CA2250242C - Quantitative immunochromatographic assays - Google Patents
Quantitative immunochromatographic assays Download PDFInfo
- Publication number
- CA2250242C CA2250242C CA002250242A CA2250242A CA2250242C CA 2250242 C CA2250242 C CA 2250242C CA 002250242 A CA002250242 A CA 002250242A CA 2250242 A CA2250242 A CA 2250242A CA 2250242 C CA2250242 C CA 2250242C
- Authority
- CA
- Canada
- Prior art keywords
- antibody
- analyte
- particles
- interest
- control
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000003556 assay Methods 0.000 title abstract description 51
- 239000012528 membrane Substances 0.000 claims abstract description 242
- 239000002245 particle Substances 0.000 claims abstract description 213
- 238000001514 detection method Methods 0.000 claims abstract description 197
- 239000012491 analyte Substances 0.000 claims abstract description 158
- 239000012530 fluid Substances 0.000 claims abstract description 107
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 92
- 230000009471 action Effects 0.000 claims abstract description 31
- 108060008245 Thrombospondin Proteins 0.000 claims description 91
- 102000002938 Thrombospondin Human genes 0.000 claims description 91
- 239000004816 latex Substances 0.000 claims description 52
- 229920000126 latex Polymers 0.000 claims description 52
- 239000000872 buffer Substances 0.000 claims description 46
- 238000006243 chemical reaction Methods 0.000 claims description 38
- 238000000034 method Methods 0.000 claims description 35
- 210000002966 serum Anatomy 0.000 claims description 27
- 239000008280 blood Substances 0.000 claims description 21
- 210000004369 blood Anatomy 0.000 claims description 20
- 238000005259 measurement Methods 0.000 claims description 20
- 239000003795 chemical substances by application Substances 0.000 claims description 18
- 239000011324 bead Substances 0.000 claims description 17
- 239000000020 Nitrocellulose Substances 0.000 claims description 16
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 claims description 16
- 229920001220 nitrocellulos Polymers 0.000 claims description 16
- 239000000427 antigen Substances 0.000 claims description 15
- 108091007433 antigens Proteins 0.000 claims description 15
- 102000036639 antigens Human genes 0.000 claims description 15
- 239000003365 glass fiber Substances 0.000 claims description 15
- 102000036675 Myoglobin Human genes 0.000 claims description 12
- 108010062374 Myoglobin Proteins 0.000 claims description 12
- 102000009027 Albumins Human genes 0.000 claims description 11
- 108010088751 Albumins Proteins 0.000 claims description 11
- 210000002700 urine Anatomy 0.000 claims description 10
- 210000004623 platelet-rich plasma Anatomy 0.000 claims description 9
- 230000002485 urinary effect Effects 0.000 claims description 7
- 210000002381 plasma Anatomy 0.000 claims description 5
- 239000007850 fluorescent dye Substances 0.000 claims description 4
- 239000000523 sample Substances 0.000 description 71
- 102000008100 Human Serum Albumin Human genes 0.000 description 33
- 108091006905 Human Serum Albumin Proteins 0.000 description 33
- 239000000243 solution Substances 0.000 description 32
- 239000002981 blocking agent Substances 0.000 description 25
- 210000001772 blood platelet Anatomy 0.000 description 18
- 230000005012 migration Effects 0.000 description 16
- 238000013508 migration Methods 0.000 description 16
- 239000000126 substance Substances 0.000 description 15
- 238000002474 experimental method Methods 0.000 description 14
- 239000011148 porous material Substances 0.000 description 13
- 238000012360 testing method Methods 0.000 description 13
- 239000004677 Nylon Substances 0.000 description 12
- 229920001778 nylon Polymers 0.000 description 12
- 230000000717 retained effect Effects 0.000 description 9
- 239000013068 control sample Substances 0.000 description 7
- 230000006870 function Effects 0.000 description 7
- 229920001213 Polysorbate 20 Polymers 0.000 description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 6
- 229930006000 Sucrose Natural products 0.000 description 6
- 229920002678 cellulose Polymers 0.000 description 6
- 239000001913 cellulose Substances 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 229920001223 polyethylene glycol Polymers 0.000 description 6
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 6
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 6
- 239000005720 sucrose Substances 0.000 description 6
- 238000009736 wetting Methods 0.000 description 6
- 230000000903 blocking effect Effects 0.000 description 5
- 239000003599 detergent Substances 0.000 description 5
- 102000004506 Blood Proteins Human genes 0.000 description 4
- 108010017384 Blood Proteins Proteins 0.000 description 4
- 239000002250 absorbent Substances 0.000 description 4
- 230000002745 absorbent Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000003018 immunoassay Methods 0.000 description 4
- 238000011534 incubation Methods 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 239000002502 liposome Substances 0.000 description 4
- -1 organic molecules Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 229920003169 water-soluble polymer Polymers 0.000 description 4
- 229920002307 Dextran Polymers 0.000 description 3
- 238000002965 ELISA Methods 0.000 description 3
- 229920002065 Pluronic® P 105 Polymers 0.000 description 3
- 239000004695 Polyether sulfone Substances 0.000 description 3
- 239000007983 Tris buffer Substances 0.000 description 3
- 239000013504 Triton X-100 Substances 0.000 description 3
- 229920004890 Triton X-100 Polymers 0.000 description 3
- 229920006243 acrylic copolymer Polymers 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 229920002301 cellulose acetate Polymers 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 3
- 230000002163 immunogen Effects 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 239000003014 ion exchange membrane Substances 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 229920000867 polyelectrolyte Polymers 0.000 description 3
- 229920006393 polyether sulfone Polymers 0.000 description 3
- 238000004080 punching Methods 0.000 description 3
- 238000001179 sorption measurement Methods 0.000 description 3
- 230000032258 transport Effects 0.000 description 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 239000004793 Polystyrene Substances 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 206010043458 Thirst Diseases 0.000 description 2
- 108090000190 Thrombin Proteins 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 230000009833 antibody interaction Effects 0.000 description 2
- 230000009831 antigen interaction Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 230000003683 cardiac damage Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000010191 image analysis Methods 0.000 description 2
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 208000010125 myocardial infarction Diseases 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 229920000620 organic polymer Polymers 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 229920001983 poloxamer Polymers 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 201000001474 proteinuria Diseases 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 238000012207 quantitative assay Methods 0.000 description 2
- 235000020183 skimmed milk Nutrition 0.000 description 2
- 238000002791 soaking Methods 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 229960004072 thrombin Drugs 0.000 description 2
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- HIYAVKIYRIFSCZ-CYEMHPAKSA-N 5-(methylamino)-2-[[(2S,3R,5R,6S,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylic acid Chemical compound O=C([C@@H](C)[C@H]1O[C@@]2([C@@H](C[C@H]1C)C)O[C@@H]([C@@H](CC2)C)CC=1OC2=CC=C(C(=C2N=1)C(O)=O)NC)C1=CC=CN1 HIYAVKIYRIFSCZ-CYEMHPAKSA-N 0.000 description 1
- 108010032595 Antibody Binding Sites Proteins 0.000 description 1
- 102400001362 Beta-thromboglobulin Human genes 0.000 description 1
- 101800003265 Beta-thromboglobulin Proteins 0.000 description 1
- 229920002799 BoPET Polymers 0.000 description 1
- 241000819038 Chichester Species 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 240000006497 Dianthus caryophyllus Species 0.000 description 1
- 235000009355 Dianthus caryophyllus Nutrition 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- 238000012286 ELISA Assay Methods 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- GYHNNYVSQQEPJS-UHFFFAOYSA-N Gallium Chemical compound [Ga] GYHNNYVSQQEPJS-UHFFFAOYSA-N 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 239000005041 Mylar™ Substances 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229910052797 bismuth Inorganic materials 0.000 description 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 1
- HIYAVKIYRIFSCZ-UHFFFAOYSA-N calcium ionophore A23187 Natural products N=1C2=C(C(O)=O)C(NC)=CC=C2OC=1CC(C(CC1)C)OC1(C(CC1C)C)OC1C(C)C(=O)C1=CC=CN1 HIYAVKIYRIFSCZ-UHFFFAOYSA-N 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 238000000835 electrochemical detection Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- 229910052733 gallium Inorganic materials 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000005660 hydrophilic surface Effects 0.000 description 1
- 230000005661 hydrophobic surface Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 229910052738 indium Inorganic materials 0.000 description 1
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 description 1
- ICIWUVCWSCSTAQ-UHFFFAOYSA-M iodate Chemical compound [O-]I(=O)=O ICIWUVCWSCSTAQ-UHFFFAOYSA-M 0.000 description 1
- 230000002083 iodinating effect Effects 0.000 description 1
- 229910000358 iron sulfate Inorganic materials 0.000 description 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 239000002923 metal particle Substances 0.000 description 1
- 229910001463 metal phosphate Inorganic materials 0.000 description 1
- 229910052976 metal sulfide Inorganic materials 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 150000004633 phorbol derivatives Chemical class 0.000 description 1
- 239000002644 phorbol ester Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000008085 renal dysfunction Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- GGYFMLJDMAMTAB-UHFFFAOYSA-N selanylidenelead Chemical compound [Pb]=[Se] GGYFMLJDMAMTAB-UHFFFAOYSA-N 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 229910052714 tellurium Inorganic materials 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000004832 voltammetry Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229910000859 α-Fe Inorganic materials 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
- G01N33/54387—Immunochromatographic test strips
- G01N33/54388—Immunochromatographic test strips based on lateral flow
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/625,048 | 1996-03-29 | ||
| US08/625,048 US5753517A (en) | 1996-03-29 | 1996-03-29 | Quantitative immunochromatographic assays |
| PCT/US1997/004754 WO1997037222A1 (en) | 1996-03-29 | 1997-03-27 | Quantitative immunochromatographic assays |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2250242A1 CA2250242A1 (en) | 1997-10-09 |
| CA2250242C true CA2250242C (en) | 2005-07-26 |
Family
ID=24504361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002250242A Expired - Fee Related CA2250242C (en) | 1996-03-29 | 1997-03-27 | Quantitative immunochromatographic assays |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5753517A (enExample) |
| EP (1) | EP0890103B1 (enExample) |
| JP (1) | JP3753741B2 (enExample) |
| AT (1) | ATE226729T1 (enExample) |
| CA (1) | CA2250242C (enExample) |
| DE (1) | DE69716589D1 (enExample) |
| WO (1) | WO1997037222A1 (enExample) |
Families Citing this family (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2684488A (en) | 1988-06-27 | 1990-01-04 | Carter-Wallace, Inc. | Test device and method for colored particle immunoassay |
| EP0888552A1 (en) * | 1996-03-20 | 1999-01-07 | Serex, Inc. | Chromatographic immunoassay device and method utilizing particle valency for quantitation |
| ATE203828T1 (de) * | 1996-03-29 | 2001-08-15 | Univ British Columbia | Bestimmung der plättchenzahl unter verwendung eines plättchen-körnchenproteins |
| IT1292163B1 (it) * | 1997-06-13 | 1999-01-25 | Giorgio Torelli | Dispositivo immunocromatografico a fissazione dell'analita |
| AU8489698A (en) | 1997-07-16 | 1999-02-10 | Charm Sciences, Inc. | A test device and method for detecting the presence of a residue analyte in a sample |
| US5985675A (en) | 1997-12-31 | 1999-11-16 | Charm Sciences, Inc. | Test device for detection of an analyte |
| US7713703B1 (en) | 2000-11-13 | 2010-05-11 | Biosite, Inc. | Methods for monitoring the status of assays and immunoassays |
| US6194222B1 (en) * | 1998-01-05 | 2001-02-27 | Biosite Diagnostics, Inc. | Methods for monitoring the status of assays and immunoassays |
| US6394952B1 (en) | 1998-02-03 | 2002-05-28 | Adeza Biomedical Corporation | Point of care diagnostic systems |
| EP1062510A2 (en) | 1998-03-10 | 2000-12-27 | Strategic Diagnostics Inc. | Integrated assay device and methods of production and use |
| ATE485834T1 (de) * | 1998-09-08 | 2010-11-15 | Ford Henry Health System | Verfahren zum nachweis von bindegewebswachstumsfaktor zur diagnose von nierkrankheiten |
| CA2254223A1 (en) | 1998-11-16 | 2000-05-16 | Biophys, Inc. | Device and method for analyzing a biologic sample |
| US6136610A (en) * | 1998-11-23 | 2000-10-24 | Praxsys Biosystems, Inc. | Method and apparatus for performing a lateral flow assay |
| US6485983B1 (en) * | 1999-05-05 | 2002-11-26 | Intec Science, Inc. | System for electrochemical quantitative analysis of analytes within a solid phase and affinity chromatographic test strip |
| US6528323B1 (en) | 1999-06-14 | 2003-03-04 | Praxsys Biosystems, Inc. | Bidirectional lateral flow test strip and method |
| US6670115B1 (en) | 1999-11-24 | 2003-12-30 | Biotronic Technologies, Inc. | Devices and methods for detecting analytes using electrosensor having capture reagent |
| US6509196B1 (en) | 2000-01-04 | 2003-01-21 | Response Biomedical Corp. | Compensation for non-specific signals in quantitative immunoassays |
| US6316205B1 (en) * | 2000-01-28 | 2001-11-13 | Genelabs Diagnostics Pte Ltd. | Assay devices and methods of analyte detection |
| JP3680090B2 (ja) | 2000-05-25 | 2005-08-10 | 株式会社ニチレイ | 分析装置 |
| EP1249696B1 (en) * | 2000-09-25 | 2012-09-19 | Panasonic Corporation | Device for chromatographic quantitative measurement |
| US6887714B2 (en) * | 2000-10-16 | 2005-05-03 | Board Of Trustees Of The University Of Arkansas, N.A. | Microvolume immunoabsorbant assays with amplified electrochemical detection |
| US20040241876A1 (en) * | 2000-12-22 | 2004-12-02 | France Fannes | Flow through assay device, diagnostic kit comprising said assay device and use of said assay device in the detection of an analyte present in a sample |
| US20030162236A1 (en) * | 2001-03-26 | 2003-08-28 | Response Biomedical Corporation | Compensation for variability in specific binding in quantitative assays |
| US6767710B2 (en) * | 2001-03-30 | 2004-07-27 | Praxsys Biosystems, Llc | Prewetting stop flow test strip |
| KR20010085007A (ko) * | 2001-07-12 | 2001-09-07 | 김희태 | 반정량 멤브레인 면역 크로마토그래프 기법 및 이의제조방법. |
| US7605004B2 (en) * | 2001-07-18 | 2009-10-20 | Relia Diagnostic Systems Llc | Test strip for a lateral flow assay for a sample containing whole cells |
| US8934968B2 (en) * | 2001-08-03 | 2015-01-13 | Cardiac Pacemakers, Inc. | Neurostimulation and coronary artery disease treatment |
| US7481759B2 (en) * | 2001-08-03 | 2009-01-27 | Cardiac Pacemakers, Inc. | Systems and methods for treatment of coronary artery disease |
| US6855561B2 (en) * | 2001-09-10 | 2005-02-15 | Quidel Corporation | Method for adding an apparent non-signal line to a lateral flow assay |
| US7308303B2 (en) * | 2001-11-01 | 2007-12-11 | Advanced Bionics Corporation | Thrombolysis and chronic anticoagulation therapy |
| US8481334B1 (en) | 2001-11-06 | 2013-07-09 | Charm Sciences, Inc. | Method of attaching a ligand to a solid support |
| US7098041B2 (en) | 2001-12-11 | 2006-08-29 | Kimberly-Clark Worldwide, Inc. | Methods to view and analyze the results from diffraction-based diagnostics |
| US7102752B2 (en) * | 2001-12-11 | 2006-09-05 | Kimberly-Clark Worldwide, Inc. | Systems to view and analyze the results from diffraction-based diagnostics |
| US20030119203A1 (en) | 2001-12-24 | 2003-06-26 | Kimberly-Clark Worldwide, Inc. | Lateral flow assay devices and methods for conducting assays |
| US8367013B2 (en) * | 2001-12-24 | 2013-02-05 | Kimberly-Clark Worldwide, Inc. | Reading device, method, and system for conducting lateral flow assays |
| US6837171B1 (en) | 2002-04-29 | 2005-01-04 | Palmer/Snyder Furniture Company | Lightweight table with unitized table top |
| KR100500774B1 (ko) * | 2002-01-29 | 2005-07-12 | 영동제약 주식회사 | 뇨 알브민 측정용 바코드 표시방식의 면역분석장치 및 그분석방법 |
| US20030175991A1 (en) * | 2002-03-18 | 2003-09-18 | Ho Winston Z. | Optically-assisted high precision pregnancy progress monitoring |
| EP1493029B1 (en) * | 2002-04-10 | 2010-03-31 | Response Biomedical Corporation | Sensitive immunochromatographic assay |
| US7175992B2 (en) * | 2002-04-10 | 2007-02-13 | Response Biomedical Corporation | Sensitive immunochromatographic assay |
| CN1270186C (zh) * | 2002-06-03 | 2006-08-16 | 李祖强 | 能够测定多项生理指标的家庭多功能健康检测仪 |
| US7655411B2 (en) * | 2002-08-23 | 2010-02-02 | W2 Holdings, Inc. | Thrombospondin fragments and binding agents in the detection, diagnosis and evaluation of cancer |
| US7314763B2 (en) * | 2002-08-27 | 2008-01-01 | Kimberly-Clark Worldwide, Inc. | Fluidics-based assay devices |
| US7285424B2 (en) * | 2002-08-27 | 2007-10-23 | Kimberly-Clark Worldwide, Inc. | Membrane-based assay devices |
| US7432105B2 (en) | 2002-08-27 | 2008-10-07 | Kimberly-Clark Worldwide, Inc. | Self-calibration system for a magnetic binding assay |
| US7176036B2 (en) * | 2002-09-20 | 2007-02-13 | Arrowhead Center, Inc. | Electroactive microspheres and methods |
| US7781172B2 (en) * | 2003-11-21 | 2010-08-24 | Kimberly-Clark Worldwide, Inc. | Method for extending the dynamic detection range of assay devices |
| US20040101822A1 (en) * | 2002-11-26 | 2004-05-27 | Ulrich Wiesner | Fluorescent silica-based nanoparticles |
| US20040106190A1 (en) * | 2002-12-03 | 2004-06-03 | Kimberly-Clark Worldwide, Inc. | Flow-through assay devices |
| US20040126897A1 (en) * | 2002-12-19 | 2004-07-01 | 3M Innovative Properties Company | Colorimetric sensors constructed of diacetylene materials |
| US7247500B2 (en) * | 2002-12-19 | 2007-07-24 | Kimberly-Clark Worldwide, Inc. | Reduction of the hook effect in membrane-based assay devices |
| US6963007B2 (en) * | 2002-12-19 | 2005-11-08 | 3M Innovative Properties Company | Diacetylenic materials for sensing applications |
| US7585641B2 (en) * | 2003-01-21 | 2009-09-08 | Agdia, Inc. | Immunoassay and method of use |
| US20040197819A1 (en) * | 2003-04-03 | 2004-10-07 | Kimberly-Clark Worldwide, Inc. | Assay devices that utilize hollow particles |
| US7851209B2 (en) * | 2003-04-03 | 2010-12-14 | Kimberly-Clark Worldwide, Inc. | Reduction of the hook effect in assay devices |
| US7300802B2 (en) | 2003-04-25 | 2007-11-27 | Biodigit Laboratories Corp. | Membrane strip biosensor system for point-of-care testing |
| US7393697B2 (en) * | 2003-06-06 | 2008-07-01 | Advantage Diagnostics Corporation | Diagnostic test for analytes in a sample |
| EP1641492B1 (en) * | 2003-07-08 | 2011-12-14 | Accumetrics, Inc. | Controlled platelet activation to monitor therapy of adp antagonists |
| US20070243632A1 (en) * | 2003-07-08 | 2007-10-18 | Coller Barry S | Methods for measuring platelet reactivity of patients that have received drug eluting stents |
| US7722817B2 (en) * | 2003-08-28 | 2010-05-25 | Epocal Inc. | Lateral flow diagnostic devices with instrument controlled fluidics |
| US7713748B2 (en) * | 2003-11-21 | 2010-05-11 | Kimberly-Clark Worldwide, Inc. | Method of reducing the sensitivity of assay devices |
| US7943395B2 (en) * | 2003-11-21 | 2011-05-17 | Kimberly-Clark Worldwide, Inc. | Extension of the dynamic detection range of assay devices |
| US20050112703A1 (en) | 2003-11-21 | 2005-05-26 | Kimberly-Clark Worldwide, Inc. | Membrane-based lateral flow assay devices that utilize phosphorescent detection |
| US7410808B1 (en) | 2003-12-08 | 2008-08-12 | Charm Sciences, Inc. | Method and assay for detection of residues |
| US7943089B2 (en) * | 2003-12-19 | 2011-05-17 | Kimberly-Clark Worldwide, Inc. | Laminated assay devices |
| US20050136550A1 (en) * | 2003-12-19 | 2005-06-23 | Kimberly-Clark Worldwide, Inc. | Flow control of electrochemical-based assay devices |
| WO2005071416A1 (en) * | 2003-12-30 | 2005-08-04 | 3M Innovative Properties Company | Method of enhancing signal detection of cell-wall components of cells |
| US7521226B2 (en) | 2004-06-30 | 2009-04-21 | Kimberly-Clark Worldwide, Inc. | One-step enzymatic and amine detection technique |
| CN101031798B (zh) * | 2004-07-29 | 2012-06-27 | 瑞莱诊断体系有限公司 | 侧向流系统和测定 |
| US8475735B2 (en) * | 2004-11-01 | 2013-07-02 | Uma Mahesh Babu | Disposable immunodiagnostic test system |
| CN101107523B (zh) | 2004-12-17 | 2012-12-05 | 3M创新有限公司 | 由联乙炔材料构成的比色传感器 |
| KR100706888B1 (ko) | 2005-04-15 | 2007-04-11 | 주식회사 에스디 | 전혈검사용 면역분석장치 및 이를 이용한 면역분석방법 |
| WO2006109311A2 (en) * | 2005-04-15 | 2006-10-19 | Ramot At Tel Aviv University Ltd. | Enzyme-channeling based electrochemical biosensors |
| US7439079B2 (en) * | 2005-04-29 | 2008-10-21 | Kimberly-Clark Worldwide, Inc. | Assay devices having detection capabilities within the hook effect region |
| US7858384B2 (en) * | 2005-04-29 | 2010-12-28 | Kimberly-Clark Worldwide, Inc. | Flow control technique for assay devices |
| US7803319B2 (en) * | 2005-04-29 | 2010-09-28 | Kimberly-Clark Worldwide, Inc. | Metering technique for lateral flow assay devices |
| US20070065952A1 (en) * | 2005-08-23 | 2007-03-22 | Harris Paul C | Multi-directional immunochromatographic assays |
| US20100317021A1 (en) * | 2006-11-22 | 2010-12-16 | Vinod P. Menon | Fluidic antibody-containing devices and methods |
| US20100062418A1 (en) * | 2006-11-22 | 2010-03-11 | Mach Patrick A | Inactivated and dried biological preparations |
| US7875433B2 (en) * | 2007-02-26 | 2011-01-25 | Response Biomedical Corporation | Comparative multiple analyte assay |
| CN101435823B (zh) * | 2007-11-12 | 2012-08-08 | 无锡中德伯尔生物技术有限公司 | 检测残留兽药的荧光微球免疫层析试纸条及其制备方法 |
| JP2011504236A (ja) * | 2007-11-20 | 2011-02-03 | スリーエム イノベイティブ プロパティズ カンパニー | ジアセチレンを含むポリマーセンサーを用いる細菌試料の分析方法 |
| WO2009079156A2 (en) * | 2007-11-20 | 2009-06-25 | 3M Innovative Properties Company | Detection devices and methods |
| CA2714720A1 (en) | 2008-02-28 | 2009-09-03 | 3M Innovative Properties Company | Antibodies to clostridium difficile spores and uses thereof |
| CN101603967B (zh) * | 2008-06-10 | 2015-02-18 | 英科新创(厦门)科技有限公司 | 快速检测人ABO/Rh/MN血型的方法及试剂盒 |
| US9234889B1 (en) | 2008-12-18 | 2016-01-12 | Charm Sciences, Inc. | Method and test strip for detecting residues |
| DE102009010563A1 (de) | 2009-02-16 | 2010-08-26 | Matthias W. Engel | Vorrichtung zum Nachweis von Analyten in Körperflüssigkeiten |
| EP2459730B1 (en) | 2009-07-27 | 2016-12-07 | Suresensors LTD | Improvements relating to sensor devices |
| CN102192979A (zh) * | 2010-03-08 | 2011-09-21 | 苏州浩欧博生物医药有限公司 | 非吸水性膜侧向层析一步分析法及其试剂盒 |
| RU2420740C1 (ru) * | 2010-03-24 | 2011-06-10 | Федеральное Государственное Унитарное Предприятие "Государственный научно-исследовательский институт биологического приборостроения" (ФГУП Гос НИИ БП) | Способ иммунохроматографического анализа для детектирования аналитов в образце |
| US9008373B2 (en) | 2010-05-06 | 2015-04-14 | Charm Sciences, Inc. | Device, system and method for transit testing of samples |
| CN102539751A (zh) * | 2010-12-09 | 2012-07-04 | 苏州生物医学工程技术研究所 | 一种免疫荧光试纸条及其定量检测方法 |
| CN102087293A (zh) * | 2010-12-31 | 2011-06-08 | 广州万孚生物技术有限公司 | 一种全程定量检测肌钙蛋白i的免疫层析试纸条及其制备方法 |
| US8486717B2 (en) | 2011-01-18 | 2013-07-16 | Symbolics, Llc | Lateral flow assays using two dimensional features |
| CN102539783A (zh) * | 2011-12-22 | 2012-07-04 | 正元盛邦(天津)生物科技有限公司 | 用双指示线免疫层析半定量诊断肌红蛋白的方法 |
| US9874556B2 (en) | 2012-07-18 | 2018-01-23 | Symbolics, Llc | Lateral flow assays using two dimensional features |
| CA2883969C (en) * | 2012-09-04 | 2021-07-13 | Edward L. Mamenta | System and method for spatiotemporally analyzed rapid assays |
| CN103336122B (zh) * | 2013-06-24 | 2016-01-20 | 中国科学院苏州生物医学工程技术研究所 | 一种血小板抗体检测的免疫荧光层析试纸条及检测方法 |
| CN105765384B (zh) | 2013-09-13 | 2018-02-09 | Symbolics有限责任公司 | 运用二维试验和对照信号读出模式的侧向层析检测 |
| CN105891481A (zh) * | 2015-05-30 | 2016-08-24 | 深圳市贝沃德克生物技术研究院有限公司 | 基于生物标志物的肿瘤早期检测试剂盒及其制备方法 |
| CN105628923B (zh) * | 2015-12-24 | 2017-06-27 | 杭州市农业科学研究院 | 一种半定量免疫胶体金试纸条及其应用 |
| US11119102B1 (en) | 2016-02-16 | 2021-09-14 | Charm Sciences, Inc. | Test device, method, and assembly |
| EP4022310A4 (en) * | 2019-08-29 | 2022-10-26 | Aronowitz, Mireya, C. | QUANTITATIVE DETECTION OF ANALYTES IN LATERAL FLOW IMMUNOCHEMISTRY |
| CN112098655A (zh) * | 2020-08-06 | 2020-12-18 | 南方医科大学 | 一种基于肠道菌群的心力衰竭检测试剂盒 |
| CN115976167B (zh) * | 2023-01-19 | 2025-07-08 | 江南大学 | 一种用于同时检测多种β-内酰胺类抗生素抗性基因的光热侧流分析装置及应用 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7807532A (nl) * | 1978-07-13 | 1980-01-15 | Akzo Nv | Metaal-immunotest. |
| EP0149168B1 (en) * | 1983-12-19 | 1991-04-24 | Daiichi Pure Chemicals Co. Ltd. | Immunoassay |
| US4610960A (en) * | 1983-12-21 | 1986-09-09 | Wisconsin Alumni Research Foundation | Monoclonal antibody to thrombospondin and method for assaying for and isolating thrombospondin |
| US4703017C1 (en) * | 1984-02-14 | 2001-12-04 | Becton Dickinson Co | Solid phase assay with visual readout |
| GB8414363D0 (en) * | 1984-06-05 | 1984-07-11 | Unilever Plc | Carrying out clinical chemical and biological testing |
| JPH0814582B2 (ja) * | 1986-02-20 | 1996-02-14 | 富士写真フイルム株式会社 | 免疫反応物定量用多層分析要素 |
| JPH01500059A (ja) * | 1986-05-22 | 1989-01-12 | ユニリーバー・ナームローゼ・ベンノートシヤープ | アッセイ |
| JPS6319559A (ja) * | 1986-07-11 | 1988-01-27 | Fuji Photo Film Co Ltd | 免疫分析方法 |
| GB8620893D0 (en) * | 1986-08-29 | 1986-10-08 | Unilever Plc | Assays |
| EP0271204A3 (en) * | 1986-11-07 | 1989-10-25 | Syntex (U.S.A.) Inc. | Immunochromatographic method and device |
| US5030558A (en) * | 1986-11-07 | 1991-07-09 | Syntex (U.S.A.) Inc. | Qualitative immunochromatographic method and device |
| US5232835A (en) * | 1986-11-07 | 1993-08-03 | Syntex (U.S.A.) Inc. | Qualitative immunochromatographic method and device |
| US5156952A (en) * | 1986-11-07 | 1992-10-20 | Syntex (U.S.A.) Inc. | Qualitative immunochromatographic method and device |
| GB8626767D0 (en) * | 1986-11-10 | 1986-12-10 | Unilever Plc | Assays |
| CA1303983C (en) * | 1987-03-27 | 1992-06-23 | Robert W. Rosenstein | Solid phase assay |
| ES2150428T3 (es) * | 1987-04-27 | 2000-12-01 | Unilever Nv | Ensayos de union especifica. |
| US4855240A (en) * | 1987-05-13 | 1989-08-08 | Becton Dickinson And Company | Solid phase assay employing capillary flow |
| US5275785A (en) * | 1987-10-30 | 1994-01-04 | Unilever Patent Holdings B.V. | Test device for detecting an analyte in a liquid sample |
| US5039607A (en) * | 1988-05-17 | 1991-08-13 | Syntex (U.S.A.) Inc. | Method for immunochromatographic analysis |
| US5334513A (en) * | 1988-05-17 | 1994-08-02 | Syntex (U.S.A.) Inc. | Method for immunochromatographic analysis |
| US5164294A (en) * | 1988-05-17 | 1992-11-17 | Syntex (U.S.A.) Inc. | Method for immunochromatographic analysis |
| US5096837A (en) * | 1990-02-08 | 1992-03-17 | Pacific Biotech, Inc. | Immunochromatographic assay and method of using same |
| JP3070764B2 (ja) * | 1990-03-12 | 2000-07-31 | バイオサイト・ダイアグノスティックス・インコーポレイテッド | 生物学的検定装置及びそれを用いた検定方法 |
| CA2035595A1 (en) * | 1990-04-12 | 1991-10-13 | Carol A. Miller | Immunoassay test device with thread control element |
| US5238652A (en) * | 1990-06-20 | 1993-08-24 | Drug Screening Systems, Inc. | Analytical test devices for competition assay for drugs of non-protein antigens using immunochromatographic techniques |
| ATE160019T1 (de) * | 1990-07-13 | 1997-11-15 | Canon Kk | Nachweisreagens |
| US5266497A (en) * | 1990-08-31 | 1993-11-30 | Japan Synthetic Rubber Co., Ltd. | Immunochromatographic assay with improved colored latex |
| JP3108115B2 (ja) * | 1991-03-28 | 2000-11-13 | ロート製薬株式会社 | イムノクロマトグラフ法による物質検出法 |
| CA2110920A1 (en) * | 1991-06-13 | 1992-12-23 | Sinfu Tzeng | Assay for the detection of specific ligands |
| JPH06509646A (ja) * | 1991-07-26 | 1994-10-27 | デイド・ケミストリイ・システムズ・インコーポレーテツド | 懸濁された固体支持体の存在下でのシグナル検出アッセイ |
| WO1993018067A1 (en) * | 1992-03-06 | 1993-09-16 | Abbott Laboratories | Immunocapture assay for direct quantitation of specific lipoprotein cholesterol levels |
| DK88293A (da) * | 1992-08-03 | 1994-02-04 | Becton Dickinson Co | Fastfaseanalyse |
| AU659754B2 (en) * | 1992-09-04 | 1995-05-25 | Becton Dickinson & Company | Chromatographic antigen sandwich test for detection of specific antibody and device therefor |
| EP0705426A4 (en) * | 1993-06-09 | 1998-07-08 | Quidel Corp | SPECIFIC ONE-STEP TITRATIONS OF AN ANTIGEN |
| AU7563294A (en) * | 1993-08-24 | 1995-03-21 | Metrika Laboratories, Inc. | Novel disposable electronic assay device |
| US5385847A (en) * | 1993-12-02 | 1995-01-31 | Miles Inc. | Method for the determination of urinary protein and creatinine |
| FR2721112B1 (fr) * | 1994-06-13 | 1996-08-14 | Gks Technologies | Dispositif de diagnostic rapide de toute molécule glyquée et procédé de mise en Óoeuvre. |
| AUPN527995A0 (en) * | 1995-09-07 | 1995-09-28 | Agen Biomedical Limited | Method and apparatus for semiquantification of an analyte |
-
1996
- 1996-03-29 US US08/625,048 patent/US5753517A/en not_active Expired - Lifetime
-
1997
- 1997-03-27 WO PCT/US1997/004754 patent/WO1997037222A1/en not_active Ceased
- 1997-03-27 AT AT97916959T patent/ATE226729T1/de not_active IP Right Cessation
- 1997-03-27 JP JP53535997A patent/JP3753741B2/ja not_active Expired - Fee Related
- 1997-03-27 CA CA002250242A patent/CA2250242C/en not_active Expired - Fee Related
- 1997-03-27 DE DE69716589T patent/DE69716589D1/de not_active Expired - Lifetime
- 1997-03-27 EP EP97916959A patent/EP0890103B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE226729T1 (de) | 2002-11-15 |
| JP3753741B2 (ja) | 2006-03-08 |
| WO1997037222A1 (en) | 1997-10-09 |
| JP2001500249A (ja) | 2001-01-09 |
| EP0890103A1 (en) | 1999-01-13 |
| US5753517A (en) | 1998-05-19 |
| CA2250242A1 (en) | 1997-10-09 |
| EP0890103B1 (en) | 2002-10-23 |
| DE69716589D1 (de) | 2002-11-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2250242C (en) | Quantitative immunochromatographic assays | |
| JP2504923B2 (ja) | 免疫学的測定方法 | |
| US5166051A (en) | Membranes, membrane overlays for exclusion of erythrocytes, and method for immunoassay of whole blood analytes | |
| JP5181058B2 (ja) | ヒトａｂｏ／ｒｈ／ｍｎ血液型を迅速に判定する方法及びキット | |
| USRE39664E1 (en) | Lateral flow chromatographic binding assay device | |
| EP0306772B1 (en) | Lateral flow chromatographic binding assay device | |
| EP0560411B1 (en) | Specific binding assays | |
| US5824268A (en) | Rapid self-contained assay format | |
| US4020151A (en) | Method for quantitation of antigens or antibodies on a solid surface | |
| US5160486A (en) | Test carrier utilizing reaction of two bioaffine binding partners | |
| US7384796B2 (en) | Assays | |
| US7175992B2 (en) | Sensitive immunochromatographic assay | |
| US20040018576A1 (en) | Bence Jones protein testing cassette | |
| US20070148717A1 (en) | Sensitive immunochromatographic assay | |
| JPH11230963A (ja) | 血漿または血清試料の測定用装置 | |
| US4340564A (en) | Immunoadsorptive surface coating for solid-phase immunosubstrate and solid-phase immunosubstrate | |
| US5958339A (en) | Format for immunoassay in thin film | |
| CZ287467B6 (en) | Method of quick determination of an organ state based on detection one or more isoenzymes of glutathione S-transferase and apparatus for making the same | |
| EP0253581A1 (en) | Analytical element having water-soluble polymers and determinations using same | |
| EP0254457A1 (en) | Analytical element having spread control zone | |
| GB2186078A (en) | Method and apparatus for carrying out biochemical assay | |
| JP2574068B2 (ja) | 診断用アッセイ系 | |
| JP3284896B2 (ja) | 酵素免疫アッセイ装置及び方法 | |
| JP2001133457A (ja) | 安定性の向上した免疫分析装置および免疫分析装置の安定性を向上させる方法 | |
| JPH0694718A (ja) | 免疫クロマト試験方法およびこれに用いる試験具 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |