DK0988391T3 - Rekombinante adenovirusvektorer der omfatter en splejsningssekvens - Google Patents

Rekombinante adenovirusvektorer der omfatter en splejsningssekvens

Info

Publication number
DK0988391T3
DK0988391T3 DK98928412T DK98928412T DK0988391T3 DK 0988391 T3 DK0988391 T3 DK 0988391T3 DK 98928412 T DK98928412 T DK 98928412T DK 98928412 T DK98928412 T DK 98928412T DK 0988391 T3 DK0988391 T3 DK 0988391T3
Authority
DK
Denmark
Prior art keywords
splicing sequence
host cell
adenoviral vector
concerns
expression
Prior art date
Application number
DK98928412T
Other languages
English (en)
Inventor
Majid Mehtali
Pierre Leroy
Anne-Isabelle Michou
Original Assignee
Transgene Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transgene Sa filed Critical Transgene Sa
Application granted granted Critical
Publication of DK0988391T3 publication Critical patent/DK0988391T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Signal Processing For Digital Recording And Reproducing (AREA)
  • Tyre Moulding (AREA)
  • Image Processing (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Communication Control (AREA)
DK98928412T 1997-06-02 1998-06-02 Rekombinante adenovirusvektorer der omfatter en splejsningssekvens DK0988391T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9706757A FR2763959A1 (fr) 1997-06-02 1997-06-02 Nouveaux vecteurs adenoviraux recombinants comprenant une sequence d'epissage
PCT/FR1998/001105 WO1998055639A2 (fr) 1997-06-02 1998-06-02 Vecteurs adenoviraux recombinants comprenant une sequence d'epissage

Publications (1)

Publication Number Publication Date
DK0988391T3 true DK0988391T3 (da) 2005-07-25

Family

ID=9507493

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98928412T DK0988391T3 (da) 1997-06-02 1998-06-02 Rekombinante adenovirusvektorer der omfatter en splejsningssekvens

Country Status (12)

Country Link
US (1) US6399587B1 (da)
EP (1) EP0988391B1 (da)
JP (1) JP4386971B2 (da)
AT (1) ATE284969T1 (da)
AU (1) AU753809B2 (da)
CA (1) CA2292792C (da)
DE (1) DE69828167T2 (da)
DK (1) DK0988391T3 (da)
ES (1) ES2232950T3 (da)
FR (1) FR2763959A1 (da)
PT (1) PT988391E (da)
WO (1) WO1998055639A2 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2162497A1 (en) 1993-06-10 1994-12-22 Sheila Connelly Adenoviral vectors for treatment of hemophilia
IL126757A0 (en) * 1998-09-07 1999-08-17 Yissum Res Dev Co Regulation of gene expression through manipulation of mRNA splicing and its uses
EP1048736A1 (en) 1999-04-27 2000-11-02 Aventis Behring Gesellschaft mit beschränkter Haftung DNA-construct for the tissue specific expression of a blood coagulation factor
EP1048726B1 (en) * 1999-04-27 2006-07-26 Négrier, Claude Modified factor VIII cDNA
EP1038959A1 (en) * 1999-03-17 2000-09-27 Aventis Behring Gesellschaft mit beschränkter Haftung Factor VIII without B-domain, comprising one or more insertions of a truncated intron I of factor IX
AU6280600A (en) * 1999-08-06 2001-03-05 Develogen Aktiengesellschaft Fur Entwicklungsbiologische Forschung Non-human adenoviral vector for gene transfer, its use and the production thereof
US20020064859A1 (en) * 2000-07-14 2002-05-30 Tikoo Suresh K. Adenovirus vectors comprising introns
EP1233064A1 (en) 2001-02-09 2002-08-21 Aventis Behring Gesellschaft mit beschränkter Haftung Modified factor VIII cDNA and its use for the production of factor VIII
US20030026783A1 (en) * 2001-08-03 2003-02-06 Amine Abina Method of modulating neutralizing antibodies formation in mammals, and uses thereof in gene therapy, animal transgenesis and in functional inactivation of an endogenous proteins
EP1283263A1 (en) * 2001-08-08 2003-02-12 Aventis Behring GmbH Modified cDNA for high expression levels of factor VIII and its derivatives
EP1284290A1 (en) * 2001-08-08 2003-02-19 Aventis Behring GmbH Increase of the expression levels of factor VIII by insertion of spliceable nucleotide sequences into factor VIII cDNA
ITMI20012110A1 (it) * 2001-10-12 2003-04-12 Keryos Spa Vettori multi-cistronici utilizzabili in protocolli di trsferimento genico
AU2002365084A1 (en) * 2001-10-19 2003-07-24 Sirna Therapeutics, Inc Method and reagent for the detection of proteins and peptides
CA2531773A1 (en) 2003-07-21 2005-02-17 Transgene S.A. Novel multifunctional cytokines
RS52187B (en) * 2004-10-14 2012-10-31 Crucell Holland B.V. Vaccines for the induction and stimulation of the immune response for malaria
EP1998804B1 (en) * 2006-03-27 2014-04-16 Crucell Holland B.V. Compositions comprising a recombinant adenovirus and an adjuvant
CN104870477B (zh) 2012-10-23 2018-10-09 爱默蕾大学 Gm-csf和il-4轭合物、组合物以及与其相关的方法
EP2986635B1 (en) * 2013-04-18 2018-10-03 Fondazione Telethon Effective delivery of large genes by dual aav vectors
KR102252423B1 (ko) * 2019-02-22 2021-05-13 알지노믹스 주식회사 암 특이적 트랜스-스플라이싱 리보자임 및 이의 용도

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5518913A (en) * 1991-10-10 1996-05-21 National Research Council Of Canada High level recombinant protein production using conditional helper-free adenovirus vector
EP0905253A3 (en) * 1992-12-03 2000-11-02 Genzyme Corporation Adenoviral vector deleted of all E4-ORF except ORF6
ES2118965T3 (es) 1993-04-23 1998-10-01 Eliasson Torbjorn Proteccion impermeable desechable.
CA2162497A1 (en) * 1993-06-10 1994-12-22 Sheila Connelly Adenoviral vectors for treatment of hemophilia
WO1995016772A1 (en) * 1993-12-14 1995-06-22 Cornell Research Foundation, Inc. Adenovirus gene expression system
JP3770333B2 (ja) * 1995-03-15 2006-04-26 大日本住友製薬株式会社 組換えｄｎａウイルスおよびその製造方法
JPH11503910A (ja) * 1995-04-17 1999-04-06 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム アデノウイルスヘルパーウイルスシステム
FR2737222B1 (fr) 1995-07-24 1997-10-17 Transgene Sa Nouveaux vecteurs viraux et lignee pour la therapie genique

Also Published As

Publication number Publication date
WO1998055639A2 (fr) 1998-12-10
ES2232950T3 (es) 2005-06-01
EP0988391B1 (fr) 2004-12-15
AU8024798A (en) 1998-12-21
DE69828167T2 (de) 2005-12-22
AU753809B2 (en) 2002-10-31
WO1998055639A3 (fr) 1999-03-04
US6399587B1 (en) 2002-06-04
PT988391E (pt) 2005-05-31
JP4386971B2 (ja) 2009-12-16
FR2763959A1 (fr) 1998-12-04
ATE284969T1 (de) 2005-01-15
CA2292792C (fr) 2010-03-30
EP0988391A2 (fr) 2000-03-29
DE69828167D1 (de) 2005-01-20
CA2292792A1 (fr) 1998-12-10
JP2002511751A (ja) 2002-04-16

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