CA2305016A1 - Proteinase de degradation de la proteine de complement humain c3, tiree du streptococcus pneumoniae - Google Patents

Proteinase de degradation de la proteine de complement humain c3, tiree du streptococcus pneumoniae Download PDF

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Publication number
CA2305016A1
CA2305016A1 CA002305016A CA2305016A CA2305016A1 CA 2305016 A1 CA2305016 A1 CA 2305016A1 CA 002305016 A CA002305016 A CA 002305016A CA 2305016 A CA2305016 A CA 2305016A CA 2305016 A1 CA2305016 A1 CA 2305016A1
Authority
CA
Canada
Prior art keywords
protein
seq
nucleic acid
isolated
pneumoniae
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002305016A
Other languages
English (en)
Inventor
Margaret K. Hostetter
David J. Finkel
Qi Cheng
Bruce A. Green
Amy W. Masi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
University of Minnesota
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2305016A1 publication Critical patent/CA2305016A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Abstract

Cette invention se rapporte à l'identification et à l'utilisation d'une famille de protéinases dégradant la protéine de complément humain C3, qui sont exprimées par S. Pneumoniae. Une telle protéinase possède un poids moléculaire compris entre 15 kD environ et 25 kD environ. Une protéinase préférée de cette invention contient la séquence d'acides aminés ayant le numéro d'identification de séquence 2 (SEQ ID NO:2).
CA002305016A 1997-09-24 1998-09-24 Proteinase de degradation de la proteine de complement humain c3, tiree du streptococcus pneumoniae Abandoned CA2305016A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5990797P 1997-09-24 1997-09-24
US60/059,907 1997-09-24
PCT/US1998/020186 WO1999015675A1 (fr) 1997-09-24 1998-09-24 PROTEINASE DE DEGRADATION DE LA PROTEINE DE COMPLEMENT HUMAIN C3, TIREE DU $i(STREPTOCOCCUS PNEUMONIAE)

Publications (1)

Publication Number Publication Date
CA2305016A1 true CA2305016A1 (fr) 1999-04-01

Family

ID=22026061

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002305016A Abandoned CA2305016A1 (fr) 1997-09-24 1998-09-24 Proteinase de degradation de la proteine de complement humain c3, tiree du streptococcus pneumoniae

Country Status (8)

Country Link
EP (1) EP1017828A1 (fr)
JP (1) JP2001517449A (fr)
KR (1) KR20010024299A (fr)
CN (1) CN1291233A (fr)
AU (1) AU9510598A (fr)
BR (1) BR9812525A (fr)
CA (1) CA2305016A1 (fr)
WO (1) WO1999015675A1 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6245335B1 (en) 1996-05-01 2001-06-12 The Rockefeller University Choline binding proteins for anti-pneumococcal vaccines
DE69739981D1 (de) 1996-10-31 2010-10-14 Human Genome Sciences Inc Streptococcus pneumoniae-Antigene und Impfstoffe
US6676943B1 (en) 1997-04-24 2004-01-13 Regents Of The University Of Minnesota Human complement C3-degrading protein from Streptococcus pneumoniae
EP1783224A3 (fr) * 1998-07-27 2007-08-15 Sanofi Pasteur Limited Protéines de Streptococcus pneumoniae et molécules d'acide nucléique
US6936252B2 (en) 1998-07-27 2005-08-30 Microbial Technics Limited Streptococcus pneumoniae proteins and nucleic acid molecules
CA2343931A1 (fr) * 1998-09-24 2000-03-30 Regents Of The University Of Minnesota Polypeptide de degradation du complement humain c3 de $i(streptococcus pneumoniae)
ES2322306T3 (es) * 1998-12-21 2009-06-18 Medimmune, Inc. Proteinas de streptpcpccus pneumoniae y fragmentos inmunogenicos para vacunas.
US7128918B1 (en) 1998-12-23 2006-10-31 Id Biomedical Corporation Streptococcus antigens
EP1950302B1 (fr) * 1998-12-23 2012-12-05 ID Biomedical Corporation of Quebec Nouveaux antigènes de streptocoque
AU2005209689B2 (en) * 1998-12-23 2008-07-17 Id Biomedical Corporation Of Quebec Novel streptococcus antigens
TR200200633T2 (tr) * 1998-12-23 2002-06-21 Shire Biochem Inc. Yeni streptococcus antijenleri
US7074415B2 (en) 2000-06-20 2006-07-11 Id Biomedical Corporation Streptococcus antigens
MXPA03000103A (es) * 2000-06-20 2003-06-19 Shire Biochem Inc Antigenos de streptococcus.
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
ES2359625T3 (es) * 2000-12-28 2011-05-25 Wyeth Llc Proteina protectora recombinante de.
AU2002351623A1 (en) 2001-12-20 2003-07-09 Shire Biochem Inc. Streptococcus antigens
JP5219819B2 (ja) * 2005-10-21 2013-06-26 カタリスト・バイオサイエンシーズ・インコーポレイテッド 補体活性化を阻害する修飾プロテアーゼ
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
MY148141A (en) 2005-12-22 2013-03-15 Glaxosmithkline Biolog Sa Vaccine
EP2167120A2 (fr) 2007-06-26 2010-03-31 GlaxoSmithKline Biologicals S.A. Vaccin contenant des conjugues de polysaccharide capsulaire de streptococcus pneumoniae
ES2553113T3 (es) 2008-04-16 2015-12-04 Glaxosmithkline Biologicals S.A. Vacuna
GB201003920D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Method of treatment
GB201003924D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Immunogenic composition
US20140072622A1 (en) 2011-05-17 2014-03-13 Glaxosmithkline Biologicals S.A. Vaccine against streptococcus pneumoniae
CN102731739B (zh) * 2012-07-05 2013-11-06 富阳经略化工技术有限公司 用作润滑油粘度指数改进剂的星形聚合物及其制备方法和应用
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69739981D1 (de) * 1996-10-31 2010-10-14 Human Genome Sciences Inc Streptococcus pneumoniae-Antigene und Impfstoffe
BR9809405A (pt) * 1997-04-24 2000-06-13 Univ Minnesota Proteinase de streptococcus pneumoniae que degrada complemento humano c3

Also Published As

Publication number Publication date
BR9812525A (pt) 2000-07-25
JP2001517449A (ja) 2001-10-09
WO1999015675A1 (fr) 1999-04-01
AU9510598A (en) 1999-04-12
EP1017828A1 (fr) 2000-07-12
KR20010024299A (ko) 2001-03-26
CN1291233A (zh) 2001-04-11

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Legal Events

Date Code Title Description
FZDE Discontinued