IL122414A0 - Synthetic mammalian chromosome and methods for construction - Google Patents

Synthetic mammalian chromosome and methods for construction

Info

Publication number
IL122414A0
IL122414A0 IL12241496A IL12241496A IL122414A0 IL 122414 A0 IL122414 A0 IL 122414A0 IL 12241496 A IL12241496 A IL 12241496A IL 12241496 A IL12241496 A IL 12241496A IL 122414 A0 IL122414 A0 IL 122414A0
Authority
IL
Israel
Prior art keywords
construction
methods
mammalian chromosome
synthetic mammalian
synthetic
Prior art date
Application number
IL12241496A
Other languages
English (en)
Original Assignee
Univ Case Western Reserve
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/487,989 external-priority patent/US5695967A/en
Application filed by Univ Case Western Reserve filed Critical Univ Case Western Reserve
Priority to IL15619896A priority Critical patent/IL156198A0/xx
Publication of IL122414A0 publication Critical patent/IL122414A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/20—Pseudochromosomes, minichrosomosomes
    • C12N2800/204—Pseudochromosomes, minichrosomosomes of bacterial origin, e.g. BAC
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/20—Pseudochromosomes, minichrosomosomes
    • C12N2800/208—Pseudochromosomes, minichrosomosomes of mammalian origin, e.g. minichromosome

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL12241496A 1995-06-07 1996-06-07 Synthetic mammalian chromosome and methods for construction IL122414A0 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL15619896A IL156198A0 (en) 1995-06-07 1996-06-07 Methods for cloning repeating units of dna and vectors containing sequences consisting of repeating dna arrays

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/487,989 US5695967A (en) 1995-06-07 1995-06-07 Method for stably cloning large repeating units of DNA
US08/643,554 US6348353B1 (en) 1995-06-07 1996-05-06 Artificial mammalian chromosome

Publications (1)

Publication Number Publication Date
IL122414A0 true IL122414A0 (en) 1998-06-15

Family

ID=27049198

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12241496A IL122414A0 (en) 1995-06-07 1996-06-07 Synthetic mammalian chromosome and methods for construction

Country Status (12)

Country Link
US (3) US6348353B1 (enExample)
EP (1) EP0832273A1 (enExample)
JP (1) JPH11507540A (enExample)
CN (1) CN1191574A (enExample)
AU (1) AU724695B2 (enExample)
BR (1) BR9608586A (enExample)
CA (1) CA2224114A1 (enExample)
HU (1) HUP9901072A2 (enExample)
IL (1) IL122414A0 (enExample)
MX (1) MX9709317A (enExample)
NZ (1) NZ311448A (enExample)
WO (1) WO1996040965A1 (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869294A (en) * 1995-06-07 1999-02-09 Case Western Reserve University Method for stably cloning large repeating DNA sequences
US6348353B1 (en) * 1995-06-07 2002-02-19 Case Western Reserve University Artificial mammalian chromosome
US6632976B1 (en) 1995-08-29 2003-10-14 Kirin Beer Kabushiki Kaisha Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene
US6077697A (en) * 1996-04-10 2000-06-20 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US6025155A (en) * 1996-04-10 2000-02-15 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
JP4022835B2 (ja) 1996-08-26 2007-12-19 株式会社クロモリサーチ 哺乳類人工染色体
WO1998051790A1 (en) 1997-05-13 1998-11-19 Amrad Operations Pty. Ltd. A novel nucleic acid molecule
DE19720839B4 (de) * 1997-05-17 2007-08-16 Dirk Dr. Schindelhauer Baukastenprinzip-Technologie zur Herstellung von langen, exakten DNA-Konstrukten in vitro, insbesondere für die Herstellung von Konstrukten zur Erzeugung von künstlichen Chromosomen (MAC, mammalian artificial chromosome) aus zwei stabil klonierten DNA-Komponenten und der ditelomerische Vektor-Prototyp PTAT
US7235716B2 (en) 1997-06-03 2007-06-26 Chromatin, Inc. Plant centromere compositions
US6900012B1 (en) 1997-06-03 2005-05-31 The University Of Chicago Plant artificial chromosome compositions and methods
US7227057B2 (en) 1997-06-03 2007-06-05 Chromatin, Inc. Plant centromere compositions
US7119250B2 (en) * 1997-06-03 2006-10-10 The University Of Chicago Plant centromere compositions
US7193128B2 (en) 1997-06-03 2007-03-20 Chromatin, Inc. Methods for generating or increasing revenues from crops
US6090584A (en) * 1997-08-21 2000-07-18 University Technologies International Inc. Baculovirus artificial chromosomes and methods of use
DE50015858D1 (de) * 1999-02-19 2010-03-18 Febit Holding Gmbh Verfahren zur Herstellung von Polymeren
US7989202B1 (en) 1999-03-18 2011-08-02 The University Of Chicago Plant centromere compositions
WO2001045749A1 (en) * 1999-12-22 2001-06-28 The Trustees Of The University Of Pennsylvania Cosmid dna constructs and methods of making and using the same
CN100448992C (zh) * 2001-05-11 2009-01-07 麒麟医药株式会社 含人抗体λ轻链基因的人类人工染色体
US20040210955A1 (en) * 2001-10-26 2004-10-21 Hidenori Akutsu Preparation of spermatozoa for ICSI-mediated transgenesis and methods of using the same
AU2002953516A0 (en) * 2002-12-23 2003-01-16 Murdoch Childrens Research Institute Genetic therapy and genetic modification
WO2005010142A2 (en) * 2003-06-27 2005-02-03 Chromatin, Inc. Plant centromere compositions
WO2005014786A2 (en) * 2003-08-07 2005-02-17 Athersys, Inc. Enhanced engineered chromosome formation from alpha satellite with artificially increased density of cenp-b boxes
EP1718754A1 (en) * 2004-02-23 2006-11-08 Chromatin, Inc. Plants modified with mini-chromosomes
ES2679282T3 (es) 2004-10-22 2018-08-23 Revivicor Inc. Porcinos transgénicos que carecen de cadena ligera de inmunoglobulina endógena
EP1929019A2 (en) * 2005-09-08 2008-06-11 Chromatin, Inc. Plants modified with mini-chromosomes
US8614089B2 (en) * 2007-03-15 2013-12-24 Chromatin, Inc. Centromere sequences and minichromosomes
US9593329B2 (en) * 2007-10-08 2017-03-14 Synthetic Genomics, Inc. Assembly of large nucleic acids
DK2348827T3 (en) 2008-10-27 2015-07-20 Revivicor Inc IMMUNICIPLY COMPROMATED PETS
CA2767724A1 (en) 2009-07-23 2011-01-27 Chromatin, Inc. Sorghum centromere sequences and minichromosomes
EP3256582A4 (en) * 2015-02-09 2018-06-20 Edward Perkins Compositions and methods for monitoring in real-time construction and bioengineering of mammalian synthetic chromosomes
CN106318965B (zh) * 2015-06-26 2019-05-07 深圳华大生命科学研究院 人工半合成染色体的整合方法及含有完整合成染色体的微生物

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202256A (en) 1984-09-13 1993-04-13 Enzon Labs, Inc. Bioadhesive precursor protein expression vectors
US5242808A (en) 1984-09-13 1993-09-07 Enzon, Inc. Production of bioadhesive precursor protein analogs by genetically engineered organisms
US5049504A (en) 1986-11-24 1991-09-17 Genex Corporation Bioadhesive coding sequences
US5149657A (en) 1984-09-13 1992-09-22 Enzon Labs Inc. Escherichia coli expression vector encoding bioadhesive precursor protein analogs comprising three to twenty repeats of the decapeptide (Ala-Lys-Pro-Ser-Tyr-Pro-Pro-Thr-Tyr-Lys)
US5202236A (en) 1984-09-13 1993-04-13 Enzon Labs Inc. Method of producing bioadhesive protein
FR2593827B1 (fr) 1986-01-31 1989-12-22 Inst Nat Sante Rech Med Fragments d'adn utilisables dans des vecteurs pour le maintien hereditaire de genes etrangers a l'etat autonome dans des animaux transgeniques, procede pour leur obtention et applications biologiques
US4889806A (en) * 1987-04-15 1989-12-26 Washington University Large DNA cloning system based on yeast artificial chromosomes
US4889906A (en) * 1988-11-25 1989-12-26 Monsanto Company Amine salts of 1,4,2-oxazaphospholidine-4-acetic acid, 2-alkoxy-2-oxides
WO1991007496A1 (en) 1989-11-09 1991-05-30 Allied-Signal Inc. Cloning and expression of genes encoding for polypeptides comprised of one or more repeating amino acid sequences
WO1992007080A1 (en) 1990-10-17 1992-04-30 Board Of Regents, The University Of Texas System A eukaryotic episomal dna cloning and expression vector
US5288625A (en) 1991-09-13 1994-02-22 Biologic Research Center Of The Hungarian Academy Of Sciences Mammalian artificial chromosomes
GB9410446D0 (en) * 1994-05-25 1994-07-13 Cancer Res Campaign Tech Novel chromosome fragment
US5869294A (en) 1995-06-07 1999-02-09 Case Western Reserve University Method for stably cloning large repeating DNA sequences
US5695967A (en) 1995-06-07 1997-12-09 Case Western Reserve University Method for stably cloning large repeating units of DNA
US6348353B1 (en) 1995-06-07 2002-02-19 Case Western Reserve University Artificial mammalian chromosome
US6077697A (en) * 1996-04-10 2000-06-20 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes

Also Published As

Publication number Publication date
WO1996040965A1 (en) 1996-12-19
US20050196837A1 (en) 2005-09-08
CN1191574A (zh) 1998-08-26
HUP9901072A2 (hu) 1999-07-28
US20030003466A1 (en) 2003-01-02
AU724695B2 (en) 2000-09-28
AU6278196A (en) 1996-12-30
EP0832273A1 (en) 1998-04-01
JPH11507540A (ja) 1999-07-06
CA2224114A1 (en) 1996-12-19
NZ311448A (en) 2004-12-24
MX9709317A (es) 1998-08-30
BR9608586A (pt) 1998-12-29
US6348353B1 (en) 2002-02-19

Similar Documents

Publication Publication Date Title
IL122414A0 (en) Synthetic mammalian chromosome and methods for construction
IL125126A0 (en) Electroconversion cell
GB9518220D0 (en) Checkpoint gene
SG55098A1 (en) Naphthyl compounds intermediates compounds and methods
EP0851759A4 (en) COMPOUNDS AND RELATED METHODS
IL133582A0 (en) Mammalian neuro-growth factor like protein
GB9512486D0 (en) Support
GB9605453D0 (en) Cultured cells
EP0854941A4 (en) ELECTROCHEMICAL SYSTEM
GB2302588B (en) Probe changing system
EP0733746A3 (de) Halter
AUPN366695A0 (en) Cultured pearls
GB9522756D0 (en) Cell line and method
AU7238796A (en) Methods for inducing selected cell types
IL117145A0 (en) B cell differentiation and proliferation factors and methods for obtaining and using the same
GB9722556D0 (en) Methods
AU5611296A (en) Cultured pearls
GB9610809D0 (en) Differentiation agents
GB9511502D0 (en) Electrochemical methods
GB9510472D0 (en) Support
HUP9900243A2 (hu) Sejtdifferenciálódást befolyásoló hatóanyagok
GB9520271D0 (en) Photobioreactors
AU5636496A (en) Improved methods for transfecting t cells
GB9619597D0 (en) Culture system
GB9513428D0 (en) Culturing of cells