BR9808562A - Polinucleotìdeo isolado, célula hospedeira, proteìna, oligonucleotìdeo, anticorpo, processos para produzir uma proteìna codificada pelo polinucleotìdeo, para determinar um polinucleotìdeo que codifica uma proteìna de ligação a peptìdeo beta-amilóide (bbp) em uma amostra, para detectar em uma amostra um polipeptìdeo, para diagnosticar uma doença compreendendo a expressão aberrante de peptìdeo beta-amilóide humano (bap), de diagnóstico, para identificar compostos que regulam a atividade de uma proteìna de ligação a peptìdeo beta-amilóide e para o tratamento de um paciente tendo necessidade de inibir o acúmulo de peptìdeo beta-amilóide no cérebro, e, animal transgênico ou quimérico. - Google Patents
Polinucleotìdeo isolado, célula hospedeira, proteìna, oligonucleotìdeo, anticorpo, processos para produzir uma proteìna codificada pelo polinucleotìdeo, para determinar um polinucleotìdeo que codifica uma proteìna de ligação a peptìdeo beta-amilóide (bbp) em uma amostra, para detectar em uma amostra um polipeptìdeo, para diagnosticar uma doença compreendendo a expressão aberrante de peptìdeo beta-amilóide humano (bap), de diagnóstico, para identificar compostos que regulam a atividade de uma proteìna de ligação a peptìdeo beta-amilóide e para o tratamento de um paciente tendo necessidade de inibir o acúmulo de peptìdeo beta-amilóide no cérebro, e, animal transgênico ou quimérico.Info
- Publication number
- BR9808562A BR9808562A BR9808562-0A BR9808562A BR9808562A BR 9808562 A BR9808562 A BR 9808562A BR 9808562 A BR9808562 A BR 9808562A BR 9808562 A BR9808562 A BR 9808562A
- Authority
- BR
- Brazil
- Prior art keywords
- beta
- amyloid peptide
- protein
- polynucleotide
- diagnose
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 9
- 108090000623 proteins and genes Proteins 0.000 title abstract 9
- 102000040430 polynucleotide Human genes 0.000 title abstract 6
- 108091033319 polynucleotide Proteins 0.000 title abstract 6
- 239000002157 polynucleotide Substances 0.000 title abstract 6
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 241001465754 Metazoa Species 0.000 title abstract 2
- 238000009825 accumulation Methods 0.000 title abstract 2
- 210000004556 brain Anatomy 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- 230000009261 transgenic effect Effects 0.000 title abstract 2
- 101000638018 Homo sapiens TM2 domain-containing protein 1 Proteins 0.000 title 2
- 102100032067 TM2 domain-containing protein 1 Human genes 0.000 title 2
- 108091034117 Oligonucleotide Proteins 0.000 title 1
- 230000001594 aberrant effect Effects 0.000 title 1
- -1 host cell Proteins 0.000 title 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 238000012854 evaluation process Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6458397P | 1997-04-16 | 1997-04-16 | |
| PCT/US1998/007462 WO1998046636A2 (en) | 1997-04-16 | 1998-04-14 | β-AMYLOID PEPTIDE-BINDING PROTEINS AND POLYNUCLEOTIDES ENCODING THE SAME |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9808562A true BR9808562A (pt) | 2000-05-23 |
Family
ID=22056941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9808562-0A BR9808562A (pt) | 1997-04-16 | 1998-04-14 | Polinucleotìdeo isolado, célula hospedeira, proteìna, oligonucleotìdeo, anticorpo, processos para produzir uma proteìna codificada pelo polinucleotìdeo, para determinar um polinucleotìdeo que codifica uma proteìna de ligação a peptìdeo beta-amilóide (bbp) em uma amostra, para detectar em uma amostra um polipeptìdeo, para diagnosticar uma doença compreendendo a expressão aberrante de peptìdeo beta-amilóide humano (bap), de diagnóstico, para identificar compostos que regulam a atividade de uma proteìna de ligação a peptìdeo beta-amilóide e para o tratamento de um paciente tendo necessidade de inibir o acúmulo de peptìdeo beta-amilóide no cérebro, e, animal transgênico ou quimérico. |
Country Status (18)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6787319B2 (en) | 1997-04-16 | 2004-09-07 | American Home Products Corp. | β-amyloid peptide-binding proteins and polynucleotides encoding the same |
| US7005295B1 (en) | 1997-04-16 | 2006-02-28 | Wyeth | β-amyloid peptide-binding proteins and polynucleotides encoding the same |
| JP2002527064A (ja) * | 1998-10-13 | 2002-08-27 | アメリカン・ホーム・プロダクツ・コーポレイション | ６−蛋白結合受容体様蛋白、それらによりコードされるポリヌクレオチド、ならびにそれらの使用方法 |
| US6455082B1 (en) * | 1999-04-26 | 2002-09-24 | Nestec S.A. | Shelf-stable calcium fortified milk and dairy products |
| WO2001029225A1 (en) * | 1999-10-21 | 2001-04-26 | Panorama Research, Inc. | A general method for optimizing the expression of heterologous proteins |
| US8663650B2 (en) | 2003-02-21 | 2014-03-04 | Ac Immune Sa | Methods and compositions comprising supramolecular constructs |
| US7807171B2 (en) | 2003-07-25 | 2010-10-05 | Ac Immune Sa | Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers |
| EP2603233A1 (en) | 2010-08-12 | 2013-06-19 | AC Immune S.A. | Vaccine engineering |
| KR101854943B1 (ko) | 2010-10-26 | 2018-05-04 | 에이씨 이뮨 에스.에이. | 소수성 부분을 통해 변형된 펩티드를 포함하는 리포솜 기반 구조체 |
| CN102060912B (zh) * | 2010-11-22 | 2012-11-14 | 清华大学 | 淀粉样蛋白寡聚体构象型抗原表位多肽及其应用 |
| CN111320678B (zh) * | 2020-03-09 | 2023-06-09 | 安亭生物有限责任公司 | 抗菌肽突变体及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2120401T3 (es) * | 1986-11-17 | 1998-11-01 | Scios Inc | Proteina recombinante amiloide relacionados con la enfermedad de alzheimer. |
| IL115743A0 (en) * | 1994-10-28 | 1996-01-19 | American Nat Red Cross | A mammal with cells containing a transgene and its production |
| US5786180A (en) * | 1995-02-14 | 1998-07-28 | Bayer Corporation | Monoclonal antibody 369.2B specific for β A4 peptide |
-
1998
- 1998-04-14 AU AU71156/98A patent/AU740445B2/en not_active Ceased
- 1998-04-14 EE EEP199900482A patent/EE9900482A/xx unknown
- 1998-04-14 HU HU0003116A patent/HUP0003116A3/hu unknown
- 1998-04-14 CN CNA200510052975XA patent/CN1690203A/zh active Pending
- 1998-04-14 EA EA199900941A patent/EA004256B1/ru not_active IP Right Cessation
- 1998-04-14 CN CNB988043173A patent/CN1196785C/zh not_active Expired - Fee Related
- 1998-04-14 ID IDW991187D patent/ID24914A/id unknown
- 1998-04-14 GE GE3744A patent/GEP20043386B/en unknown
- 1998-04-14 UA UA99116193A patent/UA72875C2/uk unknown
- 1998-04-14 WO PCT/US1998/007462 patent/WO1998046636A2/en active Application Filing
- 1998-04-14 CA CA002286484A patent/CA2286484A1/en not_active Abandoned
- 1998-04-14 IL IL13223698A patent/IL132236A0/xx active IP Right Grant
- 1998-04-14 SK SK1432-99A patent/SK143299A3/sk unknown
- 1998-04-14 JP JP54419698A patent/JP2001523093A/ja active Pending
- 1998-04-14 NZ NZ500216A patent/NZ500216A/xx unknown
- 1998-04-14 KR KR1019997009480A patent/KR20010006393A/ko not_active Ceased
- 1998-04-14 EP EP98918186A patent/EP0975753A2/en not_active Withdrawn
- 1998-04-14 BR BR9808562-0A patent/BR9808562A/pt not_active Application Discontinuation
-
1999
- 1999-10-06 IL IL132236A patent/IL132236A/en not_active IP Right Cessation
- 1999-10-15 NO NO995062A patent/NO995062L/no not_active Application Discontinuation
-
2006
- 2006-11-05 IL IL179047A patent/IL179047A0/en unknown
-
2007
- 2007-12-28 JP JP2007339660A patent/JP2008104465A/ja active Pending
-
2008
- 2008-06-18 JP JP2008159606A patent/JP2008253275A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008253275A (ja) | 2008-10-23 |
| AU7115698A (en) | 1998-11-11 |
| IL179047A0 (en) | 2007-03-08 |
| JP2008104465A (ja) | 2008-05-08 |
| GEP20043386B (en) | 2004-02-10 |
| EA004256B1 (ru) | 2004-02-26 |
| CN1268973A (zh) | 2000-10-04 |
| EA199900941A1 (ru) | 2000-06-26 |
| WO1998046636A3 (en) | 1999-01-28 |
| CN1196785C (zh) | 2005-04-13 |
| AU740445B2 (en) | 2001-11-01 |
| WO1998046636A2 (en) | 1998-10-22 |
| SK143299A3 (en) | 2000-09-12 |
| NO995062D0 (no) | 1999-10-15 |
| EE9900482A (enrdf_load_stackoverflow) | 2000-06-15 |
| CN1690203A (zh) | 2005-11-02 |
| HUP0003116A2 (hu) | 2001-01-29 |
| NO995062L (no) | 1999-12-14 |
| HUP0003116A3 (en) | 2003-03-28 |
| IL132236A (en) | 2007-03-08 |
| IL132236A0 (en) | 2001-03-19 |
| ID24914A (id) | 2000-08-31 |
| CA2286484A1 (en) | 1998-10-22 |
| NZ500216A (en) | 2001-06-29 |
| EP0975753A2 (en) | 2000-02-02 |
| UA72875C2 (uk) | 2005-05-16 |
| JP2001523093A (ja) | 2001-11-20 |
| KR20010006393A (ko) | 2001-01-26 |
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