DE69729647T2 - Verfahren zur Herstellung von wenigkristallinem Calciumphosphat und Verfahren zu dessen Verwendung - Google Patents

Verfahren zur Herstellung von wenigkristallinem Calciumphosphat und Verfahren zu dessen Verwendung Download PDF

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Publication number
DE69729647T2
DE69729647T2 DE69729647T DE69729647T DE69729647T2 DE 69729647 T2 DE69729647 T2 DE 69729647T2 DE 69729647 T DE69729647 T DE 69729647T DE 69729647 T DE69729647 T DE 69729647T DE 69729647 T2 DE69729647 T2 DE 69729647T2
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DE
Germany
Prior art keywords
calcium phosphate
pca
bone
phosphate
calcium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69729647T
Other languages
German (de)
English (en)
Other versions
DE69729647D1 (de
Inventor
D. Dosuk LEE
Christian Rey
Maria Aiolova
Aliassghar Belmont TOFIGHI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Etex Corp
Original Assignee
Etex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/732,016 external-priority patent/US6027742A/en
Priority claimed from US08/729,344 external-priority patent/US6117456A/en
Priority claimed from US08/729,343 external-priority patent/US20020136696A1/en
Application filed by Etex Corp filed Critical Etex Corp
Publication of DE69729647D1 publication Critical patent/DE69729647D1/de
Application granted granted Critical
Publication of DE69729647T2 publication Critical patent/DE69729647T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/02Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02Inorganic materials
    • A61L27/12Phosphorus-containing materials, e.g. apatite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/425Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005The prosthesis being constructed from a particular material
    • A61F2310/00179Ceramics or ceramic-like structures
    • A61F2310/00293Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/02Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Surgery (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69729647T 1996-10-16 1997-10-16 Verfahren zur Herstellung von wenigkristallinem Calciumphosphat und Verfahren zu dessen Verwendung Expired - Lifetime DE69729647T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US729343 1996-10-16
US08/732,016 US6027742A (en) 1995-05-19 1996-10-16 Bioresorbable ceramic composites
US08/729,344 US6117456A (en) 1995-05-19 1996-10-16 Methods and products related to the physical conversion of reactive amorphous calcium phosphate
US729344 1996-10-16
US08/729,343 US20020136696A1 (en) 1995-05-19 1996-10-16 Orthopedic and dental ceramic implants
US732016 1996-10-16
PCT/US1997/018631 WO1998016268A2 (en) 1996-10-16 1997-10-16 Method of preparing a poorly crystalline calcium phosphate and methods of its use

Publications (2)

Publication Number Publication Date
DE69729647D1 DE69729647D1 (de) 2004-07-29
DE69729647T2 true DE69729647T2 (de) 2005-07-07

Family

ID=27419129

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69729647T Expired - Lifetime DE69729647T2 (de) 1996-10-16 1997-10-16 Verfahren zur Herstellung von wenigkristallinem Calciumphosphat und Verfahren zu dessen Verwendung

Country Status (9)

Country Link
EP (1) EP0936929B1 (enExample)
JP (1) JP4781494B2 (enExample)
AT (1) ATE269720T1 (enExample)
AU (1) AU742748B2 (enExample)
CA (1) CA2270185C (enExample)
DE (1) DE69729647T2 (enExample)
DK (1) DK0936929T3 (enExample)
ES (1) ES2227719T3 (enExample)
WO (1) WO1998016268A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005022176A1 (de) * 2005-05-09 2007-01-25 Martin-Luther-Universität Halle-Wittenberg Verfahren zur Herstellung von bioresorbierbaren Verbundmaterialien und seine Verwendung als Implantatmaterial
DE102007048591A1 (de) * 2007-10-05 2009-04-09 Matthias Prof. Dr. Epple Implantat und Verfahren zu seiner Herstellung
US9486558B2 (en) 2003-03-27 2016-11-08 Locate Therapeutics Limited Porous matrix

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US6554803B1 (en) 1997-04-02 2003-04-29 Arthur Ashman Combination syringe and aspirator for bone regeneration material and method for using the syringe
IT1299563B1 (it) * 1998-07-17 2000-03-16 Giovanni Dolci Uso odontostomatologico di materiali a base apatitica nanostrutturati
CA2350638C (en) 1998-09-11 2009-11-24 Gerhard Schmidmaier Biologically active implants coated with a biodegradable polymer
ATE291386T1 (de) * 1999-10-21 2005-04-15 Arthur Ashman Kombination von spritze und sauger für knochenregenerationsmaterial
JP4669932B2 (ja) * 2000-05-02 2011-04-13 学校法人日本大学 生体材料用組成物及びその硬化体
JP4726281B2 (ja) * 2000-07-27 2011-07-20 テルモ株式会社 体内注入可能な組成物
CA2426406A1 (en) * 2000-10-24 2002-05-02 Sdgi Holdings, Inc. Spinal fusion methods and devices
AU2002220069B2 (en) * 2000-10-24 2005-12-15 Warsaw Orthopedic, Inc. Methods and instruments for treating pseudoarthrosis
JP2002226241A (ja) * 2001-01-30 2002-08-14 Mitsui Constr Co Ltd 真空凍結乾燥によるコンクリート材料のリサイクル方法
JP2002296205A (ja) * 2001-03-29 2002-10-09 Japan Tissue Engineering:Kk 培養組織の元素組成分析方法、移植適性判定方法及び品質管理方法並びに、移植適性を有する培養組織の製造方法及び移植適性を有する培養組織
US6730324B2 (en) 2001-04-20 2004-05-04 The University Of British Columbia Biofunctional hydroxyapatite coatings and microspheres for in-situ drug encapsulation
JP4473576B2 (ja) 2001-11-19 2010-06-02 スキール テヒノロギー ゲーエムベーハー 骨誘導性および骨伝導特性を有するデバイス
US6840961B2 (en) * 2001-12-21 2005-01-11 Etex Corporation Machinable preformed calcium phosphate bone substitute material implants
JP4358741B2 (ja) 2002-09-10 2009-11-04 スキール テヒノロギー ゲーエムベーハー 低酸素濃度下において骨誘導性タンパク質で被覆された金属インプラント
US7776594B2 (en) 2002-10-10 2010-08-17 Wright Medical Technology, Inc. Bone marrow infusion chamber and method
FR2850282B1 (fr) 2003-01-27 2007-04-06 Jerome Asius Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation
US20050101964A1 (en) * 2003-11-07 2005-05-12 Calcitec, Inc. Spinal fusion procedure using an injectable bone substitute
DE10357460A1 (de) * 2003-12-04 2005-07-07 Friedrich-Baur-Gmbh Bioresorbierbares Material
US20050136764A1 (en) 2003-12-18 2005-06-23 Sherman Michael C. Designed composite degradation for spinal implants
US7459018B2 (en) 2005-04-08 2008-12-02 Howmedica Leibinger Inc. Injectable calcium phosphate cement
US7416602B2 (en) 2005-04-08 2008-08-26 Howmedica Leibinger, Inc. Calcium phosphate cement
WO2009087421A2 (en) * 2008-01-09 2009-07-16 Oswestry Tissue Bank Ltd Bone repair composition and a method of making the same
AU2015215892B2 (en) * 2008-04-15 2017-11-30 Life Science Enterprises, Inc. Minimally invasive treatment of vertebra (mitv) using a calcium phosphate combination bone cement
WO2009129316A2 (en) * 2008-04-15 2009-10-22 Etex Corporation Minimally invasive treatment of vertebra (mitv) using a calcium phosphate combination bone cement
EP2358651A2 (en) 2008-11-12 2011-08-24 Engqvist, Håkan Hydraulic cements, methods and products
WO2011058443A1 (en) * 2009-11-13 2011-05-19 Barralet Jake E Method and device to induce collagen biomineralisation
CN105125323B (zh) 2010-03-10 2017-04-12 奥斯-Q公司 用于修复组织缺损的植入体和方法
WO2012062360A1 (en) 2010-11-10 2012-05-18 Stryker Trauma Gmbh Polymeric bone foam composition and method
US9463046B2 (en) 2011-08-22 2016-10-11 Ossdsign Ab Implants and methods for using such implants to fill holes in bone tissue
US8591645B2 (en) 2011-09-09 2013-11-26 Ossdsign Ab Hydraulic cements with optimized grain size distribution, methods, articles and kits
US20130066327A1 (en) 2011-09-09 2013-03-14 Håkan Engqvist Hydraulic cement compositions with low ph methods, articles and kits
DE102012108320A1 (de) * 2012-09-07 2014-03-13 Aap Biomaterials Gmbh Knochenzement sowie unter Verwendung eines Knochenzements hergestellter Formkörper
HK1216085A1 (zh) 2012-12-14 2016-10-14 Ossdsign Ab 形成水泥的组合物、三斜磷钙石水泥、植入物及用於矫正骨缺损的方法
HK1217632A1 (zh) 2013-02-12 2017-01-20 Ossdsign Ab 镶嵌型植人物、试剂盒和用於矫正骨缺损的方法
CN106999214B (zh) 2014-08-14 2020-03-13 奥斯设计公司 镶嵌式植入物及其制造方法、支撑结构和植入物
KR101631387B1 (ko) * 2014-11-27 2016-06-16 에스케이이노베이션 주식회사 2,3-부탄디올로부터 1,3-부타디엔 및 메틸에틸케톤을 제조하는 데 사용되는 무정형 칼슘 포스페이트 촉매 및 촉매 제조 방법
JP2016209599A (ja) * 2016-05-20 2016-12-15 ライフ サイエンス エンタープライジズ インコーポレイテッド リン酸カルシウム配合骨セメントを用いる脊椎骨の最小侵襲治療(mitv)
CN109663147B (zh) * 2019-02-19 2022-07-05 邢叔星 一种附着磷酸三钙缓释抗生素的peek植骨体及其制备方法
CN118806988B (zh) * 2023-04-21 2025-09-23 浙江大学 一种仿生多级球状矿化胶原支架的制备方法及应用
CN116836022B (zh) * 2023-06-25 2025-09-12 中国地质大学(武汉) 一种多功能矿物土壤调理剂及其制备方法
CN117383529A (zh) * 2023-09-12 2024-01-12 华南理工大学 一种降低无定形磷酸钙稳定性的方法

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9486558B2 (en) 2003-03-27 2016-11-08 Locate Therapeutics Limited Porous matrix
US10232087B2 (en) 2003-03-27 2019-03-19 Locate Therapeutics Limited Porous matrix
DE102005022176A1 (de) * 2005-05-09 2007-01-25 Martin-Luther-Universität Halle-Wittenberg Verfahren zur Herstellung von bioresorbierbaren Verbundmaterialien und seine Verwendung als Implantatmaterial
DE102005022176B4 (de) * 2005-05-09 2009-06-25 Martin-Luther-Universität Halle-Wittenberg Verfahren zur Herstellung von bioresorbierbaren Verbundmaterialien und seine Verwendung als Implantatmaterial sowie bioresorbiebaren Verbundmaterialien
DE102007048591A1 (de) * 2007-10-05 2009-04-09 Matthias Prof. Dr. Epple Implantat und Verfahren zu seiner Herstellung

Also Published As

Publication number Publication date
CA2270185C (en) 2009-01-06
AU4674697A (en) 1998-05-11
JP2001502215A (ja) 2001-02-20
ATE269720T1 (de) 2004-07-15
EP0936929A2 (en) 1999-08-25
AU742748B2 (en) 2002-01-10
WO1998016268A3 (en) 1998-07-30
WO1998016268A2 (en) 1998-04-23
ES2227719T3 (es) 2005-04-01
DE69729647D1 (de) 2004-07-29
JP4781494B2 (ja) 2011-09-28
DK0936929T3 (da) 2004-11-08
EP0936929B1 (en) 2004-06-23
CA2270185A1 (en) 1998-04-23

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