CA2224114A1 - Synthetic mammalian chromosome and methods for construction - Google Patents
Synthetic mammalian chromosome and methods for construction Download PDFInfo
- Publication number
- CA2224114A1 CA2224114A1 CA002224114A CA2224114A CA2224114A1 CA 2224114 A1 CA2224114 A1 CA 2224114A1 CA 002224114 A CA002224114 A CA 002224114A CA 2224114 A CA2224114 A CA 2224114A CA 2224114 A1 CA2224114 A1 CA 2224114A1
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- dna
- genomic dna
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/20—Pseudochromosomes, minichrosomosomes
- C12N2800/204—Pseudochromosomes, minichrosomosomes of bacterial origin, e.g. BAC
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/20—Pseudochromosomes, minichrosomosomes
- C12N2800/208—Pseudochromosomes, minichrosomosomes of mammalian origin, e.g. minichromosome
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/487,989 US5695967A (en) | 1995-06-07 | 1995-06-07 | Method for stably cloning large repeating units of DNA |
| US08/487,989 | 1995-06-07 | ||
| US08/643,554 US6348353B1 (en) | 1995-06-07 | 1996-05-06 | Artificial mammalian chromosome |
| US08/643,554 | 1996-05-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2224114A1 true CA2224114A1 (en) | 1996-12-19 |
Family
ID=27049198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002224114A Abandoned CA2224114A1 (en) | 1995-06-07 | 1996-06-07 | Synthetic mammalian chromosome and methods for construction |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US6348353B1 (enExample) |
| EP (1) | EP0832273A1 (enExample) |
| JP (1) | JPH11507540A (enExample) |
| CN (1) | CN1191574A (enExample) |
| AU (1) | AU724695B2 (enExample) |
| BR (1) | BR9608586A (enExample) |
| CA (1) | CA2224114A1 (enExample) |
| HU (1) | HUP9901072A2 (enExample) |
| IL (1) | IL122414A0 (enExample) |
| MX (1) | MX9709317A (enExample) |
| NZ (1) | NZ311448A (enExample) |
| WO (1) | WO1996040965A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5869294A (en) * | 1995-06-07 | 1999-02-09 | Case Western Reserve University | Method for stably cloning large repeating DNA sequences |
| US6348353B1 (en) * | 1995-06-07 | 2002-02-19 | Case Western Reserve University | Artificial mammalian chromosome |
| US6632976B1 (en) | 1995-08-29 | 2003-10-14 | Kirin Beer Kabushiki Kaisha | Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene |
| US6077697A (en) * | 1996-04-10 | 2000-06-20 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
| US6025155A (en) * | 1996-04-10 | 2000-02-15 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
| JP4022835B2 (ja) | 1996-08-26 | 2007-12-19 | 株式会社クロモリサーチ | 哺乳類人工染色体 |
| WO1998051790A1 (en) | 1997-05-13 | 1998-11-19 | Amrad Operations Pty. Ltd. | A novel nucleic acid molecule |
| DE19720839B4 (de) * | 1997-05-17 | 2007-08-16 | Dirk Dr. Schindelhauer | Baukastenprinzip-Technologie zur Herstellung von langen, exakten DNA-Konstrukten in vitro, insbesondere für die Herstellung von Konstrukten zur Erzeugung von künstlichen Chromosomen (MAC, mammalian artificial chromosome) aus zwei stabil klonierten DNA-Komponenten und der ditelomerische Vektor-Prototyp PTAT |
| US7235716B2 (en) | 1997-06-03 | 2007-06-26 | Chromatin, Inc. | Plant centromere compositions |
| US6900012B1 (en) | 1997-06-03 | 2005-05-31 | The University Of Chicago | Plant artificial chromosome compositions and methods |
| US7227057B2 (en) | 1997-06-03 | 2007-06-05 | Chromatin, Inc. | Plant centromere compositions |
| US7119250B2 (en) * | 1997-06-03 | 2006-10-10 | The University Of Chicago | Plant centromere compositions |
| US7193128B2 (en) | 1997-06-03 | 2007-03-20 | Chromatin, Inc. | Methods for generating or increasing revenues from crops |
| US6090584A (en) * | 1997-08-21 | 2000-07-18 | University Technologies International Inc. | Baculovirus artificial chromosomes and methods of use |
| DE50015858D1 (de) * | 1999-02-19 | 2010-03-18 | Febit Holding Gmbh | Verfahren zur Herstellung von Polymeren |
| US7989202B1 (en) | 1999-03-18 | 2011-08-02 | The University Of Chicago | Plant centromere compositions |
| WO2001045749A1 (en) * | 1999-12-22 | 2001-06-28 | The Trustees Of The University Of Pennsylvania | Cosmid dna constructs and methods of making and using the same |
| CN100448992C (zh) * | 2001-05-11 | 2009-01-07 | 麒麟医药株式会社 | 含人抗体λ轻链基因的人类人工染色体 |
| US20040210955A1 (en) * | 2001-10-26 | 2004-10-21 | Hidenori Akutsu | Preparation of spermatozoa for ICSI-mediated transgenesis and methods of using the same |
| AU2002953516A0 (en) * | 2002-12-23 | 2003-01-16 | Murdoch Childrens Research Institute | Genetic therapy and genetic modification |
| WO2005010142A2 (en) * | 2003-06-27 | 2005-02-03 | Chromatin, Inc. | Plant centromere compositions |
| WO2005014786A2 (en) * | 2003-08-07 | 2005-02-17 | Athersys, Inc. | Enhanced engineered chromosome formation from alpha satellite with artificially increased density of cenp-b boxes |
| EP1718754A1 (en) * | 2004-02-23 | 2006-11-08 | Chromatin, Inc. | Plants modified with mini-chromosomes |
| ES2679282T3 (es) | 2004-10-22 | 2018-08-23 | Revivicor Inc. | Porcinos transgénicos que carecen de cadena ligera de inmunoglobulina endógena |
| EP1929019A2 (en) * | 2005-09-08 | 2008-06-11 | Chromatin, Inc. | Plants modified with mini-chromosomes |
| US8614089B2 (en) * | 2007-03-15 | 2013-12-24 | Chromatin, Inc. | Centromere sequences and minichromosomes |
| US9593329B2 (en) * | 2007-10-08 | 2017-03-14 | Synthetic Genomics, Inc. | Assembly of large nucleic acids |
| DK2348827T3 (en) | 2008-10-27 | 2015-07-20 | Revivicor Inc | IMMUNICIPLY COMPROMATED PETS |
| CA2767724A1 (en) | 2009-07-23 | 2011-01-27 | Chromatin, Inc. | Sorghum centromere sequences and minichromosomes |
| EP3256582A4 (en) * | 2015-02-09 | 2018-06-20 | Edward Perkins | Compositions and methods for monitoring in real-time construction and bioengineering of mammalian synthetic chromosomes |
| CN106318965B (zh) * | 2015-06-26 | 2019-05-07 | 深圳华大生命科学研究院 | 人工半合成染色体的整合方法及含有完整合成染色体的微生物 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5202256A (en) | 1984-09-13 | 1993-04-13 | Enzon Labs, Inc. | Bioadhesive precursor protein expression vectors |
| US5242808A (en) | 1984-09-13 | 1993-09-07 | Enzon, Inc. | Production of bioadhesive precursor protein analogs by genetically engineered organisms |
| US5049504A (en) | 1986-11-24 | 1991-09-17 | Genex Corporation | Bioadhesive coding sequences |
| US5149657A (en) | 1984-09-13 | 1992-09-22 | Enzon Labs Inc. | Escherichia coli expression vector encoding bioadhesive precursor protein analogs comprising three to twenty repeats of the decapeptide (Ala-Lys-Pro-Ser-Tyr-Pro-Pro-Thr-Tyr-Lys) |
| US5202236A (en) | 1984-09-13 | 1993-04-13 | Enzon Labs Inc. | Method of producing bioadhesive protein |
| FR2593827B1 (fr) | 1986-01-31 | 1989-12-22 | Inst Nat Sante Rech Med | Fragments d'adn utilisables dans des vecteurs pour le maintien hereditaire de genes etrangers a l'etat autonome dans des animaux transgeniques, procede pour leur obtention et applications biologiques |
| US4889806A (en) * | 1987-04-15 | 1989-12-26 | Washington University | Large DNA cloning system based on yeast artificial chromosomes |
| US4889906A (en) * | 1988-11-25 | 1989-12-26 | Monsanto Company | Amine salts of 1,4,2-oxazaphospholidine-4-acetic acid, 2-alkoxy-2-oxides |
| WO1991007496A1 (en) | 1989-11-09 | 1991-05-30 | Allied-Signal Inc. | Cloning and expression of genes encoding for polypeptides comprised of one or more repeating amino acid sequences |
| WO1992007080A1 (en) | 1990-10-17 | 1992-04-30 | Board Of Regents, The University Of Texas System | A eukaryotic episomal dna cloning and expression vector |
| US5288625A (en) | 1991-09-13 | 1994-02-22 | Biologic Research Center Of The Hungarian Academy Of Sciences | Mammalian artificial chromosomes |
| GB9410446D0 (en) * | 1994-05-25 | 1994-07-13 | Cancer Res Campaign Tech | Novel chromosome fragment |
| US5869294A (en) | 1995-06-07 | 1999-02-09 | Case Western Reserve University | Method for stably cloning large repeating DNA sequences |
| US5695967A (en) | 1995-06-07 | 1997-12-09 | Case Western Reserve University | Method for stably cloning large repeating units of DNA |
| US6348353B1 (en) | 1995-06-07 | 2002-02-19 | Case Western Reserve University | Artificial mammalian chromosome |
| US6077697A (en) * | 1996-04-10 | 2000-06-20 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
-
1996
- 1996-05-06 US US08/643,554 patent/US6348353B1/en not_active Expired - Fee Related
- 1996-06-07 IL IL12241496A patent/IL122414A0/xx unknown
- 1996-06-07 NZ NZ31144896A patent/NZ311448A/xx unknown
- 1996-06-07 EP EP96921588A patent/EP0832273A1/en not_active Withdrawn
- 1996-06-07 AU AU62781/96A patent/AU724695B2/en not_active Ceased
- 1996-06-07 BR BR9608586A patent/BR9608586A/pt unknown
- 1996-06-07 JP JP9502261A patent/JPH11507540A/ja not_active Ceased
- 1996-06-07 WO PCT/US1996/010248 patent/WO1996040965A1/en not_active Ceased
- 1996-06-07 HU HU9901072A patent/HUP9901072A2/hu unknown
- 1996-06-07 CN CN96195654A patent/CN1191574A/zh active Pending
- 1996-06-07 CA CA002224114A patent/CA2224114A1/en not_active Abandoned
-
1997
- 1997-12-01 MX MX9709317A patent/MX9709317A/es not_active IP Right Cessation
-
2001
- 2001-12-19 US US10/023,033 patent/US20030003466A1/en not_active Abandoned
-
2004
- 2004-10-26 US US10/972,786 patent/US20050196837A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996040965A1 (en) | 1996-12-19 |
| US20050196837A1 (en) | 2005-09-08 |
| CN1191574A (zh) | 1998-08-26 |
| HUP9901072A2 (hu) | 1999-07-28 |
| US20030003466A1 (en) | 2003-01-02 |
| AU724695B2 (en) | 2000-09-28 |
| AU6278196A (en) | 1996-12-30 |
| EP0832273A1 (en) | 1998-04-01 |
| JPH11507540A (ja) | 1999-07-06 |
| NZ311448A (en) | 2004-12-24 |
| IL122414A0 (en) | 1998-06-15 |
| MX9709317A (es) | 1998-08-30 |
| BR9608586A (pt) | 1998-12-29 |
| US6348353B1 (en) | 2002-02-19 |
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |