BR9813917A - Vetores de expressão induzìveis hipertérmicospara terapia de genetica e métodos de uso dos mesmos - Google Patents

Vetores de expressão induzìveis hipertérmicospara terapia de genetica e métodos de uso dos mesmos

Info

Publication number
BR9813917A
BR9813917A BR9813917-7A BR9813917A BR9813917A BR 9813917 A BR9813917 A BR 9813917A BR 9813917 A BR9813917 A BR 9813917A BR 9813917 A BR9813917 A BR 9813917A
Authority
BR
Brazil
Prior art keywords
methods
expression
hyperthermic
expression vectors
gene therapy
Prior art date
Application number
BR9813917-7A
Other languages
English (en)
Inventor
Tom Tsang
Eugene W Gerner
David T Harris
Evan Hersh
Original Assignee
Univ Arizona
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Arizona filed Critical Univ Arizona
Publication of BR9813917A publication Critical patent/BR9813917A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Patente de Invenção: "VETORES DE EXPRESSãO INDUZìVEISHIPERTéRMICOS PARA TERAPIA GENéTICA E MéTODOS DEUSO DOS MESMOS". São fornecidos métodos e composiçõespara expressão de transgenes em células alvo. São fornecidasconstruções de expressão usando um sistema de ampliaçãoinduzível para causar a expressão de um gene terapêutico ououtro gene de interesse em células hospedeiras mamíferas, assimcomo métodos para a mesma. A expressão induzível dostransgenes em níveis altos em condições fisiológicas resulta daindução por condições hipertérmicas em relação à temperaturabasal das células hospedeiras.
BR9813917-7A 1997-11-03 1998-11-03 Vetores de expressão induzìveis hipertérmicospara terapia de genetica e métodos de uso dos mesmos BR9813917A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6408897P 1997-11-03 1997-11-03
PCT/US1998/023387 WO1999023216A2 (en) 1997-11-03 1998-11-03 Hyperthermic inducible expression vectors for gene therapy and methods of use thereof

Publications (1)

Publication Number Publication Date
BR9813917A true BR9813917A (pt) 2001-10-30

Family

ID=22053477

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9813917-7A BR9813917A (pt) 1997-11-03 1998-11-03 Vetores de expressão induzìveis hipertérmicospara terapia de genetica e métodos de uso dos mesmos

Country Status (9)

Country Link
EP (1) EP1029041A2 (pt)
JP (1) JP2001521740A (pt)
KR (1) KR20010031762A (pt)
CN (1) CN1299411A (pt)
AU (1) AU1377299A (pt)
BR (1) BR9813917A (pt)
CA (1) CA2308575A1 (pt)
IL (1) IL135943A0 (pt)
WO (1) WO1999023216A2 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19951765A1 (de) * 1999-10-27 2001-05-03 Thomas Schweder Wirts-Vektor-Systeme zur Überproduktion von thermolabilen Enzymen psychrophiler Organismen
US6579522B1 (en) 2000-06-27 2003-06-17 Genvec, Inc. Replication deficient adenoviral TNF vector
US7285414B2 (en) 2000-09-26 2007-10-23 Emory University Viruses targeted to hypoxic cells and tissues
CA2423833C (en) * 2000-09-26 2011-02-22 Emory University Viruses targeted to hypoxic cells and tissues
US20030086903A1 (en) 2001-11-02 2003-05-08 Genvec, Inc. Therapeutic regimen for treating cancer
EP1541674B9 (en) 2002-06-18 2011-09-14 Eisai R&D Management Co., Ltd. Primary cultured adipocytes for gene therapy
AU2003278079A1 (en) * 2002-10-14 2004-05-04 Develogen Aktiengesellschaft Fur Entwicklungsbiologische Forschung Proteins involved in the regulation of energy homeostasis
JP2008048601A (ja) * 2004-06-15 2008-03-06 Nippon Kosei Kagaku Kenkyusho:Kk 治療に有用な産物の生産法およびシステム
EP1879622A2 (en) * 2005-05-03 2008-01-23 Veterinärmedizinische Universität Wien Permeable capsules
RU2499599C2 (ru) * 2007-09-28 2013-11-27 Интрексон Корпорейшн Конструкции терапевтического переключения генов и биореакторы для экспрессии биотерапевтических молекул и их применение
CN103667345B (zh) * 2013-12-02 2015-10-28 东南大学 一种抗肿瘤基因磁性复合纳米颗粒及制备方法
WO2017133175A1 (en) * 2016-02-04 2017-08-10 Nanjing Legend Biotech Co., Ltd. Engineered mammalian cells for cancer therapy
CN108913661A (zh) * 2018-06-22 2018-11-30 安徽 一种人体研究用造血干细胞的制备和提取方法
CN114317588B (zh) * 2020-09-29 2023-06-27 中国农业科学院生物技术研究所 一种作物高温响应型基因组精准甲基化调控回路
IT202200000788A1 (it) * 2022-01-19 2023-07-19 Bruno Cell S R L Induzione sensibile alla temperatura del programma miogenico e/o adipogenico in cellule per la produzione di tessuto muscolare e/o adiposo
CN116536349B (zh) * 2023-05-22 2024-02-20 安徽农业大学 一种大豆GmMLP34基因在调控植物耐高温性上的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3991770A (en) * 1974-01-24 1976-11-16 Leveen Harry H Method for treating benign and malignant tumors utilizing radio frequency, electromagnetic radiation
EP0299127A1 (en) * 1987-07-16 1989-01-18 IntraCel Corporation A method for the expression of recombinant genes under stimulation from an inducively expressed activator protein
EP0455424A3 (en) * 1990-05-02 1992-04-29 Merck & Co. Inc. Mammalian inducible promoter cascade system
FR2717187B1 (fr) * 1994-03-10 1996-05-31 Transgene Sa Usage combiné de deux cassettes d'expression pour la production d'une protéine d'intérêt.

Also Published As

Publication number Publication date
EP1029041A2 (en) 2000-08-23
CN1299411A (zh) 2001-06-13
KR20010031762A (ko) 2001-04-16
AU1377299A (en) 1999-05-24
CA2308575A1 (en) 1999-05-14
JP2001521740A (ja) 2001-11-13
WO1999023216A3 (en) 1999-08-05
WO1999023216A2 (en) 1999-05-14
IL135943A0 (en) 2001-05-20

Similar Documents

Publication Publication Date Title
BR9813917A (pt) Vetores de expressão induzìveis hipertérmicospara terapia de genetica e métodos de uso dos mesmos
Yu et al. Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genes
Mori et al. Identification of the interferon regulatory factor 5 gene (IRF-5) as a direct target for p53
Kartasheva et al. p53 induces the expression of its antagonist p73ΔN, establishing an autoregulatory feedback loop
Kobayashi et al. Novel gene therapy for rheumatoid arthritis by FADD gene transfer: induction of apoptosis of rheumatoid synoviocytes but not chondrocytes
Yang et al. PSTPIP2 connects DNA methylation to macrophage polarization in CCL4-induced mouse model of hepatic fibrosis
Biglari et al. Effects of ectopic decorin in modulating intracranial glioma progression in vivo, in a rat syngeneic model
SG141233A1 (en) Control of gene expression
ATE362542T1 (de) Nukleinsäuresequenzen des adeno-assoziierten virus des serotyps i, und vektoren und wirtszellen, die diese enthalten
Sadasivam et al. Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis
ATE269402T1 (de) Ikk-beta proteine, nukleinsäuren und verfahren
Rafty et al. NF1/X represses PDGF A-chain transcription by interacting with Sp1 and antagonizing Sp1 occupancy of the promoter
Razin et al. Nuclear matrix attachment regions and topoisomerase II binding and reaction sites in the vicinity of a chicken DNA replication origin
WO2003023000A3 (en) Linear dna fragments for gene expression
DE69808743T2 (de) Netrinrezeptoren
Lin et al. MAR characteristic motifs mediate episomal vector in CHO cells
DK0988391T3 (da) Rekombinante adenovirusvektorer der omfatter en splejsningssekvens
Waldschmidt et al. TFIIA is required for in vitro transcription of mammalian U6 genes by RNA polymerase III.
BG104883A (en) Human bmp-7 promoter and method for exploring bone-related substance by using the same
Li et al. Involvement of Sp1 elements in the promoter activity of the α1-proteinase inhibitor gene
BR0008313A (pt) Composições e métodos para ativação não-direcionada de genes endógenos
Periyasamy et al. Repression of transforming growth factor-β receptor type I promoter expression by Sp1 deficiency
DK0655926T3 (da) Ny sonde til tumordiagnose eller tumorterapi
Greco et al. Synergy between the RE-1 silencer of transcription and NFκB in the repression of the neurotransmitter gene TAC1 in human mesenchymal stem cells
KR20000049243A (ko) 인터페론-알파 핵산의 운반 및 발현 방법 및 이를 위한 조성물

Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]
B15K Others concerning applications: alteration of classification

Ipc: C12N 15/63 (2006.01), A61K 48/00 (2006.0