CA2302867A1 - Virus syncytiaux respiratoires attenues - Google Patents

Virus syncytiaux respiratoires attenues Download PDF

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Publication number
CA2302867A1
CA2302867A1 CA002302867A CA2302867A CA2302867A1 CA 2302867 A1 CA2302867 A1 CA 2302867A1 CA 002302867 A CA002302867 A CA 002302867A CA 2302867 A CA2302867 A CA 2302867A CA 2302867 A1 CA2302867 A1 CA 2302867A1
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Canada
Prior art keywords
leu
ile
ser
asn
lys
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Abandoned
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CA002302867A
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English (en)
Inventor
Stephen A. Udem
Mohinderjit S. Sidhu
Valerie B. Randolph
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Wyeth Holdings LLC
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Individual
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Publication of CA2302867A1 publication Critical patent/CA2302867A1/fr
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18561—Methods of inactivation or attenuation
    • C12N2760/18564—Methods of inactivation or attenuation by serial passage

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Virus syncytiaux respiratoires atténués, isolés, générés par recombinaison, appartenant au sous-groupe B et possédant au moins une mutation d'atténuation dans le gène de polymérase d'ARN. Formulations de vaccins comprenant ces virus, ainsi qu'un véhicule acceptable sur le plan physiologique. On utilise ces vaccins dans le but d'immuniser un individu afin d'induire une protection contre le virus syncytial respiratoire.
CA002302867A 1997-09-19 1998-09-15 Virus syncytiaux respiratoires attenues Abandoned CA2302867A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5955297P 1997-09-19 1997-09-19
US60/059,552 1997-09-19
PCT/US1998/019145 WO1999015672A1 (fr) 1997-09-19 1998-09-15 Virus syncytiaux respiratoires attenues

Publications (1)

Publication Number Publication Date
CA2302867A1 true CA2302867A1 (fr) 1999-04-01

Family

ID=22023716

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002302867A Abandoned CA2302867A1 (fr) 1997-09-19 1998-09-15 Virus syncytiaux respiratoires attenues

Country Status (8)

Country Link
EP (1) EP1015594A1 (fr)
JP (1) JP2001517448A (fr)
KR (1) KR20010030630A (fr)
CN (1) CN1273603A (fr)
AU (1) AU9389998A (fr)
BR (1) BR9812232A (fr)
CA (1) CA2302867A1 (fr)
WO (1) WO1999015672A1 (fr)

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PT1098961E (pt) 1998-06-12 2008-04-23 Mount Sinai School Of Med Of T Vírus atenuados produzidos por engenharia genética indutores de interferão
IL140264A0 (en) 1998-06-12 2002-02-10 Sinai School Medicine Attenuated negative strand viruses with altered interferon antagonist activity for use as vaccines and pharmaceuticals
US6544785B1 (en) 1998-09-14 2003-04-08 Mount Sinai School Of Medicine Of New York University Helper-free rescue of recombinant negative strand RNA viruses
US6146642A (en) 1998-09-14 2000-11-14 Mount Sinai School Of Medicine, Of The City University Of New York Recombinant new castle disease virus RNA expression systems and vaccines
US6764685B1 (en) 2000-03-21 2004-07-20 Medimmune Vaccines, Inc. Recombinant parainfluenza virus expression systems and vaccines
WO2001077394A1 (fr) 2000-04-10 2001-10-18 Mount Sinai School Of Medicine Of New York University Methodes de criblage destinees a l'identification de proteines virales au moyen de fonctions antagonistes d'interferons et d'agents antiviraux potentiels
HUP0500244A3 (en) 2001-01-19 2011-03-28 Vironovative Bv A virus causing respiratory tract illness in suspectible mammals
US8715922B2 (en) 2001-01-19 2014-05-06 ViroNovative Virus causing respiratory tract illness in susceptible mammals
CA2743750A1 (fr) 2002-02-21 2003-09-04 Medimmune, Llc Systemes d'expression de virus recombinant parainfluenza et vaccins comprenant des antigenes heterologues derives d'un virus syncytial respiratoire
US7465456B2 (en) 2002-04-26 2008-12-16 Medimmune, Llc Multi plasmid system for the production of influenza virus
CN1678345B (zh) 2002-04-26 2013-09-11 米迪缪尼有限公司 制备流感病毒的多质粒系统
WO2004096993A2 (fr) 2003-04-25 2004-11-11 Medimmune Vaccines, Inc. Souches de metapneumovirus et leur utilisation dans des preparations de vaccin et en tant que vecteurs pour l'expression de sequences d'antigenes et procedes pour propager un virus
EP2581093B1 (fr) 2003-06-16 2015-03-18 MedImmune, LLC Hémagglutinine de la grippe et variantes de la neuraminidase
ES2345492T3 (es) 2003-12-23 2010-09-24 Medimmune, Llc Sistema multiplasmido para la produccion del virus de la gripe.
WO2005116258A2 (fr) 2004-05-25 2005-12-08 Medimmune Vaccines, Inc. Variantes d'hemagglutinine influenza et de neuraminidasevariantes d'hemagglutinine influenza et de neuraminidase
BRPI0511776B1 (pt) 2004-06-01 2016-11-29 Sinai School Medicine vírus atenuado de influenza de suínos geneticamente engenheirado, formulação imunogênica, formulação farmacêutica, uso da formulação imunogênica, uso do vírus atenuado de influenza de suínos geneticamente engenheirado, uso da formulação farmacêutica e método para produzir uma vacina, uma formulação imunogênica ou uma formulação farmacêutica
WO2006088481A2 (fr) 2005-02-15 2006-08-24 Mount Sinai School Of Medicine Of New York University Virus de la grippe equine genetiquement modifie et utilisations associees
EP1856271A4 (fr) 2005-03-08 2009-11-18 Medimmune Vaccines Inc Variants d'hemagglutinine et de neuraminidase du virus influenza
TWI531652B (zh) 2005-12-02 2016-05-01 美國紐約大學西奈山醫學院 表現非原生表面蛋白質之嵌合病毒及其用途
DK2016194T3 (en) 2006-04-19 2015-06-15 Medimmune Llc METHODS AND COMPOSITIONS FOR EXPRESSION OF VIRAL NEGATIVE SENSE RNA IN DOG CELLS
WO2008133701A1 (fr) 2006-07-21 2008-11-06 Medimmune, Llc. Procédés et compositions permettant d'accroître la capacité de réplication d'un virus de la grippe
AU2007286161B2 (en) 2006-08-09 2013-05-02 Medimmune, Llc Influenza hemagglutinin and neuraminidase variants
ES2523587T3 (es) 2007-06-18 2014-11-27 Medimmune, Llc Virus influenza B que tienen alteraciones en el polipéptido hemaglutinina
JP2011527581A (ja) 2008-07-11 2011-11-04 メディミューン，エルエルシー インフルエンザ赤血球凝集素およびノイラミニダーゼ変異体
EP2987856B1 (fr) 2009-02-05 2018-07-25 Icahn School of Medicine at Mount Sinai Virus chimériques de la maladie de newcastle et utilisations de ceux-ci
BRPI1008549A2 (pt) 2009-02-12 2016-03-15 Medimmune Llc variantes de neuraminidase e hemaglutinina de influenza
EP2413962A1 (fr) 2009-03-30 2012-02-08 Mount Sinai School of Medicine Vaccins pour le virus influenza et leurs utilisations
US9217157B2 (en) 2009-07-27 2015-12-22 Icahn School Of Medicine At Mount Sinai Recombinant influenza viruses and uses thereof
WO2011014645A1 (fr) 2009-07-30 2011-02-03 Mount Sinai School Of Medicine Of New York University Virus de la grippe et leurs utilisations
EP3248615A1 (fr) 2010-03-30 2017-11-29 Mount Sinai School of Medicine of New York University Vaccins contre le virus de la grippe et utilisations associées
IN2014CN02114A (fr) 2011-09-20 2015-05-29 Sinai School Medicine
EP4154907A1 (fr) 2012-12-18 2023-03-29 Icahn School of Medicine at Mount Sinai Vaccins contre la grippe et utilisations associées
CN111172120A (zh) 2013-03-14 2020-05-19 西奈山伊坎医学院 新城疫病毒及其用途
US9908930B2 (en) 2013-03-14 2018-03-06 Icahn School Of Medicine At Mount Sinai Antibodies against influenza virus hemagglutinin and uses thereof
EP3441084A1 (fr) 2014-02-27 2019-02-13 Viralytics Limited Un virus oncolytique et un agent immunostimulateur pour le traitement du cancer combiné
AU2016209032A1 (en) 2015-01-23 2017-08-10 Icahn School Of Medicine At Mount Sinai Influenza virus vaccination regimens
BR112017015789A2 (pt) 2015-02-26 2018-03-27 Boehringer Ingelheim Vetmedica Gmbh vacina de vírus da influenza suína bivalente
US10548966B2 (en) 2015-08-20 2020-02-04 University Of Rochester Single-cycle virus for the development of canine influenza vaccines
CA2995382A1 (fr) 2015-08-20 2017-02-23 University Of Rochester Vaccin vivant attenue comprenant des mutations de polymerase virale pour le traitement et la prevention de virus de la grippe canine
US10973903B2 (en) 2015-08-20 2021-04-13 University Of Rochester NS1 truncated virus for the development of canine influenza vaccines
CN109414488A (zh) 2016-06-03 2019-03-01 罗切斯特大学 马流感病毒减毒活疫苗
MX2018015755A (es) 2016-06-15 2019-08-29 Icahn School Med Mount Sinai Proteinas de hemaglutinina de virus de influenza y usos de las mismas.
CA3058652A1 (fr) 2017-04-07 2018-10-11 Icahn School Of Medicine At Mount Sinai Anticorps anti-neuraminidase du virus influenza de type b et leurs utilisations
JOP20190256A1 (ar) 2017-05-12 2019-10-28 Icahn School Med Mount Sinai فيروسات داء نيوكاسل واستخداماتها
MX2020008927A (es) 2018-02-27 2021-01-08 Univ Rochester Vacuna contra la influenza atenuada viva multivalente para la prevencion y el control del virus de la influenza equina (eiv) en caballos.
CN111073861B (zh) * 2018-10-19 2023-04-14 兰州生物制品研究所有限责任公司 人呼吸道合胞病毒毒株、应用、抗体或杂交瘤细胞或抗血清
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Family Cites Families (4)

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TW275632B (fr) * 1992-04-21 1996-05-11 American Cyanamid Co
CA2250883A1 (fr) * 1996-04-04 1997-10-16 The Regents Of The University Of Michigan Virus respiratoire syncytial attenue
ES2345643T3 (es) * 1996-07-15 2010-09-28 The Government Of The Usa, As Represented By The Department Of Health And Human Services Produccion de vacunas a base de virus respiratorio sincitial atenuado, a partir de secuencias nucleotidicas clonadas.
BR9712138A (pt) * 1996-09-27 2000-01-18 American Cyanamid Co Vìrus de rna isolado, vacina, processo para imunizr um indivìduo para induzir proteção contra um vìrus de rna não segmentado, sentido negativo, de filamento único, da ordem mononegavirales e para produzir vìrus de rna, molécula de ácido nucleico isolada e composição.

Also Published As

Publication number Publication date
EP1015594A1 (fr) 2000-07-05
KR20010030630A (ko) 2001-04-16
BR9812232A (pt) 2000-07-18
JP2001517448A (ja) 2001-10-09
CN1273603A (zh) 2000-11-15
AU9389998A (en) 1999-04-12
WO1999015672A1 (fr) 1999-04-01

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FZDE Discontinued