CA2301990A1 - Nouveaux derives dimeriques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux derives dimeriques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Download PDF

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CA2301990A1
CA2301990A1 CA002301990A CA2301990A CA2301990A1 CA 2301990 A1 CA2301990 A1 CA 2301990A1 CA 002301990 A CA002301990 A CA 002301990A CA 2301990 A CA2301990 A CA 2301990A CA 2301990 A1 CA2301990 A1 CA 2301990A1
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CA2301990C (fr
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Daniel Lesieur
Said Yous
Carole Descamps-Francois
Francois Lefoulon
Gerald Guillaumet
Marie-Claude Viaud
Caroline Bennejean
Philippe Delagrange
Pierre Renard
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Laboratoires Servier SAS
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ADIR SARL
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  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne de nouveaux composés répondant à la formule (I): A-G1-Cy-G2-Cy-G3-B (I) dans laquelle A représente un groupement de formule <IMG> m <IMG> ou <IMG> dans lesquelles Q représente un atome de soufre ou d'oxygène, R1, R2 et R3, identiques ou différents, représentent un atome d'hydrogène ou un groupement R a, R a représentant un groupement alkyle, alkényle, alkynyle, cycloalkyle, cycloalkyle alkyle, aryle, polyhalogénoalkyle, arylalkyle, arylalkényle, hétéroaryle, hétéroarylalkyle, hétéroarylalkényle, ou les groupements R2 et R3 forment avec l'atome d'azote qui les porte un groupement choisi parmi pipérazinyle, pipéridinyle et pyrrolidinyle; B représente un groupement de formule <IMG> ou -NR2R3 dans lesquelles Q, R1, R2 et R3 sont tels que définis précédemment; G1 et G3, identiques ou différents, représentent une chaîne alkylène éventuellement substituée; Cy représente une structure cyclique de formule (II): <IMG> dans laquelle X et Y, identiques ou différents, représentent un atome de soufre, d'oxygène ou de carbone, ou un groupement CH ou CH2, R4 représente un atome d'hydrogène ou d'halogène ou un groupement CF3, hydroxy, carboxy, formyle, amino, NHR a, NR a R1a, NHCOR a, CONHR a, R a, OR a, COR a ou COOR a, où R a est tel que défini précédemment et R1a prend toutes les valeurs de R a, et la représentation ~ signifie que les liaisons sont simples ou doubles, G2 substituant le cycle benzénique, et G1 et G3 substituant le cycle contenant X et Y; ou Cy représente une structure cyclique de formule (III): <IMG> dans laquelle Z représente un atome de soufre ou d'oxygène, ou un groupement CH, CH2, NH, NSO2Ph ou NR a, où R a est tel que défini précédemment, D représente un cycle benzénique ou pyridinique, R4 est tel que défini précédemment, et la représentation ~ signifie que la liaison est simple ou double, G2 substituant le cycle D, et G1 et G3 substituent le cycle contenant Z; et G2 représente une chaîne de formule (IV): <IMG> dans laquelle W1, W2 et W3, identiques ou différents, représentent une liaison, un atome d'oxygène ou de soufre, ou un groupement CH2, CHR a, NH ou NR a, où R a est tel que défini précédemment, n représente un entier tel que 0 ~ n ~ 6, m représente un entier tel que 0 ~ m ~ 6, étant entendu que l'on ne peut pas avoir deux hétéroatomes consécutifs; leurs énantiomères et diastéréoisomères, ainsi que leurs sels d'addition à un acide ou une base pharmaceutiquement acceptable. Les composés selon l'invention sont utiles pour la fabrication de médicaments destinés au traitement des troubles liés au système mélatoninergique.
CA002301990A 1999-03-25 2000-03-23 Nouveaux derives dimeriques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Expired - Fee Related CA2301990C (fr)

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FR99/03717 1999-03-25
FR9903717A FR2791344B1 (fr) 1999-03-25 1999-03-25 Nouveaux derives dimeriques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

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US7078541B2 (en) * 2002-02-07 2006-07-18 Galileo Pharmaceuticals, Inc. Benzofuran derivatives
US6653346B1 (en) * 2002-02-07 2003-11-25 Galileo Pharmaceuticals, Inc. Cytoprotective benzofuran derivatives
TWI284124B (en) * 2002-12-03 2007-07-21 Hoffmann La Roche Aminoalkoxyindoles
EP2352501B1 (fr) * 2008-11-03 2014-01-01 ChemoCentryx, Inc. Composés pour l'utilisation dans le traitement de l'ostéoporose
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DE4012338A1 (de) * 1990-04-18 1991-10-24 Bayer Ag Substituierte pyridazinone, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
US5273999A (en) * 1991-09-10 1993-12-28 Hoffmann-La Roche Inc. Carboxylic acid leukotriene B4 antagonists
DK78692D0 (da) * 1992-06-12 1992-06-12 Lundbeck & Co As H Dimere piperidin- og piperazinderivater
FR2713636B1 (fr) * 1993-12-07 1996-01-05 Adir Nouveaux dérivés naphtaléniques, leur procédé de préparation, et les compositions pharmaceutiques qui les contiennent.
US5753700A (en) * 1994-12-28 1998-05-19 Ono Pharmaceutical Co., Ltd. Naphthyloxyacetic acid derivatives
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EP1038863B1 (fr) 2003-06-04
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JP2000319242A (ja) 2000-11-21
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US6635650B2 (en) 2003-10-21
US6319930B1 (en) 2001-11-20
HUP0001249A3 (en) 2003-05-28
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AU761605B2 (en) 2003-06-05
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PT1038863E (pt) 2003-09-30
FR2791344A1 (fr) 2000-09-29
FR2791344B1 (fr) 2002-02-15
EA200000261A3 (ru) 2000-12-25
CN1273967A (zh) 2000-11-22
DE60003103D1 (de) 2003-07-10
HU0001249D0 (en) 2000-06-28
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SI1038863T1 (en) 2003-10-31
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KR100450314B1 (ko) 2004-09-30
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NO20001541D0 (no) 2000-03-24
HUP0001249A2 (hu) 2000-10-28
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EP1038863A3 (fr) 2000-11-02
US20020035114A1 (en) 2002-03-21
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