BR9808562A - Isolated polynucleotide, host cell, protein, oligonucleotide, antibody, processes to produce a protein encoded by the polynucleotide, to determine a polynucleotide that encodes a beta-amyloid peptide-binding protein (bbp) in a sample, to detect in a sample a polypeptide , to diagnose a disease comprising the aberrant expression of human beta-amyloid peptide (bap), to diagnose, to identify compounds that regulate the activity of a beta-amyloid peptide-binding protein and to treat a patient needing to inhibit the accumulation of beta-amyloid peptide in the brain, and, transgenic or chimeric animal. - Google Patents
Isolated polynucleotide, host cell, protein, oligonucleotide, antibody, processes to produce a protein encoded by the polynucleotide, to determine a polynucleotide that encodes a beta-amyloid peptide-binding protein (bbp) in a sample, to detect in a sample a polypeptide , to diagnose a disease comprising the aberrant expression of human beta-amyloid peptide (bap), to diagnose, to identify compounds that regulate the activity of a beta-amyloid peptide-binding protein and to treat a patient needing to inhibit the accumulation of beta-amyloid peptide in the brain, and, transgenic or chimeric animal.Info
- Publication number
- BR9808562A BR9808562A BR9808562-0A BR9808562A BR9808562A BR 9808562 A BR9808562 A BR 9808562A BR 9808562 A BR9808562 A BR 9808562A BR 9808562 A BR9808562 A BR 9808562A
- Authority
- BR
- Brazil
- Prior art keywords
- beta
- amyloid peptide
- protein
- polynucleotide
- diagnose
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
"POLINUCLEOTìDEO ISOLADO, CéLULA HOSPEDEIRA, PROTEìNA, OLIGONUCLEOTìDEO, ANTICORPO, PROCESSOS PARA PRODUZIR UMA PROTEìNA CODIFICADA PELO POLINUCLEOTìDEO, PARA DETERMINAR UM POLINUCLEOTìDEO QUE CODIFICA UMA PROTEìNA DE LIGAçãO A PEPTìDEO BETA-AMILóIDE (BBP) EM UMA AMOSTRA, PARA DETECTAR EM UMA AMOSTRA UM POLIPEPTìDEO, PARA DIAGNOSTICAR UMA DOENçA COMPREENDENDO A EXPRESSãO ABERRANTE DE PEPTìDEO BETA-AMILóIDE HUMANO (BAP), DE DIAGNóSTICO, PARA IDENTIFICAR COMPOSTOS QUE REGULAM A ATIVIDADE DE UMA PROTEìNA DE LIGAçãO A PEPTìDEO BETA-AMILóIDE E PARA O TRATAMENTO DE UM PACIENTE TENDO NECESSIDADE DE INIBIR O ACúMULO DE PEPTìDEO BETA-AMILóIDE NO CéREBRO, E, ANIMAL TRANSGêNICO OU QUIMéRICO". Proporcionam-se novas proteínas que ligam o peptídeo <225>-amilóide humano, polinucleotídeos que codificam estas proteínas, e processos para produzir estas proteínas. Proporcionam-se também processos diagnósticos, terapêuticos e de avaliação, que empregam os polinucleotídeos e polipeptídeos da presente invenção."ISOLATED POLYNUCLEOTYDE, HOST, CELL, PROTEIN, OLIGONUCLEOTYDE, ANTIBODY, PROCESSES TO PRODUCE A PROTEIN ENCODED BY POLYNUCLEOTID, TO DETERMINE A POLYNUCLEOTIDE AMETHING A PROTEIN EMITERATOR, EMPTY ATEATTIC EMITERATOR POLYPEPTIDE, TO DIAGNOSE A DISEASE UNDERSTANDING THE OPENING EXPRESSION OF HUMAN BETA-AMYLOID PEPTIDE (BAP), OF DIAGNOSIS, TO IDENTIFY COMPOUNDS THAT REGULATE THE ACTIVITY OF A PEACEFUL BINDING PROTEIN FOR TEPTENTION TREATMENT INHIBIT THE ACCUMULATION OF BETA-AMYLOID PEPTIDE IN THE BRAIN, AND, TRANSGENIC OR CHIMERIC ANIMAL ". New proteins are provided that bind the human β-amyloid peptide, polynucleotides that encode these proteins, and processes for producing these proteins. Diagnostic, therapeutic and evaluation processes are also provided, which employ the polynucleotides and polypeptides of the present invention.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6458397P | 1997-04-16 | 1997-04-16 | |
PCT/US1998/007462 WO1998046636A2 (en) | 1997-04-16 | 1998-04-14 | β-AMYLOID PEPTIDE-BINDING PROTEINS AND POLYNUCLEOTIDES ENCODING THE SAME |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9808562A true BR9808562A (en) | 2000-05-23 |
Family
ID=22056941
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9808562-0A BR9808562A (en) | 1997-04-16 | 1998-04-14 | Isolated polynucleotide, host cell, protein, oligonucleotide, antibody, processes to produce a protein encoded by the polynucleotide, to determine a polynucleotide that encodes a beta-amyloid peptide-binding protein (bbp) in a sample, to detect in a sample a polypeptide , to diagnose a disease comprising the aberrant expression of human beta-amyloid peptide (bap), to diagnose, to identify compounds that regulate the activity of a beta-amyloid peptide-binding protein and to treat a patient needing to inhibit the accumulation of beta-amyloid peptide in the brain, and, transgenic or chimeric animal. |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0975753A2 (en) |
JP (3) | JP2001523093A (en) |
KR (1) | KR20010006393A (en) |
CN (2) | CN1690203A (en) |
AU (1) | AU740445B2 (en) |
BR (1) | BR9808562A (en) |
CA (1) | CA2286484A1 (en) |
EA (1) | EA004256B1 (en) |
EE (1) | EE9900482A (en) |
GE (1) | GEP20043386B (en) |
HU (1) | HUP0003116A3 (en) |
ID (1) | ID24914A (en) |
IL (3) | IL132236A0 (en) |
NO (1) | NO995062L (en) |
NZ (1) | NZ500216A (en) |
SK (1) | SK143299A3 (en) |
UA (1) | UA72875C2 (en) |
WO (1) | WO1998046636A2 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6787319B2 (en) | 1997-04-16 | 2004-09-07 | American Home Products Corp. | β-amyloid peptide-binding proteins and polynucleotides encoding the same |
US7005295B1 (en) | 1997-04-16 | 2006-02-28 | Wyeth | β-amyloid peptide-binding proteins and polynucleotides encoding the same |
CA2346008A1 (en) * | 1998-10-13 | 2000-04-20 | American Home Products Corporation | G-protein-coupled receptor-like proteins, polynucleotides encoded by them, and methods of using same |
US6455082B1 (en) * | 1999-04-26 | 2002-09-24 | Nestec S.A. | Shelf-stable calcium fortified milk and dairy products |
WO2001029225A1 (en) * | 1999-10-21 | 2001-04-26 | Panorama Research, Inc. | A general method for optimizing the expression of heterologous proteins |
US8663650B2 (en) | 2003-02-21 | 2014-03-04 | Ac Immune Sa | Methods and compositions comprising supramolecular constructs |
US7807171B2 (en) | 2003-07-25 | 2010-10-05 | Ac Immune Sa | Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers |
WO2012020124A1 (en) | 2010-08-12 | 2012-02-16 | Ac Immune S.A. | Vaccine engineering |
CN103189050B (en) | 2010-10-26 | 2017-09-29 | Ac免疫有限公司 | The construct based on liposome comprising the peptide modified by hydrophobic part |
CN102060912B (en) * | 2010-11-22 | 2012-11-14 | 清华大学 | Amyloid protein oligomer conformation type epitope polypeptide and application thereof |
CN111320678B (en) * | 2020-03-09 | 2023-06-09 | 安亭生物有限责任公司 | Antibacterial peptide mutant and application thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0332640A1 (en) * | 1986-11-17 | 1989-09-20 | California Biotechnology, Inc. | Recombinant alzheimer's amyloid protein |
IL115743A0 (en) * | 1994-10-28 | 1996-01-19 | American Nat Red Cross | A mammal with cells containing a transgene and its production |
US5786180A (en) * | 1995-02-14 | 1998-07-28 | Bayer Corporation | Monoclonal antibody 369.2B specific for β A4 peptide |
-
1998
- 1998-04-14 EE EEP199900482A patent/EE9900482A/xx unknown
- 1998-04-14 EA EA199900941A patent/EA004256B1/en not_active IP Right Cessation
- 1998-04-14 ID IDW991187D patent/ID24914A/en unknown
- 1998-04-14 KR KR1019997009480A patent/KR20010006393A/en not_active Application Discontinuation
- 1998-04-14 BR BR9808562-0A patent/BR9808562A/en not_active Application Discontinuation
- 1998-04-14 EP EP98918186A patent/EP0975753A2/en not_active Withdrawn
- 1998-04-14 HU HU0003116A patent/HUP0003116A3/en unknown
- 1998-04-14 JP JP54419698A patent/JP2001523093A/en active Pending
- 1998-04-14 UA UA99116193A patent/UA72875C2/en unknown
- 1998-04-14 NZ NZ500216A patent/NZ500216A/en unknown
- 1998-04-14 GE GE3744A patent/GEP20043386B/en unknown
- 1998-04-14 SK SK1432-99A patent/SK143299A3/en unknown
- 1998-04-14 CN CNA200510052975XA patent/CN1690203A/en active Pending
- 1998-04-14 IL IL13223698A patent/IL132236A0/en active IP Right Grant
- 1998-04-14 AU AU71156/98A patent/AU740445B2/en not_active Ceased
- 1998-04-14 CA CA002286484A patent/CA2286484A1/en not_active Abandoned
- 1998-04-14 CN CNB988043173A patent/CN1196785C/en not_active Expired - Fee Related
- 1998-04-14 WO PCT/US1998/007462 patent/WO1998046636A2/en active Application Filing
-
1999
- 1999-10-06 IL IL132236A patent/IL132236A/en not_active IP Right Cessation
- 1999-10-15 NO NO995062A patent/NO995062L/en not_active Application Discontinuation
-
2006
- 2006-11-05 IL IL179047A patent/IL179047A0/en unknown
-
2007
- 2007-12-28 JP JP2007339660A patent/JP2008104465A/en active Pending
-
2008
- 2008-06-18 JP JP2008159606A patent/JP2008253275A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
SK143299A3 (en) | 2000-09-12 |
CN1268973A (en) | 2000-10-04 |
AU740445B2 (en) | 2001-11-01 |
WO1998046636A2 (en) | 1998-10-22 |
JP2001523093A (en) | 2001-11-20 |
IL132236A0 (en) | 2001-03-19 |
GEP20043386B (en) | 2004-02-10 |
NO995062L (en) | 1999-12-14 |
KR20010006393A (en) | 2001-01-26 |
HUP0003116A2 (en) | 2001-01-29 |
IL132236A (en) | 2007-03-08 |
JP2008253275A (en) | 2008-10-23 |
EP0975753A2 (en) | 2000-02-02 |
CN1690203A (en) | 2005-11-02 |
ID24914A (en) | 2000-08-31 |
UA72875C2 (en) | 2005-05-16 |
NZ500216A (en) | 2001-06-29 |
EA199900941A1 (en) | 2000-06-26 |
IL179047A0 (en) | 2007-03-08 |
EA004256B1 (en) | 2004-02-26 |
CA2286484A1 (en) | 1998-10-22 |
HUP0003116A3 (en) | 2003-03-28 |
NO995062D0 (en) | 1999-10-15 |
EE9900482A (en) | 2000-06-15 |
WO1998046636A3 (en) | 1999-01-28 |
CN1196785C (en) | 2005-04-13 |
JP2008104465A (en) | 2008-05-08 |
AU7115698A (en) | 1998-11-11 |
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Legal Events
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TC | Change of name | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 37, INDEFIRO O PRESENTE PEDIDO COM BASE O ARTIGO 8O COMBINADO AO ART. 13 E ARTS. 10 (IX), 18 (III), 24 E 25 DA LEI 9.279/96. |
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B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |