CA2255658C - Method and apparatus for controlling magnetic particles by pipetting machine - Google Patents
Method and apparatus for controlling magnetic particles by pipetting machine Download PDFInfo
- Publication number
- CA2255658C CA2255658C CA002255658A CA2255658A CA2255658C CA 2255658 C CA2255658 C CA 2255658C CA 002255658 A CA002255658 A CA 002255658A CA 2255658 A CA2255658 A CA 2255658A CA 2255658 C CA2255658 C CA 2255658C
- Authority
- CA
- Canada
- Prior art keywords
- liquid
- processing
- sample
- pipette
- suction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000006249 magnetic particle Substances 0.000 title claims abstract description 218
- 238000000034 method Methods 0.000 title claims abstract description 166
- 239000007788 liquid Substances 0.000 claims abstract description 433
- 238000012545 processing Methods 0.000 claims abstract description 304
- 238000000926 separation method Methods 0.000 claims abstract description 91
- 238000007599 discharging Methods 0.000 claims abstract description 8
- 238000009826 distribution Methods 0.000 claims description 96
- 238000004140 cleaning Methods 0.000 claims description 88
- 239000003153 chemical reaction reagent Substances 0.000 claims description 87
- 238000006243 chemical reaction Methods 0.000 claims description 78
- 238000013019 agitation Methods 0.000 claims description 58
- 238000011534 incubation Methods 0.000 claims description 58
- 230000008569 process Effects 0.000 claims description 45
- 239000000463 material Substances 0.000 claims description 23
- 239000013076 target substance Substances 0.000 claims description 23
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- 238000007781 pre-processing Methods 0.000 claims description 16
- 230000033001 locomotion Effects 0.000 claims description 13
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- 238000004458 analytical method Methods 0.000 claims description 7
- 238000000605 extraction Methods 0.000 claims description 5
- 238000012205 qualitative assay Methods 0.000 claims description 4
- 238000012207 quantitative assay Methods 0.000 claims description 4
- 230000005855 radiation Effects 0.000 claims description 4
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- 239000010409 thin film Substances 0.000 claims description 2
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- 230000035945 sensitivity Effects 0.000 abstract description 3
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- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/28—Magnetic plugs and dipsticks
- B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
- Y10T436/114998—Automated chemical analysis with conveyance of sample along a test line in a container or rack with treatment or replacement of aspirator element [e.g., cleaning, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/119163—Automated chemical analysis with aspirator of claimed structure
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25625—Dilution
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Landscapes
- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP1996/001333 WO1997044671A1 (fr) | 1996-05-20 | 1996-05-20 | Procede et appareil pour commander des particules magnetiques a l'aide d'une machine de pipettage |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2255658A1 CA2255658A1 (en) | 1997-11-27 |
| CA2255658C true CA2255658C (en) | 2007-07-17 |
Family
ID=14153304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002255658A Expired - Fee Related CA2255658C (en) | 1996-05-20 | 1996-05-20 | Method and apparatus for controlling magnetic particles by pipetting machine |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6509193B1 (enExample) |
| EP (1) | EP0965842B1 (enExample) |
| JP (1) | JP3682302B2 (enExample) |
| AU (1) | AU738336B2 (enExample) |
| CA (1) | CA2255658C (enExample) |
| DE (1) | DE69638151D1 (enExample) |
| NO (1) | NO330495B1 (enExample) |
| WO (1) | WO1997044671A1 (enExample) |
Families Citing this family (134)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6048734A (en) | 1995-09-15 | 2000-04-11 | The Regents Of The University Of Michigan | Thermal microvalves in a fluid flow method |
| US6660228B1 (en) * | 1998-03-02 | 2003-12-09 | Cepheid | Apparatus for performing heat-exchanging, chemical reactions |
| JP4431276B2 (ja) * | 1998-03-19 | 2010-03-10 | プレシジョン・システム・サイエンス株式会社 | 磁性粒子処理集積化装置及びその制御方法 |
| DE19823719B4 (de) * | 1998-05-27 | 2011-12-15 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren zum Aufkonzentrieren von Substanzen |
| ES2258429T3 (es) | 1999-07-15 | 2006-09-01 | Qiagen Gmbh | Metodos para separar sustratos en particulas de una solucion, al tiempo que se minimiza la perdida de particulas. |
| JP3647023B2 (ja) * | 2000-04-13 | 2005-05-11 | アロカ株式会社 | 分注装置及び方法 |
| CN1193234C (zh) * | 2000-06-30 | 2005-03-16 | 株式会社日立制作所 | 液体分注方法及装置 |
| US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
| US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
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| KR101354764B1 (ko) | 2005-09-05 | 2014-01-22 | 유니바사루 바이오 리사치 가부시키가이샤 | 각종 물질 유지체, 각종 물질 유지체 처리장치, 및 그처리방법 |
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| EP0965842A4 (enExample) | 1999-12-22 |
| DE69638151D1 (de) | 2010-04-29 |
| AU5703096A (en) | 1997-12-09 |
| NO330495B1 (no) | 2011-05-02 |
| EP0965842B1 (en) | 2010-03-17 |
| WO1997044671A1 (fr) | 1997-11-27 |
| AU738336B2 (en) | 2001-09-13 |
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