CA2288759A1 - Carprofene inhibant selectivement cox-2 et utilise dans le traitement de la douleur et des inflammations chez les chiens - Google Patents
Carprofene inhibant selectivement cox-2 et utilise dans le traitement de la douleur et des inflammations chez les chiens Download PDFInfo
- Publication number
- CA2288759A1 CA2288759A1 CA002288759A CA2288759A CA2288759A1 CA 2288759 A1 CA2288759 A1 CA 2288759A1 CA 002288759 A CA002288759 A CA 002288759A CA 2288759 A CA2288759 A CA 2288759A CA 2288759 A1 CA2288759 A1 CA 2288759A1
- Authority
- CA
- Canada
- Prior art keywords
- cox
- carprofen
- inflammatory
- activity
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
L'invention porte sur des procédés de traitement ou de prévention des inflammations chez les chiens ou des maladies associées à l'activité de cyclo-oxygénase-2 (COX-2) inductive, et simultanément sur la réduction ou l'élimination d'effets secondaires indésirables associés à l'inhibition simultanée de l'activité de cyclo-oxygénase-1 (COX-1) constitutive en sélectionnant sélectivement l'activité de COX-2 en tenant compte de l'activité de COX-1, le rapport de sélectivité ou d'inhibition de l'activité de COX-2 : COX-1 étant au moins de 3 : 1 sur la base des taux d'inhibition ex vivo relevés dans le sang entier; l'inhibiteur est un élément sélectionné dans le groupe des composés anti-inflammatoires constitués principalement des dérives d'acide salicylique, des dérivés de p-aminophénol, d'indole et des acides acétiques d'indène, des acides acétiques d'hétéroaryle, des acides arylproprioniques, des acides anthraniliques, des acides énoliques et des alcanones; l'inhibiteur comprend notamment (+)(S)-énantiomère de l'acide 6-chloro-.alpha.-méthyl-9H-carbazole-2-acétique.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4563597P | 1997-05-05 | 1997-05-05 | |
| US60/045635 | 1997-05-05 | ||
| PCT/IB1998/000662 WO1998050033A1 (fr) | 1997-05-05 | 1998-05-01 | Carprofene inhibant selectivement cox-2 et utilise dans le traitement de la douleur et des inflammations chez les chiens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2288759A1 true CA2288759A1 (fr) | 1998-11-12 |
Family
ID=21939053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002288759A Abandoned CA2288759A1 (fr) | 1997-05-05 | 1998-05-01 | Carprofene inhibant selectivement cox-2 et utilise dans le traitement de la douleur et des inflammations chez les chiens |
Country Status (32)
| Country | Link |
|---|---|
| EP (1) | EP0988034A1 (fr) |
| JP (1) | JP2000513020A (fr) |
| KR (2) | KR20010012300A (fr) |
| CN (1) | CN1255059A (fr) |
| AP (1) | AP9801234A0 (fr) |
| AR (2) | AR011726A1 (fr) |
| AU (1) | AU6932198A (fr) |
| BG (1) | BG103852A (fr) |
| BR (1) | BR9808720A (fr) |
| CA (1) | CA2288759A1 (fr) |
| DZ (1) | DZ2479A1 (fr) |
| EA (1) | EA003696B1 (fr) |
| GT (1) | GT199800063A (fr) |
| HR (1) | HRP980244A2 (fr) |
| HU (1) | HUP0001286A3 (fr) |
| ID (1) | ID21311A (fr) |
| IL (1) | IL132570A0 (fr) |
| IS (1) | IS5220A (fr) |
| MA (1) | MA26491A1 (fr) |
| NO (1) | NO995389L (fr) |
| NZ (1) | NZ500183A (fr) |
| OA (1) | OA11213A (fr) |
| PA (1) | PA8450601A1 (fr) |
| PE (1) | PE72599A1 (fr) |
| PL (1) | PL337003A1 (fr) |
| SK (1) | SK148199A3 (fr) |
| TN (1) | TNSN98059A1 (fr) |
| TW (1) | TW590773B (fr) |
| UY (1) | UY24989A1 (fr) |
| WO (1) | WO1998050033A1 (fr) |
| YU (1) | YU55899A (fr) |
| ZA (1) | ZA983722B (fr) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6245797B1 (en) | 1997-10-22 | 2001-06-12 | Merck & Co., Inc. | Combination therapy for reducing the risks associated with cardio-and-cerebrovascular disease |
| AU2003204888B2 (en) * | 1998-05-22 | 2005-07-28 | Pfizer Products Inc. | Treating or Preventing the Early Stages of Degeneration of Articular Cartilage or Subchondral Bone in Mammals Using Carprofen and Derivatives |
| US6506785B2 (en) * | 1998-05-22 | 2003-01-14 | Pfizer, Inc. | Treating or preventing the early stages of degeneration of articular cartilage or subchondral bone in mammals using carprofen and derivatives |
| CA2347365A1 (fr) * | 1998-10-23 | 2000-05-04 | Merck Frosst Canada & Co. | Produit de combinaison comprenant un ligand de prostaglandine de type e et un inhibiteur selectif de cox-2, et procedes d'utilisation dudit produit |
| DE60023119T2 (de) * | 1999-03-10 | 2006-07-20 | G.D. Searle Llc | Zusammensetzungen zur verabreichung eines cyclooxygenase-2-hemmers an tiere |
| WO2001034204A1 (fr) * | 1999-11-11 | 2001-05-17 | Eli Lilly And Company | Produits composes oncolytiques destines au traitement du cancer |
| WO2001087343A2 (fr) * | 2000-05-15 | 2001-11-22 | Merck Frosst Canada & Co. | Polytherapie faisant appel a un inhibiteur selectif de cox-2 et a un inhibiteur de la thromboxane ainsi que des compositions contenant ceux-ci |
| PL206268B1 (pl) | 2000-06-13 | 2010-07-30 | Wyethwyeth | Kompozycja przeciwbólowa i/lub przeciwzapalna oraz jej zastosowanie |
| DE10032132A1 (de) * | 2000-07-01 | 2002-01-17 | Lohmann Therapie Syst Lts | Dermales Therapeutisches System enthaltend nichtsteroidale Antiphlogistika mit selektiver COX-2-Hemmung |
| EP1307585B1 (fr) | 2000-08-07 | 2009-01-21 | Vanderbilt University | Compositions et methodes destinees a detecter et quantifier l'activite de la cox-2 et les metabolites du 2-arachidonylglycerol |
| WO2003007875A2 (fr) * | 2001-07-16 | 2003-01-30 | Hoegestaett Edward | Substances organoleptiques d'acetaminophene et composes associes utilises comme substrats pour conjugaison d'acides gras et utilisation de ces substances dans le traitement de la douleur, de la fievre et des inflammations |
| ES2275218T3 (es) | 2003-05-07 | 2007-06-01 | Osteologix A/S | Sales de estroncio hidrosolubles para el tratamiento de afecciones de cartilagos y/o huesos. |
| MXPA06001288A (es) * | 2003-07-31 | 2006-04-11 | Upjohn Co | Formulacion dispersable de un agente anti-inflamatorio. |
| EA200702280A1 (ru) * | 2005-05-20 | 2008-04-28 | Пфайзер Лимитед | Синергические комбинации |
| JP2010523554A (ja) | 2007-04-04 | 2010-07-15 | シグモイド・ファーマ・リミテッド | タクロリムスの医薬組成物 |
| US8951570B2 (en) | 2007-04-26 | 2015-02-10 | Sigmoid Pharma Limited | Manufacture of multiple minicapsules |
| GB2483815B (en) | 2009-05-18 | 2013-12-25 | Sigmoid Pharma Ltd | Composition comprising oil drops |
| CN107582526A (zh) | 2009-08-12 | 2018-01-16 | 希格默伊德药业有限公司 | 包含聚合物基质和油相的免疫调节组合物 |
| GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
| GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
| GB201319791D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
| CN105939713A (zh) | 2014-03-06 | 2016-09-14 | 阿莱塔纳治疗学股份有限公司 | 格拉匹纶组合物及其使用方法 |
| AU2015341695B2 (en) | 2014-11-07 | 2021-07-08 | Sublimity Therapeutics Limited | Compositions comprising cyclosporin |
| WO2016112312A1 (fr) * | 2015-01-09 | 2016-07-14 | Jaguar Animal Health | Méthodes de traitement de la diarrhée chez des animaux de compagnie |
| WO2021195346A1 (fr) * | 2020-03-25 | 2021-09-30 | Sri International | Inhibiteurs de lipoxygénase |
| US11116737B1 (en) | 2020-04-10 | 2021-09-14 | University Of Georgia Research Foundation, Inc. | Methods of using probenecid for treatment of coronavirus infections |
| KR102404883B1 (ko) | 2020-11-30 | 2022-06-07 | (주)이노보테라퓨틱스 | 벤즈브로마론을 포함하는 켈로이드 또는 비대흉터 예방 또는 치료용 약학 조성물 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3896145A (en) * | 1972-07-24 | 1975-07-22 | Hoffmann La Roche | Carbazoles |
| CA1319886C (fr) * | 1987-02-03 | 1993-07-06 | Alberto Ferro | Solutions de micelles mixtes |
-
1998
- 1998-03-02 DZ DZ980089A patent/DZ2479A1/fr active
- 1998-04-30 TW TW087106689A patent/TW590773B/zh not_active IP Right Cessation
- 1998-05-01 ID IDP980651A patent/ID21311A/id unknown
- 1998-05-01 HU HU0001286A patent/HUP0001286A3/hu unknown
- 1998-05-01 WO PCT/IB1998/000662 patent/WO1998050033A1/fr not_active Application Discontinuation
- 1998-05-01 YU YU55899A patent/YU55899A/sh unknown
- 1998-05-01 SK SK1481-99A patent/SK148199A3/sk unknown
- 1998-05-01 JP JP10547869A patent/JP2000513020A/ja active Pending
- 1998-05-01 NZ NZ500183A patent/NZ500183A/en unknown
- 1998-05-01 CN CN98804845A patent/CN1255059A/zh active Pending
- 1998-05-01 PL PL98337003A patent/PL337003A1/xx unknown
- 1998-05-01 EP EP98915041A patent/EP0988034A1/fr not_active Withdrawn
- 1998-05-01 AU AU69321/98A patent/AU6932198A/en not_active Abandoned
- 1998-05-01 IL IL13257098A patent/IL132570A0/xx unknown
- 1998-05-01 KR KR1019997010252A patent/KR20010012300A/ko not_active Application Discontinuation
- 1998-05-01 KR KR10-2003-7005258A patent/KR20040004406A/ko not_active Application Discontinuation
- 1998-05-01 BR BR9808720-7A patent/BR9808720A/pt not_active IP Right Cessation
- 1998-05-01 CA CA002288759A patent/CA2288759A1/fr not_active Abandoned
- 1998-05-01 EA EA199900895A patent/EA003696B1/ru not_active IP Right Cessation
- 1998-05-04 AP APAP/P/1998/001234A patent/AP9801234A0/en unknown
- 1998-05-04 GT GT199800063A patent/GT199800063A/es unknown
- 1998-05-04 PE PE1998000335A patent/PE72599A1/es not_active Application Discontinuation
- 1998-05-04 UY UY24989A patent/UY24989A1/es not_active Application Discontinuation
- 1998-05-04 MA MA25059A patent/MA26491A1/fr unknown
- 1998-05-04 TN TNTNSN98059A patent/TNSN98059A1/fr unknown
- 1998-05-04 ZA ZA9803722A patent/ZA983722B/xx unknown
- 1998-05-05 AR ARP980102089A patent/AR011726A1/es unknown
- 1998-05-05 HR HR60/045,635A patent/HRP980244A2/hr not_active Application Discontinuation
- 1998-05-05 PA PA19988450601A patent/PA8450601A1/es unknown
-
1999
- 1999-10-19 IS IS5220A patent/IS5220A/is unknown
- 1999-11-02 OA OA9900242A patent/OA11213A/en unknown
- 1999-11-03 BG BG103852A patent/BG103852A/xx unknown
- 1999-11-04 NO NO995389A patent/NO995389L/no not_active Application Discontinuation
-
2003
- 2003-04-09 AR ARP030101251A patent/AR039628A2/es unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2288759A1 (fr) | Carprofene inhibant selectivement cox-2 et utilise dans le traitement de la douleur et des inflammations chez les chiens | |
| Shi et al. | Clinical use and pharmacological properties of selective COX-2 inhibitors | |
| Duggan | Esaxerenone: first global approval | |
| Breyer et al. | Cyclooxygenase 2 and the kidney | |
| US8389563B2 (en) | C-substituted diindolylmethane compositions and methods for the treatment of multiple cancers | |
| Moreno-Sánchez et al. | Inhibition and uncoupling of oxidative phosphorylation by nonsteroidal anti-inflammatory drugs: study in mitochondria, submitochondrial particles, cells, and whole heart | |
| US6399647B2 (en) | Amide derivatives for antiangiogenic and/or antitumorigenic use | |
| ES2544482T3 (es) | Compuesto rexinoide que tiene un grupo alcoxi | |
| TW201002311A (en) | Novel compositions and methods for treating hyperproliferative diseases | |
| US20030212123A1 (en) | COX-2 selective carprofen for treating pain and inflammation in dogs | |
| Shen | The proliferation of non-steroidal anti-inflammatory drugs (NSAIDS) | |
| US6689382B2 (en) | Soft shell gelatin capsules containing non-steroidal anti-inflammatories | |
| JP2001514655A (ja) | アルツハイマー病予防へのｒ−ｎｓａｉｄ’ｓの利用 | |
| JP2003526663A (ja) | Ｃｏｍｔ阻害剤の鎮痛剤としての用途 | |
| AU773615B2 (en) | COX-2 selective carprofen for treating pain and inflammation in dogs | |
| RU2730855C2 (ru) | Кфтр регуляторы и способы их применения | |
| CN101563321B (zh) | 4-(杂环基)烷基-n-(芳基磺酰基)吲哚化合物及其作为5-ht6配体的用途 | |
| NZ516914A (en) | Compositions containing COX-2 selective carprofen and derivatives thereof for treating pain and inflammation in dogs | |
| JP5579958B2 (ja) | Ｃｏｘ−２インヒビターを含有する鎮痛及び抗炎症性組成物 | |
| CZ9903896A3 (cs) | Léčivo, farmaceutický přípravek a souprava pro léčení nebo prevenci bolesti a zánětlivých procesů | |
| JP2004511436A (ja) | 失禁用医薬 | |
| US20150065486A1 (en) | Methods for treating polycystic kidney disease | |
| JP2007529510A (ja) | 細胞接着を抑制するメチマゾール誘導体及び互変異性環状チオン | |
| JP2007504164A (ja) | ＰＰＡＲ−γ経路およびＨＥＲ−キナーゼ軸の調節に基づく癌および他の生理学的状態の処置のための組成物および方法 | |
| TW201637650A (zh) | 含雙醋瑞因之製劑及使用其於降低尿酸血中濃度的方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |