CA2244136A1 - 1-(pyrazol-3-yl-ethyl)-4-(indol-3-yl)-piperidine utilisee comme medicaments agissant sur le systeme nerveux central - Google Patents

1-(pyrazol-3-yl-ethyl)-4-(indol-3-yl)-piperidine utilisee comme medicaments agissant sur le systeme nerveux central Download PDF

Info

Publication number
CA2244136A1
CA2244136A1 CA002244136A CA2244136A CA2244136A1 CA 2244136 A1 CA2244136 A1 CA 2244136A1 CA 002244136 A CA002244136 A CA 002244136A CA 2244136 A CA2244136 A CA 2244136A CA 2244136 A1 CA2244136 A1 CA 2244136A1
Authority
CA
Canada
Prior art keywords
ethyl
methyl
indole
pyrazolyl
piperidyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002244136A
Other languages
English (en)
Inventor
Henning Bottcher
Joachim Marz
Gerd Bartoszyk
Hartmut Greiner
Jurgen Harting
Christoph Seyfried
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2244136A1 publication Critical patent/CA2244136A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne de nouveaux dérivés de la 1-pyrazol-3-yléthyl-4-indol-3-pipéridine, de formule (I), où R?1¿ est H ou A; R?2¿ est H, phényle 1 à 3 fois substitué par Hal, NO¿2?, CON(R?4¿)¿2?, SO¿2?N(R?4¿)¿2?, cyano, A ou R?4¿-O; R?3¿ est H, Hal, A, A-O-, amino, cyano, carboxamide, NO¿2?, SO¿2?N(R?4¿)¿2?; R?4¿ est H ou A; R?5¿ est H ou A; A est alkyle contenant 1 à 6 atomes de carbone ou alkyle contenant 1 à 6 atomes de carbone et 1 à 3 fois substitué par fluor; Hal est F, Cl, Br ou J. L'invention concerne également les sels desdits dérivés. On a découvert que ces substances ont une activité pharmaceutique intéressante.
CA002244136A 1996-01-25 1997-01-17 1-(pyrazol-3-yl-ethyl)-4-(indol-3-yl)-piperidine utilisee comme medicaments agissant sur le systeme nerveux central Abandoned CA2244136A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19602505A DE19602505A1 (de) 1996-01-25 1996-01-25 1-(Pyrazol-4-Indol-3-yl)-Piperidine
DE19602505.2 1996-01-25

Publications (1)

Publication Number Publication Date
CA2244136A1 true CA2244136A1 (fr) 1997-07-31

Family

ID=7783568

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002244136A Abandoned CA2244136A1 (fr) 1996-01-25 1997-01-17 1-(pyrazol-3-yl-ethyl)-4-(indol-3-yl)-piperidine utilisee comme medicaments agissant sur le systeme nerveux central

Country Status (16)

Country Link
EP (1) EP0879234A1 (fr)
JP (1) JP2000503972A (fr)
KR (1) KR19990081970A (fr)
CN (1) CN1209807A (fr)
AR (1) AR005549A1 (fr)
AU (1) AU715785B2 (fr)
BR (1) BR9707467A (fr)
CA (1) CA2244136A1 (fr)
CZ (1) CZ231898A3 (fr)
DE (1) DE19602505A1 (fr)
HU (1) HUP9900980A2 (fr)
NO (1) NO983439L (fr)
PL (1) PL328228A1 (fr)
SK (1) SK99298A3 (fr)
WO (1) WO1997027186A1 (fr)
ZA (1) ZA97572B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1214312E (pt) * 1999-09-09 2004-08-31 Lundbeck & Co As H Indoles 5-aminoalquilo e 5-aminocarbonilo substituidos
BR0015466A (pt) 1999-11-10 2002-08-06 Takeda Chemical Industries Ltd Composto, prodroga, composição farmacêutica, agentes para evitar ou tratar diabetes mellitus, hiperlipidemia e toler ncia à glicose prejudicada, para regular a função do receptor relacionado a retinóide e para melhorar a resistência à insulina e uso de um composto
US7332494B2 (en) 2000-08-14 2008-02-19 Janssen Pharmaceutica, N.V. Method for treating allergies using substituted pyrazoles
DK1309591T3 (da) 2000-08-14 2007-03-26 Ortho Mcneil Pharm Inc Substituerede pyrazoler
CA2467081A1 (fr) * 2001-11-14 2003-05-22 Henning Boettcher Derives de pyrazole utilises en tant que produits psychopharmaceutiques
CN101287738B (zh) 2005-10-11 2011-08-10 弗·哈夫曼-拉罗切有限公司 咪唑并苯并二氮杂*衍生物
US20080015214A1 (en) * 2005-10-24 2008-01-17 Bignan Gilles C 3-piperidin-4-yl-indole orl-1 receptor modulators
TWI548630B (zh) * 2011-04-06 2016-09-11 Ｌｇ生命科學有限公司 １－（３－氰基－１－異丙基－吲哚－５－基）吡唑－４－羧酸結晶型及其製造方法
EP4218755A4 (fr) * 2020-11-04 2024-03-27 Lg Chemical Ltd Procédé de préparation de particules cristallines d'acide 1-(3-cyano-1-isopropyl-indole-5-yl)pyrazole-4-carboxylique, et composition pharmaceutique les comprenant

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2060816C3 (de) * 1970-12-10 1980-09-04 Merck Patent Gmbh, 6100 Darmstadt 4-Phenylpiperidinderivate Verfahren zu ihrer Herstellung und pharmazeutische Zubereitungen enthaltend diese Verbindungen
DE2258033A1 (de) * 1972-11-27 1974-05-30 Merck Patent Gmbh Verfahren zur herstellung von pyrazolderivaten
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
US5045550A (en) * 1990-09-20 1991-09-03 Warner-Lambert Co. Substituted tetrahydropyridines as central nervous system agents
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine

Also Published As

Publication number Publication date
ZA97572B (en) 1997-08-04
NO983439D0 (no) 1998-07-24
SK99298A3 (en) 1999-01-11
AR005549A1 (es) 1999-06-23
NO983439L (no) 1998-09-25
JP2000503972A (ja) 2000-04-04
CZ231898A3 (cs) 1998-10-14
DE19602505A1 (de) 1997-07-31
AU715785B2 (en) 2000-02-10
AU1443297A (en) 1997-08-20
CN1209807A (zh) 1999-03-03
PL328228A1 (en) 1999-01-18
EP0879234A1 (fr) 1998-11-25
WO1997027186A1 (fr) 1997-07-31
HUP9900980A2 (hu) 1999-07-28
BR9707467A (pt) 1999-07-20
KR19990081970A (ko) 1999-11-15

Similar Documents

Publication Publication Date Title
RU2132848C1 (ru) Производные пиперидина и пиперазина, способ их получения, содержащие их фармацевтические композиции и способ их получения
US5698553A (en) Benzylpiperidine derivatives
RU2159238C2 (ru) Бензофураны и способ их получения
RU2168508C2 (ru) Бензонитрилы и бензофториды, способ их получения, фармацевтическая композиция, способ ее получения
KR100361950B1 (ko) 3-인돌릴피페리딘
EP0389861A1 (fr) Dérivés de benzopyranne et procédé pour leur préparation
US20130102783A1 (en) Substituted diketopiperazines and their use as oxytocin antagonists
JPH01265100A (ja) ２―置換アデノシン誘導体
KR20000005505A (ko) 피페리딘 및 피롤리딘
AU715785B2 (en) 1-(pyrazol-3-ylethyl)-4-(indol-3-yl) piperdines as compositions affecting the central nervous system
CA2128380C (fr) Derives de la 4-aryloxy- et de la 4-arylthiopiperidine
KR100384978B1 (ko) 유착수용체길항물질
JP2886570B2 (ja) 縮合ヘテロ環を有する化合物
JPH0699420B2 (ja) 水素添加された１−ベンゾオキサシクロアルキルピリジンカルボン酸化合物，その製造方法及び該化合物を含む医薬製剤
KR100384261B1 (ko) 나프틸옥시아세트산유도체
RU2175970C2 (ru) Производные пиперидинилметилоксазолидин-2-она, способ их получения и фармацевтическая композиция на их основе
FR2758329A1 (fr) Derives d'imidazole-4-butane boronique, leur preparation et leur utilisation en therapeutique
HU218274B (en) N,n'-bis hydroxyalkyl and alkoxyalkyl-pyridine-2,4-dicarboxylic acid diamide derivatives and pharmaceutical compositions comprising such compounds and process for producing them
JPS59118784A (ja) 置換イミダゾ〔１，５−ａ〕ピリジン及びその製造方法，並びに該化合物を含有する医薬
MXPA96003567A (es) Derivados de la piperidinilmetiloxazolidin-2-ona
EP0602458A1 (fr) Dérivés de 1,4-benzoxazine
KR890003357B1 (ko) 신규 티아졸 화합물의 제조방법
JPS62226977A (ja) ピリジン誘導体
JPH0673008A (ja) アンジオテンシンｉｉ拮抗性ピリジン誘導体
JPH0259571A (ja) ピリドン誘導体又はその塩類

Legal Events

Date Code Title Description
FZDE Discontinued