CA2270185C - Method of preparing a poorly crystalline calcium phosphate and methods of its use - Google Patents
Method of preparing a poorly crystalline calcium phosphate and methods of its use Download PDFInfo
- Publication number
- CA2270185C CA2270185C CA002270185A CA2270185A CA2270185C CA 2270185 C CA2270185 C CA 2270185C CA 002270185 A CA002270185 A CA 002270185A CA 2270185 A CA2270185 A CA 2270185A CA 2270185 C CA2270185 C CA 2270185C
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- Prior art keywords
- calcium phosphate
- pca
- bone
- composition
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title claims abstract description 570
- 239000001506 calcium phosphate Substances 0.000 title claims abstract description 563
- 235000011010 calcium phosphates Nutrition 0.000 title claims abstract description 555
- 229910000389 calcium phosphate Inorganic materials 0.000 title claims abstract description 528
- 238000000034 method Methods 0.000 title claims abstract description 143
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 334
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 94
- 229910001868 water Inorganic materials 0.000 claims abstract description 81
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 66
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 65
- 230000007547 defect Effects 0.000 claims abstract description 61
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- 239000000203 mixture Substances 0.000 claims description 173
- 239000000843 powder Substances 0.000 claims description 69
- 239000011575 calcium Substances 0.000 claims description 62
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- 238000004519 manufacturing process Methods 0.000 claims description 43
- 239000003462 bioceramic Substances 0.000 claims description 42
- 238000002513 implantation Methods 0.000 claims description 41
- -1 poly(L-lactide) Polymers 0.000 claims description 35
- 238000001727 in vivo Methods 0.000 claims description 32
- 239000002245 particle Substances 0.000 claims description 29
- 229910052791 calcium Inorganic materials 0.000 claims description 27
- 235000001465 calcium Nutrition 0.000 claims description 27
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical group [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 26
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- 238000002441 X-ray diffraction Methods 0.000 claims description 23
- 229920000642 polymer Polymers 0.000 claims description 23
- 239000011230 binding agent Substances 0.000 claims description 18
- 239000002639 bone cement Substances 0.000 claims description 18
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 claims description 18
- 239000000835 fiber Substances 0.000 claims description 18
- 239000000314 lubricant Substances 0.000 claims description 16
- 238000007918 intramuscular administration Methods 0.000 claims description 15
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 14
- 229920001432 poly(L-lactide) Polymers 0.000 claims description 13
- 230000036571 hydration Effects 0.000 claims description 12
- 238000006703 hydration reaction Methods 0.000 claims description 12
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims description 12
- 239000005313 bioactive glass Substances 0.000 claims description 11
- 239000000499 gel Substances 0.000 claims description 11
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 11
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 10
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 9
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 claims description 8
- 235000019821 dicalcium diphosphate Nutrition 0.000 claims description 8
- ODINCKMPIJJUCX-UHFFFAOYSA-N Calcium oxide Chemical compound [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims description 7
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- 108010035532 Collagen Proteins 0.000 claims description 7
- 229920000954 Polyglycolide Polymers 0.000 claims description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 7
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- 239000008366 buffered solution Substances 0.000 claims description 6
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 6
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- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 5
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 3
- 235000019739 Dicalciumphosphate Nutrition 0.000 claims description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 3
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- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 claims description 3
- 239000001639 calcium acetate Substances 0.000 claims description 3
- 235000011092 calcium acetate Nutrition 0.000 claims description 3
- 229960005147 calcium acetate Drugs 0.000 claims description 3
- ROPDWRCJTIRLTR-UHFFFAOYSA-L calcium metaphosphate Chemical group [Ca+2].[O-]P(=O)=O.[O-]P(=O)=O ROPDWRCJTIRLTR-UHFFFAOYSA-L 0.000 claims description 3
- 229910052681 coesite Inorganic materials 0.000 claims description 3
- 229910052906 cristobalite Inorganic materials 0.000 claims description 3
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims description 3
- 229910000390 dicalcium phosphate Inorganic materials 0.000 claims description 3
- 229940038472 dicalcium phosphate Drugs 0.000 claims description 3
- OLSDWRNWUGHKSY-UHFFFAOYSA-J dicalcium;phosphonato phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O OLSDWRNWUGHKSY-UHFFFAOYSA-J 0.000 claims description 3
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- YIGWVOWKHUSYER-UHFFFAOYSA-F tetracalcium;hydrogen phosphate;diphosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].OP([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O YIGWVOWKHUSYER-UHFFFAOYSA-F 0.000 claims description 3
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
- A61L27/425—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Surgery (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/729,344 | 1996-10-16 | ||
| US08/732,016 US6027742A (en) | 1995-05-19 | 1996-10-16 | Bioresorbable ceramic composites |
| US08/729,343 | 1996-10-16 | ||
| US08/729,344 US6117456A (en) | 1995-05-19 | 1996-10-16 | Methods and products related to the physical conversion of reactive amorphous calcium phosphate |
| US08/732,016 | 1996-10-16 | ||
| US08/729,343 US20020136696A1 (en) | 1995-05-19 | 1996-10-16 | Orthopedic and dental ceramic implants |
| PCT/US1997/018631 WO1998016268A2 (en) | 1996-10-16 | 1997-10-16 | Method of preparing a poorly crystalline calcium phosphate and methods of its use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2270185A1 CA2270185A1 (en) | 1998-04-23 |
| CA2270185C true CA2270185C (en) | 2009-01-06 |
Family
ID=27419129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002270185A Expired - Fee Related CA2270185C (en) | 1996-10-16 | 1997-10-16 | Method of preparing a poorly crystalline calcium phosphate and methods of its use |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0936929B1 (enExample) |
| JP (1) | JP4781494B2 (enExample) |
| AT (1) | ATE269720T1 (enExample) |
| AU (1) | AU742748B2 (enExample) |
| CA (1) | CA2270185C (enExample) |
| DE (1) | DE69729647T2 (enExample) |
| DK (1) | DK0936929T3 (enExample) |
| ES (1) | ES2227719T3 (enExample) |
| WO (1) | WO1998016268A2 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6554803B1 (en) | 1997-04-02 | 2003-04-29 | Arthur Ashman | Combination syringe and aspirator for bone regeneration material and method for using the syringe |
| IT1299563B1 (it) * | 1998-07-17 | 2000-03-16 | Giovanni Dolci | Uso odontostomatologico di materiali a base apatitica nanostrutturati |
| CA2350638C (en) | 1998-09-11 | 2009-11-24 | Gerhard Schmidmaier | Biologically active implants coated with a biodegradable polymer |
| ATE291386T1 (de) * | 1999-10-21 | 2005-04-15 | Arthur Ashman | Kombination von spritze und sauger für knochenregenerationsmaterial |
| JP4669932B2 (ja) * | 2000-05-02 | 2011-04-13 | 学校法人日本大学 | 生体材料用組成物及びその硬化体 |
| JP4726281B2 (ja) * | 2000-07-27 | 2011-07-20 | テルモ株式会社 | 体内注入可能な組成物 |
| CA2426406A1 (en) * | 2000-10-24 | 2002-05-02 | Sdgi Holdings, Inc. | Spinal fusion methods and devices |
| AU2002220069B2 (en) * | 2000-10-24 | 2005-12-15 | Warsaw Orthopedic, Inc. | Methods and instruments for treating pseudoarthrosis |
| JP2002226241A (ja) * | 2001-01-30 | 2002-08-14 | Mitsui Constr Co Ltd | 真空凍結乾燥によるコンクリート材料のリサイクル方法 |
| JP2002296205A (ja) * | 2001-03-29 | 2002-10-09 | Japan Tissue Engineering:Kk | 培養組織の元素組成分析方法、移植適性判定方法及び品質管理方法並びに、移植適性を有する培養組織の製造方法及び移植適性を有する培養組織 |
| US6730324B2 (en) | 2001-04-20 | 2004-05-04 | The University Of British Columbia | Biofunctional hydroxyapatite coatings and microspheres for in-situ drug encapsulation |
| JP4473576B2 (ja) | 2001-11-19 | 2010-06-02 | スキール テヒノロギー ゲーエムベーハー | 骨誘導性および骨伝導特性を有するデバイス |
| US6840961B2 (en) * | 2001-12-21 | 2005-01-11 | Etex Corporation | Machinable preformed calcium phosphate bone substitute material implants |
| JP4358741B2 (ja) | 2002-09-10 | 2009-11-04 | スキール テヒノロギー ゲーエムベーハー | 低酸素濃度下において骨誘導性タンパク質で被覆された金属インプラント |
| US7776594B2 (en) | 2002-10-10 | 2010-08-17 | Wright Medical Technology, Inc. | Bone marrow infusion chamber and method |
| FR2850282B1 (fr) | 2003-01-27 | 2007-04-06 | Jerome Asius | Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation |
| GB0307011D0 (en) | 2003-03-27 | 2003-04-30 | Regentec Ltd | Porous matrix |
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| CN109663147B (zh) * | 2019-02-19 | 2022-07-05 | 邢叔星 | 一种附着磷酸三钙缓释抗生素的peek植骨体及其制备方法 |
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| JPS6117409A (ja) * | 1984-07-02 | 1986-01-25 | Meishin Toryo Kk | 非晶質リン酸カルシウムの製法およびこれを主成分とする生体適応性組成物 |
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| JPH01166765A (ja) * | 1987-12-23 | 1989-06-30 | Kobe Steel Ltd | 代替骨およびその製造方法 |
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| JP3115642B2 (ja) * | 1991-06-07 | 2000-12-11 | 日揮株式会社 | 人工骨材 |
| EP0520690B1 (en) * | 1991-06-26 | 1995-11-02 | Nitta Gelatin Inc. | Calcium phosphate type hardening material for repairing living hard tissue |
| GB9215356D0 (en) * | 1992-07-20 | 1992-09-02 | Univ Reading The | Bone materials |
| EP0672117A4 (en) * | 1992-08-13 | 1996-06-12 | Univ Pennsylvania | MATRIX BASED ON A BIOACTIVE MATERIAL FOR THE SYNTHESIS -i (IN VITRO) OF BONE TISSUE. |
| US5525148A (en) * | 1993-09-24 | 1996-06-11 | American Dental Association Health Foundation | Self-setting calcium phosphate cements and methods for preparing and using them |
| US5676976A (en) * | 1995-05-19 | 1997-10-14 | Etex Corporation | Synthesis of reactive amorphous calcium phosphates |
| US5783217A (en) * | 1995-11-07 | 1998-07-21 | Etex Corporation | Low temperature calcium phosphate apatite and a method of its manufacture |
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1997
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- 1997-10-16 DK DK97945578T patent/DK0936929T3/da active
- 1997-10-16 ES ES97945578T patent/ES2227719T3/es not_active Expired - Lifetime
- 1997-10-16 JP JP51857598A patent/JP4781494B2/ja not_active Expired - Lifetime
- 1997-10-16 DE DE69729647T patent/DE69729647T2/de not_active Expired - Lifetime
- 1997-10-16 EP EP97945578A patent/EP0936929B1/en not_active Expired - Lifetime
- 1997-10-16 AU AU46746/97A patent/AU742748B2/en not_active Ceased
- 1997-10-16 WO PCT/US1997/018631 patent/WO1998016268A2/en not_active Ceased
- 1997-10-16 CA CA002270185A patent/CA2270185C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU4674697A (en) | 1998-05-11 |
| JP2001502215A (ja) | 2001-02-20 |
| ATE269720T1 (de) | 2004-07-15 |
| EP0936929A2 (en) | 1999-08-25 |
| AU742748B2 (en) | 2002-01-10 |
| WO1998016268A3 (en) | 1998-07-30 |
| WO1998016268A2 (en) | 1998-04-23 |
| ES2227719T3 (es) | 2005-04-01 |
| DE69729647D1 (de) | 2004-07-29 |
| JP4781494B2 (ja) | 2011-09-28 |
| DK0936929T3 (da) | 2004-11-08 |
| EP0936929B1 (en) | 2004-06-23 |
| CA2270185A1 (en) | 1998-04-23 |
| DE69729647T2 (de) | 2005-07-07 |
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