CA2286484A1 - .beta.-amyloid peptide-binding proteins and polynucleotides encoding the same - Google Patents
.beta.-amyloid peptide-binding proteins and polynucleotides encoding the same Download PDFInfo
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- CA2286484A1 CA2286484A1 CA002286484A CA2286484A CA2286484A1 CA 2286484 A1 CA2286484 A1 CA 2286484A1 CA 002286484 A CA002286484 A CA 002286484A CA 2286484 A CA2286484 A CA 2286484A CA 2286484 A1 CA2286484 A1 CA 2286484A1
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- protein
- amino acid
- beta
- polynucleotide
- amyloid peptide
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- 238000000159 protein binding assay Methods 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 230000004850 protein–protein interaction Effects 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 230000006337 proteolytic cleavage Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000010839 reverse transcription Methods 0.000 description 1
- 102000014452 scavenger receptors Human genes 0.000 description 1
- 108010078070 scavenger receptors Proteins 0.000 description 1
- 238000005204 segregation Methods 0.000 description 1
- 230000009834 selective interaction Effects 0.000 description 1
- 239000003001 serine protease inhibitor Substances 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 238000002764 solid phase assay Methods 0.000 description 1
- 210000001082 somatic cell Anatomy 0.000 description 1
- 230000000392 somatic effect Effects 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 238000012916 structural analysis Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000000946 synaptic effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
- 230000014621 translational initiation Effects 0.000 description 1
- 238000010246 ultrastructural analysis Methods 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
- 238000001086 yeast two-hybrid system Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6458397P | 1997-04-16 | 1997-04-16 | |
| US60/064,583 | 1997-04-16 | ||
| PCT/US1998/007462 WO1998046636A2 (en) | 1997-04-16 | 1998-04-14 | β-AMYLOID PEPTIDE-BINDING PROTEINS AND POLYNUCLEOTIDES ENCODING THE SAME |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2286484A1 true CA2286484A1 (en) | 1998-10-22 |
Family
ID=22056941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002286484A Abandoned CA2286484A1 (en) | 1997-04-16 | 1998-04-14 | .beta.-amyloid peptide-binding proteins and polynucleotides encoding the same |
Country Status (18)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6787319B2 (en) | 1997-04-16 | 2004-09-07 | American Home Products Corp. | β-amyloid peptide-binding proteins and polynucleotides encoding the same |
| US7005295B1 (en) | 1997-04-16 | 2006-02-28 | Wyeth | β-amyloid peptide-binding proteins and polynucleotides encoding the same |
| JP2002527064A (ja) * | 1998-10-13 | 2002-08-27 | アメリカン・ホーム・プロダクツ・コーポレイション | ６−蛋白結合受容体様蛋白、それらによりコードされるポリヌクレオチド、ならびにそれらの使用方法 |
| US6455082B1 (en) * | 1999-04-26 | 2002-09-24 | Nestec S.A. | Shelf-stable calcium fortified milk and dairy products |
| WO2001029225A1 (en) * | 1999-10-21 | 2001-04-26 | Panorama Research, Inc. | A general method for optimizing the expression of heterologous proteins |
| US8663650B2 (en) | 2003-02-21 | 2014-03-04 | Ac Immune Sa | Methods and compositions comprising supramolecular constructs |
| US7807171B2 (en) | 2003-07-25 | 2010-10-05 | Ac Immune Sa | Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers |
| EP2603233A1 (en) | 2010-08-12 | 2013-06-19 | AC Immune S.A. | Vaccine engineering |
| KR101854943B1 (ko) | 2010-10-26 | 2018-05-04 | 에이씨 이뮨 에스.에이. | 소수성 부분을 통해 변형된 펩티드를 포함하는 리포솜 기반 구조체 |
| CN102060912B (zh) * | 2010-11-22 | 2012-11-14 | 清华大学 | 淀粉样蛋白寡聚体构象型抗原表位多肽及其应用 |
| CN111320678B (zh) * | 2020-03-09 | 2023-06-09 | 安亭生物有限责任公司 | 抗菌肽突变体及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2120401T3 (es) * | 1986-11-17 | 1998-11-01 | Scios Inc | Proteina recombinante amiloide relacionados con la enfermedad de alzheimer. |
| IL115743A0 (en) * | 1994-10-28 | 1996-01-19 | American Nat Red Cross | A mammal with cells containing a transgene and its production |
| US5786180A (en) * | 1995-02-14 | 1998-07-28 | Bayer Corporation | Monoclonal antibody 369.2B specific for β A4 peptide |
-
1998
- 1998-04-14 AU AU71156/98A patent/AU740445B2/en not_active Ceased
- 1998-04-14 EE EEP199900482A patent/EE9900482A/xx unknown
- 1998-04-14 HU HU0003116A patent/HUP0003116A3/hu unknown
- 1998-04-14 CN CNA200510052975XA patent/CN1690203A/zh active Pending
- 1998-04-14 EA EA199900941A patent/EA004256B1/ru not_active IP Right Cessation
- 1998-04-14 CN CNB988043173A patent/CN1196785C/zh not_active Expired - Fee Related
- 1998-04-14 ID IDW991187D patent/ID24914A/id unknown
- 1998-04-14 GE GE3744A patent/GEP20043386B/en unknown
- 1998-04-14 UA UA99116193A patent/UA72875C2/uk unknown
- 1998-04-14 WO PCT/US1998/007462 patent/WO1998046636A2/en active Application Filing
- 1998-04-14 CA CA002286484A patent/CA2286484A1/en not_active Abandoned
- 1998-04-14 IL IL13223698A patent/IL132236A0/xx active IP Right Grant
- 1998-04-14 SK SK1432-99A patent/SK143299A3/sk unknown
- 1998-04-14 JP JP54419698A patent/JP2001523093A/ja active Pending
- 1998-04-14 NZ NZ500216A patent/NZ500216A/xx unknown
- 1998-04-14 KR KR1019997009480A patent/KR20010006393A/ko not_active Ceased
- 1998-04-14 EP EP98918186A patent/EP0975753A2/en not_active Withdrawn
- 1998-04-14 BR BR9808562-0A patent/BR9808562A/pt not_active Application Discontinuation
-
1999
- 1999-10-06 IL IL132236A patent/IL132236A/en not_active IP Right Cessation
- 1999-10-15 NO NO995062A patent/NO995062L/no not_active Application Discontinuation
-
2006
- 2006-11-05 IL IL179047A patent/IL179047A0/en unknown
-
2007
- 2007-12-28 JP JP2007339660A patent/JP2008104465A/ja active Pending
-
2008
- 2008-06-18 JP JP2008159606A patent/JP2008253275A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008253275A (ja) | 2008-10-23 |
| AU7115698A (en) | 1998-11-11 |
| IL179047A0 (en) | 2007-03-08 |
| JP2008104465A (ja) | 2008-05-08 |
| GEP20043386B (en) | 2004-02-10 |
| EA004256B1 (ru) | 2004-02-26 |
| CN1268973A (zh) | 2000-10-04 |
| EA199900941A1 (ru) | 2000-06-26 |
| WO1998046636A3 (en) | 1999-01-28 |
| CN1196785C (zh) | 2005-04-13 |
| AU740445B2 (en) | 2001-11-01 |
| WO1998046636A2 (en) | 1998-10-22 |
| SK143299A3 (en) | 2000-09-12 |
| BR9808562A (pt) | 2000-05-23 |
| NO995062D0 (no) | 1999-10-15 |
| EE9900482A (enrdf_load_stackoverflow) | 2000-06-15 |
| CN1690203A (zh) | 2005-11-02 |
| HUP0003116A2 (hu) | 2001-01-29 |
| NO995062L (no) | 1999-12-14 |
| HUP0003116A3 (en) | 2003-03-28 |
| IL132236A (en) | 2007-03-08 |
| IL132236A0 (en) | 2001-03-19 |
| ID24914A (id) | 2000-08-31 |
| NZ500216A (en) | 2001-06-29 |
| EP0975753A2 (en) | 2000-02-02 |
| UA72875C2 (uk) | 2005-05-16 |
| JP2001523093A (ja) | 2001-11-20 |
| KR20010006393A (ko) | 2001-01-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |