ES2194998T3 - Composiciones y formulaciones para producir analgesia y para inhibir la progresion de trastornos de dolor neuropatico. - Google Patents

Composiciones y formulaciones para producir analgesia y para inhibir la progresion de trastornos de dolor neuropatico.

Info

Publication number
ES2194998T3
ES2194998T3 ES96923511T ES96923511T ES2194998T3 ES 2194998 T3 ES2194998 T3 ES 2194998T3 ES 96923511 T ES96923511 T ES 96923511T ES 96923511 T ES96923511 T ES 96923511T ES 2194998 T3 ES2194998 T3 ES 2194998T3
Authority
ES
Spain
Prior art keywords
progression
neuropathic pain
formulations
inhibit
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96923511T
Other languages
English (en)
Inventor
Gary Arthur Amstutz
Stephen Scott Bowersox
Kishorchandra Gohil
Peter Isadore Adriaenssens
Ramasharma Kristipati
Theresa Gadbois
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Pharmaceuticals LLC
Original Assignee
Elan Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/496,847 external-priority patent/US5795864A/en
Priority claimed from US08/613,400 external-priority patent/US6054429A/en
Application filed by Elan Pharmaceuticals LLC filed Critical Elan Pharmaceuticals LLC
Application granted granted Critical
Publication of ES2194998T3 publication Critical patent/ES2194998T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Control Of El Displays (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE DESCRIBEN MEDICAMENTOS QUE CONTIENEN OMEGA - CONOPEPTIDOS PARA INHIBIR EL AVANCE DE TRASTORNOS DE DOLOR NEUROPATICOS. LA INVENCION TAMBIEN INCLUYE UN FORMULADO DE OMEGA - CONOPEPTIDOS QUE EVITA LA OXIDACION DEL PEPTIDO, ASI COMO LOS NUEVOS OMEGA CONOPEPTIDOS SNX - 273 Y SNX - 279. EN UN ASPECTO RELACIONADO, LA INVENCION INCLUYE UN PROCEDIMIENTO MEJORADO DE ADMINISTRACION EPIDURAL DE OMEGA - CONOPEPTIDOS.
ES96923511T 1995-06-27 1996-06-26 Composiciones y formulaciones para producir analgesia y para inhibir la progresion de trastornos de dolor neuropatico. Expired - Lifetime ES2194998T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/496,847 US5795864A (en) 1995-06-27 1995-06-27 Stable omega conopetide formulations
US08/613,400 US6054429A (en) 1996-03-08 1996-03-08 Epidural method of producing analgesia

Publications (1)

Publication Number Publication Date
ES2194998T3 true ES2194998T3 (es) 2003-12-01

Family

ID=27052304

Family Applications (2)

Application Number Title Priority Date Filing Date
ES03007342T Expired - Lifetime ES2283671T3 (es) 1995-06-27 1996-06-26 Composiciones y formulaciones para producir analgesia y para inhibir la progresion de transtornos de dolor neuropatico.
ES96923511T Expired - Lifetime ES2194998T3 (es) 1995-06-27 1996-06-26 Composiciones y formulaciones para producir analgesia y para inhibir la progresion de trastornos de dolor neuropatico.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES03007342T Expired - Lifetime ES2283671T3 (es) 1995-06-27 1996-06-26 Composiciones y formulaciones para producir analgesia y para inhibir la progresion de transtornos de dolor neuropatico.

Country Status (14)

Country Link
EP (2) EP0835126B1 (es)
JP (1) JP2838073B2 (es)
AT (2) ATE359086T1 (es)
AU (1) AU695166B2 (es)
CA (1) CA2224795C (es)
DE (3) DE69627153T2 (es)
DK (2) DK0835126T3 (es)
ES (2) ES2283671T3 (es)
FR (1) FR05C0027I2 (es)
HK (1) HK1058146A1 (es)
LU (1) LU91181I2 (es)
NL (1) NL300201I2 (es)
PT (2) PT835126E (es)
WO (1) WO1997001351A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5931809A (en) * 1995-07-14 1999-08-03 Depotech Corporation Epidural administration of therapeutic compounds with sustained rate of release
EP1054896A1 (en) * 1998-02-20 2000-11-29 Zeneca Limited ANALGESIC PEPTIDES FROM VENOM OF $i(GRAMMOSTOLA SPATULATA) AND USE THEREOF
AUPP627498A0 (en) 1998-10-02 1998-10-22 University Of Queensland, The Novel peptides - i
EP2412719A1 (en) 2002-12-02 2012-02-01 Xenome Ltd Chi-conotoxin peptides
ES2383358T3 (es) 2002-12-02 2012-06-20 Xenome Ltd Péptidos de chi-conotoxina que tienen un ácido piroglutámico N-terminal
SG192300A1 (en) 2003-01-28 2013-08-30 Ironwood Pharmaceuticals Inc Methods and compositions for the treatment of gastrointestinal disorders
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EP1689401A1 (en) 2003-10-02 2006-08-16 Elan Pharmaceuticals, Inc. Method for reducing pain
GB0410215D0 (en) * 2004-05-07 2004-06-09 Lescroart Pol Nerve damage
US8188048B2 (en) 2006-06-23 2012-05-29 Xenome Limited Combination therapy
JP2010509209A (ja) * 2006-11-04 2010-03-25 エニジェン カンパニー リミテッド 新規なω−コノトキシン
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
EP2300044A4 (en) * 2008-05-06 2012-04-18 Relevare Aust Pty Ltd METHOD AND COMPOSITIONS FOR TREATING PAIN WITH OMEGA CONOTOXINES
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2010009319A2 (en) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
WO2010065751A2 (en) 2008-12-03 2010-06-10 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase c agonists and methods of use
WO2010078449A2 (en) 2008-12-31 2010-07-08 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN104902930A (zh) 2012-08-21 2015-09-09 阿德利克斯公司 在治疗与液体潴留或盐分过载相关的疾病和胃肠道疾病中用于抑制nhe-介导的反向转运的化合物和方法
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
HUE044550T2 (hu) 2013-04-12 2019-11-28 Ardelyx Inc NHE-3 megkötõ vegyületek és foszfát transzport gátlási módszerek
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
CN110267944B (zh) 2017-01-09 2024-03-08 阿德利克斯股份有限公司 可用于治疗胃肠道病症的化合物
JP2020505333A (ja) 2017-01-09 2020-02-20 アルデリックス， インコーポレイテッド Ｎｈｅ媒介性アンチポートの阻害薬

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3926287A1 (de) * 1989-08-09 1991-02-21 Bernhard Clasbrummel Medizinische anwendung von omega-conotoxin gvia oder omega-conotoxin gvia-analoga zur sympathikolyse
US5051403A (en) * 1989-11-22 1991-09-24 Neurex Corporation Method of treating ischemia-related neuronal damage
WO1993010145A1 (en) * 1991-11-12 1993-05-27 Neurex Corporation Compositions for delayed treatment of ischemia-related neuronal damage
AU689438B2 (en) * 1991-12-30 1998-04-02 Azur Pharma International Limited Methods of producing analgesia and enhancing opiate analgesia
JPH06247879A (ja) * 1993-02-17 1994-09-06 Bristol Myers Squibb Co デオキシチミジンヌクレオシドを含有する注射用製剤の安定化方法およびその方法によって得られる安定化注射用製剤

Also Published As

Publication number Publication date
PT1336409E (pt) 2007-06-29
DE69637021D1 (de) 2007-05-24
EP0835126B1 (en) 2003-04-02
ES2283671T3 (es) 2007-11-01
DK1336409T3 (da) 2007-08-13
DE69627153D1 (de) 2003-05-08
HK1058146A1 (en) 2004-05-07
DE69627153T2 (de) 2003-12-04
EP1336409B1 (en) 2007-04-11
LU91181I2 (fr) 2005-09-06
ATE235914T1 (de) 2003-04-15
AU6400296A (en) 1997-01-30
CA2224795A1 (en) 1997-01-16
JP2838073B2 (ja) 1998-12-16
CA2224795C (en) 2001-04-03
DE122005000043I2 (de) 2006-08-03
FR05C0027I2 (es) 2006-12-29
EP1336409A1 (en) 2003-08-20
NL300201I2 (nl) 2006-02-01
JPH09104634A (ja) 1997-04-22
NL300201I1 (nl) 2005-09-01
DK0835126T3 (da) 2003-07-14
DE122005000043I1 (de) 2006-06-29
DE69637021T2 (de) 2008-01-10
ATE359086T1 (de) 2007-05-15
PT835126E (pt) 2003-07-31
FR05C0027I1 (es) 2005-08-12
WO1997001351A1 (en) 1997-01-16
AU695166B2 (en) 1998-08-06
EP0835126A1 (en) 1998-04-15

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