CA2308575A1 - Hyperthermic inducible expression vectors for gene therapy and methods of use thereof - Google Patents

Hyperthermic inducible expression vectors for gene therapy and methods of use thereof Download PDF

Info

Publication number
CA2308575A1
CA2308575A1 CA002308575A CA2308575A CA2308575A1 CA 2308575 A1 CA2308575 A1 CA 2308575A1 CA 002308575 A CA002308575 A CA 002308575A CA 2308575 A CA2308575 A CA 2308575A CA 2308575 A1 CA2308575 A1 CA 2308575A1
Authority
CA
Canada
Prior art keywords
promoter
expression
cell
expression construct
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002308575A
Other languages
English (en)
French (fr)
Inventor
Tom Tsang
Eugene Gerner
David T. Harris
Evan Hersh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arizona Board of Regents of University of Arizona
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2308575A1 publication Critical patent/CA2308575A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002308575A 1997-11-03 1998-11-03 Hyperthermic inducible expression vectors for gene therapy and methods of use thereof Abandoned CA2308575A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6408897P 1997-11-03 1997-11-03
US60/064,088 1997-11-03
PCT/US1998/023387 WO1999023216A2 (en) 1997-11-03 1998-11-03 Hyperthermic inducible expression vectors for gene therapy and methods of use thereof

Publications (1)

Publication Number Publication Date
CA2308575A1 true CA2308575A1 (en) 1999-05-14

Family

ID=22053477

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002308575A Abandoned CA2308575A1 (en) 1997-11-03 1998-11-03 Hyperthermic inducible expression vectors for gene therapy and methods of use thereof

Country Status (9)

Country Link
EP (1) EP1029041A2 (ja)
JP (1) JP2001521740A (ja)
KR (1) KR20010031762A (ja)
CN (1) CN1299411A (ja)
AU (1) AU1377299A (ja)
BR (1) BR9813917A (ja)
CA (1) CA2308575A1 (ja)
IL (1) IL135943A0 (ja)
WO (1) WO1999023216A2 (ja)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19951765A1 (de) * 1999-10-27 2001-05-03 Thomas Schweder Wirts-Vektor-Systeme zur Überproduktion von thermolabilen Enzymen psychrophiler Organismen
US6579522B1 (en) 2000-06-27 2003-06-17 Genvec, Inc. Replication deficient adenoviral TNF vector
US7285414B2 (en) 2000-09-26 2007-10-23 Emory University Viruses targeted to hypoxic cells and tissues
AU2001294793B2 (en) * 2000-09-26 2006-06-29 Emory University Viruses targeted to hypoxic cells and tissues
US20030086903A1 (en) 2001-11-02 2003-05-08 Genvec, Inc. Therapeutic regimen for treating cancer
WO2003106663A1 (ja) 2002-06-18 2003-12-24 エーザイ株式会社 遺伝子治療用初代培養脂肪細胞
EP1551443A2 (en) * 2002-10-14 2005-07-13 DeveloGen Aktiengesellschaft für entwicklungsbiologische Forschung Proteins involved in the regulation of energy homeostasis
JP2008048601A (ja) * 2004-06-15 2008-03-06 Nippon Kosei Kagaku Kenkyusho:Kk 治療に有用な産物の生産法およびシステム
EP1879622A2 (en) * 2005-05-03 2008-01-23 Veterinärmedizinische Universität Wien Permeable capsules
CA2715080C (en) * 2007-09-28 2021-09-28 Intrexon Corporation Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof
CN103667345B (zh) * 2013-12-02 2015-10-28 东南大学 一种抗肿瘤基因磁性复合纳米颗粒及制备方法
WO2017133175A1 (en) * 2016-02-04 2017-08-10 Nanjing Legend Biotech Co., Ltd. Engineered mammalian cells for cancer therapy
CN108913661A (zh) * 2018-06-22 2018-11-30 安徽 一种人体研究用造血干细胞的制备和提取方法
CN114317588B (zh) * 2020-09-29 2023-06-27 中国农业科学院生物技术研究所 一种作物高温响应型基因组精准甲基化调控回路
IT202200000788A1 (it) * 2022-01-19 2023-07-19 Bruno Cell S R L Induzione sensibile alla temperatura del programma miogenico e/o adipogenico in cellule per la produzione di tessuto muscolare e/o adiposo
CN116536349B (zh) * 2023-05-22 2024-02-20 安徽农业大学 一种大豆GmMLP34基因在调控植物耐高温性上的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3991770A (en) * 1974-01-24 1976-11-16 Leveen Harry H Method for treating benign and malignant tumors utilizing radio frequency, electromagnetic radiation
EP0299127A1 (en) * 1987-07-16 1989-01-18 IntraCel Corporation A method for the expression of recombinant genes under stimulation from an inducively expressed activator protein
EP0455424A3 (en) * 1990-05-02 1992-04-29 Merck & Co. Inc. Mammalian inducible promoter cascade system
FR2717187B1 (fr) * 1994-03-10 1996-05-31 Transgene Sa Usage combiné de deux cassettes d'expression pour la production d'une protéine d'intérêt.

Also Published As

Publication number Publication date
WO1999023216A2 (en) 1999-05-14
JP2001521740A (ja) 2001-11-13
BR9813917A (pt) 2001-10-30
EP1029041A2 (en) 2000-08-23
CN1299411A (zh) 2001-06-13
IL135943A0 (en) 2001-05-20
KR20010031762A (ko) 2001-04-16
AU1377299A (en) 1999-05-24
WO1999023216A3 (en) 1999-08-05

Similar Documents

Publication Publication Date Title
CA2308575A1 (en) Hyperthermic inducible expression vectors for gene therapy and methods of use thereof
EP0784693B1 (fr) Vecteurs viraux pour la therapie genique
AU1755299A (en) Vector for tissue-specific replication and gene expression
WO1994012629A9 (en) Episomal vectors for gene therapy
US20070244064A1 (en) Methods and compositions to induce antitumor response
JPH10509880A (ja) 組織特異的複製のためのベクター
JP2004501650A (ja) 複製欠損アデノウイルスｔｎｆベクター
JP2002506651A (ja) 多重遺伝子ベクター
US6709858B1 (en) Hyperthermic inducible expression vectors for gene therapy and methods of use thereof
US7056897B2 (en) Inducible expression vectors and methods of use thereof
ES2268695T3 (es) Adenovirus recombinantes defectivos con una gen iva2 inactivado.
US6451579B1 (en) Regulated expression of recombinant proteins using RNA viruses
Tomita et al. Gene therapy with transcription factor decoy oligonucleotides as a potential treatment for cardiovascular diseases
Kouraklis Gene therapy for cancer
US7098191B2 (en) Hyperthermic inducible expression vectors for gene therapy and methods of use thereof
WO1997016547A1 (en) ADENOVIRUS-ANTISENSE K-ras EXPRESSION VECTORS AND THEIR APPLICATION IN CANCER THERAPY
Palapattu et al. GENE THERAPY FOR PROSTATE CANCER: New Perspectives on an Old Problem
MXPA00004293A (en) Hyperthermic inducible expression vectors for gene therapy and methods of use thereof
WO2000022124A2 (en) Methods and compositions to induce antitumor response
Clayman Gene therapy for head and neck cancer
JP7406263B2 (ja) 改変アデノウイルス及びこれを含む医薬
JPH10127287A (ja) 生体内でヒト遺伝子を導入するための新規アデノウィルス・ベクター
US5863794A (en) SV40 viral vectors for targeted integration into cells
US20040146856A1 (en) Anti-neoplastic viral agents
FR2737221A1 (fr) Nouveaux vecteurs viraux pour la therapie genique

Legal Events

Date Code Title Description
FZDE Discontinued