CA2224795C - Compositions and formulations for producing analgesia and for inhibiting progression of neuropathic pain disorders - Google Patents
Compositions and formulations for producing analgesia and for inhibiting progression of neuropathic pain disorders Download PDFInfo
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- CA2224795C CA2224795C CA002224795A CA2224795A CA2224795C CA 2224795 C CA2224795 C CA 2224795C CA 002224795 A CA002224795 A CA 002224795A CA 2224795 A CA2224795 A CA 2224795A CA 2224795 C CA2224795 C CA 2224795C
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- conopeptide
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- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 150000003668 tyrosines Chemical class 0.000 description 1
- 210000001170 unmyelinated nerve fiber Anatomy 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- KNJNGVKTAFTUFL-OCMUWRIYSA-N ω-conotoxin Chemical compound N([C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]1C(N[C@@H](CSSC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H]1C(N[C@@H](CCCN=C(N)N)C(=O)N[C@H](CO)C(=O)NCC(=O)N[C@H](CCCCN)C(=O)N[C@H](CSSC1)C(N)=O)=O)=O)C(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CCCCN)C(=O)NCC(=O)N[C@H](CCCCN)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](CCCCN)C(=O)N1 KNJNGVKTAFTUFL-OCMUWRIYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Control Of El Displays (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/496,847 US5795864A (en) | 1995-06-27 | 1995-06-27 | Stable omega conopetide formulations |
| US08/613,400 | 1996-03-08 | ||
| US08/496,847 | 1996-03-08 | ||
| US08/613,400 US6054429A (en) | 1996-03-08 | 1996-03-08 | Epidural method of producing analgesia |
| PCT/US1996/011041 WO1997001351A1 (en) | 1995-06-27 | 1996-06-26 | Compositions and formulations for producing analgesia and for inhibiting progression of neuropathic pain disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2224795A1 CA2224795A1 (en) | 1997-01-16 |
| CA2224795C true CA2224795C (en) | 2001-04-03 |
Family
ID=27052304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002224795A Expired - Fee Related CA2224795C (en) | 1995-06-27 | 1996-06-26 | Compositions and formulations for producing analgesia and for inhibiting progression of neuropathic pain disorders |
Country Status (13)
| Country | Link |
|---|---|
| EP (2) | EP1336409B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2838073B2 (cg-RX-API-DMAC7.html) |
| AT (2) | ATE235914T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU695166B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2224795C (cg-RX-API-DMAC7.html) |
| DE (3) | DE69637021T2 (cg-RX-API-DMAC7.html) |
| DK (2) | DK1336409T3 (cg-RX-API-DMAC7.html) |
| ES (2) | ES2194998T3 (cg-RX-API-DMAC7.html) |
| FR (1) | FR05C0027I2 (cg-RX-API-DMAC7.html) |
| LU (1) | LU91181I2 (cg-RX-API-DMAC7.html) |
| NL (1) | NL300201I2 (cg-RX-API-DMAC7.html) |
| PT (2) | PT835126E (cg-RX-API-DMAC7.html) |
| WO (1) | WO1997001351A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5931809A (en) | 1995-07-14 | 1999-08-03 | Depotech Corporation | Epidural administration of therapeutic compounds with sustained rate of release |
| JP2002509080A (ja) * | 1998-02-20 | 2002-03-26 | シンジェンタ リミテッド | グラモストラ・スパチュラタの毒から得られる鎮痛性ペプチドおよびその使用 |
| AUPP627498A0 (en) | 1998-10-02 | 1998-10-22 | University Of Queensland, The | Novel peptides - i |
| EP2412719A1 (en) | 2002-12-02 | 2012-02-01 | Xenome Ltd | Chi-conotoxin peptides |
| WO2004050690A1 (en) | 2002-12-02 | 2004-06-17 | Xenome Ltd | NOVEL χ-CONOTOXIN PEPTIDES (-I) |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| DE602004028678D1 (de) | 2003-01-28 | 2010-09-23 | Ironwood Pharmaceuticals Inc | Zusammensetzungen zur Behandlung von Magen-Darm-Störungen |
| JP2007507538A (ja) | 2003-10-02 | 2007-03-29 | エラン ファーマシューティカルズ，インコーポレイテッド | 疼痛軽減方法 |
| GB0410215D0 (en) * | 2004-05-07 | 2004-06-09 | Lescroart Pol | Nerve damage |
| US8188048B2 (en) | 2006-06-23 | 2012-05-29 | Xenome Limited | Combination therapy |
| US8673856B2 (en) * | 2006-11-04 | 2014-03-18 | Anygen Co., Ltd. | Omega conotoxins |
| MX354786B (es) | 2007-06-04 | 2018-03-21 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos. |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| US20110129508A1 (en) * | 2008-05-06 | 2011-06-02 | Relevare Aust. Pty Ltd | Methods and compositions for the management of pain using omega-conotoxins |
| CA2930674A1 (en) | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| JP2011528375A (ja) | 2008-07-16 | 2011-11-17 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト |
| CA2994066A1 (en) | 2008-12-03 | 2010-06-10 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase c agonists and methods of use |
| KR20220042487A (ko) | 2008-12-31 | 2022-04-05 | 알데릭스, 인코포레이티드 | 체액 저류 또는 염 과부하와 연관된 장애 및 위장관 장애의 치료 시에 ｎｈｅ-매개된 역수송을 억제하는 화합물 및 방법 |
| WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| JP6392754B2 (ja) | 2012-08-21 | 2018-09-19 | アーデリクス，インコーポレーテッド | 体液貯留又は塩過負荷に関係する疾患及び消化管疾患の治療におけるｎｈｅ仲介の逆輸送を阻害するための化合物並びに方法 |
| CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| BR112015025805A2 (pt) | 2013-04-12 | 2017-07-25 | Ardelyx Inc | compostos de ligação de nh3 e métodos para inibir o transporte de fosfato |
| EP4424697A3 (en) | 2013-06-05 | 2024-12-25 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
| WO2018129552A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds useful for treating gastrointestinal tract disorders |
| BR112019013963A2 (pt) | 2017-01-09 | 2020-04-28 | Ardelyx Inc | inibidores de antiporte mediado por nhe |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3926287A1 (de) * | 1989-08-09 | 1991-02-21 | Bernhard Clasbrummel | Medizinische anwendung von omega-conotoxin gvia oder omega-conotoxin gvia-analoga zur sympathikolyse |
| US5051403A (en) * | 1989-11-22 | 1991-09-24 | Neurex Corporation | Method of treating ischemia-related neuronal damage |
| AU3074592A (en) * | 1991-11-12 | 1993-06-15 | Neurex Corporation | Compositions for delayed treatment of ischemia-related neuronal damage |
| WO1993013128A1 (en) * | 1991-12-30 | 1993-07-08 | Neurex Corporation | Methods of producing analgesia and enhancing opiate analgesia |
| JPH06247879A (ja) * | 1993-02-17 | 1994-09-06 | Bristol Myers Squibb Co | デオキシチミジンヌクレオシドを含有する注射用製剤の安定化方法およびその方法によって得られる安定化注射用製剤 |
-
1996
- 1996-06-26 DE DE69637021T patent/DE69637021T2/de not_active Expired - Lifetime
- 1996-06-26 AT AT96923511T patent/ATE235914T1/de active
- 1996-06-26 ES ES96923511T patent/ES2194998T3/es not_active Expired - Lifetime
- 1996-06-26 AU AU64002/96A patent/AU695166B2/en not_active Ceased
- 1996-06-26 EP EP03007342A patent/EP1336409B1/en not_active Expired - Lifetime
- 1996-06-26 CA CA002224795A patent/CA2224795C/en not_active Expired - Fee Related
- 1996-06-26 EP EP96923511A patent/EP0835126B1/en not_active Expired - Lifetime
- 1996-06-26 WO PCT/US1996/011041 patent/WO1997001351A1/en not_active Ceased
- 1996-06-26 DE DE69627153T patent/DE69627153T2/de not_active Expired - Lifetime
- 1996-06-26 ES ES03007342T patent/ES2283671T3/es not_active Expired - Lifetime
- 1996-06-26 PT PT96923511T patent/PT835126E/pt unknown
- 1996-06-26 PT PT03007342T patent/PT1336409E/pt unknown
- 1996-06-26 DK DK03007342T patent/DK1336409T3/da active
- 1996-06-26 DK DK96923511T patent/DK0835126T3/da active
- 1996-06-26 AT AT03007342T patent/ATE359086T1/de active
- 1996-06-26 DE DE1996627153 patent/DE122005000043I2/de active Active
- 1996-06-27 JP JP8188120A patent/JP2838073B2/ja not_active Expired - Fee Related
-
2005
- 2005-06-23 FR FR05C0027C patent/FR05C0027I2/fr active Active
- 2005-07-06 LU LU91181C patent/LU91181I2/fr unknown
- 2005-07-13 NL NL300201C patent/NL300201I2/nl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU6400296A (en) | 1997-01-30 |
| DE69637021D1 (de) | 2007-05-24 |
| EP1336409A1 (en) | 2003-08-20 |
| DE69627153D1 (de) | 2003-05-08 |
| DE69627153T2 (de) | 2003-12-04 |
| EP0835126A1 (en) | 1998-04-15 |
| NL300201I2 (nl) | 2006-02-01 |
| EP1336409B1 (en) | 2007-04-11 |
| JP2838073B2 (ja) | 1998-12-16 |
| DE69637021T2 (de) | 2008-01-10 |
| DE122005000043I1 (de) | 2006-06-29 |
| DE122005000043I2 (de) | 2006-08-03 |
| FR05C0027I2 (cg-RX-API-DMAC7.html) | 2006-12-29 |
| PT1336409E (pt) | 2007-06-29 |
| EP0835126B1 (en) | 2003-04-02 |
| CA2224795A1 (en) | 1997-01-16 |
| AU695166B2 (en) | 1998-08-06 |
| ES2194998T3 (es) | 2003-12-01 |
| WO1997001351A1 (en) | 1997-01-16 |
| HK1058146A1 (en) | 2004-05-07 |
| LU91181I2 (fr) | 2005-09-06 |
| PT835126E (pt) | 2003-07-31 |
| ATE359086T1 (de) | 2007-05-15 |
| FR05C0027I1 (cg-RX-API-DMAC7.html) | 2005-08-12 |
| ES2283671T3 (es) | 2007-11-01 |
| JPH09104634A (ja) | 1997-04-22 |
| DK1336409T3 (da) | 2007-08-13 |
| DK0835126T3 (da) | 2003-07-14 |
| ATE235914T1 (de) | 2003-04-15 |
| NL300201I1 (nl) | 2005-09-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20140626 |