003-03-12 | 2013-05-21 | Takeda Pharmaceutical Company Limited | Gonadal function improving agents |
| JP4639052B2 (ja) * | 2003-03-12 | 2011-02-23 | 武田薬品工業株式会社 | 性腺機能改善剤 |
| EP1464652A1 (en) * | 2003-04-02 | 2004-10-06 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | GPR54 receptor agonist and antagonist useful for the treatment of gonadotropin related diseases |
| WO2004096855A2 (en) * | 2003-04-28 | 2004-11-11 | Wyeth | Methods utilising g-protein coupled receptor 54 |
| WO2004101747A2 (en) * | 2003-05-07 | 2004-11-25 | The General Hospital Corporation | Identification and use of gpr54 and its ligands for reproductive disorders and contraception |
| WO2005040833A1 (en) * | 2003-10-21 | 2005-05-06 | Bayer Healthcare Ag | Regulation of human metastin recognising receptors |
| AR049938A1 (es) | 2004-06-25 | 2006-09-13 | Takeda Pharmaceutical | Derivados de metastina y utilizacion de los mismos |
| US20090099334A1 (en) * | 2005-12-22 | 2009-04-16 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| US8404643B2 (en) * | 2005-12-22 | 2013-03-26 | Takeda Pharmaceutical Company Limited | Metastin derivatives and use thereof |
| AR058584A1 (es) * | 2005-12-22 | 2008-02-13 | Takeda Pharmaceutical | Derivados de metastina y uso de los mismos |
| ITMI20061607A1 (it) | 2006-08-09 | 2008-02-10 | Maria Vincenza Carriero | Peptidi con attivita farmacologica |
| TWI404726B (zh) | 2006-10-25 | 2013-08-11 | Takeda Pharmaceutical | 腫瘤轉移抑制素衍生物及其用途 |
| US20110118172A1 (en) * | 2008-04-24 | 2011-05-19 | Takeda Pharmaceutical Company Limited | Metastin derivative and use thereof |
| EP2314609B1 (en) | 2008-07-30 | 2016-11-30 | Takeda Pharmaceutical Company Limited | Metastin derivative and use thereof |
| EP2350118B1 (en) * | 2008-09-19 | 2016-03-30 | Nektar Therapeutics | Carbohydrate-based drug delivery polymers and conjugates thereof |
| US20110171160A1 (en) * | 2008-09-19 | 2011-07-14 | Nektar Therapeutics | Polymer conjugates of kiss1 peptides |
| US8716228B2 (en) | 2009-05-27 | 2014-05-06 | Yeda Research And Development Co. Ltd. | GPR54 agonists or antagonists for treatment of diseases presenting behavioral abnormalities |
| US20150157619A1 (en) | 2012-07-10 | 2015-06-11 | Takeda Pharmaceutical Company Limited | Pharmaceutical preparation for injection |
| US11427615B2 (en) | 2017-07-05 | 2022-08-30 | Xdcexplorer (Shanghai) Co., Ltd. | Peptide compound and application thereof, and composition containing peptide compound |
| CN109212217B (zh) * | 2018-11-07 | 2021-09-10 | 李玉民 | 基于amy1a蛋白胃癌检测试剂盒及其使用方法 |
Family Cites Families (10)
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| US5436155A (en) * | 1991-12-31 | 1995-07-25 | Arch Development Corporation | Isolated DNA encoding a somatostatin receptor |
| CN1101854C (zh) | 1994-08-11 | 2003-02-19 | 武田药品工业株式会社 | G蛋白偶联受体蛋白质及其产生方法和用途 |
| AU7399296A (en) | 1995-10-11 | 1997-04-30 | Penn State Research Foundation, The | A metastasis suppressor gene |
| US6010877A (en) | 1997-01-10 | 2000-01-04 | Smithkline Beecham Corporation | cDNA clone HE8CS41 that encodes a novel 7-transmembrane receptor |
| US5851798A (en) | 1997-01-27 | 1998-12-22 | Smithkline Beecham Corporation | Nucleic acid encoding human GPR14 receptor |
| WO1998039448A2 (en) | 1997-03-07 | 1998-09-11 | Human Genome Sciences, Inc. | 186 human secreted proteins |
| US6420526B1 (en) * | 1997-03-07 | 2002-07-16 | Human Genome Sciences, Inc. | 186 human secreted proteins |
| WO2000050563A2 (en) * | 1999-02-24 | 2000-08-31 | Merck & Co., Inc. | G protein-coupled receptor resembling galanin receptors |
| US20020077469A1 (en) * | 1999-03-10 | 2002-06-20 | Borowsky Beth E. | DNA encoding orphan SNORF11 receptor |
| CA2518541C (en) * | 2003-03-12 | 2013-05-21 | Takeda Pharmaceutical Company Limited | Gonadal function improving agents |
-
1999
- 1999-09-29 JP JP27622599A patent/JP4486187B2/ja not_active Expired - Fee Related
- 1999-10-26 PL PL99347553A patent/PL347553A1/xx not_active Application Discontinuation
- 1999-10-26 AT AT99949421T patent/ATE394485T1/de not_active IP Right Cessation
- 1999-10-26 AU AU62306/99A patent/AU6230699A/en not_active Abandoned
- 1999-10-26 SK SK550-2001A patent/SK5502001A3/sk unknown
- 1999-10-26 CN CN99812722A patent/CN1324405A/zh active Pending
- 1999-10-26 US US09/830,428 patent/US6699965B1/en not_active Expired - Fee Related
- 1999-10-26 BR BR9914835-8A patent/BR9914835A/pt not_active IP Right Cessation
- 1999-10-26 EP EP99949421A patent/EP1126028B1/en not_active Expired - Lifetime
- 1999-10-26 CA CA002347294A patent/CA2347294A1/en not_active Abandoned
- 1999-10-26 NZ NZ510977A patent/NZ510977A/xx unknown
- 1999-10-26 WO PCT/JP1999/005905 patent/WO2000024890A1/ja not_active Ceased
- 1999-10-26 HU HU0104937A patent/HUP0104937A2/hu unknown
- 1999-10-26 IL IL14242899A patent/IL142428A0/xx unknown
- 1999-10-26 KR KR1020017005344A patent/KR20010085974A/ko not_active Withdrawn
- 1999-10-26 DE DE69938666T patent/DE69938666D1/de not_active Expired - Lifetime
- 1999-10-26 CZ CZ20011358A patent/CZ20011358A3/cs unknown
- 1999-10-27 ID IDW20010936A patent/ID28288A/id unknown
-
2001
- 2001-04-26 NO NO20012059A patent/NO20012059L/no not_active Application Discontinuation
-
2004
- 2004-02-05 US US10/771,417 patent/US7314754B2/en not_active Expired - Fee Related
-
2007
- 2007-10-24 US US11/976,414 patent/US7608409B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000312590A (ja) | 2000-11-14 |
| DE69938666D1 (de) | 2008-06-19 |
| BR9914835A (pt) | 2002-06-18 |
| NZ510977A (en) | 2002-10-25 |
| KR20010085974A (ko) | 2001-09-07 |
| HUP0104937A2 (hu) | 2002-04-29 |
| PL347553A1 (en) | 2002-04-08 |
| NO20012059L (no) | 2001-06-26 |
| US20040180407A1 (en) | 2004-09-16 |
| EP1126028B1 (en) | 2008-05-07 |
| US20080131976A1 (en) | 2008-06-05 |
| IL142428A0 (en) | 2002-03-10 |
| US7608409B2 (en) | 2009-10-27 |
| CZ20011358A3 (cs) | 2001-08-15 |
| ATE394485T1 (de) | 2008-05-15 |
| EP1126028A1 (en) | 2001-08-22 |
| ID28288A (id) | 2001-05-10 |
| WO2000024890A1 (en) | 2000-05-04 |
| US7314754B2 (en) | 2008-01-01 |
| US6699965B1 (en) | 2004-03-02 |
| SK5502001A3 (en) | 2002-01-07 |
| NO20012059D0 (no) | 2001-04-26 |
| EP1126028A4 (en) | 2002-11-27 |
| AU6230699A (en) | 2000-05-15 |
| CN1324405A (zh) | 2001-11-28 |
| JP4486187B2 (ja) | 2010-06-23 |
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