WO1998046636A3 - β-AMYLOID PEPTIDE-BINDING PROTEINS AND POLYNUCLEOTIDES ENCODING THE SAME - Google Patents

β-AMYLOID PEPTIDE-BINDING PROTEINS AND POLYNUCLEOTIDES ENCODING THE SAME Download PDF

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Publication number
WO1998046636A3
WO1998046636A3 PCT/US1998/007462 US9807462W WO9846636A3 WO 1998046636 A3 WO1998046636 A3 WO 1998046636A3 US 9807462 W US9807462 W US 9807462W WO 9846636 A3 WO9846636 A3 WO 9846636A3
Authority
WO
WIPO (PCT)
Prior art keywords
amyloid peptide
same
binding proteins
polynucleotides encoding
proteins
Prior art date
Application number
PCT/US1998/007462
Other languages
French (fr)
Other versions
WO1998046636A2 (en
Inventor
Bradley Alton Ozenberger
Eileen Marie Kajkowski
Jack Steven Jacobsen
Jonathan Adam Bard
Stephen Glenn Walker
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BR9808562-0A priority Critical patent/BR9808562A/en
Priority to IL13223698A priority patent/IL132236A0/en
Priority to AU71156/98A priority patent/AU740445B2/en
Priority to CA002286484A priority patent/CA2286484A1/en
Priority to EA199900941A priority patent/EA004256B1/en
Priority to SK1432-99A priority patent/SK143299A3/en
Priority to NZ500216A priority patent/NZ500216A/en
Priority to EP98918186A priority patent/EP0975753A2/en
Application filed by American Home Prod filed Critical American Home Prod
Priority to UA99116193A priority patent/UA72875C2/en
Priority to KR1019997009480A priority patent/KR20010006393A/en
Priority to EEP199900482A priority patent/EE9900482A/xx
Priority to JP54419698A priority patent/JP2001523093A/en
Publication of WO1998046636A2 publication Critical patent/WO1998046636A2/en
Publication of WO1998046636A3 publication Critical patent/WO1998046636A3/en
Priority to IL132236A priority patent/IL132236A/en
Priority to NO995062A priority patent/NO995062L/en
Priority to IL179047A priority patent/IL179047A0/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711Alzheimer's disease; Amyloid plaque core protein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Novel proteins which bind human β-amyloid peptide, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided.
PCT/US1998/007462 1997-04-16 1998-04-14 β-AMYLOID PEPTIDE-BINDING PROTEINS AND POLYNUCLEOTIDES ENCODING THE SAME WO1998046636A2 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
UA99116193A UA72875C2 (en) 1997-04-16 1998-04-14 Novel proteins which bind human <sub>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-amyloid peptide, polynucleotides which encode theM
IL13223698A IL132236A0 (en) 1997-04-16 1998-04-14 Beta - amyloid peptide - binding proteins and polynucleotides encoding the same
KR1019997009480A KR20010006393A (en) 1997-04-16 1998-04-14 β-AMYLOID PEPTIDE-BINDING PROTEINS AND POLYNUCLEOTIDES ENCODING THE SAME
EA199900941A EA004256B1 (en) 1997-04-16 1998-04-14 beta-AMINOLOID PEPTIDE BINDING PROTEIN, POLYNUCLEOTIDE ENCODING THEREOF AND METHODS FOR USING THE SAME
SK1432-99A SK143299A3 (en) 1997-04-16 1998-04-14 BETA-AMYLOID PEPTIDE-BINDING PROTEINS AND POLYNUCLEOTIDESì (54) ENCODING THE SAME
NZ500216A NZ500216A (en) 1997-04-16 1998-04-14 Beta-amyloid peptide-binding proteins and pharmaceutical use
EP98918186A EP0975753A2 (en) 1997-04-16 1998-04-14 $g(b)-AMYLOID PEPTIDE-BINDING PROTEINS AND POLYNUCLEOTIDES ENCODING THE SAME
BR9808562-0A BR9808562A (en) 1997-04-16 1998-04-14 Isolated polynucleotide, host cell, protein, oligonucleotide, antibody, processes to produce a protein encoded by the polynucleotide, to determine a polynucleotide that encodes a beta-amyloid peptide-binding protein (bbp) in a sample, to detect in a sample a polypeptide , to diagnose a disease comprising the aberrant expression of human beta-amyloid peptide (bap), to diagnose, to identify compounds that regulate the activity of a beta-amyloid peptide-binding protein and to treat a patient needing to inhibit the accumulation of beta-amyloid peptide in the brain, and, transgenic or chimeric animal.
AU71156/98A AU740445B2 (en) 1997-04-16 1998-04-14 Beta-amyloid peptide-binding proteins and polynucleotides encoding the same
CA002286484A CA2286484A1 (en) 1997-04-16 1998-04-14 .beta.-amyloid peptide-binding proteins and polynucleotides encoding the same
EEP199900482A EE9900482A (en) 1997-04-16 1998-04-14
JP54419698A JP2001523093A (en) 1997-04-16 1998-04-14 β-amyloid peptide binding proteins and polynucleotides encoding them
IL132236A IL132236A (en) 1997-04-16 1999-10-06 ??-amyloid peptide binding proteins and polynucleotides encoding the same
NO995062A NO995062L (en) 1997-04-16 1999-10-15 <Beta> -anyloid peptide binding proteins and polynuldeotides encoding the same
IL179047A IL179047A0 (en) 1997-04-16 2006-11-05 ??-amyloid peptide- binding proteins and polynucleotides encoding the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6458397P 1997-04-16 1997-04-16
US60/064,583 1997-04-16

Publications (2)

Publication Number Publication Date
WO1998046636A2 WO1998046636A2 (en) 1998-10-22
WO1998046636A3 true WO1998046636A3 (en) 1999-01-28

Family

ID=22056941

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/007462 WO1998046636A2 (en) 1997-04-16 1998-04-14 β-AMYLOID PEPTIDE-BINDING PROTEINS AND POLYNUCLEOTIDES ENCODING THE SAME

Country Status (18)

Country Link
EP (1) EP0975753A2 (en)
JP (3) JP2001523093A (en)
KR (1) KR20010006393A (en)
CN (2) CN1690203A (en)
AU (1) AU740445B2 (en)
BR (1) BR9808562A (en)
CA (1) CA2286484A1 (en)
EA (1) EA004256B1 (en)
EE (1) EE9900482A (en)
GE (1) GEP20043386B (en)
HU (1) HUP0003116A3 (en)
ID (1) ID24914A (en)
IL (3) IL132236A0 (en)
NO (1) NO995062L (en)
NZ (1) NZ500216A (en)
SK (1) SK143299A3 (en)
UA (1) UA72875C2 (en)
WO (1) WO1998046636A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6787319B2 (en) 1997-04-16 2004-09-07 American Home Products Corp. β-amyloid peptide-binding proteins and polynucleotides encoding the same
US7005295B1 (en) 1997-04-16 2006-02-28 Wyeth β-amyloid peptide-binding proteins and polynucleotides encoding the same
CA2346008A1 (en) * 1998-10-13 2000-04-20 American Home Products Corporation G-protein-coupled receptor-like proteins, polynucleotides encoded by them, and methods of using same
US6455082B1 (en) * 1999-04-26 2002-09-24 Nestec S.A. Shelf-stable calcium fortified milk and dairy products
WO2001029225A1 (en) * 1999-10-21 2001-04-26 Panorama Research, Inc. A general method for optimizing the expression of heterologous proteins
US8663650B2 (en) 2003-02-21 2014-03-04 Ac Immune Sa Methods and compositions comprising supramolecular constructs
US7807171B2 (en) 2003-07-25 2010-10-05 Ac Immune Sa Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers
WO2012020124A1 (en) 2010-08-12 2012-02-16 Ac Immune S.A. Vaccine engineering
CN103189050B (en) 2010-10-26 2017-09-29 Ac免疫有限公司 The construct based on liposome comprising the peptide modified by hydrophobic part
CN102060912B (en) * 2010-11-22 2012-11-14 清华大学 Amyloid protein oligomer conformation type epitope polypeptide and application thereof
CN111320678B (en) * 2020-03-09 2023-06-09 安亭生物有限责任公司 Antibacterial peptide mutant and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988003951A1 (en) * 1986-11-17 1988-06-02 California Biotechnology, Inc. Recombinant alzheimer's amyloid protein
WO1996013513A1 (en) * 1994-10-28 1996-05-09 American National Red Cross Alzheimer's peptide
WO1996025435A1 (en) * 1995-02-14 1996-08-22 Bayer Corporation MONOCLONAL ANTIBODY SPECIFIC FOR βA4 PEPTIDE

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988003951A1 (en) * 1986-11-17 1988-06-02 California Biotechnology, Inc. Recombinant alzheimer's amyloid protein
WO1996013513A1 (en) * 1994-10-28 1996-05-09 American National Red Cross Alzheimer's peptide
WO1996025435A1 (en) * 1995-02-14 1996-08-22 Bayer Corporation MONOCLONAL ANTIBODY SPECIFIC FOR βA4 PEPTIDE

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, - 10 May 1996 (1996-05-10), HINXTON, GB, XP002081598 *
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 22 July 1998 (1998-07-22), HINXTON, GB, XP002081601 *
DATABASE EMBL NUCLEOTIDE AND PROTEIN SEQUENCES, 31 January 1998 (1998-01-31), HINXTON, GB, XP002081600 *
L.O. TJERNBERG ET AL.,: "Arrest of beta-amyloid fibril formation by a peptapeptide ligand", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 15, 1996, BETHESDA, MD, US, pages 8545 - 8548, XP002050226 *
T. YAMATSUJI ET AL.,: "G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP", SCIENCE, vol. 272, 1996, WASHINGTON, DC, US, pages 1349 - 1352, XP002081599 *

Also Published As

Publication number Publication date
SK143299A3 (en) 2000-09-12
CN1268973A (en) 2000-10-04
AU740445B2 (en) 2001-11-01
WO1998046636A2 (en) 1998-10-22
JP2001523093A (en) 2001-11-20
IL132236A0 (en) 2001-03-19
GEP20043386B (en) 2004-02-10
NO995062L (en) 1999-12-14
KR20010006393A (en) 2001-01-26
HUP0003116A2 (en) 2001-01-29
IL132236A (en) 2007-03-08
JP2008253275A (en) 2008-10-23
EP0975753A2 (en) 2000-02-02
CN1690203A (en) 2005-11-02
ID24914A (en) 2000-08-31
UA72875C2 (en) 2005-05-16
NZ500216A (en) 2001-06-29
EA199900941A1 (en) 2000-06-26
IL179047A0 (en) 2007-03-08
EA004256B1 (en) 2004-02-26
CA2286484A1 (en) 1998-10-22
HUP0003116A3 (en) 2003-03-28
NO995062D0 (en) 1999-10-15
EE9900482A (en) 2000-06-15
BR9808562A (en) 2000-05-23
CN1196785C (en) 2005-04-13
JP2008104465A (en) 2008-05-08
AU7115698A (en) 1998-11-11

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